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公开(公告)号：US20130178496A1
公开(公告)日：2013-07-11
申请号：US13778949
申请日：2013-02-27
申请人： Hayley Binch , Peter D.J. Grootenhuis , Sara S. Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T.D. Fanning
发明人： Hayley Binch , Peter D.J. Grootenhuis , Sara S. Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T.D. Fanning
IPC分类号： A61K31/4375 , C07D471/04
CPC分类号： A61K31/4375 , C07D471/04
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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2.发明申请MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 有权CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR的调节剂公开(公告)号：US20130018070A1
公开(公告)日：2013-01-17
申请号：US13453193
申请日：2012-04-23
申请人： Hayley Binch , Peter D.J. Grootenhuis , Sara S Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T.D. Fanning
发明人： Hayley Binch , Peter D.J. Grootenhuis , Sara S Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T.D. Fanning
IPC分类号： A61K31/4375 , A61P37/00 , A61P3/06 , A61P3/02 , A61P3/10 , C12N5/07 , A61P25/28 , A61P25/16 , A61P11/00 , A61P27/04 , A61P21/00 , A61K31/4545 , A61P35/00
CPC分类号： A61K31/4375 , C07D471/04
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（ABC）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20100261750A1
公开(公告)日：2010-10-14
申请号：US12722642
申请日：2010-03-12
申请人： Hayley Binch , Peter D.J. Grootenhuis , Sara S. Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T.D. Fanning
发明人： Hayley Binch , Peter D.J. Grootenhuis , Sara S. Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T.D. Fanning
IPC分类号： A61K31/4375 , A61P3/10 , A61P5/18 , A61P11/00 , A61P25/16 , A61P25/28 , C07D471/04 , C12N5/00 , C07K1/00
CPC分类号： A61K31/4375 , C07D471/04
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20100184739A1
公开(公告)日：2010-07-22
申请号：US12635927
申请日：2009-12-11
申请人： Urvi Sheth , Lev T.D. Fanning , Mehdi Michael Djamel Numa , Hayley Binch , Dennis Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick van Goor , Peter D.J. Grootenhuis , Martyn Botfield
发明人： Urvi Sheth , Lev T.D. Fanning , Mehdi Michael Djamel Numa , Hayley Binch , Dennis Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick van Goor , Peter D.J. Grootenhuis , Martyn Botfield
IPC分类号： A61K31/4709 , C07D215/56 , A61K31/47 , C07D413/12 , A61K31/5377 , A61K31/496 , C07D401/12 , A61P11/06 , A61P1/10 , A61P1/18 , A61P1/16 , A61P3/10 , A61P5/18 , A61P35/00 , A61P5/16 , A61P25/16 , A61P25/28 , A61P27/02 , A61P19/10 , A61P25/08 , A61P25/14 , C12Q1/02
CPC分类号： C07C215/76 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/42 , C07D209/94 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/38 , C07D215/56 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/10
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08188283B2
公开(公告)日：2012-05-29
申请号：US12722642
申请日：2010-03-12
申请人： Hayley Binch , Peter D. J. Grootenhuis , Sara S. Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T. D. Fanning
发明人： Hayley Binch , Peter D. J. Grootenhuis , Sara S. Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T. D. Fanning
IPC分类号： C07K1/00
CPC分类号： A61K31/4375 , C07D471/04
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08410132B2
公开(公告)日：2013-04-02
申请号：US13453193
申请日：2012-04-23
申请人： Hayley Binch , Peter D. J. Grootenhuis , Sara S Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T. D. Fanning
发明人： Hayley Binch , Peter D. J. Grootenhuis , Sara S Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T. D. Fanning
IPC分类号： A61K31/4375 , A61P3/10 , A61P5/18 , A61P11/00 , A61P25/16 , A61P25/28 , C07D471/04 , C12N5/00 , C07K1/00
CPC分类号： A61K31/4375 , C07D471/04
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（ABC）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20090298876A1
公开(公告)日：2009-12-03
申请号：US12351447
申请日：2009-01-09
申请人： Sara Hadida Ruah , Anna Hazlewood , Peter D.J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida Ruah , Anna Hazlewood , Peter D.J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20090227797A1
公开(公告)日：2009-09-10
申请号：US12351401
申请日：2009-01-09
申请人： Sara Hadida Ruah , Anna Hazlewood , Peter D.J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida Ruah , Anna Hazlewood , Peter D.J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC分类号： C07D401/12 , C07D417/12 , C07D413/12
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：US08101767B2
公开(公告)日：2012-01-24
申请号：US12351401
申请日：2009-01-09
申请人： Sara Hadida Ruah , Anna Hazlewood , Peter D. J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida Ruah , Anna Hazlewood , Peter D. J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC分类号： C07D215/38
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08324242B2
公开(公告)日：2012-12-04
申请号：US12351447
申请日：2009-01-09
申请人： Sara Hadida Ruah , Anna Hazlewood , Peter D. J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida Ruah , Anna Hazlewood , Peter D. J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（ABC）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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