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    Powder inhaler having dispersing, discharge, and dwell-time chambers, along with an acceleration channel
    1.
    发明授权
    Powder inhaler having dispersing, discharge, and dwell-time chambers, along with an acceleration channel 失效
    具有分散，排出和停留时间的粉末吸入器以及加速通道

    公开(公告)号：US5435301A

    公开(公告)日：1995-07-25

    申请号：US153708

    申请日：1993-11-17

    申请人： Heiko Herold ,  Axel Wollenschlager ,  Harald Landen ,  Franz Schmitt

    发明人： Heiko Herold ,  Axel Wollenschlager ,  Harald Landen ,  Franz Schmitt

    IPC分类号： A61M13/00 ,  A61M1/00 ,  A61M15/00 ,  A61M16/10 ,  B05D7/14 ,  B65D83/06

    CPC分类号： A61M15/0065 ,  A61M15/0015 ,  A61M2202/064 ,  A61M2206/16

    摘要： The powder inhaler is based on a supply container (3) for the drug, which supply container is partially or completely closed off at its lower end by a rotatable or displaceable, manually actuated metering plate (4) for the repeated reception and delivery of a predetermined, reproducible quantity of the drug from the container (3), and of a mouthpiece (14) for inhaling, upstream of which a dispersing chamber (12) is connected. The metering plate (4) is provided with at least one depression (5) which is filled with the drug on actuation of the inhaler. Seen in the flow direction, an acceleration channel is arranged ahead of the dispersing chamber (12), which acceleration channel (8) partially covers the metering plate (4) with part of its longitudinal surface and opens out tangentially into a cylindrical dwell-time chamber (9). The dwell-time chamber (9) is, in turn, connected via a central outlet (10) of smaller diameter than the cylindrical dwell-time chamber (9) to a circular discharge chamber (11 ) which the dispersing chamber ( 12) adjoins tangentially.

    摘要翻译： 粉末吸入器基于用于药物的供应容器（3），其供应容器在其下端部分或完全地通过可旋转或可位移的手动致动计量板（4）部分或完全封闭，用于重复接收和递送 来自容器（3）的预定量的可重复使用的药物和用于吸入的吸口（14），其上连接有分散室（12）。 计量板（4）设置有至少一个在吸入器致动时填充有药物的凹陷（5）。 在流动方向上看到，加速通道布置在分散室（12）的前方，该加速通道（8）部分地覆盖计量板（4），其部分纵向表面以切向方式打开成圆柱形停留时间 室（9）。 停留时间室（9）又通过比圆柱形停留时间室（9）更小直径的中心出口（10）连接到分散室（12）邻接的圆形排出室（11） 切向

    Nasal applicator
    2.
    发明授权
    Nasal applicator 失效
    鼻贴

    公开(公告)号：US5702362A

    公开(公告)日：1997-12-30

    申请号：US646828

    申请日：1996-05-21

    申请人： Heiko Herold ,  Axel Wollenschlager ,  Alfred von Schuckmann

    发明人： Heiko Herold ,  Axel Wollenschlager ,  Alfred von Schuckmann

    IPC分类号： A61B17/24 ,  A61M13/00 ,  A61M15/08 ,  A61M31/00 ,  B05B11/06

    CPC分类号： A61M15/08 ,  A61M15/0065 ,  A61M31/00 ,  B05B11/062 ,  A61B17/24 ,  A61M2202/064 ,  A61M2205/075

    摘要： Nasal applicators are an important aid for introducing powdery, pharmacologically active medicaments into the nasopharyngeal space of a patient. The present nasal applicator is based on a manually actuated compressed air source connected to an inflow channel (8) for generating a compressed air jet, a storage container (3) for the medicament and a metering device for making available a portioned-off quantity of the medicament which is caught by the compressed air jet and transported through an outflow channel (9) into the nose. The metering device consists of a metering drum (5) in which the storage container (3) for the medicament is formed by the interior of the metering drum (5). In addition, the inflow channel (8) is connected to one end of a metering channel (7) and the outflow channel (9) to the other end of the metering channel (7). The quantity of medicament made available in one portioning chamber (13) of the metering drum (5) protrudes into the metering channel (7) in such a manner that it is completely caught by the compressed air jet and transported into the nasal cavities.

    摘要翻译： 鼻施用器是将粉末状，药理活性药物引入患者鼻咽部的重要辅助物质。 本鼻施用器基于连接到用于产生压缩空气射流的流入通道（8）的手动致动压缩空气源，用于药物的储存容器（3）和用于提供分配量的 被压缩空气射流捕获并通过流出通道（9）输送到鼻中的药物。 计量装置由计量鼓（5）组成，用于药物的储存容器（3）由计量鼓（5）的内部形成。 此外，流入通道（8）连接到计量通道（7）的一端和流出通道（9）连接到计量通道（7）的另一端。 在计量鼓（5）的一个分隔室（13）中可用的药物的量以这样的方式突出到计量通道（7）中，使得其被压缩空气射流完全捕获并输送到鼻腔中。

    Precipitation system for a powder inhaler
    3.
    发明授权
    Precipitation system for a powder inhaler 失效
    粉末吸入器沉淀系统

    公开(公告)号：US5947117A

    公开(公告)日：1999-09-07

    申请号：US555023

    申请日：1995-11-08

    申请人： Heiko Herold ,  Axel Wollenschlager

    发明人： Heiko Herold ,  Axel Wollenschlager

    IPC分类号： A61M11/00 ,  A61M15/00 ,  A61M15/06

    CPC分类号： A61M15/0086 ,  A61M11/002 ,  A61M2202/064 ,  A61M2206/14

    摘要： The precipitation system comprises a collection tube (1) which can be fitted onto the powder inhaler with a mouthpiece (3) and a centrifugal precipitator (2,6) arranged in the collection tube (1). This centrifugal precipitator has at least one spin-producing surface (2) which produces a spin flow in the collection tube (1), as a result of which the heavy coarse powder particles are precipitated on the inner wall of the collection tube (1) while the lighter fine powder particles pass into the mouthpiece (3) due to a flow which is essentially restricted to the area surrounding the tube axis.

    摘要翻译： 沉淀系统包括收集管（1），该收集管可以安装在具有接口（3）和布置在收集管（1）中的离心除尘器（2,6））的粉末吸入器上。 这种离心除尘器具有至少一个在收集管（1）中产生自旋流的旋转产生表面（2），结果是重的粗粉末颗粒沉淀在收集管（1）的内壁上， 而较轻的细粉末颗粒由于基本上限制在围绕管轴线的区域的流动而进入吹口（3）。

    Device for inhalation
    4.
    发明授权
    Device for inhalation 失效
    吸入装置

    公开(公告)号：US5505196A

    公开(公告)日：1996-04-09

    申请号：US344049

    申请日：1994-11-23

    申请人： Heiko Herold ,  Axel Wollenschlager ,  Ahmed Hegazy ,  Matthias Herboth ,  Reiner Diederich ,  Roland Kleissendorf ,  Alfred von Schuckmann

    发明人： Heiko Herold ,  Axel Wollenschlager ,  Ahmed Hegazy ,  Matthias Herboth ,  Reiner Diederich ,  Roland Kleissendorf ,  Alfred von Schuckmann

    IPC分类号： A61M13/00 ,  A61M15/00

    CPC分类号： A61M15/0065 ,  A61M2202/064

    摘要： The device for inhalation of a powdery, pharmacologically active drug consists of a supply container (3) for the drug (4), a manually actuated metering unit for providing a portioned-off quantity of inhalation substance which is picked up by the air current drawn in during inhalation and is swirled, an air inlet channel (9), a swirl chamber (W), and a connection channel (8) between the swirl cheer (W) and the metering unit, as well as a mouthpiece channel issuing from the swirl chamber (W). The metering unit here consists of a metering drum (D) which has, in its interior (5), a supply container (3) for the drug. Furthermore, the air inlet channel (9) and the connection channel (8) are arranged in such a way that they run towards each other in a V-shape. During a metering procedure, a portioned-off quantity of drug for inhalation present in the shape of a dome is provided in each case at the apex of the two air channels (8) and (9) running towards each other in a V-shape.

    摘要翻译： 用于吸入粉末状药物活性药物的装置包括用于药物（4）的供应容器（3），一个手动致动的计量单元，用于提供抽吸量的吸入物质，该吸入物质被抽出的气流 在吸入期间并旋转，在旋流促进器（W）和计量单元之间的空气入口通道（9），旋流室（W）和连接通道（8）以及从该开口通道 涡流室（W）。 这里的计量单元包括在其内部（5）中具有用于药物的供应容器（3）的计量鼓（D）。 此外，空气入口通道（9）和连接通道（8）以这样的方式设置，使得它们以V形的方式彼此相对运动。 在计量过程中，在两个空气通道（8）和（9）的顶点处，以V形形状彼此相向地设置以圆顶形式存在的用于吸入的药物的分配量 。

    Process for the production of isocyanates in the gas phase
    7.
    发明授权
    Process for the production of isocyanates in the gas phase 有权
    在气相中生产异氰酸酯的方法

    公开(公告)号：US06803482B2

    公开(公告)日：2004-10-12

    申请号：US10437509

    申请日：2003-05-14

    申请人： Marc Jenne ,  Heiko Herold ,  Martin Friedrich ,  Herbert Stutz

    发明人： Marc Jenne ,  Heiko Herold ,  Martin Friedrich ,  Herbert Stutz

    IPC分类号： C07C11800

    CPC分类号： C07C263/10 ,  C07C265/14

    摘要： Isocyanates are produced in the gas phase in a manner such that temperature fluctuations over time and temperature distribution asymmetry are prevented. In this improved process, performance of the reaction in tubular reactors is accomplished by flow-related measures such as homogenization and centering of the educt streams. The formation of polymeric secondary products, which result in baked-on deposits in the reactor and a reduction in reactor service life, is consequently prevented.

    摘要翻译： 在气相中产生异氰酸酯，使得可以防止随时间的温度波动和温度分布不对称性。 在这种改进的方法中，管式反应器中的反应的性能通过流动相关的测量来实现，例如匀浆和离心流的对中。 因此，防止了在反应器中产生烘烤沉积并降低反应器使用寿命的聚合二次产物的形成。

    Process for quenching a gaseous reaction mixture during the gas phase phosgenation of diamines
    8.
    发明授权
    Process for quenching a gaseous reaction mixture during the gas phase phosgenation of diamines 有权
    在二胺气相光气化期间淬灭气态反应混合物的方法

    公开(公告)号：US06800781B2

    公开(公告)日：2004-10-05

    申请号：US10670409

    申请日：2003-09-25

    申请人： Heiko Herold ,  Herbert Stutz ,  Hans-Joachim Brockhaus ,  Volker Michele

    发明人： Heiko Herold ,  Herbert Stutz ,  Hans-Joachim Brockhaus ,  Volker Michele

    IPC分类号： C07C26300

    CPC分类号： C07C263/10 ,  C07C265/14

    摘要： The present invention provides a process for quenching a gaseous reaction mixture during the phosgenation of diamines in the gas phase to produce diisocyanates. The gaseous reaction mixture contains at least a diisocyanate, phosgene and hydrogen chloride. The quenching liquid is injected into the gas mixture continuously flowing out of a cylindrical reaction zone into the downstream cylindrical quenching zone with the aid of at least two spray nozzles which are arranged at the entrance to the quenching zone at equal distances along the circumference of the quenching zone.

    摘要翻译： 本发明提供了一种在气相二光气化期间淬灭气态反应混合物以产生二异氰酸酯的方法。 气态反应混合物至少含有二异氰酸酯，光气和氯化氢。 借助于至少两个喷雾喷嘴将连续流出圆柱形反应区域的气体混合物中的淬火液体注入到沿淬火区域入口处等距离沿着圆周方向的淬火区域 淬火区。

    Process and apparatus for conducting the hot gas in the dry spinning process
    10.
    发明授权
    Process and apparatus for conducting the hot gas in the dry spinning process 失效
    在干纺工艺中进行热气的工艺和设备

    公开(公告)号：US4431602A

    公开(公告)日：1984-02-14

    申请号：US426307

    申请日：1982-09-29

    申请人： Hans-Josef Behrens ,  Heiko Herold ,  Edgar Muschelknautz ,  Roland Vogelsgesang

    发明人： Hans-Josef Behrens ,  Heiko Herold ,  Edgar Muschelknautz ,  Roland Vogelsgesang

    IPC分类号： D01D5/04 ,  D01D5/084 ,  B29F3/08

    CPC分类号： D01D5/04 ,  D01D5/084

    摘要： In order to conduct thoroughly pre-mixed hot gas into a ring spinning nozzle by a rotational flow in such a manner that sufficient quantities of hot gas are available for drying the filaments situated on the inside without causing backflow and without any significant movement of the filaments by turbulence, an annular chamber with tangential inlet is placed around the ring spinning nozzle. The internal wall of the chamber is separated from a circular chamber by equalizers in its upper region while on its underside it is separated from the spinning chamber by equalizers and metal gauzes at the level of the lower edge of the spinning nozzle. The circular chamber is also separated on its underside from the spinning chamber by equalizers and metal gauzes.

    摘要翻译： 为了通过旋转流将彻底预混合的热气体进入旋转喷嘴，使得足够量的热气体可用于干燥位于内部的细丝，而不会引起回流，并且丝束没有任何明显的移动 通过湍流，环形旋转喷嘴周围放置具有切向入口的环形室。 室的内壁在其上部区域中通过均衡器与圆形室分离，而在其下侧，其通过在纺丝喷嘴的下边缘的水平处的均衡器和金属纱布与纺丝室分离。 圆形室也通过均衡器和金属纱布在其下侧与纺纱室分离。