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公开(公告)号：US11097272B2
公开(公告)日：2021-08-24
申请号：US16099172
申请日：2016-07-26
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Chantelle Domingue , Tod Woodford , Manish Giri , Matthew David Smith , George H Corrigan, III , Masoud Zavarehi , Joshua M. Yu
Abstract: According to an example, a microfluidic apparatus may include a fluid slot and a foyer that is in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer. The microfluidic apparatus may also include an electrical sensor to measure a change in an electrical field caused by a particle of interest in a fluid passing through the channel from the fluid slot to the foyer, an actuator to apply pressure onto fluid contained in the foyer, and a controller to receive the measured change in the electrical field from the electrical sensor, determine, from the received change in the electrical field, an electrical signature of the particle of interest, and control the actuator to control movement of the particle of interest based upon the determined electrical signature of the particle of interest.
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公开(公告)号：US11007525B2
公开(公告)日：2021-05-18
申请号：US15547756
申请日：2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Jeremy Sells , Chantelle E. Domingue , Robert Moline , Manish Giri
IPC: B01L3/00 , G01N33/487 , C12M3/06 , C12M1/00 , C12M1/36
Abstract: Vented microfluidic reservoirs can include a housing and a vent coupled to the housing to vent air associated with a fluid sample communicated into the housing to an environment surrounding a microfluidic device coupled to the housing.
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公开(公告)号：US10241066B2
公开(公告)日：2019-03-26
申请号：US15112639
申请日：2014-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Nicholas Matthew Cooper McGuinness , Melinda M. Valencia , Manish Giri , Chantelle Elizabeth Domingue , Jeremy Sells , Matthew David Smith
Abstract: A microfluidic sensing device comprises a channel and an impedance sensor within the channel. The impedance sensor comprises a local ground and an electrode within the channel. The local ground and the electrode are to form an electric field region that is elongated along the channel.
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公开(公告)号：US20180264470A1
公开(公告)日：2018-09-20
申请号：US15546392
申请日：2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Sirena Lu , Manish Giri , Matthew David Smith , Melinda M. Valencia
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L2200/147 , B01L2300/023 , B01L2300/0645 , B01L2300/0816 , B01L2400/0415 , G01N33/4875 , G08C15/00
Abstract: A controller is connected to controlled devices on a microfluidic chip with a multiplexer. Signal transmission band width is differently allocated amongst the plurality of controlled devices on the microfluidic chip.
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公开(公告)号：US20180229236A1
公开(公告)日：2018-08-16
申请号：US15749036
申请日：2016-01-29
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Sadiq Bengali , Manish Giri
IPC: B01L3/00 , G01N33/553
CPC classification number: B01L3/502707 , B01L3/00 , B01L2300/0663 , B01L2300/1827 , B01L2400/0442 , G01N33/553
Abstract: A microfluidic diagnostic chip may, in an example, include a number of microfluidic channels defined in a substrate each microfluidic channel fluidly coupled to at least one fluidic slot; the at least one fluidic slot to receive a number of fluids, and a number of gold sensors each gold sensor having a thickness of between 1500 and 5000 angstroms (Å).
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Patent Agency Ranking
公开(公告)号：US20180021778A1
公开(公告)日：2018-01-25
申请号：US15547756
申请日：2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Jeremy Sells , Chantelle E. Domingue , Robert Moline , Manish Giri
IPC: B01L3/00
CPC classification number: B01L3/502723 , B01L2200/0684 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2400/0439 , B01L2400/0442 , C12M23/16 , C12M29/20 , C12M41/48 , G01N33/48707
Abstract: Vented microfluidic reservoirs can include a housing and a vent coupled to the housing to vent air associated with a fluid sample communicated into the housing to an environment surrounding a microfluidic device coupled to the housing.
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公开(公告)号：US20180015457A1
公开(公告)日：2018-01-18
申请号：US15546735
申请日：2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Nicholas McGuinness , Chantelle Domingue , Manish Giri , Jeremy Sells
IPC: B01L3/00
CPC classification number: B01L3/50273 , B01L3/502715 , B01L2200/10 , B01L2300/023 , B01L2300/024 , B01L2300/027 , B01L2300/0627 , B01L2300/0816 , B01L2300/088 , B01L2300/0883 , B01L2300/1827 , B01L2400/0442 , B01L2400/0487 , B01L2400/086 , G01N27/07 , G01N33/48785
Abstract: A microfluidic diagnostic device may comprise a fluid inlet to receive a fluid from a fluidic slot, a main microfluidic channel fluidly coupled to the fluid inlet, and a main microfluidic pump interposed between the fluid inlet and the main microfluidic channel to continuously circulate a fluid through the fluidic slot, fluid inlet, and main microfluidic channel wherein the width of the fluid inlet is different from the width of the main microfluidic channel. A diagnostic device, comprising a fluidic slot, a fluid inlet fluidly coupled to the fluidic slot, a main channel fluidly coupled to the fluid inlet, and an inlet pump interposed between the fluid inlet and channel wherein the cross-sectional area of the fluid inlet is relatively larger at least one point than the cross-sectional area of the channel.
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公开(公告)号：US20180003611A1
公开(公告)日：2018-01-04
申请号：US15546342
申请日：2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Jeremy Sells , Nick McGuinness , Chantelle Domingue , Manish Giri
CPC classification number: G01N15/1056 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0627 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2400/0439 , B01L2400/0442 , G01N15/1031 , G01N2015/1006 , G01N2015/1062
Abstract: A device including a microfluidic channel structure formed on a substrate and including a first channel and a fluid actuator within the microfluidic channel structure. A sense region within the first channel is to receive a fluid flow of target biologic particles for counting in a single file pattern, with the sense region having a volume on a same order of magnitude as a volume of a single one of the target biologic particles.
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公开(公告)号：US20170368549A1
公开(公告)日：2017-12-28
申请号：US15546511
申请日：2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Manish Giri , Chantelle Elizabeth Domingue , Nicholas Matthew Cooper McGuinness , Jeremy Sells , Sirena Lu , Melinda M. Valencia
IPC: B01L3/00 , G01N33/543
CPC classification number: B01L3/502753 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/141 , B01L2200/143 , B01L2300/023 , B01L2300/024 , B01L2300/027 , B01L2300/0636 , B01L2300/0663 , B01L2300/088 , B01L2300/1827 , B01L2400/046 , C12Q1/005 , C12Q1/6804 , G01N15/0656 , G01N33/54373 , G01N33/5438 , G01N2015/0065 , G01N2015/0687 , C12Q2531/113 , C12Q2531/143 , C12Q2563/131 , C12Q2565/607 , C12Q2565/629
Abstract: A microfluidic diagnostic chip may comprise a microfluidic channel, a functionalizable enzymatic sensor in the microfluidic channel, the functionalizable enzymatic sensor comprising a binding surface to bind with a biomarker in a fluid, and a microfluidic pump to pass the fluid over the binding surface. A microfluidic device may comprise a number of pumps to pump a fluid though the number of microfluidic channels and a number of microfluidic channels comprising at least one sensor to detect a change in a chemical characteristic of the fluid in response to presence of the fluid on the sensor
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公开(公告)号：US20170328882A1
公开(公告)日：2017-11-16
申请号：US15522831
申请日：2015-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Melinda M Valencia , Chantelle E Domingue , Jeremy Sells , Manish Giri , Sadiq Bengali
Abstract: Example implementations relate to coagulation sensing. For example, a microfluidic chip for coagulation sensing may include a microfluidic channel, an outlet at an end of the microfluidic channel having an air interface, and an impedance sensor located within the microfluidic channel and within a particular proximity to the air interface, the impedance sensor to determine a stage of a coagulation cascade of a blood sample flowing through the microfluidic channel to the impedance sensor.
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