公开(公告)号：US11921245B2

公开(公告)日：2024-03-05

申请号：US18133578

申请日：2023-04-12

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tadashi Maruno ,  Eiji Toda ,  Mao Nakajima ,  Teruo Takahashi ,  Takafumi Higuchi

IPC: G01T1/24 ,  G01T1/208 ,  H04N25/65 ,  H04N25/74 ,  H04N25/75 ,  H04N25/767 ,  H04N25/772 ,  H04N25/778

CPC classification number: G01T1/247 ,  H04N25/65 ,  H04N25/74 ,  H04N25/75 ,  H04N25/767 ,  H04N25/772 ,  H04N25/778 ,  G01T1/208

Abstract: A photon counting device includes a plurality of pixels each including a photoelectric conversion element configured to convert input light to charge, and an amplifier configured to amplify the charge converted by the photoelectric conversion element and convert the charge to a voltage, an A/D converter configured to convert the voltages output from the amplifiers of the plurality of pixels to digital values; and a conversion unit configured to convert the digital value output from the A/D converter to the number of photons by referring to reference data, for each of the plurality of pixels, and the reference data is created based on a gain and an offset value for each of the plurality of pixels.

公开(公告)号：US11835667B2

公开(公告)日：2023-12-05

申请号：US17501398

申请日：2021-10-14

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tadashi Maruno ,  Eiji Toda ,  Mao Nakajima ,  Teruo Takahashi ,  Takafumi Higuchi

IPC: G01T1/24 ,  H04N25/65 ,  H04N25/74 ,  H04N25/75 ,  H04N25/767 ,  H04N25/772 ,  H04N25/778 ,  G01T1/208

CPC classification number: G01T1/247 ,  H04N25/65 ,  H04N25/74 ,  H04N25/75 ,  H04N25/767 ,  H04N25/772 ,  H04N25/778 ,  G01T1/208

Abstract: A photon counting device includes a plurality of pixels each including a photoelectric conversion element configured to convert input light to charge, and an amplifier configured to amplify the charge converted by the photoelectric conversion element and convert the charge to a voltage, an A/D converter configured to convert the voltage output from the amplifier of each of the plurality of pixels to a digital value and output the digital value, a correction unit configured to correct the digital value output from the A/D converter so that an influence of a variation in a gain and an offset value among the plurality of pixels is curbed, a calculation unit configured to output a summed value obtained by summing the corrected digital values corresponding to at least two pixels, and a conversion unit configured to convert the summed value output from the calculation unit to a number of photons.

公开(公告)号：US09423601B2

公开(公告)日：2016-08-23

申请号：US14413602

申请日：2014-01-22

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Eiji Toda ,  Takuo Kameyama

IPC: G02B21/16 ,  H04N5/225 ,  H04N5/232 ,  H04N3/14 ,  H04N5/378 ,  H04N5/359 ,  G02B21/00 ,  G02B21/36 ,  H04N5/341 ,  H04N5/235 ,  H04N5/353

CPC classification number: H04N5/3532 ,  G02B21/002 ,  G02B21/0036 ,  G02B21/008 ,  G02B21/16 ,  G02B21/365 ,  G02B21/367 ,  H04N3/1512 ,  H04N5/225 ,  H04N5/2256 ,  H04N5/232 ,  H04N5/2354 ,  H04N5/341 ,  H04N5/359 ,  H04N5/378

Abstract: An image acquisition system 1 includes: a light source 3 which outputs illumination light; an optical scanner 7 which scans a sample S with the illumination light; an optical scanner control unit 9; a detection optical system 15, 17 which focuses fluorescence from the sample S; an imaging device 19 which has a light receiving surface 19c in which a plurality of pixel rows 19d are arranged, and an imaging control section 19b, and which can perform signal readout of each of the plurality of pixel rows 19d from the light receiving surface 19c; and a calculation unit 21 which calculates an interval of signal readout between adjacent pixel rows 19d, based on a moving speed of an illuminated region on the light receiving surface 19c; the imaging control section 19b controls signal readout of each pixel row 19d, based on the interval of the signal readout thus calculated.

Abstract translation: 图像采集系统1包括：输出照明光的光源3; 光学扫描器7，其用照明光扫描样品S; 光学扫描器控制单元9; 检测光学系统15,17，其聚焦来自样品S的荧光; 具有布置有多个像素行19d的受光面19c的摄像装置19和摄像控制部19b，能够从受光面19c进行多个像素列19d的每一个的信号读出 ; 以及计算单元21，其基于光接收表面19c上的照明区域的移动速度来计算相邻像素行19d之间的信号读出的间隔; 成像控制部分19b基于如此计算的信号读出的间隔控制每个像素行19d的信号读出。

公开(公告)号：US12078767B2

公开(公告)日：2024-09-03

申请号：US18206806

申请日：2023-06-07

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tadashi Maruno ,  Eiji Toda ,  Mao Nakajima ,  Teruo Takahashi ,  Takafumi Higuchi

IPC: G01T1/24 ,  H04N25/65 ,  H04N25/74 ,  H04N25/75 ,  H04N25/767 ,  H04N25/772 ,  H04N25/778 ,  G01T1/208

CPC classification number: G01T1/247 ,  H04N25/65 ,  H04N25/74 ,  H04N25/75 ,  H04N25/767 ,  H04N25/772 ,  H04N25/778 ,  G01T1/208

Abstract: A photon counting device includes a plurality of pixels each including a photoelectric conversion element configured to convert input light to charge, and an amplifier configured to amplify the charge converted by the photoelectric conversion element and convert the charge to a voltage, an A/D converter configured to convert the voltage output from the amplifier of each of the plurality of pixels to a digital value and output the digital value, a correction unit configured to correct the digital value output from the A/D converter so that an influence of a variation in a gain and an offset value among the plurality of pixels is curbed, a calculation unit configured to output a summed value obtained by summing the corrected digital values corresponding to at least two pixels, and a conversion unit configured to convert the summed value output from the calculation unit to a number of photons.

公开(公告)号：US11796692B2

公开(公告)日：2023-10-24

申请号：US17501398

申请日：2021-10-14

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tadashi Maruno ,  Eiji Toda ,  Mao Nakajima ,  Teruo Takahashi ,  Takafumi Higuchi

IPC: G01T1/24 ,  H04N25/65 ,  H04N25/74 ,  H04N25/75 ,  H04N25/767 ,  H04N25/772 ,  H04N25/778 ,  G01T1/208

CPC classification number: G01T1/247 ,  H04N25/65 ,  H04N25/74 ,  H04N25/75 ,  H04N25/767 ,  H04N25/772 ,  H04N25/778 ,  G01T1/208

Abstract: A photon counting device includes a plurality of pixels each including a photoelectric conversion element configured to convert input light to charge, and an amplifier configured to amplify the charge converted by the photoelectric conversion element and convert the charge to a voltage, an A/D converter configured to convert the voltage output from the amplifier of each of the plurality of pixels to a digital value and output the digital value, a correction unit configured to correct the digital value output from the A/D converter so that an influence of a variation in a gain and an offset value among the plurality of pixels is curbed, a calculation unit configured to output a summed value obtained by summing the corrected digital values corresponding to at least two pixels, and a conversion unit configured to convert the summed value output from the calculation unit to a number of photons.

公开(公告)号：US11215717B2

公开(公告)日：2022-01-04

申请号：US16764053

申请日：2018-06-18

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tadashi Maruno ,  Eiji Toda ,  Mao Nakajima ,  Teruo Takahashi ,  Takafumi Higuchi

IPC: G01T1/24 ,  H04N5/374 ,  H04N5/376 ,  H04N5/363 ,  H04N5/3745 ,  H04N5/378 ,  G01T1/208

Abstract: A photon counting device includes a plurality of pixels each including a photoelectric conversion element configured to convert input light to charge, and an amplifier configured to amplify the charge converted by the photoelectric conversion element and convert the charge to a voltage, an A/D converter configured to convert the voltage output from the amplifier of each of the plurality of pixels to a digital value and output the digital value, a correction unit configured to correct the digital value output from the A/D converter so that an influence of a variation in a gain and an offset value among the plurality of pixels is curbed, a calculation unit configured to output a summed value obtained by summing the corrected digital values corresponding to at least two pixels, and a conversion unit configured to convert the summed value output from the calculation unit to a number of photons.

公开(公告)号：US20240393484A1

公开(公告)日：2024-11-28

申请号：US18794569

申请日：2024-08-05

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tadashi MARUNO ,  Eiji Toda ,  Mao Nakajima ,  Teruo Takahashi ,  Takafumi Higuchi

IPC: G01T1/24 ,  G01T1/208 ,  H04N25/65 ,  H04N25/74 ,  H04N25/75 ,  H04N25/767 ,  H04N25/772 ,  H04N25/778

Abstract: A photon counting device includes a plurality of pixels each including a photoelectric conversion element configured to convert input light to charge, and an amplifier configured to amplify the charge converted by the photoelectric conversion element and convert the charge to a voltage, an A/D converter configured to convert the voltage output from the amplifier of each of the plurality of pixels to a digital value and output the digital value, a correction unit configured to correct the digital value output from the A/D converter so that an influence of a variation in a gain and an offset value among the plurality of pixels is curbed, a calculation unit configured to output a summed value obtained by summing the corrected digital values corresponding to at least two pixels, and a conversion unit configured to convert the summed value output from the calculation unit to a number of photons.

公开(公告)号：US10602087B2

公开(公告)日：2020-03-24

申请号：US16435084

申请日：2019-06-07

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Eiji Toda ,  Takuo Kameyama

IPC: H04N5/353 ,  H04N5/225 ,  H04N5/232 ,  H04N3/14 ,  H04N5/378 ,  H04N5/359 ,  G02B21/00 ,  G02B21/36 ,  H04N5/235 ,  H04N5/341 ,  G02B21/16

Abstract: An image acquisition system 1 includes: a light source 3 which outputs illumination light; an optical scanner 7 which scans a sample S with the illumination light; an optical scanner control unit 9; a detection optical system 15, 17 which focuses fluorescence from the sample S; an imaging device 19 which has a light receiving surface 19c in which a plurality of pixel rows 19d are arranged, and an imaging control section 19b, and which can perform signal readout of each of the plurality of pixel rows 19d from the light receiving surface 19c; and a calculation unit 21 which calculates an interval of signal readout between adjacent pixel rows 19d, based on a moving speed of an illuminated region on the light receiving surface 19c; the imaging control section 19b controls signal readout of each pixel row 19d, based on the interval of the signal readout thus calculated.

公开(公告)号：US10142566B2

公开(公告)日：2018-11-27

申请号：US15145031

申请日：2016-05-03

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Eiji Toda ,  Takuo Kameyama

IPC: H04N5/353 ,  H04N5/225 ,  H04N5/232 ,  H04N3/14 ,  H04N5/378 ,  H04N5/359 ,  G02B21/00 ,  G02B21/36 ,  H04N5/341 ,  G02B21/16 ,  H04N5/235

Abstract: An image acquisition system 1 includes: a light source 3 which outputs illumination light; an optical scanner 7 which scans a sample S with the illumination light; an optical scanner control unit 9; a detection optical system 15, 17 which focuses fluorescence from the sample S; an imaging device 19 which has a light receiving surface 19c in which a plurality of pixel rows 19d are arranged, and an imaging control section 19b, and which can perform signal readout of each of the plurality of pixel rows 19d from the light receiving surface 19c; and a calculation unit 21 which calculates an interval of signal readout between adjacent pixel rows 19d, based on a moving speed of an illuminated region on the light receiving surface 19c; the imaging control section 19b controls signal readout of each pixel row 19d, based on the interval of the signal readout thus calculated.

公开(公告)号：US11656374B2

公开(公告)日：2023-05-23

申请号：US17502424

申请日：2021-10-15

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tadashi Maruno ,  Eiji Toda ,  Mao Nakajima ,  Teruo Takahashi ,  Takafumi Higuchi

IPC: G01T1/24 ,  H04N5/374 ,  H04N5/3745 ,  H01L27/146 ,  G01J1/02 ,  H04N5/376 ,  H04N5/363 ,  H04N5/378 ,  G01T1/208

CPC classification number: G01T1/247 ,  H04N5/363 ,  H04N5/376 ,  H04N5/378 ,  H04N5/3742 ,  H04N5/37455 ,  H04N5/37457 ,  G01T1/208

Abstract: A photon counting device includes a plurality of pixels each including a photoelectric conversion element configured to convert input light to charge, and an amplifier configured to amplify the charge converted by the photoelectric conversion element and convert the charge to a voltage, an A/D converter configured to convert the voltages output from the amplifiers of the plurality of pixels to digital values; and a conversion unit configured to convert the digital value output from the A/D converter to the number of photons by referring to reference data, for each of the plurality of pixels, and the reference data is created based on a gain and an offset value for each of the plurality of pixels.