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公开(公告)号:US10725019B2
公开(公告)日:2020-07-28
申请号:US15522831
申请日:2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: Melinda M Valencia , Chantelle E Domingue , Jeremy Sells , Manish Giri , Sadiq Bengali
Abstract: Example implementations relate to coagulation sensing. For example, a microfluidic chip for coagulation sensing may include a microfluidic channel, an outlet at an end of the microfluidic channel having an air interface, and an impedance sensor located within the microfluidic channel and within a particular proximity to the air interface, the impedance sensor to determine a stage of a coagulation cascade of a blood sample flowing through the microfluidic channel to the impedance sensor.
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公开(公告)号:US20190127219A1
公开(公告)日:2019-05-02
申请号:US16094411
申请日:2016-07-22
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: Sadiq Bengali , Manish Giri
Abstract: Example sensor apparatus for microfluidic devices and related methods are disclosed. In examples disclosed herein, a method of fabricating a sensor apparatus for a microfluidic device includes etching a portion of an intermediate layer to form a sensor chamber in a substrate assembly, where the substrate assembly has a base layer and the intermediate layer, and where the base layer comprises a first material and the intermediate layer comprises a second material different than the first material. The method includes forming a first electrode and a second electrode in the sensor chamber. The method also includes forming a fluidic transport channel in fluid communication with the sensor chamber, where the fluidic transport channel comprises a third material different than the first material and the second material.
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公开(公告)号:US11008214B2
公开(公告)日:2021-05-18
申请号:US16094411
申请日:2016-07-22
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: Sadiq Bengali , Manish Giri
Abstract: Example sensor apparatus for microfluidic devices and related methods are disclosed. In examples disclosed herein, a method of fabricating a sensor apparatus for a microfluidic device includes etching a portion of an intermediate layer to form a sensor chamber in a substrate assembly, where the substrate assembly has a base layer and the intermediate layer, and where the base layer comprises a first material and the intermediate layer comprises a second material different than the first material. The method includes forming a first electrode and a second electrode in the sensor chamber. The method also includes forming a fluidic transport channel in fluid communication with the sensor chamber, where the fluidic transport channel comprises a third material different than the first material and the second material.
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公开(公告)号:US20180229236A1
公开(公告)日:2018-08-16
申请号:US15749036
申请日:2016-01-29
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: Sadiq Bengali , Manish Giri
IPC: B01L3/00 , G01N33/553
CPC classification number: B01L3/502707 , B01L3/00 , B01L2300/0663 , B01L2300/1827 , B01L2400/0442 , G01N33/553
Abstract: A microfluidic diagnostic chip may, in an example, include a number of microfluidic channels defined in a substrate each microfluidic channel fluidly coupled to at least one fluidic slot; the at least one fluidic slot to receive a number of fluids, and a number of gold sensors each gold sensor having a thickness of between 1500 and 5000 angstroms (Å).
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公开(公告)号:US20170328882A1
公开(公告)日:2017-11-16
申请号:US15522831
申请日:2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: Melinda M Valencia , Chantelle E Domingue , Jeremy Sells , Manish Giri , Sadiq Bengali
Abstract: Example implementations relate to coagulation sensing. For example, a microfluidic chip for coagulation sensing may include a microfluidic channel, an outlet at an end of the microfluidic channel having an air interface, and an impedance sensor located within the microfluidic channel and within a particular proximity to the air interface, the impedance sensor to determine a stage of a coagulation cascade of a blood sample flowing through the microfluidic channel to the impedance sensor.
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公开(公告)号:US10850275B2
公开(公告)日:2020-12-01
申请号:US15749036
申请日:2016-01-29
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: Sadiq Bengali , Manish Giri
IPC: B01L3/00 , G01N33/553
Abstract: A microfluidic diagnostic chip may, in an example, include a number of microfluidic channels defined in a substrate each microfluidic channel fluidly coupled to at least one fluidic slot; the at least one fluidic slot to receive a number of fluids, and a number of gold sensors each gold sensor having a thickness of between 1500 and 5000 angstroms (Å).
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公开(公告)号:US20180236765A1
公开(公告)日:2018-08-23
申请号:US15749067
申请日:2016-01-25
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: Manish Giri , Sadiq Bengali
CPC classification number: B41J2/14153 , B41J2/14129 , B41J2/1601 , B41J2/1603 , B41J2/1628 , B41J2/1629 , B41J2/1631 , B41J2/1642
Abstract: A device including a substrate and a channel formed in a layer disposed on the substrate. The layer includes a cavitation layer and a passivation layer to mitigate the effects of hydrodynamic cavitation on a surface of the channel. The passivation and cavitation material and thickness are optimized thermally to nucleate and eject a bubble at low voltages. A resistive heating element is disposed within the channel that is activated to create a micro-fluidic pump to advance a fluid through the channel. A sensor is disposed within the channel to measure a characteristic of the fluid passing through the channel.
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公开(公告)号:US20180043356A1
公开(公告)日:2018-02-15
申请号:US15545396
申请日:2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: Chantelle Domingue , Manish Giri , Sadiq Bengali
CPC classification number: B01L3/5027 , B01L3/50273 , B01L7/00 , B01L7/52 , B01L2200/10 , B01L2200/147 , B01L2300/023 , B01L2300/0861 , B01L2300/1827 , B01L2400/0442 , B81B7/0087
Abstract: A device includes a microfluidic channel structure on a substrate and a first resistive structure on the substrate to control the temperature of at least the substrate. The first resistive structure is separate from, and independent of the, microfluidic channel structure. In some instances, the device includes a second resistive structure.
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