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1.发明授权公开(公告)号：US08785594B2
公开(公告)日：2014-07-22
申请号：US12733672
申请日：2008-09-24
申请人： Gyula Dekany , Károly Ágoston , István Bajza , Marie Bøjstrup , Lars Kröger
发明人： Gyula Dekany , Károly Ágoston , István Bajza , Marie Bøjstrup , Lars Kröger
CPC分类号： C07K1/1077 , A61K47/549 , C07K14/00
摘要： The present application discloses novel glycoproteins and a related glycosylcarbamoylation methodology suitable for the preparation of glycopeptides (in particular glycoproteins and glycosylated cells), as well as the use of such glycoproteins in medicine, e.g. as pharmaceuticals and diagnostics or in diagnostic kits. A method for the preparation of a carbohydrate-peptide conjugate includes reacting a cyclic carbamate with a peptide which has at least one primary amino group.
摘要翻译： 本申请公开了适用于制备糖肽（特别是糖蛋白和糖基化细胞）的新型糖蛋白和相关的糖基氨基甲酰化方法，以及这些糖蛋白在医学中的应用。 作为药物和诊断或诊断试剂盒。 制备碳水化合物 - 肽缀合物的方法包括使环状氨基甲酸酯与具有至少一个伯氨基的肽反应。
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公开(公告)号：US08796434B2
公开(公告)日：2014-08-05
申请号：US13054314
申请日：2009-07-15
申请人： Gyula Dekany , Károly Ágoston , István Bajza , Marie Bøjstrup , Ignacio Fegueroa Pérez , Lars Kröger , Christoph H. Röhrig
发明人： Gyula Dekany , Károly Ágoston , István Bajza , Marie Bøjstrup , Ignacio Fegueroa Pérez , Lars Kröger , Christoph H. Röhrig
摘要： α-Lactosamine hydrochloride, substantially free of β-lactosamine hydrochloride; a method of preparing α-lactosamine hydrochloride monohydrate from an anomeric mixture of lactosamine hydrochloride, including: preparing a solution including the anomeric mixture of lactosamine hydrochloride, water and at least one water-miscible organic solvent at a temperature of 0-100° C., and cooling the solution to cause crystallization of α-lactosamine hydrochloride monohydrate; a method of preparing anhydrous α-lactosamine hydrochloride; and use of α-lactosamine hydrochloride as a food supplement or intermediate in synthesis.
摘要翻译： α-乳糖胺盐酸盐，基本上不含β-乳糖胺盐酸盐; 一种从乳糖胺盐酸盐的端基异构体混合物制备α-乳糖胺盐酸盐一水合物的方法，包括：在0-100℃的温度下制备包括乳糖胺盐酸盐，水和至少一种水混溶性有机溶剂的端基异构体混合物的溶液 并冷却溶液使α-乳糖胺盐酸盐一水合物结晶; 制备无水α-乳糖胺盐酸盐的方法; 并使用盐酸α-乳糖胺作为食品添加剂或中间体。
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3.发明授权1,2-dideoxy-1,2-diamino oligosaccharides and polysaccharides and derivatives thereof 有权1,2-二脱氧-1,2-二氨基寡糖及其多糖及其衍生物公开(公告)号：US08802841B2
公开(公告)日：2014-08-12
申请号：US12741973
申请日：2008-11-03
申请人： Gyula Dekany , István Bajza , Marie Bøjstrup , Károly Ágoston , Lars Kröger , Ignacio Figueroa Pérez , Christoph H. Röhrig , Paulo Vital , Erzsébet Czinege
发明人： Gyula Dekany , István Bajza , Marie Bøjstrup , Károly Ágoston , Lars Kröger , Ignacio Figueroa Pérez , Christoph H. Röhrig , Paulo Vital , Erzsébet Czinege
IPC分类号： A61K31/7016 , C07H5/06 , C07H15/12 , C07H15/16 , C07H15/203 , C08B37/00
CPC分类号： C07H15/12 , C07H5/06 , C07H15/203
摘要： A 1,2-dideoxy-1,2-diamino oligosaccharide or polysaccharide in its free base, salt or metal-complex form as shown in General Formula 1 and derivative thereof is described. R1, R2 and R3 are each independently selected from the group consisting of H and a carbohydrate moiety, with the proviso that at least one of the groups R1, R2 or R3 is a carbohydrate moiety; R4 is selected from the group consisting of: H, optionally substituted C1-20-alkyl, optionally substituted heteroalkyl, optionally substituted C2-20-alkenyl, optionally substituted C2-20-alkynyl, optionally substituted C3-10-cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl.
摘要翻译： 描述了其通式1及其衍生物所示的其游离碱，盐或金属络合物形式的1,2-二脱氧-1,2-二氨基寡糖或多糖。 R 1，R 2和R 3各自独立地选自H和碳水化合物部分，条件是基团R 1，R 2或R 3中的至少一个是碳水化合物部分; R 4选自：H，任选取代的C 1-20 - 烷基，任选取代的杂烷基，任选取代的C 2-20 - 烯基，任选取代的C 2-20 - 炔基，任选取代的C 3-10 - 环烷基，任选取代的杂环基 ，任选取代的芳基和任选取代的杂芳基。
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公开(公告)号：US08889637B2
公开(公告)日：2014-11-18
申请号：US13701085
申请日：2011-06-01
申请人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa-Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
发明人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa-Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
摘要： The present invention relates to novel polymorphs of the trisaccharide 2′-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及式（1）的三糖2'-O-岩藻糖基乳糖（2-FL）的新型多晶型物，制备所述多晶型物的方法及其在药物或营养组合物中的用途。
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5.发明授权Method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt) containing N-acetyllactosamine 有权制备含N-乙酰乳糖胺的四糖乳-N-新四糖（LNnt）的方法公开(公告)号：US08993740B2
公开(公告)日：2015-03-31
申请号：US13579741
申请日：2011-02-21
申请人： István Bajza , Gyula Dekany , Károly Ágoston , Ignacio Figuero-Pérez , Julien Boutet , Markus Hederos , Ferenc Horváth , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Péter Trinka , László Kalmár , Irme Kovács , Sándor Demkó , Ágnes Ágoston , Christian Risinger
发明人： István Bajza , Gyula Dekany , Károly Ágoston , Ignacio Figuero-Pérez , Julien Boutet , Markus Hederos , Ferenc Horváth , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Péter Trinka , László Kalmár , Irme Kovács , Sándor Demkó , Ágnes Ágoston , Christian Risinger
IPC分类号： C07H15/04 , C07H15/14 , C07H15/203 , C07H17/02 , C07H13/04 , A61K31/715 , A61K31/7016 , C08B37/00 , C07H15/18 , A23L1/09 , A23L1/30 , C07H11/00
CPC分类号： C07H3/06 , A23L5/00 , A23L7/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23V2002/00 , C07H1/00 , C07H11/00 , C07H13/04 , C07H15/18 , A23V2250/28
摘要： The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及一种特别是大规模制备四糖乳-N-新四糖（LNnt，式（I））的方法，以及合成中的中间体，一种LNnt的新晶型（多晶型物）和 在药物或营养组合物中的应用。
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公开(公告)号：US09237764B2
公开(公告)日：2016-01-19
申请号：US13579738
申请日：2011-02-21
申请人： Ignacio Figueroa Pérez , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
发明人： Ignacio Figueroa Pérez , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
IPC分类号： C07H1/00 , C07H3/04 , C07H5/04 , C07H5/10 , A23L1/308 , C07H3/06 , C07H15/18 , A61K31/702 , C07H13/04 , A23L1/30
CPC分类号： A23L1/308 , A23L33/10 , A23L33/21 , A61K31/702 , C07H1/00 , C07H3/06 , C07H13/04 , C07H15/18
摘要： The present invention relates to a method for preparation of the trisaccharide 6′-O-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6′-O-sialyllactose salts in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及三糖6'-O-唾液乳糖（式（I））或其盐的制备方法以及在制备或营养中合成和使用6'-O-唾液酸乳糖盐的中间体 组合物。
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公开(公告)号：US20130165406A1
公开(公告)日：2013-06-27
申请号：US13701085
申请日：2011-06-01
申请人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
发明人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
摘要： The present invention relates to novel polymorphs of the trisaccharide 2′-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及式（1）的三糖2'-O-岩藻糖基乳糖（2-FL）的新型多晶型物，制备所述多晶型物的方法及其在药物或营养组合物中的用途。
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公开(公告)号：US20130035481A1
公开(公告)日：2013-02-07
申请号：US13579738
申请日：2011-02-21
申请人： Ignacio Pérez Figueroa , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
发明人： Ignacio Pérez Figueroa , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
CPC分类号： A23L1/308 , A23L33/10 , A23L33/21 , A61K31/702 , C07H1/00 , C07H3/06 , C07H13/04 , C07H15/18
摘要： The present invention relates to a method for preparation of the trisaccharide 6′-0-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6′-0-sialyllactose salts in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及制备三糖6'-唾液酸乳糖（式（I））或其盐的方法，以及在药物或营养物质中合成和使用6'-O-唾液酸乳糖盐的中间体 组合物。
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9.发明申请METHOD FOR PREPARATION OF THE TETRASACCHARIDE LACTO-N-NEOTETRAOSE (LNNT) CONTAINING N-ACETYLLACTOSAMINE 有权含有N-乙酰基氨基甲酰胺的四氯化钛 - 新近硝酸酯（LNNT）的制备方法公开(公告)号：US20120309949A1
公开(公告)日：2012-12-06
申请号：US13579741
申请日：2011-02-21
申请人： István Bajza , Gyula Dekany , Károly Ágoston , Ignacio Pérez Figueroa , Julien Boutet , Markus Hederos , Ferenc Horváth , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Péter Trinka , László Kalmár , Irme Kovács , Sándor Demkó , Ágnes Ágoston , Christian Risinger
发明人： István Bajza , Gyula Dekany , Károly Ágoston , Ignacio Pérez Figueroa , Julien Boutet , Markus Hederos , Ferenc Horváth , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Péter Trinka , László Kalmár , Irme Kovács , Sándor Demkó , Ágnes Ágoston , Christian Risinger
IPC分类号： C08B37/00 , C07H15/203
CPC分类号： C07H3/06 , A23L5/00 , A23L7/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23V2002/00 , C07H1/00 , C07H11/00 , C07H13/04 , C07H15/18 , A23V2250/28
摘要： The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及一种特别是大规模制备四糖乳-N-新四糖（LNnt，式（I））的方法，以及合成中的中间体，一种LNnt的新晶型（多晶型物）和 在药物或营养组合物中的应用。
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公开(公告)号：US20110060139A1
公开(公告)日：2011-03-10
申请号：US12741973
申请日：2008-11-03
申请人： Gyula Dekany , István Bajza , Marie Bøjstrup , Karoly Agoston , Lars Kröger , Figueroa Peréz , Christoph Röhrig , Paulo Vital , Erzsébet Czinege
发明人： Gyula Dekany , István Bajza , Marie Bøjstrup , Karoly Agoston , Lars Kröger , Figueroa Peréz , Christoph Röhrig , Paulo Vital , Erzsébet Czinege
CPC分类号： C07H15/12 , C07H5/06 , C07H15/203
摘要： A 1,2-dideoxy-1,2-diamino oligosaccharide or polysaccharide in its free base, salt or metal-complex form as shown in General Formula 1 and derivative thereof is described. R1, R2 and R3 are each independently selected from the group consisting of H and a carbohydrate moiety, with the proviso that at least one of the groups R1, R2 or R3 is a carbohydrate moiety; R4 is selected from the group consisting of: H, optionally substituted C1-20-alkyl, optionally substituted heteroalkyl, optionally substituted C2-20-alkenyl, optionally substituted C2-20-alkynyl, optionally substituted C3-10-cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl.
摘要翻译： 描述了其通式1及其衍生物所示的其游离碱，盐或金属络合物形式的1,2-二脱氧-1,2-二氨基寡糖或多糖。 R 1，R 2和R 3各自独立地选自H和碳水化合物部分，条件是基团R 1，R 2或R 3中的至少一个是碳水化合物部分; R 4选自：H，任选取代的C 1-20 - 烷基，任选取代的杂烷基，任选取代的C 2-20 - 烯基，任选取代的C 2-20 - 炔基，任选取代的C 3-10 - 环烷基，任选取代的杂环基 ，任选取代的芳基和任选取代的杂芳基。
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