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1.发明授权Compounds from biopolymers and effector substances which are linked via optically active amino acid derivatives, processes for the preparation thereof and the use thereof 失效通过光学活性氨基酸衍生物连接的生物聚合物和效应物质的化合物，其制备方法及其用途
公开(公告)号：US5773271A
公开(公告)日：1998-06-30
申请号：US483060
申请日：1995-06-07
IPC分类号： G01N33/531 , C07D207/40 , C07D207/416 , C07D207/452 , C07K1/113 , C07K14/00 , C07K16/00 , C12N9/00 , G01N33/535 , G01N33/543 , C12N9/96 , C07K16/44
CPC分类号： C07D207/416 , G01N33/531 , G01N33/54353 , Y10S424/809
摘要： Compounds from biopolymers and effector substances which are linked via optically active amino acid derivatives, processes for the preparation thereof and the use thereof. The invention relates to compounds from biopolymers and effector substances which are linked with the aid of derivatives of optically active amino acids in which the amino group has been converted into a maleimido group and the carboxyl group into an active easter group.
摘要翻译： 通过光学活性氨基酸衍生物连接的生物聚合物和效应物质的化合物，其制备方法及其用途。 本发明涉及来自生物聚合物和效应物质的化合物，其借助于其中氨基已经转化成马来酰亚胺基并且羧基成为活性复活子组的光学活性氨基酸的衍生物连接。
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2.发明授权Magnetic protein conjugates, a process for the preparation thereof and the use thereof 失效磁性蛋白质结合体，其制备方法及其用途
公开(公告)号：US5095097A
公开(公告)日：1992-03-10
申请号：US538753
申请日：1990-06-15
IPC分类号： G01N33/50 , A61K9/50 , A61K38/00 , A61K38/22 , A61K38/36 , A61K38/43 , A61K39/395 , A61K47/48 , A61K49/18 , A61K49/20 , A61P37/00 , C07K1/113 , C07K14/00 , C07K14/42 , C07K14/52 , C07K14/575 , C07K14/705 , C07K16/00 , C07K16/08 , C07K16/12 , C07K16/20 , C07K16/30 , C07K16/42 , C12N9/00 , C12P21/08 , G01N33/547 , G01N33/553 , G01N33/563 , G01N33/577
CPC分类号： A61K49/1821 , A61K47/48007 , A61K49/20 , A61K9/5094 , G01N2446/90
摘要： The invention relates to magnetic protein conjugates of the formula IM--NH--CO--(CH.sub.2).sub.n --S--P' Iwith n=1-6, preferably with a n=1 or 2 and particularly preferably with n=1, in which M is a dispersible, magnetically reacting material or particle which carries amino groups, and P' is a protein, to a process for the preparation thereof and to the use thereof for the specific removal of cells or soluble antigens, receptors, substrates, cofactors or carbohydrate determinants from aqueous salt solutions or body fluids or as part of a diagnostic method or as a diagnostic aid, preferably for the removal of cells, preferably for bone marrow depletion or for HLA typing.
摘要翻译： 本发明涉及式I M-NH-CO-（CH2）nS-P'I与n = 1-6，优选为= 1或2，特别优选n = 1的磁性蛋白质缀合物，其中M 是一种可分散的，磁性反应的材料或颗粒，其携带氨基，P'是蛋白质，其制备方法及其用于特异性去除细胞或可溶性抗原，受体，底物，辅因子或碳水化合物 来自盐水溶液或体液的决定因素或作为诊断方法的一部分或作为诊断辅助剂，优选用于去除细胞，优选用于骨髓消耗或用于HLA分型。
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3.发明授权Biopolymer and effector substance conjugates, process for the preparation thereof and their use 失效生物聚合物和效应物质缀合物，其制备方法及其应用
公开(公告)号：US5484722A
公开(公告)日：1996-01-16
申请号：US201209
申请日：1994-02-24
IPC分类号： G01N33/531 , C07D207/40 , C07D207/416 , C07D207/452 , C07K1/113 , C07K14/00 , C07K16/00 , C12N9/00 , G01N33/535 , G01N33/543 , C12N9/96
CPC分类号： C07D207/416 , G01N33/531 , G01N33/54353 , Y10S424/809
摘要： The invention relates to compounds from biopolymers and effector substances which are linked with the aid of derivatives of optically active amino acids in which the amino group has been converted into a maleimido group and the carboxyl group into an active ester group, processes for the preparation thereof and the use thereof.
摘要翻译： 本发明涉及来自生物聚合物和效应物质的化合物，它们借助于其中氨基被转化为马来酰亚胺基并且羧基转化为活性酯基的旋光氨基酸的衍生物连接，其制备方法 及其用途。
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4.发明授权Compounds from biopolymers and effector substances which are linked via optically active amino acid derivatives, processes for the preparation thereof and the use thereof 失效通过光学活性氨基酸衍生物连接的生物聚合物和效应物质的化合物，其制备方法及其用途
公开(公告)号：US5321142A
公开(公告)日：1994-06-14
申请号：US549102
申请日：1990-07-06
IPC分类号： G01N33/531 , C07D207/40 , C07D207/416 , C07D207/452 , C07K1/113 , C07K14/00 , C07K16/00 , C12N9/00 , G01N33/535 , G01N33/543 , C07D403/06
CPC分类号： C07D207/416 , G01N33/531 , G01N33/54353 , Y10S424/809
摘要： The invention relates to compounds from biopolymers and effector substances which are linked with the aid of derivatives of optically active amino acids in which the amino group has been converted into a maleimido group and the carboxyl group into an active ester group.
摘要翻译： 本发明涉及来自生物聚合物和效应物质的化合物，它们借助于其中氨基已经转化成马来酰亚胺基并且羧基成为活性酯基的光学活性氨基酸的衍生物连接。
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5.发明授权Compounds from biopolymers and effector substances which are linked via optically active amino acid derivatives, processes for the preparation thereof and the use thereof 失效通过光学活性氨基酸衍生物连接的生物聚合物和效应物质的化合物，其制备方法及其用途
公开(公告)号：US5744315A
公开(公告)日：1998-04-28
申请号：US487647
申请日：1995-06-07
IPC分类号： G01N33/531 , C07D207/40 , C07D207/416 , C07D207/452 , C07K1/113 , C07K14/00 , C07K16/00 , C12N9/00 , G01N33/535 , G01N33/543 , A61K121/00 , G01N33/563
CPC分类号： C07D207/416 , G01N33/531 , G01N33/54353 , Y10S424/809
摘要： Compounds from biopolymers and effector substances which are linked via optically active amino acid derivatives, processes for the preparation thereof and the use thereof. The invention relates to compounds from biopolymers and effector substances which are linked with the aid of derivatives of optically active amino acids in which the amino group has been converted into a maleimido group and the carboxyl group into an active ester group.
摘要翻译： 通过光学活性氨基酸衍生物连接的生物聚合物和效应物质的化合物，其制备方法及其用途。 本发明涉及来自生物聚合物和效应物质的化合物，它们借助于其中氨基已经转化成马来酰亚胺基并且羧基成为活性酯基的光学活性氨基酸的衍生物连接。
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公开(公告)号：US4861711A
公开(公告)日：1989-08-29
申请号：US808563
申请日：1985-12-13
申请人： Heinz-Jurgen Friesen , Gerd Grenner , Hans-Erwin Pauly , Helmut Kohl , Klaus Habenstein , Joseph Stark
发明人： Heinz-Jurgen Friesen , Gerd Grenner , Hans-Erwin Pauly , Helmut Kohl , Klaus Habenstein , Joseph Stark
IPC分类号： A61K39/00 , C12Q1/00 , G01N33/52 , G01N33/543 , G01N33/558
CPC分类号： G01N33/521 , G01N33/525 , G01N33/54366 , G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S435/962 , Y10S435/97 , Y10S436/81
摘要： A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is brought into contact with a specific functional sector of the device, the fluid migrates through several functional sectors situated beside one another and containing suitable reagent components, and one or more substances of biological affinity are detected in such functional sectors which contain, for each substance to be detected, at least one combination partner of biological affinity, attached to a solid phase.
摘要翻译： 描述了用于定量测定生物流体中生物亲和力物质的固体诊断装置。 还描述了一种方法，其中使生物流体与装置的特定功能部分接触，流体通过位于彼此旁边并包含合适的试剂组分的几个功能部分迁移，并且检测到一种或多种生物亲和力的物质 在这样的功能部门中，对于每种待检测的物质，其包含附着于固相的至少一种生物亲和力的组合配偶体。
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公开(公告)号：US5015730A
公开(公告)日：1991-05-14
申请号：US386088
申请日：1989-07-14
IPC分类号： A61K38/21 , A61K38/00 , A61P31/12 , A61P35/00 , C07K1/22 , C07K14/52 , C07K14/555 , C07K14/565
CPC分类号： C07K14/565 , A61K38/00
摘要： Human fibroblast interferon has been purified to homogeneity by use of a novel procedure combining affinity chromatography and high pressure liquid chromatography (HPLC).
摘要翻译： 通过使用亲和层析和高压液相色谱（HPLC）的新方法，将人成纤维细胞干扰素纯化至均匀。
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公开(公告)号：US4289689A
公开(公告)日：1981-09-15
申请号：US160889
申请日：1980-06-19
IPC分类号： A61K38/00 , C07K14/565 , C07C103/52 , A61K45/02
CPC分类号： C07K14/565 , A61K38/00 , Y10S530/827 , Y10S530/829
摘要： Human fibroblast interferon has been purified to homogeneity by use of a novel procedure combining affinity chromatography and high pressure liquid chromatography (HPLC).
摘要翻译： 通过使用亲和层析和高压液相色谱（HPLC）的新方法，将人成纤维细胞干扰素纯化至均匀。
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