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公开(公告)号:US07662601B2
公开(公告)日:2010-02-16
申请号:US10746239
申请日:2003-12-23
申请人: Hans E. Krokan , Geir Slupphaug , Bodil Kavli , John A. Tainer , Clifford D. Mol
发明人: Hans E. Krokan , Geir Slupphaug , Bodil Kavli , John A. Tainer , Clifford D. Mol
IPC分类号: C12N9/10 , C12N15/00 , C12P21/04 , C12P19/34 , C12Q1/68 , C12Q1/48 , C07H21/04 , C12Q1/00 , C12N1/20 , C07H21/02
CPC分类号: C12Q1/6848 , C12N9/2497 , C12Q1/6869 , C12Y302/02027 , C12Q2521/531
摘要: Novel cytosine-, thymine- and uracil-DNA glycosylases, subcellular localization peptides, nucleic acid molecules containing the same, methods of identifying such enzymes and their use in various methods including mutagenesis, cell killing and DNA sequencing and modification, are desired.
摘要翻译: 新型胞嘧啶 - ,胸腺嘧啶核苷和尿嘧啶-DNA糖基化酶,亚细胞定位肽,含有该核酸分子的核酸分子,鉴定此类酶的方法及其在各种方法中的应用,包括诱变,细胞杀伤和DNA测序和修饰。
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公开(公告)号:US06713294B1
公开(公告)日:2004-03-30
申请号:US09101368
申请日:1999-03-03
申请人: Hans E. Krokan , Geir Slupphaug , Bodil Kavli , John A. Tainer , Clifford D. Mol
发明人: Hans E. Krokan , Geir Slupphaug , Bodil Kavli , John A. Tainer , Clifford D. Mol
IPC分类号: C12N914
CPC分类号: C12Q1/6848 , C12N9/2497 , C12Q1/6869 , C12Y302/02027 , C12Q2521/531
摘要: Novel cytosine-, thymine- and uracil-DNA glycosylases, subcellular localization peptides, nucleic acid molecules containing the same, methods of identifying such enzymes and their use in various methods including mutagenesis, cell killing and DNA sequencing and modification, are described.
摘要翻译: 描述了新型胞嘧啶 - ,胸腺嘧啶核苷和尿嘧啶-DNA糖基化酶,亚细胞定位肽,含有这些肽的核酸分子,鉴定这些酶的方法及其在各种方法中的应用,包括诱变,细胞杀伤和DNA测序和修饰。
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公开(公告)号:US5665865A
公开(公告)日:1997-09-09
申请号:US343658
申请日:1994-11-22
申请人: Richard A. Lerner , Victoria A. Roberts , Elizabeth D. Getzoff , John A. Tainer , Stephen J. Benkovic
发明人: Richard A. Lerner , Victoria A. Roberts , Elizabeth D. Getzoff , John A. Tainer , Stephen J. Benkovic
IPC分类号: A61K39/395 , C07K14/00 , C07K16/00 , C07K19/00 , C12N1/21 , C12N9/00 , C12N15/09 , C12P21/00 , C12P21/08 , C12R1/19 , G01N33/53
CPC分类号: C12N9/0002 , C07K16/00
摘要: The invention describes a metal binding protein capable of forming a coordination complex with a metal cation. The protein contains a sequence of amino acid residues that defines a variable domain of an immunoglobulin light chain having a L1 region and a L3 region, and also contains three contact amino acid residues in the variable domain that participate as ligands for the metal coordination complex.
摘要翻译: 本发明描述了能够与金属阳离子形成配位络合物的金属结合蛋白。 蛋白质含有限定具有L1区域和L3区域的免疫球蛋白轻链可变结构域的氨基酸残基序列,并且在可变结构域中还含有参与作为金属配位络合物配体的三个接触氨基酸残基。
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