公开(公告)号：US06288041B1

公开(公告)日：2001-09-11

申请号：US08981240

申请日：1997-12-19

申请人： Haruyuki Chaki ,  Naoko Ando ,  Tetsuo Jikihara ,  Ken-ichi Saito ,  Tomoko Yugami

发明人： Haruyuki Chaki ,  Naoko Ando ,  Tetsuo Jikihara ,  Ken-ichi Saito ,  Tomoko Yugami

IPC分类号： A61K3170

CPC分类号： C07H15/12 ,  C07H15/04 ,  C07J41/0005 ,  G01N33/50

摘要： Sialic acid derivatives represented by the following general formula: wherein R1 represents a residue of a steroid compound excluding cholestane and cholestene residues, R2 represents hydrogen or methyl group, R3 represents a C1-C6 alkyl group and other, R4 represents hydrogen or acyl group, R5 represents a group of R15O— (R15 represents a C2-C7 acyl group and other), and X represents oxygen or sulfur atom, and their derivatives. These derivatives have activating effect on choline acetyltransferase activity in the chlonergic neurons, and are useful for preventive and therapeutic treatment of dementia, memory disorder, peripheral nervous disorder and so forth.

摘要翻译： 由以下通式表示的唾液酸衍生物：其中R1表示除胆甾烷和胆固醇残基之外的类固醇化合物的残基，R 2表示氢或甲基，R 3表示C 1 -C 6烷基等，R 4表示氢或酰基， R5表示R15O-（R15表示C2-C7酰基等），X表示氧或硫原子的基团及其衍生物。 这些衍生物对胆碱能神经元中的胆碱乙酰转移酶活性具有活化作用，并且可用于预防和治疗痴呆，记忆障碍，周围神经障碍等。

公开(公告)号：US5110342A

公开(公告)日：1992-05-05

申请号：US755826

申请日：1991-09-06

申请人： Tetsuo Jikihara ,  Toyohiko Shike ,  Manabu Katsurada ,  Hisao Watanabe ,  Osamu Ikeda

发明人： Tetsuo Jikihara ,  Toyohiko Shike ,  Manabu Katsurada ,  Hisao Watanabe ,  Osamu Ikeda

IPC分类号： C07D213/50 ,  A01N35/06 ,  A01N41/04 ,  A01N43/20 ,  A01N43/40 ,  A01N43/42 ,  C07C45/64 ,  C07C45/68 ,  C07C49/683 ,  C07C49/697 ,  C07C49/747 ,  C07C205/45 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C309/75 ,  C07C309/77 ,  C07D213/61 ,  C07D213/64 ,  C07D303/32

CPC分类号： C07D303/32 ,  A01N35/06 ,  A01N41/04 ,  A01N43/20 ,  A01N43/40 ,  A01N43/42 ,  C07C205/45 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C309/75 ,  C07C309/77 ,  C07C45/64 ,  C07C45/68 ,  C07C49/683 ,  C07C49/697 ,  C07C49/747 ,  C07D213/61 ,  C07D213/64 ,  C07C2102/10

摘要： The present invention provides an indan-1,3-dione derivative represented by the following formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkyl group; R.sup.2 represents a group represented by ##STR2## wherein E represents a (substituted) phenyl group or a (substituted) pyridyl group; Y represents a hydroxyl group; and Z represents a halogen atom, a (substituted) alkylsulfonyloxy group or a (substituted) phenylsulfonyloxy group, or Y and Z are bonded to represent --O--; and A represents a (substituted) 1,3-butadienylene group or a (substituted) 1,3-azabutadienylene group, and a herbicidal composition containing the same as an active ingredient.

公开(公告)号：US4292070A

公开(公告)日：1981-09-29

申请号：US133270

申请日：1980-03-24

申请人： Osamu Wakabayashi ,  Kuni Matsuya ,  Hiroki Ohta ,  Tetsuo Jikihara ,  Seiichi Suzuki

发明人： Osamu Wakabayashi ,  Kuni Matsuya ,  Hiroki Ohta ,  Tetsuo Jikihara ,  Seiichi Suzuki

IPC分类号： A01N37/32 ,  A01N39/00 ,  C07D209/48 ,  A01N43/38

CPC分类号： C07D209/48 ,  A01N37/32 ,  A01N39/00

摘要： N-substituted-3,4,5,6-tetrahydrophthalimides in which the N-substituted group is a phenyl group having a substituted-oxy group at 3-position and a chlorine or bromine atom at 4-position and chlorine or hydrogen atom at 2-position have excellent herbicidal effect and are used as selective herbicides in a plant culturing.

摘要翻译： N-取代-3,4,5,6-四氢邻苯二甲酰亚胺，其中N-取代基是在3-位具有取代氧基的苯基和4-位的氯或溴原子以及氯原子或氢原子 2-位具有优异的除草效果，并用作植物培养中的选择性除草剂。

公开(公告)号：US4960897A

公开(公告)日：1990-10-02

申请号：US163086

申请日：1988-03-02

申请人： Tetsuo Jikihara ,  Manabu Katsurada ,  Toyohiko Shike ,  Emiko Mikami ,  Osamu Ikeda

发明人： Tetsuo Jikihara ,  Manabu Katsurada ,  Toyohiko Shike ,  Emiko Mikami ,  Osamu Ikeda

IPC分类号： A01N43/40 ,  C07D213/42 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D405/04

CPC分类号： C07D213/64 ,  A01N43/40 ,  C07D213/42 ,  C07D213/61 ,  C07D213/70 ,  C07D405/04

摘要： Disclosed herein is an N-[2-(pyridyl)propyl]-N-substituted sulfonamide represented by the following general formula (I): ##STR1## wherein J represents a phenyl group which may be substituted or benzo-condensed, A represents --CH.sub.2 --, --CH.dbd.CH--, --O-- or --N(r)-- (wherein r represents an alkyl group having 1 to 4 carbon atoms), b represents 0 or 1, R represents an alkyl group, alkenyl group, alkynyl group, alkoxy group, fluoroalkyl group or formyl group, D represents a hydroxyl group, E represents a halogen atom, an alkylsulfonyloxy group or a benzenesulfonyloxy group which may be substituted, or D and E represent --O-- in combination, and V represents a pyridyl group which may be substituted, a herbicide containing said N-[2-(pyridyl)propyl]-N-substituted sulfonamide as an active ingredient and a 1-(halogenomethyl)vinylpyridine as an intermediate thereof.

公开(公告)号：US5076830A

公开(公告)日：1991-12-31

申请号：US523748

申请日：1990-05-15

申请人： Tetsuo Jikihara ,  Toyohiko Shike ,  Manabu Katsurada ,  Hisao Watanabe ,  Osamu Ikeda

发明人： Tetsuo Jikihara ,  Toyohiko Shike ,  Manabu Katsurada ,  Hisao Watanabe ,  Osamu Ikeda

IPC分类号： C07D213/50 ,  A01N35/06 ,  A01N41/04 ,  A01N43/20 ,  A01N43/40 ,  A01N43/42 ,  C07C45/64 ,  C07C45/68 ,  C07C49/683 ,  C07C49/697 ,  C07C49/747 ,  C07C205/45 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C309/75 ,  C07C309/77 ,  C07D213/61 ,  C07D213/64 ,  C07D303/32

CPC分类号： C07D303/32 ,  A01N35/06 ,  A01N41/04 ,  A01N43/20 ,  A01N43/40 ,  A01N43/42 ,  C07C205/45 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C309/75 ,  C07C309/77 ,  C07C45/64 ,  C07C45/68 ,  C07C49/683 ,  C07C49/697 ,  C07C49/747 ,  C07D213/61 ,  C07D213/64 ,  C07C2102/10

摘要： The present invention provides indan-1,3-dione derivatives, including derivatives represented by the following formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkyl group; R.sup.2 represents a group represented by ##STR2## wherein E represents a (substituted) phenyl group or a (substituted) pyridyl group; Y represents a hydroxyl group; and Z represents a halogen atom, a (substituted) alkylsulfonyloxy group or a (substituted) phenylsulfonyloxy group, or Y and Z are bonded to represent --O--; and A represents a (substituted) 1,3-butadienylene group or a (substituted) 1,3-azabutadienylene group, and a herbicidal composition containing the same as an active ingredient.The compound of the formula (I) shows high herbicidal activity against gramineous weeds, cyperaceous weeds, etc. but shows markedly low phytotoxicity against crops.

公开(公告)号：US4249934A

公开(公告)日：1981-02-10

申请号：US943810

申请日：1978-09-19

申请人： Osamu Wakabayashi ,  Kuni Matsuya ,  Hiroki Ohta ,  Tetsuo Jikihara ,  Seiichi Suzuki

发明人： Osamu Wakabayashi ,  Kuni Matsuya ,  Hiroki Ohta ,  Tetsuo Jikihara ,  Seiichi Suzuki

IPC分类号： A01N43/64 ,  C07D487/04

CPC分类号： C07D487/04

摘要： Disclosed is a novel 1,2-alkylene-4-substituted urazole derivative which has unique biological activities, especially a herbicidal or weeding activity.

摘要翻译： 公开了一种具有独特生物活性，特别是除草或除草活性的新型1,2-亚烷基-4-取代的唑衍生物。

公开(公告)号：US5442060A

公开(公告)日：1995-08-15

申请号：US128250

申请日：1993-09-29

申请人： Tetsuo Jikihara ,  Tadashi Shirasaka ,  Kazuo Suzuki ,  Hiroko Suzuki ,  Masao Taniguchi ,  Shinya Inoue

发明人： Tetsuo Jikihara ,  Tadashi Shirasaka ,  Kazuo Suzuki ,  Hiroko Suzuki ,  Masao Taniguchi ,  Shinya Inoue

IPC分类号： C07C235/34 ,  C07C235/38 ,  C07C235/78 ,  C07C237/20 ,  C07D307/60 ,  C07D317/58 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D265/30 ,  C07D295/30

CPC分类号： C07D405/14 ,  C07C235/34 ,  C07C235/38 ,  C07C235/78 ,  C07C237/20 ,  C07D307/60 ,  C07D317/58 ,  C07D405/12 ,  C07D407/12 ,  C07C2101/08 ,  C07C2101/14

摘要： Carboxamide derivatives of the following general formula (I): ##STR1## (wherein R.sup.1 and R.sup.2 are C.sub.1 -C.sub.3 alkyl group or both taken together C.sub.1 -C.sub.3 alkylene group,R.sup.3 is hydrogen atom, dialkylamino group, etc.,R.sup.4 is hydrogen atom, C.sub.1 -C.sub.10 alkyl group,R.sup.5 is C.sub.1 -C.sub.10 alkyl group,m, n, q are an integer from 0-3,p is 0, 1,A ring is ##STR2## B ring is 5 or 6 membered nitrogen containing aromatic ring, are provided, which are useful as medicinals for treating hyperlipemia or atherosclerosis.

摘要翻译： （I）的酰胺衍生物：其中R 1和R 2是C 1 -C 3烷基或两者一起是C 1 -C 3亚烷基，R 3是氢原子，二烷基氨基等 R4是氢原子，C1-C10烷基，R5是C1-C10烷基，m，n，q是0-3的整数，p是0,1，A环是 环是5或6元含氮芳族环，其可用作治疗高脂血症或动脉粥样硬化的药物。

公开(公告)号：US4971620A

公开(公告)日：1990-11-20

申请号：US302253

申请日：1989-01-27

申请人： Tetsuo Jikihara ,  Manabu Katsurada ,  Toyohiko Shike ,  Osamu Ikeda ,  Hisao Watanabe ,  Tetsuo Takematsu ,  Koichi Yoneyama

发明人： Tetsuo Jikihara ,  Manabu Katsurada ,  Toyohiko Shike ,  Osamu Ikeda ,  Hisao Watanabe ,  Tetsuo Takematsu ,  Koichi Yoneyama

IPC分类号： C07D307/79 ,  A01N41/06 ,  A01N43/12 ,  A01N51/00 ,  C07C311/15 ,  C07C311/16 ,  C07C311/17 ,  C07C311/29 ,  C07C311/48 ,  C07D303/36

CPC分类号： A01N43/12 ,  A01N41/06 ,  A01N51/00 ,  C07C311/16 ,  C07C311/17

摘要： Disclosed herein is a sulfonamide compound represented by the formula (I): ##STR1## wherein A represents a phenyl group which may be substituted, B represents a phenyl group which may be substituted, R represents a lower alkyl group, a lower alkoxy group or a lower haloalkyl group, W represents a hydroxyl group or a halogen atom, and z represents a halogen atom, a lower alkysulfonyloxy group which may be substituted, or a phenylsulfonyloxy group which may be substituted, and a herbicidal composition containing the sulfonamide compound as an effective ingredient.

公开(公告)号：US4536209A

公开(公告)日：1985-08-20

申请号：US308825

申请日：1981-10-05

申请人： Tetsuo Jikihara ,  Masatsugu Oda ,  Bunji Natsume ,  Hisao Watanabe ,  Seiichi Suzuki

发明人： Tetsuo Jikihara ,  Masatsugu Oda ,  Bunji Natsume ,  Hisao Watanabe ,  Seiichi Suzuki

IPC分类号： A01N39/02 ,  A01N39/04 ,  C07D209/48 ,  A01N43/38

CPC分类号： C07D209/48 ,  A01N39/02 ,  A01N39/04

摘要： .DELTA.'-Tetrahydrophthalimides having a substituted oxy group at 3-position and, if necessary, a halogen atom at 4-position and/or at 2-position of phenyl group as N-substituent have excellent herbicidal activity and are useful as selective herbicides.

摘要翻译： 具有3-位取代氧基的四氢邻苯二甲酰亚胺，如果需要，作为N-取代基的苯基的4-位和/或2-位上的卤素原子具有优异的除草活性，可用作选择性除草剂。

公开(公告)号：US4420327A

公开(公告)日：1983-12-13

申请号：US308824

申请日：1981-10-05

申请人： Tetsuo Jikihara ,  Masatsugu Oda ,  Kazuyuki Ushinohama ,  Hisao Watanabe ,  Seiichi Suzuki

发明人： Tetsuo Jikihara ,  Masatsugu Oda ,  Kazuyuki Ushinohama ,  Hisao Watanabe ,  Seiichi Suzuki

IPC分类号： A01N39/00 ,  A01N43/08 ,  A01N43/28 ,  A01N43/30 ,  A01N43/32 ,  A01N47/06 ,  A01N47/24 ,  C07D209/48 ,  A01N43/38

CPC分类号： C07D209/48 ,  A01N39/00 ,  A01N43/08 ,  A01N43/28 ,  A01N43/30 ,  A01N43/32 ,  A01N47/06 ,  A01N47/24

摘要： .DELTA.'-Tetrahydrophthalimides having a substituted oxy group at 3-position and a halogen atom at 4-position if necessary, a halogen atom at 2-position of phenyl group as N-substituent have excellent herbicidal activity and are useful as selective herbicides.

摘要翻译： 如果需要，在三位上具有取代氧基的四氢邻苯二酰亚胺和4-取代的卤素原子，作为N-取代基的苯基的2-位上的卤素原子具有优异的除草活性，可用作选择性除草剂。