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    Chromatographic two-layer particles
    1.
    发明授权
    Chromatographic two-layer particles 有权
    色谱双层颗粒

    公开(公告)号：US07208093B2

    公开(公告)日：2007-04-24

    申请号：US10526088

    申请日：2003-08-18

    申请人： Hans Berg ,  Philippe Busson ,  Mats Carlsson

    发明人： Hans Berg ,  Philippe Busson ,  Mats Carlsson

    IPC分类号： B01D15/08

    CPC分类号： B01D15/363 ,  B01D15/1807 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3285 ,  B01J20/3293 ,  B01J39/26 ,  B01J41/20

    摘要： The present invention is a method of producing a chromatographic separation matrix, wherein porous polymeric particles comprised of two layers with different properties are prepared in a two-phase system by (a) providing porous polymeric particles with reactive groups on their surfaces; (b) washing said particles with a first solvent and draining the particles to enclose a first phase; (c) wetting the outer layer of the particles by adding a second solvent, which is essentially insoluble in the first solvent; (d) reacting the reactive groups in the outer layer by adding a reagent, which is essentially non-reactive in the first solvent; and (e) coupling of chromatographic binding groups to the reactive groups in the inner layer. The invention also encompasses a porous polymer particle suitable for use as a chromatographic separation matrix and a process of separation, wherein a matrix according to the invention is used.

    摘要翻译： 本发明是一种制备色谱分离基质的方法，其中通过（a）在其表面上提供具有反应性基团的多孔聚合物颗粒，在两相体系中制备由具有不同性质的两层组成的多孔聚合物颗粒。 （b）用第一溶剂洗涤所述颗粒并排出颗粒以包围第一相; （c）通过加入基本不溶于第一溶剂的第二溶剂润湿颗粒外层; （d）通过添加在第一溶剂中基本上不反应的试剂使外层中的反应性基团反应; 和（e）色谱结合基团与内层中的反应性基团的偶合。 本发明还包括适合用作色谱分离基质的多孔聚合物颗粒和分离方法，其中使用根据本发明的基质。

    Chromatographic two-layer particles
    2.
    发明申请
    Chromatographic two-layer particles 有权
    色谱双层颗粒

    公开(公告)号：US20050242037A1

    公开(公告)日：2005-11-03

    申请号：US10526088

    申请日：2003-08-18

    申请人： Hans Berg ,  Philippe Busson ,  Mats Carlsson

    发明人： Hans Berg ,  Philippe Busson ,  Mats Carlsson

    IPC分类号： B01J20/281 ,  B01D15/18 ,  B01J20/28 ,  B01J20/285 ,  B01J20/286 ,  G01N30/00 ,  G01N30/88 ,  B01D15/08

    CPC分类号： B01D15/363 ,  B01D15/1807 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3285 ,  B01J20/3293 ,  B01J39/26 ,  B01J41/20

    摘要： The present invention is a method of producing a chromatographic separation matrix, wherein porous polymeric particles comprised of two layers with different properties are prepared in a two-phase system by (a) providing porous polymeric particles with reactive groups on their surfaces; (b) washing said particles with a first solvent and draining the particles to enclose a first phase; (c) wetting the outer layer of the particles by adding a second solvent, which is essentially insoluble in the first solvent; (d) reacting the reactive groups in the outer layer by adding a reagent, which is essentially non-reactive in the first solvent; and (e) coupling of chromatographic binding groups to the reactive groups in the inner layer. The invention also encompasses a porous polymer particle suitable for use as a chromatographic separation matrix and a process of separation, wherein a matrix according to the invention is used.

    摘要翻译： 本发明是一种制备色谱分离基质的方法，其中通过（a）在其表面上提供具有反应性基团的多孔聚合物颗粒，在两相体系中制备由具有不同性质的两层组成的多孔聚合物颗粒。 （b）用第一溶剂洗涤所述颗粒并排出颗粒以包围第一相; （c）通过加入基本不溶于第一溶剂的第二溶剂润湿颗粒外层; （d）通过添加在第一溶剂中基本上不反应的试剂使外层中的反应性基团反应; 和（e）色谱结合基团与内层中的反应性基团的偶合。 本发明还包括适合用作色谱分离基质的多孔聚合物颗粒和分离方法，其中使用根据本发明的基质。

    Manufacturing process for porous material
    5.
    发明申请
    Manufacturing process for porous material 审中-公开
    多孔材料的制造工艺

    公开(公告)号：US20060025585A1

    公开(公告)日：2006-02-02

    申请号：US11224574

    申请日：2005-09-12

    申请人： Hans Berg ,  Mats Carlsson

    发明人： Hans Berg ,  Mats Carlsson

    IPC分类号： C08B37/00

    CPC分类号： C08J9/28 ,  C08B37/0039 ,  C08J3/075 ,  C08J2201/0544 ,  C08J2305/12

    摘要： A method for the manufacture of a solid porous separation material based on a polysaccharide, said method comprising the steps of: (a) providing an aqueous solution (I) of a polysaccharide, (b) solidifying the solution, preferably by transforming the solution to a gel, and (c) optionally cross-linking the polysaccharide, with the proviso that, if step (c) is present, steps (b) and (c) may be carried out simultaneously. The method is characterised in that the polysaccharide provided in step (a) is modified by being inter-molecularly cross-linked to an extent such that the viscosity of solution (I) is at least 110%, preferably at least 200%, of the viscosity of an aqueous solution (II) of the corresponding polysaccharide which has not been inter-molecularly cross-linked and which is present in the same concentration as the inter-molecularly cross-linked polysaccharide is in solution (I).

    摘要翻译： 一种制备基于多糖的固体多孔分离材料的方法，所述方法包括以下步骤：（a）提供多糖的水溶液（I），（b）固化溶液，优选通过将溶液转化为 凝胶，和（c）任选地交联多糖，条件是如果存在步骤（c），则可以同时进行步骤（b）和（c）。 该方法的特征在于，步骤（a）中提供的多糖通过分子内交联以使溶液（I）的粘度为至少110％，优选至少200％ 在溶液（I）中，未分子间交联并且与分子内交联的多糖以相同浓度存在的相应多糖的水溶液（II）的粘度是。

    Foamed material filled with inner material
    7.
    发明授权
    Foamed material filled with inner material 失效
    发泡材料充满内部材料

    公开(公告)号：US06635174B1

    公开(公告)日：2003-10-21

    申请号：US09979441

    申请日：2002-02-12

    申请人： Hans Berg ,  Mats Carlsson

    发明人： Hans Berg ,  Mats Carlsson

    IPC分类号： B01D1508

    CPC分类号： B01J20/286 ,  B01J20/26 ,  B01J20/28004 ,  B01J20/28014 ,  B01J20/28016 ,  B01J20/28023 ,  B01J20/28026 ,  B01J20/28042 ,  B01J20/28045 ,  B01J20/28085 ,  B01J20/28092 ,  B01J20/28095 ,  B01J20/28097 ,  B01J20/285 ,  B01J2220/52

    摘要： A matrix including: a) a polymeric base matrix including macropores (pore system 1) and b) an interior material, possibly porous (pore system 2), retained within the macropores. The matrix is characterized in that there is a continuous free volume between the interior material and the pore walls of the macropores. A method for manufacturing a matrix including a base matrix having macropores in which an interior material is located. The method is characterized in including the steps: (I) providing a base matrix having macropores; (ii) filling the macropores with a soluble form of the interior material; (iii) transforming the insoluble from to an insoluble form; (iv) shrinking the insoluble form; and (v) irreversibly stabilizing the material in its shrunken form. The matrix can be used in separation methods, cell culturing, solid phase synthesis of organic molecules, and in catalytic reactions (such as enzyme reactions) and other uses in which porous support matrices are used.

    摘要翻译： 一种基体，包括：a）包含大孔（孔体系1）的聚合物基质基质和b）保留在大孔内的可能是多孔（孔系统2）的内部材料。 该基质的特征在于，在大孔的内部材料和孔壁之间存在连续的自由体积。 一种制造基体的方法，其包括具有内部材料所在的大孔的基体基体。 该方法的特征在于包括以下步骤：（I）提供具有大孔的基质矩阵; （ii）用可溶形式的内部材料填充大孔; （iii）将不溶物转化为不溶形式; （iv）收缩不溶形式; 和（v）不可逆地稳定其收缩形式的材料。 该基质可用于分离方法，细胞培养，有机分子的固相合成，以及催化反应（如酶反应）以及使用多孔载体基质的其他用途。

    Method of producing hierarchical porous beads
    8.
    发明授权
    Method of producing hierarchical porous beads 有权
    生产层状多孔珠的方法

    公开(公告)号：US07074335B2

    公开(公告)日：2006-07-11

    申请号：US10500677

    申请日：2002-12-17

    申请人： Hans Berg ,  Mats Carlsson ,  Anders Larsson

    发明人： Hans Berg ,  Mats Carlsson ,  Anders Larsson

    IPC分类号： B01D15/08

    CPC分类号： G01N30/482 ,  B01J20/26 ,  B01J20/261 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28019 ,  B01J20/28054 ,  B01J20/28083 ,  B01J20/28092 ,  B01J20/285 ,  B01J20/305 ,  B01J2220/54 ,  C08J3/16 ,  C08J9/16 ,  C08J9/26 ,  C08J2201/042 ,  C08J2201/044

    摘要： The present invention is a method of producing porous beads, which comprises the steps of providing a first liquid phase comprising a bead matrix material and essentially edgy templating particle(s), said particle(s) being treated with a surface modifying agent; providing a second liquid phase which is immiscible with the first liquid phase; contacting the first phase and the second phase under conditions resulting in an emulsion of droplets comprised of the first liquid phase dispersed in the continuous second liquid phase; transforming the droplets to mesoporous beads by solidification of the liquid; and removing the templating particle(s) from the beads without causing any essential change of the surrounding bead, whereby hierarchical networks of pores are provided in the beads.

    摘要翻译： 本发明是一种生产多孔珠的方法，其包括以下步骤：提供包含珠粒基质材料和基本上前提的模板颗粒的第一液相，所述颗粒用表面改性剂处理; 提供与第一液相不混溶的第二液相; 在产生由分散在连续第二液相中的第一液相组成的液滴的乳液的条件下使第一相和第二相接触; 通过液体凝固将液滴转变成中孔珠粒; 并且从珠粒中除去模板颗粒，而不会引起周围珠粒的任何必需的变化，由此在珠粒中提供分级网孔。

    Manufacturing process for porous material
    9.
    发明授权
    Manufacturing process for porous material 失效
    多孔材料的制造工艺

    公开(公告)号：US06984733B2

    公开(公告)日：2006-01-10

    申请号：US10451194

    申请日：2001-12-19

    申请人： Hans Berg ,  Mats Carlsson

    发明人： Hans Berg ,  Mats Carlsson

    IPC分类号： C08B37/00

    CPC分类号： C08J9/28 ,  C08B37/0039 ,  C08J3/075 ,  C08J2201/0544 ,  C08J2305/12

    摘要： A method for the manufacture of a solid porous separation material based on a polysaccharide, said method comprising the steps of: (a) providing an aqueous solution (I) of a polysaccharide, (b) solidifying the solution, preferably by transforming the solution to a gel, and (c) optionally crosslinking the polysaccharide, with the proviso that, if step (c) is present, steps (b) and (c) may be carried out simultaneously. The method is characterized in that the polysaccharide provided in step (a) is modified by being inter-molecularly crosslinked to an extent such that the viscosity of the solution (I) is at least 110%, preferably at least 200%, of the viscosity of an aqueous solution (II) of the corresponding polysaccharide which has not been intermolecularly crosslinked and which is present in the same concentration as the inter-molecularly crosslinked polysaccharide is in solution (I)

    摘要翻译： 一种制备基于多糖的固体多孔分离材料的方法，所述方法包括以下步骤：（a）提供多糖的水溶液（I），（b）固化溶液，优选通过将溶液转化为 凝胶，和（c）任选地交联多糖，条件是如果存在步骤（c），则可以同时进行步骤（b）和（c）。 该方法的特征在于，步骤（a）中提供的多糖通过分子间交联而被改性，使得溶液（I）的粘度至少为粘度的110％，优选至少为200％ 未分子交联并且以与分子内交联的多糖相同的浓度存在的相应多糖的水溶液（II）在溶液（I）中，

    Process for the production of polysaccharide beads
    10.
    发明授权
    Process for the production of polysaccharide beads 失效
    生产多糖珠粒的方法

    公开(公告)号：US06590096B1

    公开(公告)日：2003-07-08

    申请号：US09806078

    申请日：2001-05-18

    申请人： Hans Berg ,  Mats Carlsson

    发明人： Hans Berg ,  Mats Carlsson

    IPC分类号： C07H504

    CPC分类号： C08J3/16 ,  C08J2305/00

    摘要： The present invention relates to a method for producing porous polysaccharide beads, comprising: (a) mixing a water-based solution of a polysaccharide under stirring with an essentially water-immiscible first organic phase to form an emulsion which separates into two continuous phases; (b) adding a second organic phase comprising an emulsifier and an organic solvent to form a three-phase system; (c) allowing the three-phase system to emulsify; and (d) decreasing the temperature below the gelling point of the polysaccharide, thereby obtaining beads having two sets of pores, said method being characterised in that the emulsifier is a water-insoluble polymer capable of stabilizing said three-phase system.

    摘要翻译： 本发明涉及一种生产多孔多糖珠粒的方法，包括：（a）将搅拌下的多糖的水基溶液与基本上与水不混溶的第一有机相混合以形成分离成两个连续相的乳液; （b）加入包含乳化剂和有机溶剂的第二有机相以形成三相体系; （c）允许三相体系乳化; 和（d）降低低于多糖胶凝点的温度，从而获得具有两组孔的珠粒，所述方法的特征在于乳化剂是能够稳定所述三相体系的水不溶性聚合物。