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    alpha, alpha-disubstituted-beta-amino propionic acids
    5.
    发明授权
    alpha, alpha-disubstituted-beta-amino propionic acids 失效
    α，α-二取代-β-氨基丙酸

    公开(公告)号：US3328436A

    公开(公告)日：1967-06-27

    申请号：US32848363

    申请日：1963-12-06

    Applicant: HOFFMANN LA ROCHE

    Inventor： GUSTAV ERLEMANN ,  PETER FAHRNI ,  OTTO SCHNIDER

    IPC: A61K8/44 ,  A61K47/18 ,  A61Q19/00 ,  B01J19/06 ,  C09D7/00 ,  C10L1/222 ,  C11D1/00

    CPC classification number: A61K8/44 ,  A61K47/183 ,  A61Q19/00 ,  B01J19/06 ,  C07C255/00 ,  C08K5/175 ,  C09D7/43 ,  C10L1/2222 ,  C10M1/08 ,  C10M2215/04 ,  C10M2215/26

    Abstract: The invention comprises compounds of the general formula wherein R1 represents an alkyl group having a chain length of at least 9 carbon atoms and containing from 9 to 22 carbon atoms and R2 represents an alkyl group having a chain length of from 1 to 10 carbon atoms, and salts thereof. The compounds are prepared by treating a compound of the general formula wherein R3 represents an esterified carboxyl group, R10 represents an alkyl or alkenyl group having a chain length of at least 9 carbon atoms and containing from 9 to 22 carbon atoms and R20 represents an alkyl or alkenyl group having a chain length of not more than 10 carbon atoms, in any desired sequence with a reducing agent and with a hydrolysing agent and then converting the resulting amino-substituted carboxylic acid into a salt if desired. The cyano-compounds used as starting materials can be prepared by reacting the sodium salt of the corresponding cyano-acetic ester, in the presence of excess cyano-acetic ester, in alcohol with an R10 halogenide in which R10 is as defined above, followed by the introduction of R20 into the resultant monosubstituted cyano-acetic ester in a similar manner. Examples are given.ALSO:Compounds of the general formula wherein R1 represents an alkyl group having a chain length of at least 9 carbon atoms and containing from 9 to 22 carbon atoms and R2 represents an alkyl group having a chain length of from 1 to 10 carbon atoms, are used as thickening or gelation agents for non-polar or slightly polar organic solvents which are used, for example, in lacquers, paints, lubricating oils and stain-cleansing agents. Specified organic solvents are petrol, petroleum ethers methylene chloride, chloroform, carbon tetrachloride, benzene, toluene, xylene, nitrobenzene, diethyl ether and dioxane. Example 1 describes a thixotropic base material, suitable for lacquers and colours, containing petroleum ether and a - dodecyl - a - propyl - b - amino - propionic acid. Example 4 describes viscous oils, suitable for use for lubrication purposes, comprising thinly liquid paraffin oil and a -hexadecyl-a - propyl - b - amino - propionic acid.

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