公开(公告)号：US11020358B2

公开(公告)日：2021-06-01

申请号：US15593141

申请日：2017-05-11

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Tzyy-Wen Chiou ,  Horng-Jyh Harn ,  Shinn-Zong Lin ,  Karthyayani Rajamani ,  Yi-Chun Lin

IPC: A61K31/11 ,  A61K35/28 ,  A61K35/545

Abstract: A method for the anti-senescence of and/or rejuvenating a stem cell is provided. The method comprising treating the stem cell with trans-cinnamaldehyde (TC). A kit is also provided. The kit comprising (1) a first part, comprising a stem cell; (2) a second part, comprising TC; and (3) a culture medium of the stem cell, placed in at least one of the first part, the second part, and a third part. In addition, a method for stem cell therapy is provided. The method comprising administering to a subject in need an effective amount of a stem cell, wherein the stem cell has been treated with TC before being administered.

公开(公告)号：US20180250216A1

公开(公告)日：2018-09-06

申请号：US15980184

申请日：2018-05-15

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Shinn-Zong Lin ,  Horng-Jyh Harn ,  Tzyy-Wen Chiou ,  Po-Cheng Lin

IPC: A61K8/64 ,  A61K8/98 ,  A61Q7/00 ,  A61Q19/08 ,  A61F7/02 ,  A61F7/00 ,  A61N5/06

CPC classification number: A61K8/64 ,  A61F7/02 ,  A61F2007/0003 ,  A61F2007/0062 ,  A61F2007/0088 ,  A61K8/981 ,  A61K2800/805 ,  A61K2800/86 ,  A61K2800/88 ,  A61N5/0625 ,  A61Q7/00 ,  A61Q19/08

Abstract: A mesenchymal stem cell extract and its use are provided, wherein the mesenchymal stem cell extract comprises a trophic factor(s), such as bone morphogenetic protein-7 (BMP-7), stromal cell-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), C-X-C chemokine receptor type-4 (CXCR4), brain-derived neurotrophic factor (BDNF), and/or interleukin-17 (IL-17), and wherein the extract is especially suitable for repairing skin aging.

公开(公告)号：US20170246123A1

公开(公告)日：2017-08-31

申请号：US15593141

申请日：2017-05-11

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Tzyy-Wen CHIOU ,  Horng-Jyh Harn ,  Shinn-Zong Lin ,  Karthyayani Rajamani ,  Yi-Chun Lin

IPC: A61K31/11 ,  A61K35/545 ,  A61K35/28

CPC classification number: A61K31/11 ,  A61K35/28 ,  A61K35/545

Abstract: A method for the anti-senescence of and/or rejuvenating a stem cell is provided. The method comprising treating the stem cell with trans-cinnamaldehyde (TC). A kit is also provided. The kit comprising (1) a first part, comprising a stem cell; (2) a second part, comprising TC; and (3) a culture medium of the stem cell, placed in at least one of the first part, the second part, and a third part. In addition, a method for stem cell therapy is provided. The method comprising administering to a subject in need an effective amount of a stem cell, wherein the stem cell has been treated with TC before being administered.

公开(公告)号：US09518251B2

公开(公告)日：2016-12-13

申请号：US15074490

申请日：2016-03-18

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Shinn-Zong Lin ,  Horng-Jyh Harn ,  Ru-Huei Fu ,  Shih-Ping Liu ,  Po-Cheng Lin ,  Ming-Hsi Chuang

IPC: C12N5/00 ,  C12N5/02 ,  C12N5/0775 ,  A61K35/545 ,  A61K35/28

CPC classification number: A61K35/28 ,  A61K31/365 ,  A61K35/545 ,  C12N5/0667 ,  C12N2501/40 ,  C12N2501/999

Abstract: A method for enhancing the therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases is provided. The method comprises pre-treating the stem cells with ligustilide to increase the expression of differentiation-promoting genes in the stem cells, increase the expression of homing-promoting genes in the stem cells, and/or decrease the expression of inflammatory genes in the stem cells, wherein the treatment is conducted in a culture medium of the stem cell.

Abstract translation: 提供了增强干细胞对自身免疫性疾病，心血管疾病和/或血液疾病的治疗效果的方法。 该方法包括用ligustilide预处理干细胞，以增加干细胞中分化促进基因的表达，增加干细胞中归巢促进基因的表达，和/或减少干细胞中炎症基因的表达 细胞，其中处理在干细胞的培养基中进行。

公开(公告)号：US20230407262A1

公开(公告)日：2023-12-21

申请号：US18055409

申请日：2022-11-14

Applicant: Gwo Xi Stem Cell Applied Technology Co., Ltd.

Inventor： Wei Wu Li ,  Tzyy-Wen Chiou ,  Horng-Jyh Harn ,  Shinn-Zong Lin ,  Ming-Hsi Chuang ,  Po-Cheng Lin ,  Chia-Hsin Lee ,  Mao-Hsuan Huang

IPC: C12N5/0775 ,  C12N5/079 ,  C07K14/435 ,  A61K38/17 ,  A61P25/00

CPC classification number: C12N5/0663 ,  C12N5/0618 ,  C07K14/435 ,  A61K38/17 ,  A61P25/00

Abstract: The present invention provides a medicine for treating a neurodegenerative disease, which employs LEFTY2 (Left-Right Determination Factor 2) generated by co-culturing mesenchymal stem cells of mammals with nerve cells having mutations in the APP (Amyloid precursor protein) gene, or a specific protein. The LEFTY2 has an effect of inhibiting Beta amyloid and a hyperphosphorylated neuronal microtubule-associated protein (Tau protein), without affecting the development of nerve cells and having the ability to promote the growth of the nerve cells; and the two types of proteins have a crucial impact on the neurodegenerative diseases.

公开(公告)号：US09533012B2

公开(公告)日：2017-01-03

申请号：US14552014

申请日：2014-11-24

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Shinn-Zong Lin ,  Horng-Jyh Harn ,  Ru-Huei Fu ,  Shih-Ping Liu ,  Po-Cheng Lin ,  Ming-Hsi Chuang

IPC: C12N5/00 ,  C12N5/02 ,  A61K35/28 ,  C12N5/0775 ,  A61K35/545 ,  A61K31/365

CPC classification number: A61K35/28 ,  A61K31/365 ,  A61K35/545 ,  C12N5/0667 ,  C12N2501/40 ,  C12N2501/999

Abstract: A method for enhancing the therapeutic effect of a stem cell is provided. The method comprises treating the stem cell with ligustilide, wherein the treatment is conducted in a culture medium of the stem cell. A method of stem cell treatment is also provided, comprising administering to a subject in need an effective amount of a stem cell or a combination of ligustilide and a stem cell, wherein the stem cell has been treated with ligustilide.

Abstract translation: 提供了增强干细胞治疗效果的方法。 该方法包括用罗替司特治疗干细胞，其中处理在干细胞的培养基中进行。 还提供了一种干细胞治疗方法，其包括对有需要的受试者施用有效量的干细胞或罗替沙特与干细胞的组合，其中所述干细胞已用罗替司列治疗。

公开(公告)号：US20180311185A1

公开(公告)日：2018-11-01

申请号：US16034234

申请日：2018-07-12

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Tzyy-Wen CHIOU ,  Horng-Jyh Harn ,  Shinn-Zong Lin ,  Karthyayani Rajamani ,  Yi-Chun Lin

IPC: A61K31/11 ,  A61K35/545 ,  A61K35/28

CPC classification number: A61K31/11 ,  A61K35/28 ,  A61K35/545

Abstract: A method for the anti-senescence of and/or rejuvenating a stem cell is provided. The method comprising treating the stem cell with trans-cinnamaldehyde (TC). A kit is also provided. The kit comprising (1) a first part, comprising a stem cell; (2) a second part, comprising TC; and (3) a culture medium of the stem cell, placed in at least one of the first part, the second part, and a third part. In addition, a method for stem cell therapy is provided. The method comprising administering to a subject in need an effective amount of a stem cell, wherein the stem cell has been treated with TC before being administered.

公开(公告)号：US09523081B2

公开(公告)日：2016-12-20

申请号：US14821309

申请日：2015-08-07

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Shinn-Zong Lin ,  Horng-Jyh Harn ,  Ru-Huei Fu ,  Shih-Ping Liu ,  Po-Cheng Lin ,  Ming-Hsi Chuang

IPC: A01N63/00 ,  A01N65/00 ,  C12N5/0775 ,  A61K35/545 ,  A61K35/28

CPC classification number: A61K35/28 ,  A61K31/365 ,  A61K35/545 ,  C12N5/0667 ,  C12N2501/40 ,  C12N2501/999

Abstract: A method for enhancing the therapeutic effect of a stem cell on autoimmune diseases, cardiovascular diseases, and/or hematological diseases is provided. The method comprises treating the stem cell with ligustilide, wherein the treatment is conducted in a culture medium of the stem cell. A method of stem cell treatment is also provided, comprising administering to a subject suffering from autoimmune diseases, cardiovascular diseases, and/or hematological diseases an effective amount of a stem cell or a combination of ligustilide and a stem cell, wherein the stem cell has been treated with ligustilide.

Abstract translation: 提供了一种用于增强干细胞对自身免疫性疾病，心血管疾病和/或血液疾病的治疗效果的方法。 该方法包括用罗替司特治疗干细胞，其中处理在干细胞的培养基中进行。 还提供了一种干细胞治疗方法，其包括对患有自身免疫性疾病，心血管疾病和/或血液疾病的受试者施用有效量的干细胞或光灭活素与干细胞的组合，其中所述干细胞具有 用ligustilide治疗。

公开(公告)号：US20160106783A1

公开(公告)日：2016-04-21

申请号：US14643977

申请日：2015-03-10

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Tzyy-Wen CHIOU ,  Horng-Jyh Harn ,  Shinn-Zong Lin ,  Karthyayani Rajamani ,  Yi-Chun Lin

IPC: A61K35/35 ,  A61K35/28

CPC classification number: A61K31/11 ,  A61K35/28 ,  A61K35/545

Abstract: A method for the anti-senescence of and/or rejuvenating a stem cell is provided. The method comprising treating the stem cell with trans-cinnamaldehyde (TC). A kit is also provided. The kit comprising (1) a first part, comprising a stem cell; (2) a second part, comprising TC; and (3) a culture medium of the stem cell, placed in at least one of the first part, the second part, and a third part. In addition, a method for stem cell therapy is provided. The method comprising administering to a subject in need an effective amount of a stem cell, wherein the stem cell has been treated with TC before being administered.

Abstract translation: 提供了一种用于干细胞抗衰老和/或恢复活力的方法。 该方法包括用反式肉桂醛（TC）处理干细胞。 还提供套件。 该试剂盒包括（1）第一部分，包括干细胞; （2）第二部分，包括TC; 和（3）干细胞的培养基，放置在第一部分，第二部分和第三部分中的至少一个中。 此外，提供了一种用于干细胞治疗的方法。 该方法包括向有需要的受试者施用有效量的干细胞，其中干细胞在施用前已用TC治疗。