公开(公告)号：US20070255328A1

公开(公告)日：2007-11-01

申请号：US11565188

申请日：2006-11-30

申请人： H. Markowitz ,  Matthew Harris ,  Trina Brand

发明人： H. Markowitz ,  Matthew Harris ,  Trina Brand

IPC分类号： A61N1/36

CPC分类号： A61N1/3627 ,  A61N1/3622 ,  A61N1/365 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/3684

摘要： A method and an apparatus for treating cardiac arrhythmias are provided. An interval between first and second consecutive beats of a heart, having first and second chamber types, is determined. The heart is paced at a first rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is less than a predetermined amount of time or if the first and second beats are both from the second chamber type. The heart is paced at a second rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is more than the predetermined amount of time.

摘要翻译： 提供了一种治疗心律失常的方法和装置。 确定具有第一和第二室类型的心脏的第一和第二连续节拍之间的间隔。 如果第一节拍来自第一室型，并且第二节拍来自第二室型，并且间隔小于预定量的时间，或者如果第一和第二节拍都来自第一室，则心脏以第一速度进行起搏 第二室型。 如果第一搏动来自第一腔室类型，第二搏动来自第二腔室类型，并且间隔大于预定时间量，心脏以第二速度进行起搏。

公开(公告)号：US20050059999A1

公开(公告)日：2005-03-17

申请号：US10663570

申请日：2003-09-15

申请人： Luc Mongeon ,  Jesus Casas-Bejar ,  H. Markowitz ,  Daisy Cross ,  Janelle Blum ,  Michael Ebert ,  Timothy Laske

发明人： Luc Mongeon ,  Jesus Casas-Bejar ,  H. Markowitz ,  Daisy Cross ,  Janelle Blum ,  Michael Ebert ,  Timothy Laske

IPC分类号： A61K48/00 ,  A61N1/05 ,  A61N1/362

CPC分类号： A61N1/0568 ,  A61K48/0008 ,  A61K48/0041 ,  A61K48/0083

摘要： Delivery of genetic material to a stimulation site causes transgene expression by tissue at the stimulation site. In some embodiments, the delivered genetic material causes increased expression of proteins, such as connexins, gap junctions, and ion channels, to increase the conductivity of the tissue at the stimulation site. In some embodiments, the delivered genetic material causes expression of a metalloproteinase, an anti-inflammatory agent, or an immunosuppressant agent. Genetic material is delivered to the stimulation site via a stimulation lead. A stimulation lead for delivering genetic material to a stimulation site includes a chamber that contains a polymeric matrix. The matrix absorbs the genetic material and elutes the genetic material to the stimulation site.

摘要翻译： 将遗传物质递送至刺激部位会在刺激部位引起组织的转基因表达。 在一些实施方案中，递送的遗传物质导致蛋白质（例如连接蛋白，间隙连接和离子通道）的表达增加，以增加刺激部位组织的电导率。 在一些实施方案中，递送的遗传物质导致金属蛋白酶，抗炎剂或免疫抑制剂的表达。 遗传物质通过刺激引线输送到刺激部位。 用于将遗传物质递送至刺激部位的刺激引线包括含有聚合物基质的腔室。 基质吸收遗传物质并将遗传物质洗脱到刺激部位。

公开(公告)号：US20060122864A1

公开(公告)日：2006-06-08

申请号：US11038835

申请日：2005-01-20

申请人： Janell Gottesman ,  H. Markowitz ,  James Willenbring ,  Christopher Manrodt ,  John Van Danacker ,  John Burnes ,  John Rueter ,  David Dvorak ,  Sarah Audet ,  James Carney ,  Gerard Hill

发明人： Janell Gottesman ,  H. Markowitz ,  James Willenbring ,  Christopher Manrodt ,  John Van Danacker ,  John Burnes ,  John Rueter ,  David Dvorak ,  Sarah Audet ,  James Carney ,  Gerard Hill

IPC分类号： G06Q10/00 ,  A61B5/00

CPC分类号： G06F19/3418 ,  G06Q50/22 ,  G16H80/00

摘要： An intelligent patient management system collects data from a variety of sources, processes that information, and provides relevant information to an appropriate caregiver in context at the proper time. The system has multiple information sources available from which to gather additional information based upon conclusions drawn or issues identified from the patient data.

摘要翻译： 智能患者管理系统从各种来源收集数据，处理该信息，并在适当的时候向适当的照顾者提供相关信息。 该系统具有多种信息来源，可根据患者数据识别的结论或问题收集附加信息。

公开(公告)号：US20050119711A1

公开(公告)日：2005-06-02

申请号：US10419404

申请日：2003-04-21

申请人： Yong Cho ,  Abed Lawabni ,  Todd Sheldon ,  H. Markowitz ,  Sameh Sowelam ,  Raylene Pitschneider

发明人： Yong Cho ,  Abed Lawabni ,  Todd Sheldon ,  H. Markowitz ,  Sameh Sowelam ,  Raylene Pitschneider

IPC分类号： A61B5/0205 ,  A61B5/08 ,  A61N1/18

CPC分类号： A61B5/4818 ,  A61B5/0205 ,  A61B5/0809 ,  A61B5/0816 ,  G06F19/00

摘要： The present invention relates to a device and method for monitoring for sleep disordered breathing or other types of disordered breathing such as Cheyne-Stokes breathing. More specifically, a device and method for detecting disordered breathing is provided that monitors a physiological parameter, which becomes cyclical due to apnea-hyperpnea (or arousal) alternation and provides the basis for the determination of a number of breathing disorder metrics.

摘要翻译： 本发明涉及一种用于监测睡眠呼吸紊乱或其他类型无序呼吸（例如Cheyne-Stokes呼吸）的装置和方法。 更具体地，提供了一种用于检测无序呼吸的装置和方法，其监测由于呼吸暂停呼吸（或唤醒）交替而变得周期性的生理参数，并且提供了确定多个呼吸障碍度量的基础。

公开(公告)号：US20070016259A1

公开(公告)日：2007-01-18

申请号：US11534910

申请日：2006-09-25

申请人： Earl Bakken ,  Rebecca Bergman ,  William Combs ,  H. Markowitz

发明人： Earl Bakken ,  Rebecca Bergman ,  William Combs ,  H. Markowitz

IPC分类号： A61N1/362

CPC分类号： A61N1/365 ,  A61N1/36592

摘要： A method and apparatus for varying a parameter in an implantable medical device that includes a plurality of electrodes stimulating heart tissue and sensing cardiac signals, a timing and control device controlling the stimulation of heart tissue by the plurality of electrodes and measuring intervals between the sensed cardiac signals, a storage device storing the measured intervals, and a microprocessor. The microprocessor determines heart rate variability in response to the stored intervals, compares the determined heart rate variability to a predetermined target rate profile, adjusts the parameter from a first setting to a second setting different from the first setting in response to the comparing of the determined heart rate variability and the predetermined target rate profile, and adjusts the parameter from the second setting to a termination setting in response to a termination event or expiration of a first predetermined time period.

摘要翻译： 一种用于改变可植入医疗装置中的参数的方法和装置，其包括刺激心脏组织和感测心脏信号的多个电极，控制多个电极对心脏组织刺激的定时和控制装置，并且测量感测的心脏 信号，存储测量的间隔的存储装置和微处理器。 微处理器响应于存储的间隔来确定心率变异性，将确定的心率变异性与预定的目标速率分布进行比较，响应于所确定的心率变异性的比较，将参数从第一设置调整到与第一设置不同的第二设置 心率变异性和预定目标速率曲线，并且响应于终止事件或第一预定时间段的期满，将参数从第二设置调整到终止设置。

公开(公告)号：US20050090871A1

公开(公告)日：2005-04-28

申请号：US10693375

申请日：2003-10-24

申请人： Yong Cho ,  H. Markowitz

发明人： Yong Cho ,  H. Markowitz

IPC分类号： A61B5/08 ,  A61N1/36 ,  A61N1/362 ,  A61N1/365

CPC分类号： A61N1/3601 ,  A61B5/08 ,  A61B5/082 ,  A61N1/36521 ,  A61N1/36557

摘要： An implantable medical device delivers augmentation therapy to intervene in a pattern of sleep-disordered breathing. Augmentation therapy includes the delivery of electrical stimulation to cardiac tissue above and/or below a capture threshold. PESP and NES/CCM are possible augmentation therapies that are used alone or in combination. In addition, augmentation therapies can be used with other pacing therapies such as atrial overdrive pacing and atrial coordinated pacing as a therapy for sleep-disordered breathing.

摘要翻译： 可植入的医疗装置提供增强疗法以介入睡眠呼吸障碍的模式。 增强疗法包括将电刺激递送到高于和/或低于捕获阈值的心脏组织。 PESP和NES / CCM是单独使用或组合使用的可能的增强疗法。 此外，增强疗法可以与其他起搏疗法一起使用，例如心房超速起搏和心房协调起搏作为睡眠呼吸障碍的治疗方法。

公开(公告)号：US20070167843A1

公开(公告)日：2007-07-19

申请号：US11565092

申请日：2006-11-30

申请人： Yong Cho ,  Steven Lu ,  Luc Mongeon ,  Scott Davie ,  Todd Sheldon ,  Mark Erickson ,  H. Markowitz

发明人： Yong Cho ,  Steven Lu ,  Luc Mongeon ,  Scott Davie ,  Todd Sheldon ,  Mark Erickson ,  H. Markowitz

IPC分类号： A61B5/02 ,  A61B5/08

CPC分类号： A61B5/0809 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/0402 ,  A61B5/1459 ,  A61B5/4818 ,  G06F19/00

摘要： A system and method for monitoring respiration including sensing a signal that varies with respiration, deriving a respiration parameter, applying criteria for detecting a respiration disturbance and determining one or more respiratory disturbance metrics. The system preferably includes an implantable sensor with an associated implantable medical device such that chronic respiration monitoring is possible. The implantable medical device may execute methods for detecting and measuring respiratory disturbances or may store data to be transferred to an external device for detecting and measuring respiratory disturbances. Respiratory disturbance detection may trigger a responsive action such as physiological data storage, a change in therapy delivery, or a clinician warning. Assessment of cardiac function may be made based on metrics of respiratory disturbances or a measure of circulatory delay time following detection of a respiratory disturbance.

摘要翻译： 一种用于监测呼吸的系统和方法，包括感测随呼吸变化的信号，导出呼吸参数，应用用于检测呼吸障碍的标准和确定一个或多个呼吸障碍度量。 该系统优选地包括具有相关联的可植入医疗装置的可植入传感器，使得可以进行慢性呼吸监测。 可植入医疗装置可以执行用于检测和测量呼吸障碍的方法，或者可以将要传送到外部设备的数据存储以检测和测量呼吸障碍。 呼吸道干扰检测可能会触发响应动作，如生理数据存储，治疗传递的变化或临床医生的警告。 心脏功能的评估可以基于呼吸紊乱的度量或检测到呼吸障碍之后的循环延迟时间的量度进行。

公开(公告)号：US20060122863A1

公开(公告)日：2006-06-08

申请号：US11038814

申请日：2005-01-20

申请人： Janell Gottesman ,  H. Markowitz ,  James Willenbring ,  Christopher Manrodt ,  John Vandanacker ,  John Burnes ,  John Rueter ,  Sarah Audet ,  James Carney ,  Gerard Hill

发明人： Janell Gottesman ,  H. Markowitz ,  James Willenbring ,  Christopher Manrodt ,  John Vandanacker ,  John Burnes ,  John Rueter ,  Sarah Audet ,  James Carney ,  Gerard Hill

IPC分类号： G06Q10/00 ,  A61K9/22

CPC分类号： G06F19/3418 ,  G06F19/3456 ,  G06Q50/22 ,  G16H10/60

摘要： An intelligent patient management system collects data from a variety of sources, processes that information, and provides relevant information to an appropriate caregiver in context at the proper time. The system has multiple information sources available from which to gather additional information based upon conclusions drawn or issues identified from the patient data.

公开(公告)号：US20070239055A1

公开(公告)日：2007-10-11

申请号：US11278187

申请日：2006-03-31

申请人： Sameh Sowelam ,  H. Markowitz ,  Mark Erickson ,  Ioana Nicolaescu

发明人： Sameh Sowelam ,  H. Markowitz ,  Mark Erickson ,  Ioana Nicolaescu

IPC分类号： A61B5/08

CPC分类号： A61B5/08 ,  A61B5/021 ,  A61B5/087 ,  A61B5/1135 ,  A61B5/1455 ,  A61B5/4818 ,  A61B7/003

摘要： A system and method for monitoring in a patient includes producing sensor signals representative of a physiologic parameter associated with respiration. A periodic breathing cycle is detected based on the sensor signals. An output is produced as a function of the cycle length.

摘要翻译： 用于在患者中监测的系统和方法包括产生代表与呼吸相关的生理参数的传感器信号。 基于传感器信号检测周期性呼吸周期。 作为循环长度的函数产生输出。

公开(公告)号：US20060241701A1

公开(公告)日：2006-10-26

申请号：US11114474

申请日：2005-04-26

申请人： H. Markowitz ,  Douglas Hettrick ,  William Combs ,  Todd Sheldon

发明人： H. Markowitz ,  Douglas Hettrick ,  William Combs ,  Todd Sheldon

IPC分类号： A61N1/39

CPC分类号： A61N1/3962 ,  A61N1/025 ,  A61N1/37211 ,  A61N1/37229 ,  A61N1/37288

摘要： Subcutaneous Implantable cardioverter-defibrillators (SubQ ICDS) are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion-defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. The SubQ ICD is implemented with other implantable and external medical devices and communicates to provide drugs and therapy in a coordinated and synergistic manner.

摘要翻译： 皮下植入式心脏复律除颤器（SubQ ICDS）被公开，其完全可植入皮下，以最小的手术入侵患者身体，并提供分布式心脏复律除颤感和刺激电极，用于在整个心脏中递送心脏复律除颤休克和起搏疗法 必要。 SubQ ICD与其他植入式和外部医疗设备一起实施，并以协调和协同的方式进行通信以提供药物和治疗。