公开(公告)号：US20150056098A1

公开(公告)日：2015-02-26

申请号：US14356962

申请日：2012-12-14

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Toru Inaba ,  Shinya Matsuoka ,  Taku Sakazume ,  Yoshihiro Yamashita ,  Masafumi Shimada

IPC: G01N27/74 ,  G01N33/553

CPC classification number: G01N27/745 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N33/553 ,  G01N2446/00

Abstract: A problem of a sample analysis device that uses magnetic particles is the difficulty in uniformly capturing magnetic particles, specifically the poor uniformity in the vicinity of channel side walls. This causes poor analysis accuracy and reproducibility. The present invention is intended to provide a means to uniformly capture magnetic particles in the vicinity of channel side walls. Specifically, the present invention provides an analysis device that includes a detection channel with an inlet and an outlet through which a sample liquid containing a specific substance and magnetic particles is flowed in and out of the channel, and magnetic field generating means capable of varying the magnitude of the magnetic field in a predetermined region of the detection channel. The width of the magnet in the detector is greater than the channel width. The detector can improve the analysis accuracy and reproducibility of the analysis device.

Abstract translation: 使用磁性颗粒的样品分析装置的问题是难以均匀地捕获磁性颗粒，特别是通道侧壁附近的均匀性差。 这导致分析精度差和重复性差。 本发明旨在提供在通道侧壁附近均匀地捕获磁性颗粒的方法。 具体而言，本发明提供一种分析装置，其具有检测通道，该检测通道具有入口和出口，通过该入口和出口将含有特定物质的样品液体和磁性颗粒流入和流出通道，以及磁场产生装置， 在检测通道的预定区域中的磁场的大小。 检测器中磁体的宽度大于通道宽度。 检测器可以提高分析装置的分析精度和再现性。

公开(公告)号：US11719714B2

公开(公告)日：2023-08-08

申请号：US16645583

申请日：2019-03-19

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION ,  ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Sayaka Sarwar ,  Masaharu Nishida ,  Yoko Inoue ,  Masafumi Shimada ,  Kenichi Yagi ,  Naohiko Fukaya ,  Andrew McCaughey

IPC: G01N35/10 ,  G01N35/00

CPC classification number: G01N35/1002 ,  G01N35/00603 ,  G01N35/1016 ,  G01N2035/1018

Abstract: The automatic analyzer includes: a liquid dispensing mechanism that performs suction of a liquid; a pressure sensor that measures a change of an internal pressure of a probe provided at the liquid dispensing mechanism; a determination section that determines whether the suction of the liquid by the probe is normal suction or air suction abnormality; an analysis section; a storage section that stores a cumulative number of times of air suction abnormality per liquid and an allowable cumulative number for the cumulative number of times of air suction abnormality; and a controller that exercises operation control over the liquid dispensing mechanism, the determination section, and the analysis section. The controller exercises control such that the cumulative number of times of air suction abnormality is updated and the updated cumulative number is stored in the storage section even if the air suction abnormality occurs non-consecutively.

公开(公告)号：US11327089B2

公开(公告)日：2022-05-10

申请号：US16483458

申请日：2018-01-16

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Masafumi Shimada ,  Isao Yamazaki ,  Masaharu Nishida ,  Yoko Inoue

IPC: G01N35/02 ,  G01N35/10

Abstract: The purpose of the present invention is to provide an automatic analysis device capable of determining, through a simple processing, whether or not idle aspirate has occurred. The automatic analysis device according to the present invention determines whether or not idle aspirate has occurred, by calculating a parameter which specifies whether or not the length of a portion of a path through which the sample passes inside a dispensing probe is shorter than that during normal aspirate, the portion being actually filled with a sample (see FIG. 4).