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    Nucleic acid construct for expressing active substances which can be activated by proteases, and preparation and use
    6.
    发明授权
    Nucleic acid construct for expressing active substances which can be activated by proteases, and preparation and use 失效
    用于表达可由蛋白酶活化的活性物质的核酸构建体，以及制备和使用

    公开(公告)号：US06670147B1

    公开(公告)日：2003-12-30

    申请号：US09256237

    申请日：1999-02-24

    申请人： Hans Heinrich Heidtmann ,  Rolf Mueller ,  Hans-Harald Sedlacek

    发明人： Hans Heinrich Heidtmann ,  Rolf Mueller ,  Hans-Harald Sedlacek

    IPC分类号： C12P2106

    CPC分类号： C12N9/6432 ,  A61K48/00 ,  C12N15/63 ,  C12N15/85 ,  C12N2830/007 ,  C12N2830/008 ,  C12N2840/20 ,  C12Y304/21006

    摘要： The invention relates to a nucleic acid construct for expressing an active substance which is activated by an enzyme which is released from mammalian cells, which construct comprises the following components: a) at least one promoter element, b) at least one DNA sequence which encodes an active compound (protein B), c) a least one DNA sequence which encodes an amino acid sequence (part structure C) which can be cleaved specifically by an enzyme which is released from a mammalian cell, and d) at least one DNA sequence which encodes a peptide or protein (part structure D) which is bound to the active compound (protein B) by way of the cleavable amino acid sequence (part structure C) and inhibits the activity of the active compound (protein B), and also to the use of the nucleic acid construct for preparing a drug for treating diseases.

    摘要翻译： 本发明涉及用于表达由哺乳动物细胞释放的酶活化的活性物质的核酸构建物，该构建体包含以下组分：a）至少一个启动子元件，b）至少一个编码 活性化合物（蛋白B），c）至少一个DNA序列，其编码可以被从哺乳动物细胞释放的酶特异性切割的氨基酸序列（部分结构C），和d）至少一个DNA序列 其编码通过可切割氨基酸序列（部分结构C）与活性化合物（蛋白B）结合并抑制活性化合物（蛋白B）的活性的肽或蛋白质（部分结构D），并且还 涉及使用核酸构建体来制备用于治疗疾病的药物。