公开(公告)号：US08333888B2

公开(公告)日：2012-12-18

申请号：US13024035

申请日：2011-02-09

Applicant: Guillaume Delapierre ,  Nicolas Sarrut ,  Gilles Marchand

Inventor： Guillaume Delapierre ,  Nicolas Sarrut ,  Gilles Marchand

IPC: B01D57/02 ,  B01D11/04

CPC classification number: B01D11/04 ,  B01D11/0496

Abstract: A microfluidic system including: a substrate, one surface of which is covered with electrodes configured to move, under effect of an electric field, microdrops of a liquid phase including at least one functionalized ionic liquid; and capillaries for introducing a liquid extraction fluid onto the surface and for extracting the liquid extraction fluid from an orifice by forced convection, to obtain an extraction bath located on the surface for extraction of at least one chemical or biological compound from the liquid phase, and the bath is open to a surrounding space on at least two of its opposite sides, for moving, in contact with the surface, the microdrop upstream and downstream of the bath.

Abstract translation: 一种微流体系统，包括：衬底，其一个表面被电极覆盖，电极被配置为在电场的作用下移动包含至少一种官能化离子液体的液相的微滴; 以及用于将液体提取液引入到表面上并通过强制对流从孔中提取液体提取流体的毛细管，以获得位于表面上的用于从液相中萃取至少一种化学或生物化合物的提取液，以及 浴在至少两个相对侧面上的周围空间开口，用于与表面接触，在浴的上游和下游移动微滴。

公开(公告)号：US07914679B2

公开(公告)日：2011-03-29

申请号：US11912077

申请日：2006-04-06

Applicant: Guillaume Delapierre ,  Nicolas Sarrut ,  Gilles Marchand

Inventor： Guillaume Delapierre ,  Nicolas Sarrut ,  Gilles Marchand

IPC: B01D11/04

CPC classification number: B01D11/04 ,  B01D11/0496

Abstract: A method for extracting at least one chemical or biological compound from a liquid phase including at least one functionalized ionic liquid, via a liquid extracting fluid that is miscible with the ionic liquid, and a microfluidic system implementing the method. The extraction method includes moving, on one surface of a microfluidic system, at least one microdrop of the liquid phase into an extraction solution that includes the extracting fluid and that is localized on the surface to obtain in output of the solution, under effect of an electric field, an extract moving away from the surface that is rich in extracting fluid and enriched in the at least one compound, and a raffinate moving on the surface that is rich in ionic liquid and deleted in the at least one compound.

Abstract translation: 一种从包含至少一种功能化的离子液体的液相中提取至少一种化学或生物化合物的方法，通过可与离子液体混溶的液体提取液，以及实施该方法的微流体系统。 提取方法包括在微流体系统的一个表面上将液相的至少一个微滴移动到包括萃取流体并且定位在表面上以在溶液的输出中获得的提取溶液中，在 电场，从表面富含萃取液并富集至少一种化合物的提取物，以及在富含离子液体的表面上移动并在至少一种化合物中缺失的萃余液。

公开(公告)号：US20100018864A1

公开(公告)日：2010-01-28

申请号：US12505395

申请日：2009-07-17

Applicant: Nicolas Sarrut ,  Olivier Constantin

Inventor： Nicolas Sarrut ,  Olivier Constantin

IPC: G01N33/48

CPC classification number: H01J49/167 ,  B01L3/0268 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0487

Abstract: A lab-on-a-chip comprising a support plate, at least one fluidic network formed in a fluidic plate bonded onto the support plate, and a cover plate bonded onto the fluidic plate and covering the fluidic network. The fluidic network, at a first end, is connected to an inlet orifice allowing entry of a liquid to be sprayed and, at a second end, to a first end of an outlet channel for the liquid to be sprayed, formed in the fluidic plate. The fluidic plate is extended by a pointed electrospray nozzle at which the second end of the outlet channel forms the electrospray outlet of the lab-on-a-chip. The cover plate has a pointed extension forming a roof for that part of the channel located in the electrospray nozzle.

Abstract translation: 一种芯片实验室，包括支撑板，形成在结合到支撑板上的流体板中的至少一个流体网络，以及结合到流体板上并覆盖流体网络的盖板。 流体网络在第一端连接到允许待喷射的液体进入的入口孔，并且在第二端处连接到用于待喷射的液体的出口通道的第一端，形成在流体板 。 流体板通过尖锐的电喷雾喷嘴延伸，出口通道的第二端形成芯片实验室的电喷雾出口。 盖板具有尖端的延伸部，其形成位于电喷雾喷嘴中的通道的该部分的顶部。

公开(公告)号：US20110215040A1

公开(公告)日：2011-09-08

申请号：US13024035

申请日：2011-02-09

Applicant: Guillaume DELAPIERRE ,  Nicolas Sarrut ,  Gilles Marchand

Inventor： Guillaume DELAPIERRE ,  Nicolas Sarrut ,  Gilles Marchand

IPC: B01D57/02 ,  B01D11/04

CPC classification number: B01D11/04 ,  B01D11/0496

Abstract: A method for extracting at least one chemical or biological compound from a liquid phase including at least one functionalized ionic liquid, via a liquid extracting fluid that is miscible with the ionic liquid, and a microfluidic system implementing the method. The extraction method includes moving, on one surface of a microfluidic system, at least one microdrop of the liquid phase into an extraction solution that includes the extracting fluid and that is localized on the surface to obtain in output of the solution, under effect of an electric field, an extract moving away from the surface that is rich in extracting fluid and enriched in the at least one compound, and a raffinate moving on the surface that is rich in ionic liquid and deleted in the at least one compound.

Abstract translation: 一种从包含至少一种功能化的离子液体的液相中提取至少一种化学或生物化合物的方法，通过可与离子液体混溶的液体提取液，以及实施该方法的微流体系统。 提取方法包括在微流体系统的一个表面上将液相的至少一个微滴移动到包括萃取流体并且定位在表面上以在溶液的输出中获得的提取溶液中，在 电场，从表面富含萃取液并富集至少一种化合物的提取物，以及在富含离子液体的表面上移动并在至少一种化合物中缺失的萃余液。

公开(公告)号：US07235405B2

公开(公告)日：2007-06-26

申请号：US10426895

申请日：2003-04-29

Applicant: Raymond Charles ,  Yves Fouillet ,  Nicolas Sarrut ,  Patricia Claustre

Inventor： Raymond Charles ,  Yves Fouillet ,  Nicolas Sarrut ,  Patricia Claustre

IPC: G01N1/10

CPC classification number: G01N35/08 ,  G01N2035/00277 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/2575

Abstract: The invention relates to a device (1) for distribution of at least one liquid product, the device comprising at least one injection tube (2) supplied by a liquid product and being provided with an outlet orifice (4) capable of cooperating with an inlet orifice (12) of a reception tube (10) for reception of each liquid product. According to the invention, the outlet orifice (4) of each injection tube (2) and the inlet orifice (12) of the reception tube (10) open up into a sealed reservoir (6) full of an immiscible liquid (8), the outlet orifice (4) of each injection tube (2) being at a spacing from the inlet orifice (12) of the reception tube (10) and able to be located close to the reception tube (12), the device (1) also comprising means (14) for pressurizing the immiscible liquid (8).

Abstract translation: 本发明涉及一种用于分配至少一种液体产品的装置（1），该装置包括由液体产品供应的至少一个注射管（2），并且设置有能够与入口 用于接收每种液体产品的接收管（10）的孔口（12）。 根据本发明，每个注入管（2）的出口孔（4）和接收管（10）的入口孔（12）打开成一个充满不混溶液体（8）的密封容器（6） 每个注射管（2）的出口孔（4）与接收管（10）的入口孔（12）间隔开并且能够靠近接收管（12）定位，装置（1） 还包括用于对不混溶液体（8）加压的装置（14）。

公开(公告)号：US07094379B2

公开(公告)日：2006-08-22

申请号：US10277754

申请日：2002-10-23

Applicant: Yves Fouillet ,  Nicolas Sarrut ,  Antoine Gruss

Inventor： Yves Fouillet ,  Nicolas Sarrut ,  Antoine Gruss

IPC: B01L3/00

CPC classification number: B01F13/0071 ,  B01F13/0076 ,  B01F13/0077 ,  B01F15/00123 ,  B01F15/00344 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00353 ,  B01J2219/00389 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/0068 ,  B01J2219/00783 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/0093 ,  B01L3/563 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/1822 ,  B01L2400/0403 ,  B01L2400/0475 ,  B01L2400/06 ,  B01L2400/082 ,  C40B60/14 ,  G01N35/08 ,  G01N2035/00237 ,  Y10T137/0391

Abstract: The invention relates to a microfluidic device for injecting series of mobile reaction chambers (102, 103) having non-miscible segmenters (101) in micro-channels (21 to 26), comprising: injection means (10) for injecting into microreaction channels alternatingly and in parallel liquid to form mobile reaction chambers and liquid for forming the segmenters; means for controlling the progression of one of the two liquids, applied to act on one zone (31) of each microchannel delimiting an injection volume of said liquid; the control means being able to cause stopping or slowing of the progression of said liquid over the zone of each microchannel by exerting an action based on a physico-chemical property of the liquid and said action not affecting the other liquid.

Abstract translation: 本发明涉及一种用于在微通道（21至26）中注入具有不可混合分段器（101）的系列移动反应室（102,103）的微流体装置，其包括：用于将交替注入微反应通道的注射装置（10） 和平行液体形成移动反应室和用于形成分段器的液体; 用于控制两个液体中的一个液体的进行的装置，用于作用于限定所述液体的喷射体积的每个微通道的一个区域（31）; 所述控制装置能够通过基于液体的物理化学性质和不影响其它液体的作用施加作用而使所述液体在每个微通道的区域上的进展停止或减慢。

公开(公告)号：US20050196328A1

公开(公告)日：2005-09-08

申请号：US10518343

申请日：2003-06-24

Applicant: Yves Fouillet ,  Patrick Pouteau ,  Nicolas Sarrut ,  Frederic Ginot ,  Dominique Masse

Inventor： Yves Fouillet ,  Patrick Pouteau ,  Nicolas Sarrut ,  Frederic Ginot ,  Dominique Masse

IPC: B01F11/00 ,  B01F13/00 ,  B01L3/00 ,  F15C1/04 ,  B01L3/02

CPC classification number: B01F11/0071 ,  B01F13/0059 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2400/0442 ,  B01L2400/06 ,  B01L2400/0688 ,  F15C1/04

Abstract: The invention relates to hydraulic device produced from one or several components, for example from a support comprising: an operative cavity, at least two ducts, for example an inlet and outlet for a liquid of interest which communicate with said operative cavity, at least two valve bodies with no moving pieces for control of said cavity. The above is characterised in that said device further comprises two trapping chambers for a gas, for example, air, in communication only and respectively with two ducts, by means of two connecting channels respectively, both pertaining to thermal exchange with a heat source.

Abstract translation: 本发明涉及从一个或多个部件产生的液压装置，例如由支撑件制成，包括：操作空腔，至少两个管道，例如用于与所述操作腔连通的感兴趣液体的入口和出口，至少两个 不具有用于控制所述空腔的移动件的阀体。 上述特征在于，所述装置还包括两个用于气体（例如空气）的捕集室，它们分别仅通过两个连接通道分别连通两个管道，这两个通道都属于与热源的热交换。

公开(公告)号：US08667845B2

公开(公告)日：2014-03-11

申请号：US12937856

申请日：2009-04-14

Applicant: Emmanuel Defay ,  Marc Aid ,  Pierre-Patrick Lassagne ,  Nicolas Sarrut-Rio

Inventor： Emmanuel Defay ,  Marc Aid ,  Pierre-Patrick Lassagne ,  Nicolas Sarrut-Rio

IPC: G01N29/036

CPC classification number: G01N29/022 ,  G01N2291/014 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427

Abstract: A device for detecting elements in a fluid environment includes at least one acoustic resonator having a surface designed for fixing of elements. The resonator is configured for generating and measuring Lamb waves fostering generation of symmetrical Lamb waves. The device analyzes the resonance frequency of the resonator to determine the variation of the resonance frequency of the symmetrical Lamb waves representative of the presence of the elements.

Abstract translation: 用于检测流体环境中的元件的装置包括至少一个具有设计用于固定元件的表面的声谐振器。 谐振器被配置用于产生和测量促进产生对称兰姆波的兰姆波。 器件分析谐振器的谐振频率，以确定代表元件存在的对称兰姆波的谐振频率的变化。

公开(公告)号：US08236156B2

公开(公告)日：2012-08-07

申请号：US11393909

申请日：2006-03-31

Applicant: Nicolas Sarrut ,  Hubert Jeanson

Inventor： Nicolas Sarrut ,  Hubert Jeanson

IPC: B67D5/00

CPC classification number: B01D11/04 ,  B01D11/0496

Abstract: A method of transferring mass of at least one solute between a liquid first phase and a fluid second phase that is immiscible with the first phase, the method comprising moving at least one droplet of said liquid first phase in a microfluidic device by using electric-type forces (electrowetting or dielectrophoresis) within a space that is filled with said fluid second phase. Said droplet is preferably moved by said electric-type forces along a path between a point for injecting said droplet into said microfluidic device, and an extraction and/or analysis zone, said path being defined in such a manner that said droplet sweeps through a significant fraction of said space filled with said fluid second phase. The method may include a step of transferring said droplet using said electric-type forces to a chemical analysis device integrated in said microfluidic device, and a step of chemically analyzing said droplet. The invention also provides a device for implementing such a method.

Abstract translation: 一种将液体第一相和与第一相不混溶的流体第二相之间的至少一种溶质的质量转移的方法，该方法包括通过使用电动式将微流体装置中的至少一个液滴的第一相移动到微流体装置中 在充满所述流体第二相的空间内的电力（电润湿或介电电泳）。 所述液滴优选地通过所述电动力沿着将所述液滴注入所述微流体装置的点之间的路径以及提取和/或分析区域移动，所述路径被限定为使得所述液滴扫过显着的 填充有所述流体第二相的所述空间的分数。 该方法可以包括使用所述电力将所述液滴转移到集成在所述微流体装置中的化学分析装置的步骤，以及化学分析所述液滴的步骤。 本发明还提供了一种用于实现这种方法的装置。

公开(公告)号：US07411184B2

公开(公告)日：2008-08-12

申请号：US10578175

申请日：2004-11-09

Applicant: Nicolas Sarrut

Inventor： Nicolas Sarrut

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/165 ,  B05B5/0255 ,  G01N35/1016 ,  Y10T137/8242 ,  Y10T137/8326

Abstract: A microfluidic device including a microfluidic chip assembled to an electrospray structure. The microfluidic chip includes at least one microfluidic channel leading through an outlet aperture to a surface area of the microfluidic chip. The electrospray structure includes at least one thin, planar point provided with a capillary slot that terminates at the end of the point so as to form an aperture for ejection of a liquid to be sprayed. The electrospray structure is arranged on the surface area of the microfluidic chip so that the point is cantilivered with respect to the microfluidic chip and so that the outlet aperture of the microfluidic device leads to the capillary slot of the point, which microfluidic device also has a mechanism to apply an electrospray voltage to the liquid to be sprayed.

Abstract translation: 一种微流体装置，其包括组装到电喷雾结构的微流体芯片。 微流体芯片包括至少一个通过出口孔通向微流体芯片的表面区域的微流体通道。 电喷雾结构包括至少一个薄的平面点，该点设置有毛细管狭槽，该毛细管槽终止于该点的末端以便形成用于喷射待喷射液体的孔。 电喷雾结构布置在微流体芯片的表面区域上，使得该点相对于微流体芯片是突出的，并且使得微流体装置的出口孔通向该点的毛细管狭槽，该微流体装置还具有 将电喷雾电压施加到待喷射的液体的机构。