公开(公告)号：US11656238B2

公开(公告)日：2023-05-23

申请号：US16473687

申请日：2018-01-12

Applicant: Hitachi High-Technologies Corporation

Inventor： Takashi Nakasawa ,  Tetsuji Kawahara ,  Masaharu Nishida ,  Yoko Inoue ,  Kenichi Yagi ,  Osamu Matsumoto ,  Sayaka Asada

IPC: G01N35/02 ,  G01N21/03 ,  G01N35/00 ,  G01N35/04 ,  G01N21/76 ,  G01N21/82

CPC classification number: G01N35/025 ,  G01N21/03 ,  G01N21/76 ,  G01N21/82 ,  G01N35/0092 ,  G01N35/04 ,  G01N2035/0437 ,  G01N2035/0453

Abstract: The automatic analyzer includes a storage unit storing the reaction containers of cleaning target by day unit in such a manner that all the reaction containers mounted on a reaction disk are to be cleaning target within a plurality of days, and a control unit exerts a control in such a manner that during an operation state after the sample of analysis object is dispensed to the reaction containers, a sample of analysis object in each of the reaction containers is analyzed, and not the sample but a detergent is dispensed to the reaction containers of cleaning target of an appointed day, the reaction containers of cleaning target of the appointed day being stored in the storage unit, to soak and wash the reaction containers for a certain time.

公开(公告)号：US11041874B2

公开(公告)日：2021-06-22

申请号：US16086085

申请日：2017-01-31

Applicant: Hitachi High-Technologies Corporation

Inventor： Saori Chida ,  Yoichi Aruga ,  Akihiro Yasui ,  Yoshiki Muramatsu ,  Yoko Inoue ,  Hideto Tamezane

IPC: G01N35/10 ,  G01N21/59 ,  G01N35/04 ,  G01N35/00

Abstract: The automatic analyzer includes: a member to be washed, such as a probe or a stirrer for contacting and stirring a liquid; a wash station in which the member to be washed is washed with a washing liquid; and a measuring part that measures an optical characteristic of an evaluation reagent contained in a reaction cell. A control unit brings the member to be washed that has been washed in the wash station into contact with the evaluation reagent, causes the measuring part to measure the optical characteristic after contact with the evaluation reagent, and calculates the amount of the washing liquid carried into the reaction cell by the member to be washed, based on the measured optical characteristic.

公开(公告)号：US09862921B2

公开(公告)日：2018-01-09

申请号：US14896123

申请日：2014-06-17

Applicant: Hitachi High-Technologies Corporation

Inventor： Naoko Senda ,  Yoko Inoue ,  Hiroaki Nakagawa ,  Akihiro Shimase ,  Ryota Nakajima ,  Kazumichi Imai ,  Shizu Takeda

IPC: C12M1/34 ,  C12M1/36 ,  G01N33/68 ,  G01N33/50

CPC classification number: C12M41/46 ,  C12M41/48 ,  G01N33/5005 ,  G01N33/6806 ,  G01N33/6812

Abstract: There is provided a method for noninvasively evaluating the cell state (proliferation, multi-layering, and differentiation) of a cell sheet as a mimic tissue at the time of culturing the cell sheet. The method is characterized in that an analysis of an amino acid is conducted with the use of the culture supernatant of a cell sheet to monitor a change in the concentration of any amino acid selected from a group of 5-species of amino acids (Ile, Val, Ser, Leu, and Ala), thereby making a determination.

公开(公告)号：US11719714B2

公开(公告)日：2023-08-08

申请号：US16645583

申请日：2019-03-19

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION ,  ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Sayaka Sarwar ,  Masaharu Nishida ,  Yoko Inoue ,  Masafumi Shimada ,  Kenichi Yagi ,  Naohiko Fukaya ,  Andrew McCaughey

IPC: G01N35/10 ,  G01N35/00

CPC classification number: G01N35/1002 ,  G01N35/00603 ,  G01N35/1016 ,  G01N2035/1018

Abstract: The automatic analyzer includes: a liquid dispensing mechanism that performs suction of a liquid; a pressure sensor that measures a change of an internal pressure of a probe provided at the liquid dispensing mechanism; a determination section that determines whether the suction of the liquid by the probe is normal suction or air suction abnormality; an analysis section; a storage section that stores a cumulative number of times of air suction abnormality per liquid and an allowable cumulative number for the cumulative number of times of air suction abnormality; and a controller that exercises operation control over the liquid dispensing mechanism, the determination section, and the analysis section. The controller exercises control such that the cumulative number of times of air suction abnormality is updated and the updated cumulative number is stored in the storage section even if the air suction abnormality occurs non-consecutively.

公开(公告)号：US11327089B2

公开(公告)日：2022-05-10

申请号：US16483458

申请日：2018-01-16

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Masafumi Shimada ,  Isao Yamazaki ,  Masaharu Nishida ,  Yoko Inoue

IPC: G01N35/02 ,  G01N35/10

Abstract: The purpose of the present invention is to provide an automatic analysis device capable of determining, through a simple processing, whether or not idle aspirate has occurred. The automatic analysis device according to the present invention determines whether or not idle aspirate has occurred, by calculating a parameter which specifies whether or not the length of a portion of a path through which the sample passes inside a dispensing probe is shorter than that during normal aspirate, the portion being actually filled with a sample (see FIG. 4).