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公开(公告)号：US06451311B2
公开(公告)日：2002-09-17
申请号：US09742375
申请日：2000-12-22
申请人： Harald Althaus , Götz Walter
发明人： Harald Althaus , Götz Walter
IPC分类号： A61K4900
CPC分类号： C07K16/26 , C07K14/585 , C07K2317/34 , Y10S435/81
摘要： The invention relates to anti-procalcitonin antibodies, their preparation and use, in particular in therapy and diagnostics. The antibodies comprise binding to procalcitonin but not to free calcitonin, free katacalcin and free N-procalcitonin.
摘要翻译： 本发明涉及抗降钙素原抗体，其制备和用途，特别是在治疗和诊断中。 抗体包括结合降钙素原但不游离降钙素，游离的卡他胶和游离的N-降钙素原。
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2.发明授权Methods and kits for determining von willebrand factor activity in the absence of ristocetin 有权用于在不存在瑞斯他汀时测定血管性血友病因子活性的方法和试剂盒公开(公告)号：US09222942B2
公开(公告)日：2015-12-29
申请号：US12652841
申请日：2010-01-06
IPC分类号： G01N33/68 , G01N33/86 , G01N33/543 , G01N33/546 , G01N33/553 , G01N33/566 , C12Q1/37
CPC分类号： G01N33/6893 , C12Q1/37 , G01N33/543 , G01N33/54313 , G01N33/553 , G01N33/566 , G01N33/68 , G01N33/86 , G01N2333/755 , G01N2333/96486 , G01N2800/222 , G01N2800/226
摘要： Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.
摘要翻译： 本文描述的是在不存在瑞斯他汀的情况下测定样品中的血管性血友病因子（VWF）活性的方法，试剂盒，试剂等。
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3.发明授权Antibodies for determining the prothrombin fragment F2/F1+2 in a homogeneous immunoassay 有权用于在均相免疫测定中测定凝血酶原片段F2 / F1 + 2的抗体公开(公告)号：US09096674B2
公开(公告)日：2015-08-04
申请号：US12566464
申请日：2009-09-24
申请人： Matthias Ehm , Bodo Fischer , Harald Althaus , Roland Barten
发明人： Matthias Ehm , Bodo Fischer , Harald Althaus , Roland Barten , Stefan Teigelkamp
IPC分类号： C07K16/36 , C07K16/42 , C12N5/20 , C12P21/08 , G01N33/563 , G01N33/573 , G01N33/86 , C12N9/74
CPC分类号： C07K16/36 , C07K16/42 , C07K2317/32 , C07K2319/00 , C12N9/6429 , C12Y304/21005 , G01N33/563 , G01N33/573 , G01N33/86 , G01N2333/96463
摘要： The present invention is in the area of coagulation analysis and relates to antibodies which bind specifically to an immune complex of prothrombin fragment F2/F1+2 and an F2/F1+2 neoepitope-specific antibody fragment, and to the preparation and the use thereof in methods for determining F2/F1+2.
摘要翻译： 本发明涉及凝血分析领域，涉及特异性结合凝血酶原片段F2 / F1 + 2和F2 / F1 + 2新表皮特异性抗体片段的免疫复合物的抗体及其制备及应用 在确定F2 / F1 + 2的方法中。
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4.发明授权Methods and kits for determining von Willebrand factor activity in the absence of ristocetin and for determining the activity of ADAMTS-13 protease 有权用于在不存在瑞斯托菌素时测定血管性血友病因子活性并用于测定ADAMTS-13蛋白酶活性的方法和试剂盒公开(公告)号：US08932820B2
公开(公告)日：2015-01-13
申请号：US13613484
申请日：2012-09-13
CPC分类号： G01N33/6893 , C12Q1/37 , G01N33/543 , G01N33/54313 , G01N33/553 , G01N33/566 , G01N33/68 , G01N33/86 , G01N2333/755 , G01N2333/96486 , G01N2800/222 , G01N2800/226
摘要： Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.
摘要翻译： 本文描述了用于在不存在瑞斯他汀的情况下测定样品中的血管性血友病因子（VWF）活性的方法，试剂盒，试剂等。
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5.发明授权Antibodies which are directed against the Marburg I polymorphism of factor VII-activating protease (FSAP), and their preparation and use 有权针对因子VII激活蛋白酶（FSAP）的Marburg I多态性的抗体及其制备和用途公开(公告)号：US07622558B2
公开(公告)日：2009-11-24
申请号：US11208881
申请日：2005-08-23
申请人： Herbert Schwarz , Harald Althaus , Bodo Fischer , Thomas Wissel
发明人： Herbert Schwarz , Harald Althaus , Bodo Fischer , Thomas Wissel
IPC分类号： C07K16/00
CPC分类号： C07K16/40 , Y10S530/806
摘要： The invention relates to antibodies which are directed against the FSAP Marburg I variant and to their preparation and use, in particular in therapy and diagnosis. The antibodies are characterized by the fact that they bind specifically to the FSAP MR I variant but not to the FSAP wild-type protein or other mutant variants which are characterized by amino acid substitutions at other positions in the FSAP protein.
摘要翻译： 本发明涉及针对FSAP Marburg I变体的抗体及其制备和用途，特别是在治疗和诊断中。 抗体的特征在于它们与FSAP MR I变体特异性结合，但不结合FSAP野生型蛋白或其它以FSAP蛋白中其他位置的氨基酸取代为特征的突变体。
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6.发明授权Peptides with the marburg I polymorphism of factor VII-activating protease (FSAP) and their preparation and uses 有权多肽与Marburg I多态性因子VII活化蛋白酶（FSAP）及其制备和用途公开(公告)号：US07951910B2
公开(公告)日：2011-05-31
申请号：US12578337
申请日：2009-10-13
申请人： Herbert Schwarz , Harald Althaus , Bodo Fischer , Thomas Wissel
发明人： Herbert Schwarz , Harald Althaus , Bodo Fischer , Thomas Wissel
IPC分类号： C07K14/745
CPC分类号： C07K16/40 , Y10S530/806
摘要： The invention relates to peptides with the Marburg I polymorphism of FSAP and to their preparation and uses, in particular in therapy and diagnosis. The peptides are suitable for use as immunizing antigens for preparing FSAP MR I specific antibodies.
摘要翻译： 本发明涉及具有FSAP的Marburg I多态性的肽及其制备和用途，特别是在治疗和诊断中。 这些肽适合用作免疫抗原来制备FSAP MR I特异性抗体。
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7.发明申请ANTIBODIES FOR DETERMINING THE PROTHROMBIN FRAGMENT F2/F1+2 IN A HOMOGENEOUS IMMUNOASSAY 有权用于在同种异体免疫中测定丙型肝炎片段F2 / F1 + 2的抗体公开(公告)号：US20100081212A1
公开(公告)日：2010-04-01
申请号：US12566464
申请日：2009-09-24
申请人： Matthias Ehm , Bodo Fischer , Harald Althaus , Roland Barten
发明人： Matthias Ehm , Bodo Fischer , Harald Althaus , Roland Barten
IPC分类号： G01N33/566 , C07K16/18 , C12N5/06
CPC分类号： C07K16/36 , C07K16/42 , C07K2317/32 , C07K2319/00 , C12N9/6429 , C12Y304/21005 , G01N33/563 , G01N33/573 , G01N33/86 , G01N2333/96463
摘要： The present invention is in the area of coagulation analysis and relates to antibodies which bind specifically to an immune complex of prothrombin fragment F2/F1+2 and an F2/F1+2 neoepitope-specific antibody fragment, and to the preparation and the use thereof in methods for determining F2/F1+2.
摘要翻译： 本发明涉及凝血分析领域，涉及特异性结合凝血酶原片段F2 / F1 + 2和F2 / F1 + 2新表皮特异性抗体片段的免疫复合物的抗体及其制备及应用 在确定F2 / F1 + 2的方法中。
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8.发明申请Binding partners of the placental growth factor, especially antibodies directed against the placental growth factor, and production and use thereof 有权胎盘生长因子的绑定伙伴，特别是针对胎盘生长因子的抗体，以及其生产和使用公开(公告)号：US20090068679A1
公开(公告)日：2009-03-12
申请号：US11920160
申请日：2006-05-08
CPC分类号： C07K16/22 , C07K14/515 , C07K2317/14 , C07K2317/34 , C07K2319/30 , C12N5/163 , G01N33/531 , G01N33/57488 , G01N33/74 , G01N2333/515
摘要： The invention relates to binding partners of the placental growth factor (or placenta growth factor, PIGF), especially antibodies directed against the placental growth factor, and production and use thereof.
摘要翻译： 本发明涉及胎盘生长因子（或胎盘生长因子，PIGF）的结合配偶体，特别是针对胎盘生长因子的抗体及其生产和使用。
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9.发明申请Methods and Kits for Determining von Willebrand Factor Activity in the Absence of Ristocetin and for Determining the Activity of ADAMTS-13 Protease 有权用于确定不含赖斯托菌素的血管性血友病因子活性和测定ADAMTS-13蛋白酶活性的方法和试剂盒公开(公告)号：US20100136589A1
公开(公告)日：2010-06-03
申请号：US12652841
申请日：2010-01-06
CPC分类号： G01N33/6893 , C12Q1/37 , G01N33/543 , G01N33/54313 , G01N33/553 , G01N33/566 , G01N33/68 , G01N33/86 , G01N2333/755 , G01N2333/96486 , G01N2800/222 , G01N2800/226
摘要： Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.
摘要翻译： 本文描述的是在不存在瑞斯他汀的情况下测定样品中的血管性血友病因子（VWF）活性的方法，试剂盒，试剂等。
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公开(公告)号：US07338770B2
公开(公告)日：2008-03-04
申请号：US11055622
申请日：2005-02-11
申请人： Harald Althaus , Hans-Peter Hauser
发明人： Harald Althaus , Hans-Peter Hauser
IPC分类号： G01N33/53 , G01N33/566 , C12N5/06 , C12N9/96 , A61K38/00
CPC分类号： C07K14/585 , A61K38/00 , C07K2319/00 , Y10S435/967
摘要： The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted into a vector; a host organism is transformed with this gene-containing vector; and the polypeptide expressed by the host organism is isolated. Furthermore the use of the polypeptides according to the invention, in particular as medicaments and diagnostic agents is described.
摘要翻译： 本发明涉及人类降钙素原及其制备和应用。 具体地，描述了一种制备人降钙素原的方法，其中将编码包含人降钙素原的氨基酸序列的多肽的基因插入载体中; 用含该基因的载体转化宿主生物; 并分离由宿主生物表达的多肽。 此外，描述了根据本发明的多肽，特别是作为药物和诊断剂的用途。
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