摘要:
A thrombin receptor antagonist having the formula useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non-toxic amount of such compound to a mammal, preferably a human.
摘要:
A banding machine provides for a controlled intermittent flow of a tubular web or sleeve of thin plastic material from a storage reel, over a tensioning arm and guiding rollers onto a group of machine elements which first open the tube somewhat, stop the flow of material, slice the tube transversely, and pass the cut segment of web over a floating mandrel to form it into the shape of a container positioned below it, while continuing the flow of tubing from the reel down onto the same group of elements to form the next band. The open segment of band is now placed over the container automatically to complete the banding operation.
摘要:
A predictive cruise control system utilizes information about the current vehicle position, and upcoming terrain to save fuel and increase driving comfort. A vehicle operating cost function is defined, based on a plurality of environmental parameters, vehicle parameters, vehicle operating parameters and route parameters. As the vehicle travels over a particular route for which route parameters, such as road gradient and curvature, are stored in a road map, sensors aboard the vehicle detect environmental and vehicle operating parameters, including at least vehicle speed and its position relative to the road map. As the vehicle proceeds, an onboard computer iteratively calculates and stores in a memory vehicle control parameters that optimize the vehicle operating cost function for a predetermined prediction horizon along the route ahead of the vehicle. The optimal vehicle control parameters for the Prediction Horizon are then stored, updated and used to control the vehicle.
摘要:
Methods of identifying activators and inhibitors of voltage-gated ion channels are provided in which the methods employ cells transfected with a voltage-gated ion channel of interest and a corollary channel to control the membrane potential of the cells by changing extracellular ion concentration. This allows for more convenient, more precise experimental manipulation of these transitions, and, coupled with efficient methods of detecting the result of ion flux through the channels, provides methods that are especially suitable for high throughput screening.
摘要:
An apparatus for stacking and separating sheets of web material provides a conveyor for transporting the sheets from a source of sheets. The sheets are conveyed in a stream that is aligned in a downstream direction from a source to a stacking location. A kicker mechanism is located along the conveyor to offset sheets in a direction that is substantially transverse to the downstream direction. A stacking mechanism is positioned at the stacking location for receiving each sheet from the conveyor and overlaying each sheet into a stack that extends downstream in a horizontal orientation that is substantially parallel to the ground. The kicker mechanism may include an elastomeric foot that engages and withdraws from each selected sheet to drive it transversely to the downstream direction. The sheets may be cut from a continuous web source.
摘要:
A stacker jam detector, for use in a sheet handling device such as a stacker and separator, comprises a source of sheets that directs sheets downstream to a delivery location. The source of sheets includes a sheet sent signal generator that transmits a sheet sent signal in response to transferral of each of the sheets from the source. A moving sensing service, such as an elastomeric wheel, is provided at a delivery location, which can comprise a vertical stack. The surface engages each of the sheets as each of the sheets is transferred to the delivery location. Movement of the sheets thereover causes proportional movement of the sensing surface. A signal, such as a pulse, is generated in response to the movement of the sensing surface. A detector measures the signal and compares the signal received relative to at least one sheet sense signal to a predetermined signal value and indicates whether a sheet has been properly delivered to the delivery location.
摘要:
Disclosed herein are novel nucleic acid molecules encoding murine low-voltage activated calcium channel proteins, designated-α1H, encoded proteins, vectors, host cells transformed therewith, as well as pharmaceutical compositions. Methods of using any of the foregoing, e.g., methods for screening for candidate agonists or antagonists utilizing the novel protein isoforms are also disclosed.
摘要:
An apparatus for stacking and separating sheets of web material provides a conveyor for transporting the sheets from a source of sheets. The sheets are conveyed in a stream that is aligned in a downstream direction from a source to a stacking location. A kicker mechanism is located along the conveyor to offset sheets in a direction that is substantially transverse to the downstream direction. A stacking mechanism is positioned at the stacking location for receiving each sheet from the conveyor and overlaying each sheet into a stack that extends downstream in a horizontal orientation that is substantially parallel to the ground. The kicker mechanism may include an elastomeric foot that engages and withdraws from each selected sheet to drive it transversely to the downstream direction. The sheets may be cut from a continuous web source.