公开(公告)号：US08546460B2

公开(公告)日：2013-10-01

申请号：US12673266

申请日：2008-09-04

申请人： Lorenz Brunner ,  Yvo Dirix ,  Hans Schmotzer ,  Shilesh C. Jani

发明人： Lorenz Brunner ,  Yvo Dirix ,  Hans Schmotzer ,  Shilesh C. Jani

IPC分类号： C08F2/42 ,  C08F2/48 ,  C08J3/28 ,  A61F2/02

CPC分类号： A61L27/26 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/428

摘要： A prosthetic device may comprise an insert having a first surface configured to contact a first prosthetic component and a bearing surface configured to articulate against a second prosthetic component. The insert comprises an ultra-high molecular weight polyethylene and vitamin E. The vitamin E may have a concentration in the range of 0.02 to 0.12 wt % first mixed with the ultra-high molecular weight polyethylene and then molded with the ultra-high molecular weight polyethylene at a temperature greater than the melting point of the ultra-high molecular weight polyethylene. The ultra-high molecular weight polyethylene and vitamin E may be gamma irradiated with a dosage of radiation between 5 and 20 Mrad. The insert may be machined prior to gamma irradiating the insert in air such that the gamma irradiation, at suitably high dosages, may also sterilize the insert.

摘要翻译： 假体装置可以包括插入物，其具有构造成接触第一假体部件的第一表面和构造成与第二假体部件铰接的支承表面。 插入物包含超高分子量聚乙烯和维生素E.维生素E可以具有0.02至0.12重量％的浓度，首先与超高分子量聚乙烯混合，然后用超高分子量 聚乙烯，其温度大于超高分子量聚乙烯的熔点。 超高分子量聚乙烯和维生素E可以用5至20Mrad之间的辐射剂量照射γ射线。 在将伽马射线照射到空气中之前，可以对插入物进行加工，使得γ射线以合适的高剂量也可以对插入物进行消毒。

公开(公告)号：US07998523B2

公开(公告)日：2011-08-16

申请号：US12092545

申请日：2006-10-12

申请人： Reto Lerf ,  Hans Schmotzer ,  Stephan Siegmann

发明人： Reto Lerf ,  Hans Schmotzer ,  Stephan Siegmann

IPC分类号： A61L33/00

CPC分类号： A61L27/56 ,  A61F2/30767 ,  A61F2002/3092 ,  A61F2002/30968 ,  A61L27/306 ,  Y10T428/12549

摘要： The invention relates to open-pore biocompatible surface layers for implants, which layers are arranged over virgin surfaces of the implants, wherein pores of the open-pore surface layers are connected to form coherent pore networks and the surface layers have a specific internal surface area of ≧0.06 μm/μm2, preferably ≧0.035 μm/μm2 and especially ≧0.025 μm/μm2, measured by image analysis as a 2D-boundary line per unit of surface area in a metallographic microsection at 100× magnification. The invention further relates to methods of producing such surface layers, to implants coated therewith and to possible uses of the surface layers.

摘要翻译： 本发明涉及用于植入物的开孔生物相容性表面层，其中层布置在植入物的原始表面上，其中开放孔表面层的孔连接以形成粘连孔网络，并且表面层具有特定的内表面积 通过在100倍放大倍率下的金相显微切片中的每单位表面积的2D边界线的图像分析测定的≥0.06μm/μm2，优选≥0.035μm/μm2，特别是≥0.025μm/μm2。 本发明还涉及生产这种表面层的方法，其中涂覆的植入物和表面层的可能用途。

公开(公告)号：US07364685B2

公开(公告)日：2008-04-29

申请号：US10468673

申请日：2002-01-31

申请人： Hans Schmotzer

发明人： Hans Schmotzer

IPC分类号： B29B13/08 ,  C08J3/28 ,  C08F110/02 ,  A61F2/02 ,  A61F2/28 ,  A62L27/16

CPC分类号： B29C35/08 ,  A61L27/16 ,  B29C35/0261 ,  B29C2035/0844 ,  B29C2035/085 ,  B29C2035/0855 ,  B29C2035/0877 ,  B29K2023/0683 ,  B29L2031/7532 ,  C08L23/06

摘要： The invention relates to a method of manufacturing implant parts made of highly cross-linked polyethylene, wherein a blank made of ultra-high-molecular-weight polyethylene is irradiated with ionizing radiation in order to produce radicals in the blank. To optimize the cross-linkage of the highly cross-linked polyethylene and to eliminate free radicals, the blank is subsequently treated by means of microwave radiation and/or ultrasound in such a way that free radicals, which have not recombined, are excited so as to ensure substantially complete recombination of the free radicals. The shape of the treated blank can then be adjusted by means of machining. The invention further relates to implant parts for application in human medicine that have been manufactured as described above.

摘要翻译： 本发明涉及一种制造由高度交联的聚乙烯制成的植入部件的方法，其中由超高分子量聚乙烯制成的坯料用电离辐射照射以在坯料中产生自由基。 为了优化高度交联的聚乙烯的交联并消除自由基，随后通过微波辐射和/或超声波处理空白物，使得未再结合的自由基被激发，使得 以确保自由基的基本上完全的复合。 然后可以通过机械加工处理的坯料的形状。 本发明还涉及如上所述制造的用于人类医学中的植入部件。

公开(公告)号：US20100069576A1

公开(公告)日：2010-03-18

申请号：US12447866

申请日：2006-10-30

申请人： Hans Schmotzer ,  Yvo Dirix ,  Paul Smith ,  Theo Tervoort ,  Lorenz Brunner

发明人： Hans Schmotzer ,  Yvo Dirix ,  Paul Smith ,  Theo Tervoort ,  Lorenz Brunner

IPC分类号： C08F10/02 ,  C08J5/00 ,  A61F2/02

CPC分类号： B29C43/003 ,  B29C43/006 ,  B29K2023/0683 ,  B29L2031/7532

摘要： Provided are processes comprising crosslinking polyethylene or using crosslinked polyethylene. Furthermore, the processes may include compacting and/or sintering the polyethylene.

摘要翻译： 提供了包括交联聚乙烯或使用交联聚乙烯的方法。 此外，该方法可以包括压实和/或烧结聚乙烯。

公开(公告)号：US20100042223A9

公开(公告)日：2010-02-18

申请号：US11722697

申请日：2005-12-22

申请人： Olivier Zinger ,  Hans Schmotzer

发明人： Olivier Zinger ,  Hans Schmotzer

IPC分类号： A61F2/30 ,  B24C1/00

CPC分类号： A61F2/30767 ,  A61C8/0012 ,  A61C2008/0046 ,  A61F2/3094 ,  A61F2/32 ,  A61F2002/30719 ,  A61F2002/30906 ,  A61F2002/30925 ,  A61F2250/0092 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00089 ,  A61F2310/00095 ,  A61F2310/00131 ,  A61L27/30 ,  A61L27/50 ,  A61L2400/18 ,  A61L2430/02 ,  B24C1/06 ,  C23G1/086 ,  C23G1/106

摘要： A method of surface finishing a bone implant comprises the steps of roughening a surface of the implant by blasting with abrasive particles and then pickling the surface-roughened implant in a pickling solution in order to loosen any partially embedded abrasive blasting particles that may be contaminating the surface of the implant. Thereafter the roughened surface of the implant is cleaned by mechanical action to detach the loosened abrasive particles there from. The pickling and cleaning steps are not intended to produce any additional roughening of the treated surface, which should be structured to the required roughness by the initial abrasive blasting, typically such that the Ra and Rt roughness parameters are 3≦Ra≦7 μm and 20≦Rt≦70 μm respectively.

摘要翻译： 骨植入物表面处理的方法包括以下步骤：通过用研磨颗粒喷砂来粗糙化植入物的表面，然后在酸洗溶液中酸化表面粗糙植入物，以便松动任何可能污染的植入物的部分包埋的喷砂颗粒 植入物的表面。 此后，通过机械作用来清洁植入物的粗糙表面，以将松散的磨料颗粒从其上分离。 酸洗和清洁步骤不是为了产生经处理的表面的任何额外的粗糙化，其应该通过初始的喷砂处理构造成所需的粗糙度，通常使得Ra和Rt粗糙度参数为3＆lt; Ra＆nlE;7μm和20＆amp; ; Rt＆nlE;70μm。

公开(公告)号：US06770098B1

公开(公告)日：2004-08-03

申请号：US10111117

申请日：2002-09-04

申请人： Thomas Hauri ,  Bernhard Hauri ,  Hans Schmotzer ,  Werner Berner

发明人： Thomas Hauri ,  Bernhard Hauri ,  Hans Schmotzer ,  Werner Berner

IPC分类号： A61F238

CPC分类号： A61F2/3868 ,  A61F2/3854

摘要： A knee-joint prosthesis with a tibial part having a flat tibial bearing surface, with a bearing body that can be shifted thereon in the anterior-posterior direction and includes two concave bearing shells within which a femoral joint part can be movably seated, and with a rotational guide that permits rotation of the bearing body on the tibial bearing surface about an axis of rotation perpendicular to said surface. The rotation guide includes a steering rod that is seated at the bearing body so as to be pivotable relative thereto and at the tibial part is guided in the medial/lateral direction and/or rotationally guided.

摘要翻译： 具有胫骨部分的膝关节假体具有平坦的胫骨支承表面，具有可以在前后方向上在其上移动的支承体，并且包括两个凹入的轴承壳，股骨关节部分可以在该凹入轴承壳内可移动地安置，并且与 旋转引导件，其允许轴承体在胫骨支承表面上围绕垂直于所述表面的旋转轴旋转。 旋转引导件包括转动杆，该转向杆位于轴承体上，以便相对于其枢转，并且在胫骨部分被引导在内侧/外侧方向和/或旋转引导。

公开(公告)号：US08586667B2

公开(公告)日：2013-11-19

申请号：US12992595

申请日：2008-05-13

申请人： Lorenz Brunner ,  Yvo Dirix ,  Hans Schmotzer

发明人： Lorenz Brunner ,  Yvo Dirix ,  Hans Schmotzer

IPC分类号： C08L23/06 ,  C08G18/08

CPC分类号： C08K5/005 ,  C08J5/10 ,  C08L23/06 ,  C08L2666/02

摘要： The present invention relates to highly cross-linked UHMWPE, which is possessed of an improved oxidation resistance, as well as a method for making the same. The UHMWPE material of the current invention is combined with an anti-oxidant compound or a free-radical scavenger prior to formation. Once the UHMWPE with the added material has been formed and treated with gamma or electron bean irradiation, it shows an improved wear resistance and also a good resistance to oxidation. Such a material, is particularly interesting for the field of making replacement joint implants.

摘要翻译： 本发明涉及具有改善的抗氧化性的高度交联的UHMWPE及其制造方法。 本发明的UHMWPE材料在形成之前与抗氧化剂或自由基清除剂组合。 一旦用添加的材料形成UHMWPE并用γ射线或电子束照射进行处理，则其显示出改进的耐磨性和良好的耐氧化性。 这种材料对于替换关节植入物的领域尤其有意义。

公开(公告)号：US20100004753A1

公开(公告)日：2010-01-07

申请号：US12092545

申请日：2006-10-12

申请人： Reto Lerf ,  Hans Schmotzer ,  Stephan Siegmann

发明人： Reto Lerf ,  Hans Schmotzer ,  Stephan Siegmann

IPC分类号： A61F2/30 ,  A61K9/00 ,  A61K33/24 ,  A61K33/42 ,  B05D3/00 ,  A61P19/00

CPC分类号： A61L27/56 ,  A61F2/30767 ,  A61F2002/3092 ,  A61F2002/30968 ,  A61L27/306 ,  Y10T428/12549

摘要： The invention relates to an open-pore biocompatible surface layer for an implant, which layer is arranged over a virgin surface of the implant, wherein pores of the open-pore surface layer are connected to form a coherent pore network and the surface layer has an internal surface area of ≧0.06 μm/μm2, preferably ≧0.035 μm/μm2 and especially ≧0.025 μm/μm2, measured by image analysis as a 2D-boundary line per unit of surface area in a metallographic microsection at 100× magnification. The invention further relates to methods of producing such a surface layer, to an implant coated therewith and to possible uses of the surface layer.

摘要翻译： 本发明涉及用于植入物的开孔生物相容性表面层，该层布置在植入物的原始表面上，其中开放孔表面层的孔连接以形成连贯孔网络，并且表面层具有 通过在100倍放大倍率下的金相显微切片中的每单位表面积的2D边界线的图像分析测量，内表面积> = 0.06mum / mum2，优选> = 0.035mum / mum2，优选≥0.035mum/ mum2。 本发明还涉及生产这种表面层，涂覆在其上的植入物和表面层的可能用途的方法。

公开(公告)号：US06364911B1

公开(公告)日：2002-04-02

申请号：US09403645

申请日：2000-03-08

申请人： Hans Schmotzer ,  Peter Schuler ,  Udo Malzer

发明人： Hans Schmotzer ,  Peter Schuler ,  Udo Malzer

IPC分类号： A61F238

CPC分类号： A61F2/3859

摘要： A femur slide has a patella shield and two convex curved condyle cups which are anteriorly rigidly joined by the patella shield. The two condyle cups and the patella shield define internally anterior and posterior matching surfaces which correspond with a femural ventral cut and with a femural dorsal cut. Relative to a reference plane which is defined by posterior slide surfaces of the condyle cups, an anterio-medial matching surface lies nearer to the reference plane than an anterio-lateral matching surface. The anterior matching surfaces are defined by a slanted surface with is continuously slanted in a direction from lateral to medial to posterior, and an angle between the slanted surface and the reference plane lies between three and ten degrees.

摘要翻译： 股骨滑块具有髌骨屏障和两个凸起弯曲的髁杯，其由髌骨盾构前部刚性连接。 两个髁杯和髌骨屏蔽限定内部的前后匹配表面，其对应于雌性腹侧切口并且具有女性背侧切口。 相对于由髁杯的后滑动表面限定的参考平面，前内侧匹配表面比前外侧匹配表面更靠近参考平面。 前部匹配表面由倾斜表面限定，其从侧向内侧到后侧的方向连续倾斜，并且倾斜表面与参考平面之间的角度在三到十度之间。

公开(公告)号：US06325829B1

公开(公告)日：2001-12-04

申请号：US09463476

申请日：2000-04-21

申请人： Hans Schmotzer

发明人： Hans Schmotzer

IPC分类号： A61F232

CPC分类号： A61F2/34 ,  A61B17/86 ,  A61F2002/30322 ,  A61F2002/3401 ,  A61F2002/3403 ,  A61F2002/3406 ,  A61F2002/3419 ,  A61F2002/345 ,  A61F2002/3456 ,  A61F2002/3461 ,  A61F2002/3462 ,  A61F2002/3466 ,  A61F2002/3482 ,  A61F2250/0026 ,  A61F2310/00023

摘要： Metal socket (10) for a joint endoprosthesis, the outer surface (11) of which comprises at least three circumferentially extending surfaces (12, 13, 14) of spherical segments each having a different radius (R1, R2, R3). A metal socket for a joint endoprosthesis has an outer surface which includes at least three circumferentially extending, outwardly convex surface regions each having a different radius. The outwardly convex surface regions are exclusively surfaces of spherical segments, centers of which lie on a common axis of rotation, such that a radius of a medial spherical-segment surface is smaller than a radius of a polar spherical-segment surface, but larger than a radius of an equatorial spherical-segment surface.

摘要翻译： 用于关节内置假体的金属插座（10），其外表面（11）包括至少三个具有不同半径（R1，R2，R3）的球形段的周向延伸表面（12,13,14）。 用于关节内假体的插座具有外表面，该外表面包括至少三个周向延伸的向外凸出的表面区域，每个具有不同的半径。 向外凸出的表面区域是球形区段的唯一表面，球形区域的中心位于共同的旋转轴线上，使得内侧球形段表面的半径小于极性球形段表面的半径，但大于 赤道球形表面的半径。