公开(公告)号：US07190770B2

公开(公告)日：2007-03-13

申请号：US10206231

申请日：2002-07-29

Applicant: Haru Ando ,  Yoshito Nejime ,  Junichi Matsuda

Inventor： Haru Ando ,  Yoshito Nejime ,  Junichi Matsuda

IPC: H04M1/64 ,  G10L15/00

CPC classification number: H04M3/4938 ,  H04M1/271 ,  H04M2201/40

Abstract: A user-requested command with both visual and hearing information is indicated. Additionally, with a user friendly method, the user understands what content to input. The user-requested command is expressed in the form of a template sentence. Template part in the template sentence is vocalized, and a slot area in the template sentence is expressed using a sound or voice. The user inputs his or her voice to be input to the slot area.

Abstract translation: 指示了具有视觉和听觉信息的用户请求命令。 另外，用户友好的方法，用户了解要输入的内容。 用户请求的命令以模板句子的形式表示。 模板句中的模板部分发声，模板句中的插槽区域用声音或声音表示。 用户输入他或她的声音以输入到插槽区域。

公开(公告)号：US07308479B2

公开(公告)日：2007-12-11

申请号：US10601954

申请日：2003-06-24

Applicant: Haru Ando ,  Junichi Matsuda

Inventor： Haru Ando ,  Junichi Matsuda

IPC: G06F15/16 ,  H04L12/58

CPC classification number: H04M1/72544 ,  G09B21/009 ,  H04M1/72552 ,  H04M3/5315 ,  H04M2207/18

Abstract: The mailing system of the invention converts the text information into movement information using animations, object information, and background information, and sends/receives the converted information as a mail. The system analyzes the information inputted or selected by a user, creates an animation movement by using the analyzed information, and selects an object and a background by using the analyzed information. The system sends/receives the created or selected animation movement information, object information, and background information as a mail, and displays the mail as if the sender and receiver were engaging in a dialogue.

Abstract translation: 本发明的邮件系统使用动画，对象信息和背景信息将文本信息转换为移动信息，并且作为邮件发送/接收转换的信息。 系统分析用户输入或选择的信息，通过使用分析的信息创建动画移动，并通过使用分析的信息来选择对象和背景。 该系统作为邮件发送/接收创建或选择的动画移动信息，对象信息和背景信息，并且像发送者和接收者正在进行对话一样显示该邮件。

公开(公告)号：US09381242B2

公开(公告)日：2016-07-05

申请号：US14004308

申请日：2012-03-09

Applicant: Chikateru Nozaki ,  Kazuyoshi Kaminaka ,  Junichi Matsuda

Inventor： Chikateru Nozaki ,  Kazuyoshi Kaminaka ,  Junichi Matsuda

IPC: A61K45/00 ,  A61K39/145 ,  A61K39/39 ,  A61K39/12 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K39/0007 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/575 ,  C12N2760/16134 ,  C12N2760/16171

Abstract: A novel adjuvant composition is provided that is excellent in safety and convenience as compared to the conventional adjuvant such as Alum. An adjuvant composition comprising citrullines, which are water soluble substance present in the living body, and/or a salt thereof; a vaccine composition comprising said adjuvant composition and an antigen; a process for preparing said adjuvant composition and said vaccine composition; and a method for administering said adjuvant composition and said vaccine composition are provided.

Abstract translation: 提供与常规佐剂如Alum相比，安全性和便利性优异的新型佐剂组合物。 包含作为存在于生物体中的水溶性物质的瓜氨酸的佐剂组合物和/或其盐; 包含所述佐剂组合物和抗原的疫苗组合物; 一种制备所述佐剂组合物和所述疫苗组合物的方法; 并提供了用于施用所述佐剂组合物和所述疫苗组合物的方法。

公开(公告)号：US09028463B2

公开(公告)日：2015-05-12

申请号：US13001995

申请日：2009-05-22

Applicant: Chikateru Nozaki ,  Kazuyoshi Kaminaka ,  Junichi Matsuda ,  Takaaki Terahara ,  Tetsuji Kuwahara ,  Seiji Tokumoto

Inventor： Chikateru Nozaki ,  Kazuyoshi Kaminaka ,  Junichi Matsuda ,  Takaaki Terahara ,  Tetsuji Kuwahara ,  Seiji Tokumoto

IPC: A61M31/00 ,  A61K39/145 ,  A61B17/20 ,  A61M37/00 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61B17/205 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/70 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0061 ,  C12N2760/16134 ,  C12N2760/16234

Abstract: The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.

Abstract translation: 本发明提供使用能够增强流感疫苗的免疫原性的微针装置增强免疫原性的方法。 根据使用本发明的微针装置的增强免疫原性的方法，将具有由聚乳酸制成的微针的微针装置涂敷于A型菌株（H1N1），A型菌株（H3N2）和A型菌株 作为活性成分的B菌株与皮肤直接接触，以便经皮施用上述流感疫苗。 在经皮给药之后，将月桂醇施用于已经与微针装置直接接触的皮肤部位。

公开(公告)号：US20120107334A1

公开(公告)日：2012-05-03

申请号：US13220452

申请日：2011-08-29

Applicant: Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

Inventor： Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

IPC: A61K39/00 ,  A61P25/28 ,  A61P37/04 ,  C07K14/435

CPC classification number: A61K39/0007 ,  A61K31/711 ,  C07K14/4711

Abstract: An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.

Abstract translation: 本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默氏病的药物，其包括淀粉样蛋白 诱导增强的免疫应答的肽。 淀粉样蛋白 肽或其部分，其中加入或插入半胱氨酸，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。 一种用于预防或治疗阿尔茨海默病的药物，其包含淀粉样蛋白 肽或其部分诱导增强的免疫应答。 可以具有相同效果的DNA疫苗，其包含编码淀粉样肽或其部分的基因，其通过加入或插入半胱氨酸诱导增强的免疫应答。

公开(公告)号：US20110268756A1

公开(公告)日：2011-11-03

申请号：US13124260

申请日：2009-10-16

Applicant: Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

Inventor： Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

IPC: A61K39/00 ,  A61P37/04 ,  A61P25/28 ,  C07K14/47 ,  C07K7/08

CPC classification number: C07K14/4711 ,  A61K39/0007 ,  A61K2039/53

Abstract: An object of the invention is to provide a peptide based on a sequence of an amyloid β peptide that may allow for induction of enhanced immune response and is safe and efficacious for prophylaxis and treatment of Alzheimer disease. An amyloid β peptide or a portion thereof with addition or insertion of cysteine or a cysteine analogue, and a method for enhancing immune response to amyloid β using said peptide, a medicament for prophylaxis and treatment of Alzheimer disease using said amyloid β peptide that induces an enhanced immune response, and a DNA vaccine comprising a gene coding for an amyloid β peptide or a sequence derived from an amyloid β peptide with addition or insertion of cysteine or a cysteine analogue, as expected to be similarly efficacious.

Abstract translation: 本发明的目的是提供一种基于淀粉样蛋白和bgr的序列的肽; 肽，其可以诱导增强的免疫应答，并且对阿尔茨海默病的预防和治疗是安全有效的。 淀粉样蛋白 肽或其部分加入或插入半胱氨酸或半胱氨酸类似物，以及增强对淀粉样蛋白的免疫应答的方法; 使用所述肽，使用所述淀粉样蛋白来预防和治疗阿尔茨海默病的药物; 诱导增强的免疫应答的肽，以及包含编码淀粉样蛋白的基因的DNA疫苗; 肽或衍生自淀粉样蛋白的序列; 具有加入或插入半胱氨酸或半胱氨酸类似物的肽，如预期类似地有效。

公开(公告)号：US20100236646A1

公开(公告)日：2010-09-23

申请号：US12664573

申请日：2008-05-19

Applicant: Masanori Anzai ,  Junichi Matsuda ,  Manabu Muraoka

Inventor： Masanori Anzai ,  Junichi Matsuda ,  Manabu Muraoka

IPC: F16K37/00 ,  G01F25/00

CPC classification number: G01F5/00 ,  G01F15/00 ,  G01F25/0007 ,  Y10T137/8158

Abstract: A body section having a main channel through which a fluid to be measured flows and sections for shunting the fluid to be measured from the main channel, and a fluid measuring section provided removably from the body section and measuring the flow rate of the fluid to be measured flowing through the main channel based on the detection results of the fluid to be measured introduced from the shunting section. The fluid measuring section is fixed to the body section and shunt ratio data, i.e. the adjustment data about measurement processing inherent to the constitution of the body section, is registered in the fluid measuring section before adjusting measurement processing.

Abstract translation: 主体部分，其具有待测流体的主通道和用于从主通道分流待测量流体的部分;以及流体测量部，其从主体部分可拆卸地设置并且将流体的流量测量为 基于从分流部引入的待测量流体的检测结果，测量流过主通道的流量。 流体测量部分固定到主体部分，并且在调整测量处理之前将分流比数据，即关于身体部分的结构固有的测量处理的调节数据登记在流体测量部分中。

公开(公告)号：US08883165B2

公开(公告)日：2014-11-11

申请号：US13392994

申请日：2010-08-23

Applicant: Kazuyoshi Kaminaka ,  Chikateru Nozaki ,  Junichi Matsuda ,  Kiyoto Nishiyama

Inventor： Kazuyoshi Kaminaka ,  Chikateru Nozaki ,  Junichi Matsuda ,  Kiyoto Nishiyama

IPC: A61K39/12 ,  A61K39/00 ,  A61K39/385 ,  A61K39/145 ,  A61K38/00 ,  C07K17/00 ,  C07K14/005

CPC classification number: A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/55505 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16134

Abstract: A modified peptide derived from matrix protein 2 (hereinafter also referred to as “M2”), one of surface layer proteins of influenza virus, and a method for utilization of the modified peptide are provided. A peptide (hereinafter also referred to as “M2eC peptide”) that is made up by inserting cysteine residue(s) into a peptide (hereinafter also referred to as “M2e”) consisting of 23 amino acid residues of from positions No. 2 to No. 24 of M2 in influenza virus type A, a fusion protein consisting of said modified peptide and a polypeptide, an influenza vaccine comprising said modified peptide or said fusion protein as an active ingredient, a device which can be delivered into the body comprising said influenza vaccine, a nucleic acid fragment consisting of a nucleotide sequence encoding the amino acid sequence of said modified peptide or said fusion protein, an expression vector in which said nucleic acid fragment is incorporated, a host in which said expression vector is introduced, and an antibody that has a protective effect against influenza virus.

Abstract translation: 提供了衍生自基质蛋白2的修饰肽（以下也称为“M2”），流感病毒的表层蛋白之一和使用修饰肽的方法。 通过将半胱氨酸残基插入由位置2〜23的23个氨基酸残基组成的肽（以下也称为“M2e”）而构成的肽（以下也称为“M2eC肽” 流感病毒A型M2的第24号，由所述修饰肽和多肽组成的融合蛋白，包含所述修饰肽或所述融合蛋白作为活性成分的流感疫苗，可以递送到身体的装置，包括所述 流感疫苗，由编码所述修饰肽或所述融合蛋白质的氨基酸序列的核苷酸序列组成的核酸片段，其中加入所述核酸片段的表达载体，导入所述表达载体的宿主和 对流感病毒具有保护作用的抗体。

公开(公告)号：US08656752B2

公开(公告)日：2014-02-25

申请号：US12664573

申请日：2008-05-19

Applicant: Masanori Anzai ,  Junichi Matsuda ,  Manabu Muraoka

Inventor： Masanori Anzai ,  Junichi Matsuda ,  Manabu Muraoka

IPC: G01F25/00

CPC classification number: G01F5/00 ,  G01F15/00 ,  G01F25/0007 ,  Y10T137/8158

Abstract: A body section having a main channel through which a fluid to be measured flows and sections for shunting the fluid to be measured from the main channel, and a fluid measuring section provided removably from the body section and measuring the flow rate of the fluid to be measured flowing through the main channel based on the detection results of the fluid to be measured introduced from the shunting section. The fluid measuring section is fixed to the body section and shunt ratio data, i.e. the adjustment data about measurement processing inherent to the constitution of the body section, is registered in the fluid measuring section before adjusting measurement processing.

Abstract translation: 主体部分，其具有待测流体的主通道和用于从主通道分流待测量流体的部分;以及流体测量部，其从主体部分可拆卸地设置并且将流体的流量测量为 基于从分流部引入的待测量流体的检测结果，测量流过主通道的流量。 流体测量部分固定到主体部分，并且在调整测量处理之前将分流比数据，即关于身体部分的结构固有的测量处理的调节数据登记在流体测量部分中。

公开(公告)号：US08623374B2

公开(公告)日：2014-01-07

申请号：US13220452

申请日：2011-08-29

Applicant: Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

Inventor： Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

IPC: A61K38/17 ,  A61K39/00 ,  A61P37/04 ,  A61P25/00 ,  C07K14/435

CPC classification number: A61K39/0007 ,  A61K31/711 ,  C07K14/4711

Abstract: An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid β peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.

Abstract translation: 本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默病的药物，其包含诱导增强的免疫应答的淀粉样蛋白β肽。 具有添加或插入半胱氨酸的淀粉样蛋白β肽或其部分，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。 一种用于预防或治疗阿尔茨海默病的药物，其包含诱导增强的免疫应答的淀粉样蛋白β肽或其部分。 可以具有相同效果的DNA疫苗，其包含编码淀粉样蛋白β肽或其部分的基因，其通过加入或插入半胱氨酸诱导增强的免疫应答。