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公开(公告)号：US20100029643A1
公开(公告)日：2010-02-04
申请号：US12514247
申请日：2007-11-08
申请人： Gurmit Grewal , Edward Hennessy , Victor Kamhi , Danyang Li , Paul Lyne , Vibha Oza , Jamal Carlos Saeh , Qibin Su , Bin Yang
发明人： Gurmit Grewal , Edward Hennessy , Victor Kamhi , Danyang Li , Paul Lyne , Vibha Oza , Jamal Carlos Saeh , Qibin Su , Bin Yang
IPC分类号： A61K31/4184 , C07D235/14 , C07D401/06 , C07D471/04 , C07D403/12 , C07D413/12 , C07D401/12 , A61K31/4439 , A61K31/437 , A61K31/538 , A61K31/4709 , A61K31/5377 , A61K31/506 , A61P35/00
CPC分类号： C07D235/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/40 , C07D487/04 , C07D491/056
摘要： The invention relates to chemical compounds of formula (I), (Ia) and (Ib) or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal, such as man.
摘要翻译： 本发明涉及具有Edg-1拮抗活性的式（I），（Ia）和（Ib）化合物或其药学上可接受的盐，因此可用于其抗癌活性，因此可用于治疗 人或动物体。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制造用于在温血动物如人中产生抗癌作用的药物中的用途。
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公开(公告)号：US20090111860A1
公开(公告)日：2009-04-30
申请号：US12297791
申请日：2007-04-20
申请人： Gurmit Grewal , Edward Hennessy , Victor Kamhi , Danyang Li , Vibha Oza , Jamal Carlos Saeh , Qibin Su
发明人： Gurmit Grewal , Edward Hennessy , Victor Kamhi , Danyang Li , Vibha Oza , Jamal Carlos Saeh , Qibin Su
IPC分类号： A61K31/425 , C07D275/02 , A61P35/00 , C07D231/12 , C07D261/08 , A61K31/42 , A61K31/415
CPC分类号： C07D231/12 , C07D231/20 , C07D231/38 , C07D261/08 , C07D261/10 , C07D261/12 , C07D275/02 , C07D275/03
摘要： The present invention relates to compounds of formula (I) that mediate Edg, including Edg-1, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases that have a significant vascularization or inflammatory component such as in tumor-related diseases. The present invention also relates to compounds that inhibit a5bl, and also that exhibit appropriate selectivity profile(s) against other integrins.
摘要翻译： 本发明涉及介导Edg的化合物，其包括Edg-1，其制备方法，含有它们作为活性成分的药物组合物，其用作药物及其在制备药物中的用途 在具有显着血管形成或炎性成分如肿瘤相关疾病的疾病的人类的温血动物中进行治疗。 本发明还涉及抑制bbl的化合物，并且还表现出对其他整联蛋白的适当选择性分布。
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公开(公告)号：US08461170B2
公开(公告)日：2013-06-11
申请号：US13196189
申请日：2011-08-02
申请人： Brian Aquila , Victor Kamhi , Bo Peng , Timothy Pontz , Jamal Carlos Saeh , Kumar Thakur , Bin Yang
发明人： Brian Aquila , Victor Kamhi , Bo Peng , Timothy Pontz , Jamal Carlos Saeh , Kumar Thakur , Bin Yang
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D401/14 , C07F9/65685
摘要： The present invention relates to compounds of Formula (I) and/or Formula (Ia): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit ALK kinase activity, and thus may be used for the treatment of cancer.
摘要翻译： 本发明涉及式（I）和/或式（Ia）化合物及其盐，药物组合物，使用方法及其制备方法。 这些化合物抑制ALK激酶活性，因此可用于治疗癌症。
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公开(公告)号：US07279475B2
公开(公告)日：2007-10-09
申请号：US10940898
申请日：2004-09-14
申请人： Pier Francesco Cirillo , Abdelhakim Hammach , Victor Kamhi , Neil Moss , Paul S Riska , Christopher Pargellis
发明人： Pier Francesco Cirillo , Abdelhakim Hammach , Victor Kamhi , Neil Moss , Paul S Riska , Christopher Pargellis
IPC分类号： A61K31/5377 , A61K31/496 , C07D413/06 , C07D403/06
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D239/34 , C07D239/47 , C07D239/52 , C07D401/12 , C07D405/12
摘要： Disclosed are compounds of formula(I): wherein R1, R2, W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物：其中式（I）的R 1，R 2，W和X如本文所定义。 该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20070142371A1
公开(公告)日：2007-06-21
申请号：US11668704
申请日：2007-01-30
申请人： Derek Cogan , Ming-Hong Hao , Victor Kamhi , Matthew Netherton , Alan Swinamer , Craig Miller
发明人： Derek Cogan , Ming-Hong Hao , Victor Kamhi , Matthew Netherton , Alan Swinamer , Craig Miller
IPC分类号： A61K31/538 , A61K31/53 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4439 , A61K31/433 , A61K31/423 , A61K31/4196 , A61K31/4192 , A61K31/4178 , C07D413/02 , C07D403/02
CPC分类号： C07D417/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04
摘要： Disclosed compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开的抑制细胞因子产生的式（I）化合物，其涉及炎症过程，因此可用于治疗涉及炎症的疾病和病理状态，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US06872726B2
公开(公告)日：2005-03-29
申请号：US10632998
申请日：2003-08-01
申请人： Pier Francesco Cirillo , Abdelhakim Hammach , Victor Kamhi , Neil Moss , Paul S. Riska , Christopher Pargellis
发明人： Pier Francesco Cirillo , Abdelhakim Hammach , Victor Kamhi , Neil Moss , Paul S. Riska , Christopher Pargellis
IPC分类号： C07D239/34 , C07D239/46 , C07D239/52 , C07D401/12 , C07D405/12 , C07D521/00 , A61K31/505 , C07D239/24
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D239/34 , C07D239/47 , C07D239/52 , C07D401/12 , C07D405/12
摘要： Disclosed are compounds of formula (I): wherein R1, R2, W and X of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物：其中式（I）的R 1，R 2，W和X在本文中定义。 该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US06743788B2
公开(公告)日：2004-06-01
申请号：US10147675
申请日：2002-05-17
IPC分类号： C07D41314
CPC分类号： C07D207/08 , C07C275/40 , C07D213/38 , C07D239/26 , C07D239/28 , C07D241/24 , C07D295/135 , C07D295/185 , C07D295/192 , C07D307/12 , C07D401/12 , C07D405/12 , C07D413/12
摘要： Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
摘要翻译： 公开了本文所述的式（I）的新型芳族化合物，其中G，E，W，Ar，X，Y和Z在本文中公开。 该化合物可用于治疗细胞因子介导的疾病或病症如慢性炎性疾病。 还公开了含有制备这些化合物的药物组合物。
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公开(公告)号：US20060235017A1
公开(公告)日：2006-10-19
申请号：US11426603
申请日：2006-06-27
申请人： Pier Cirillo , Donghong Gao , Daniel Goldberg , Abdelhakim Hammach , Ming-Hong Hao , Victor Kamhi , Neil Moss , Matthew Netherton , Kevin Qian , Mark Ralph , Lifen Wu , Zhaoming Xiong , Ronald Aungst
发明人： Pier Cirillo , Donghong Gao , Daniel Goldberg , Abdelhakim Hammach , Ming-Hong Hao , Victor Kamhi , Neil Moss , Matthew Netherton , Kevin Qian , Mark Ralph , Lifen Wu , Zhaoming Xiong , Ronald Aungst
IPC分类号： A61K31/5377 , A61K31/513 , C07D413/14 , C07D403/14
CPC分类号： C07D401/12 , C07D403/12
摘要： Disclosed are compounds of formula (I) Where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. The compounds are also useful for treating diseases or conditions related to oncology and anticoagulant or fibrinolytic therapy. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物，其中Ar 1，X，Y，Q，W，R 3，R 4，R SUP > 5，R 6和R y在本文中定义。 本发明的化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 该化合物也可用于治疗与肿瘤学和抗凝血剂或纤维蛋白溶解疗法有关的疾病或病症。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20060079519A1
公开(公告)日：2006-04-13
申请号：US11074354
申请日：2005-03-07
申请人： Derek Cogan , Ming-Hong Hao , Victor Kamhi , Matthew Netherton , Alan Swinamer , Craig Miller
发明人： Derek Cogan , Ming-Hong Hao , Victor Kamhi , Matthew Netherton , Alan Swinamer , Craig Miller
IPC分类号： A61K31/538 , A61K31/53 , A61K31/506 , A61K31/497 , C07D43/02 , C07D413/02
CPC分类号： C07D417/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04
摘要： Disclosed compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
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公开(公告)号：US20050032797A1
公开(公告)日：2005-02-10
申请号：US10940898
申请日：2004-09-14
申请人： Pier Cirillo , Abdelhakim Hammach , Victor Kamhi , Neil Moss , Paul Riska , Christopher Pargellis
发明人： Pier Cirillo , Abdelhakim Hammach , Victor Kamhi , Neil Moss , Paul Riska , Christopher Pargellis
IPC分类号： C07D239/34 , C07D239/46 , C07D239/52 , C07D401/12 , C07D405/12 , C07D521/00 , A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , C07D413/04 , C07D43/04
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D239/34 , C07D239/47 , C07D239/52 , C07D401/12 , C07D405/12
摘要： Disclosed are compounds of formula(I): wherein R1, R2, W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物：其中式（I）的R 1，R 2，W和X在本文中定义。 该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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