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11 条记录 (耗时 0.047 秒)

    STABILIZATION METHOD OF FUNCTIONAL NUCLEIC ACID
    2.
    发明申请
    STABILIZATION METHOD OF FUNCTIONAL NUCLEIC ACID 审中-公开
    功能性核酸的稳定化方法

    公开(公告)号：US20110306653A1

    公开(公告)日：2011-12-15

    申请号：US13107175

    申请日：2011-05-13

    申请人： Ichiro HIRAO ,  Michiko HIRAO ,  Shuang LIU ,  Iwao NOZAWA

    发明人： Ichiro HIRAO ,  Michiko HIRAO ,  Shuang LIU ,  Iwao NOZAWA

    IPC分类号： C07H21/04 ,  C12P19/34 ,  A61K31/7088

    CPC分类号： A61K31/7088 ,  C12N15/111 ,  C12N15/67 ,  C12N2310/13 ,  C12N2310/14 ,  C12N2310/3519 ,  C12N2320/51 ,  C12N2310/531

    摘要： This invention is intended to enhance and improve the resistance of a single- or double-stranded nucleic acid fragment comprising a base sequence of a functional nucleic acid to degradation by nucleolytic enzymes in a simple and cost-effective manner. The single- or double-stranded nucleic acid fragment comprises, ligated to at least one end thereof, hairpin-shaped DNA comprising: (A) a nucleic acid region comprising 2 to 5 arbitrary nucleotides; (B) a nucleic acid region comprising a “gna” or “gnna” base sequence, wherein each “n” represents “g”, “t”, “a”, or “c”, a base analogue, or a modified base; and (C) a nucleic acid region comprising a base sequence complementary to the nucleic acid region (A), sequentially from the 5′ end toward the 3′ end.

    摘要翻译： 本发明旨在增强和改善包含功能性核酸的碱基序列的单链或双链核酸片段以简单和成本有效的方式降解核分解酶的抗性。 单链或双链核酸片段包含连接至至少一端的发夹状DNA，其包含：（A）包含2至5个任意核苷酸的核酸区; （B）包含“gna”或“gnna”碱基序列的核酸区域，其中每个“n”表示“g”，“t”，“a”或“c”，碱基类似物或修饰碱基 ; 和（C）包含与核酸区域（A）互补的碱基序列的核酸区域，从5'端到3'端依次。

    SGLT-2 INHIBITORS, METHODS OF MAKING THEM, AND USES THEREOF
    8.
    发明申请
    SGLT-2 INHIBITORS, METHODS OF MAKING THEM, AND USES THEREOF 失效
    SGLT-2抑制剂，其制备方法及其用途

    公开(公告)号：US20110237527A1

    公开(公告)日：2011-09-29

    申请号：US13052171

    申请日：2011-03-21

    申请人： Shuang LIU ,  Cheng GUO ,  Min HU ,  Douglas B. KITCHEN ,  Peter R. GUZZO ,  Russell DEORAZIO

    发明人： Shuang LIU ,  Cheng GUO ,  Min HU ,  Douglas B. KITCHEN ,  Peter R. GUZZO ,  Russell DEORAZIO

    IPC分类号： A61K31/706 ,  C07H7/06 ,  A61P3/10 ,  A61P27/12 ,  A61P3/06 ,  A61P3/04 ,  A61P17/02 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06

    CPC分类号： A61K31/706

    摘要： The present invention relates to compounds which are inhibitors of sodium dependent glucose co-transporter-2 (SGLT-2). These compounds are used in the treatment of various disorders, including diabetes, impaired glucose tolerance, insulin resistance, retinopathy, nephropathy, neuropathy, cataracts, hyperglycemia, hyperinsulinemia, hyperchlolesterolemia, elevated blood level of free fatty acids or glycerol, hyperlipidemia, hypertriglyceridemia, obesity, wound healing, tissue ischemia, atherosclerosis, and hypertension. These compounds and compositions are also useful for treating and preventing kidney stones, hyperuricemia, gout, and hyponatremia. Methods of making these compounds are also described in the present invention.

    摘要翻译： 本发明涉及作为钠依赖性葡萄糖共转运体-2（SGLT-2）抑制剂的化合物。 这些化合物用于治疗各种疾病，包括糖尿病，葡萄糖耐量降低，胰岛素抵抗，视网膜病变，肾病，神经病，白内障，高血糖症，高胰岛素血症，高胆固醇血症，游离脂肪酸或甘油血液水平升高，高脂血症，高甘油三酯血症，肥胖 伤口愈合，组织缺血，动脉粥样硬化和高血压。 这些化合物和组合物还可用于治疗和预防肾结石，高尿酸血症，痛风和低钠血症。 制备这些化合物的方法也在本发明中描述。

    METHOD FOR PREPARING PROTEIN PEPTIDE BASED ON CONNECTIVE TISSUE AND PREPARED PROTEIN PEPTIDE AND USE THEREOF
    9.
    发明申请
    METHOD FOR PREPARING PROTEIN PEPTIDE BASED ON CONNECTIVE TISSUE AND PREPARED PROTEIN PEPTIDE AND USE THEREOF 有权

    公开(公告)号：US20210198713A1

    公开(公告)日：2021-07-01

    申请号：US16755854

    申请日：2018-10-11

    申请人： Shuang LIU

    发明人： Kecheng CHEN ,  Shuang LIU ,  Shaowei NI ,  Quankai WANG ,  Haocheng CHEN ,  Jianguo YANG ,  Li YANG ,  Yinan ZHENG ,  Qingjie LI

    IPC分类号： C12P21/06 ,  A61K35/32 ,  A61K9/19 ,  A61K35/28 ,  A61K35/36 ,  A61K35/38 ,  A61K35/34

    摘要： A novel method for preparing an active protein peptide from connective tissue which includes steps of: connective tissue acquisition, segmenting, washing, pulverization, pH adjustment, enzymolysis, filteration, ultrafiltration, nanofiltration concentration, sterilization, freeze-drying, etc. The connective tissue protein peptide obtained by the method of the invention has features of high peptide content, high activity, etc., and the prepared active protein peptide of the connective tissue is easily absorbed by the human body, and has functions of preventing and/or alleviating and/or treating related diseases. Further, the method includes operation steps that are simple and easy to perform, which has low energy consumption, appropriate and effective utilization of animal natural resources, as well as environmental friendly, non pollution of environment, and low production costs, which is suitable for large-scale industrial production, and the purpose of efficiently preparing an protein active peptide from connective tissue can be achieved.