公开(公告)号：US20230407262A1

公开(公告)日：2023-12-21

申请号：US18055409

申请日：2022-11-14

Applicant: Gwo Xi Stem Cell Applied Technology Co., Ltd.

Inventor： Wei Wu Li ,  Tzyy-Wen Chiou ,  Horng-Jyh Harn ,  Shinn-Zong Lin ,  Ming-Hsi Chuang ,  Po-Cheng Lin ,  Chia-Hsin Lee ,  Mao-Hsuan Huang

IPC: C12N5/0775 ,  C12N5/079 ,  C07K14/435 ,  A61K38/17 ,  A61P25/00

CPC classification number: C12N5/0663 ,  C12N5/0618 ,  C07K14/435 ,  A61K38/17 ,  A61P25/00

Abstract: The present invention provides a medicine for treating a neurodegenerative disease, which employs LEFTY2 (Left-Right Determination Factor 2) generated by co-culturing mesenchymal stem cells of mammals with nerve cells having mutations in the APP (Amyloid precursor protein) gene, or a specific protein. The LEFTY2 has an effect of inhibiting Beta amyloid and a hyperphosphorylated neuronal microtubule-associated protein (Tau protein), without affecting the development of nerve cells and having the ability to promote the growth of the nerve cells; and the two types of proteins have a crucial impact on the neurodegenerative diseases.

公开(公告)号：US11020358B2

公开(公告)日：2021-06-01

申请号：US15593141

申请日：2017-05-11

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Tzyy-Wen Chiou ,  Horng-Jyh Harn ,  Shinn-Zong Lin ,  Karthyayani Rajamani ,  Yi-Chun Lin

IPC: A61K31/11 ,  A61K35/28 ,  A61K35/545

Abstract: A method for the anti-senescence of and/or rejuvenating a stem cell is provided. The method comprising treating the stem cell with trans-cinnamaldehyde (TC). A kit is also provided. The kit comprising (1) a first part, comprising a stem cell; (2) a second part, comprising TC; and (3) a culture medium of the stem cell, placed in at least one of the first part, the second part, and a third part. In addition, a method for stem cell therapy is provided. The method comprising administering to a subject in need an effective amount of a stem cell, wherein the stem cell has been treated with TC before being administered.

公开(公告)号：US20150231052A1

公开(公告)日：2015-08-20

申请号：US14321954

申请日：2014-07-02

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Shinn-Zong LING ,  Horng-Jyh Harn ,  Tzyy-Wen Chiou ,  Po-Cheng Lin

IPC: A61K8/64 ,  A61N5/06 ,  A61F7/08 ,  A61K8/98 ,  A61Q19/08

CPC classification number: A61K8/64 ,  A61F7/02 ,  A61F2007/0003 ,  A61F2007/0062 ,  A61F2007/0088 ,  A61K8/981 ,  A61K2800/805 ,  A61K2800/86 ,  A61K2800/88 ,  A61N5/0625 ,  A61Q7/00 ,  A61Q19/08

Abstract: A mesenchymal stem cell extract and its use are provided, wherein the mesenchymal stem cell extract comprises a trophic factor(s), such as bone morphogenetic protein-7 (BMP-7), stromal cell-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), C-X-C chemokine receptor type-4 (CXCR4), brain-derived neurotrophic factor (BDNF), and/or interleukin-17 (IL-17), and wherein the extract is especially suitable for repairing skin aging.

Abstract translation: 提供间充质干细胞提取物及其用途，其中间充质干细胞提取物包括营养因子，如骨形态发生蛋白-7（BMP-7），基质细胞衍生因子-1（SDF-1） ，血管内皮生长因子（VEGF），CXC趋化因子受体4型（CXCR4），脑源性神经营养因子（BDNF）和/或白细胞介素-17（IL-17），其中提取物特别适用于修复皮肤 老化。

公开(公告)号：US20180250216A1

公开(公告)日：2018-09-06

申请号：US15980184

申请日：2018-05-15

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Shinn-Zong Lin ,  Horng-Jyh Harn ,  Tzyy-Wen Chiou ,  Po-Cheng Lin

IPC: A61K8/64 ,  A61K8/98 ,  A61Q7/00 ,  A61Q19/08 ,  A61F7/02 ,  A61F7/00 ,  A61N5/06

CPC classification number: A61K8/64 ,  A61F7/02 ,  A61F2007/0003 ,  A61F2007/0062 ,  A61F2007/0088 ,  A61K8/981 ,  A61K2800/805 ,  A61K2800/86 ,  A61K2800/88 ,  A61N5/0625 ,  A61Q7/00 ,  A61Q19/08

Abstract: A mesenchymal stem cell extract and its use are provided, wherein the mesenchymal stem cell extract comprises a trophic factor(s), such as bone morphogenetic protein-7 (BMP-7), stromal cell-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), C-X-C chemokine receptor type-4 (CXCR4), brain-derived neurotrophic factor (BDNF), and/or interleukin-17 (IL-17), and wherein the extract is especially suitable for repairing skin aging.

公开(公告)号：US10022313B2

公开(公告)日：2018-07-17

申请号：US14321954

申请日：2014-07-02

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Shinn-Zong Ling ,  Horng-Jyh Harn ,  Tzyy-Wen Chiou ,  Po-Cheng Lin

IPC: A61K8/64 ,  A61K8/98 ,  A61Q19/08 ,  A61Q7/00 ,  A61N5/06 ,  A61F7/00 ,  A61F7/02

Abstract: A mesenchymal stem cell extract and its use are provided, wherein the mesenchymal stem cell extract comprises a trophic factor(s), such as bone morphogenetic protein-7 (BMP-7), stromal cell-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), C-X-C chemokine receptor type-4 (CXCR4), brain-derived neurotrophic factor (BDNF), and/or interleukin-17 (IL-17), and wherein the extract is especially suitable for repairing skin aging.