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1.发明授权Magnetic protein conjugates, a process for the preparation thereof and the use thereof 失效磁性蛋白质结合体，其制备方法及其用途
公开(公告)号：US5095097A
公开(公告)日：1992-03-10
申请号：US538753
申请日：1990-06-15
IPC分类号： G01N33/50 , A61K9/50 , A61K38/00 , A61K38/22 , A61K38/36 , A61K38/43 , A61K39/395 , A61K47/48 , A61K49/18 , A61K49/20 , A61P37/00 , C07K1/113 , C07K14/00 , C07K14/42 , C07K14/52 , C07K14/575 , C07K14/705 , C07K16/00 , C07K16/08 , C07K16/12 , C07K16/20 , C07K16/30 , C07K16/42 , C12N9/00 , C12P21/08 , G01N33/547 , G01N33/553 , G01N33/563 , G01N33/577
CPC分类号： A61K49/1821 , A61K47/48007 , A61K49/20 , A61K9/5094 , G01N2446/90
摘要： The invention relates to magnetic protein conjugates of the formula IM--NH--CO--(CH.sub.2).sub.n --S--P' Iwith n=1-6, preferably with a n=1 or 2 and particularly preferably with n=1, in which M is a dispersible, magnetically reacting material or particle which carries amino groups, and P' is a protein, to a process for the preparation thereof and to the use thereof for the specific removal of cells or soluble antigens, receptors, substrates, cofactors or carbohydrate determinants from aqueous salt solutions or body fluids or as part of a diagnostic method or as a diagnostic aid, preferably for the removal of cells, preferably for bone marrow depletion or for HLA typing.
摘要翻译： 本发明涉及式I M-NH-CO-（CH2）nS-P'I与n = 1-6，优选为= 1或2，特别优选n = 1的磁性蛋白质缀合物，其中M 是一种可分散的，磁性反应的材料或颗粒，其携带氨基，P'是蛋白质，其制备方法及其用于特异性去除细胞或可溶性抗原，受体，底物，辅因子或碳水化合物 来自盐水溶液或体液的决定因素或作为诊断方法的一部分或作为诊断辅助剂，优选用于去除细胞，优选用于骨髓消耗或用于HLA分型。
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2.发明授权Magnetic protein conjugates, a process for the preparation thereof, and the use thereof 失效磁性蛋白质缀合物，其制备方法及其用途
公开(公告)号：US5672687A
公开(公告)日：1997-09-30
申请号：US375232
申请日：1995-01-19
IPC分类号： C12P21/08 , A61K9/50 , A61K38/00 , A61K38/22 , A61K38/36 , A61K39/395 , A61K39/44 , A61K47/48 , A61P7/00 , A61P35/02 , C07K1/113 , C07K14/00 , C07K14/42 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/00 , C07K16/18 , C07K16/28 , C07K17/06 , C07K17/14 , C12N5/00 , C12N5/06 , G01N33/543 , G01N33/547 , G01N33/553
CPC分类号： G01N33/54353 , A61K47/48007 , A61K47/48715 , A61K9/5094 , C07K1/1133 , C07K17/06 , C12N5/0087 , G01N33/5434 , G01N2446/90
摘要： The invention relates to magnetic protein conjugates of the formula I ##STR1## in which M represents a dispersible magnetically reacting material or particle which carries aminogroups, Ig represents a protein which carries one or more mercapto groups, and X represents an organic chemical structure which links the two ligands by chemical means, to a process for the preparation of protein conjugates of the formula I, and to the use of conjugates of this type for removing cells or soluble bioorganic molecules or components from aqueous salt solutions or body fluids, and to the use thereof within the framework of a diagnostic method or as a diagnostic aid.
摘要翻译： 本发明涉及式I的磁性蛋白质缀合物，其中M代表携带氨基的可分散的磁性反应材料或颗粒，Ig代表携带一个或多个巯基的蛋白质，X代表有机化学结构， 通过化学方法将两个配体连接到制备式I的蛋白质缀合物的方法中，以及使用这种用于从盐水溶液或体液中除去细胞或可溶性生物有机分子或组分的共轭物，以及 在诊断方法或诊断辅助框架内的使用。
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3.发明授权Use of the IL-4 receptor for the therapy prophylaxis and diagnosis of allergic viral parasitic and bacterial diseases and of fungal infections 有权IL-4受体用于预防和诊断过敏性，病毒性，寄生性和细菌性疾病以及真菌感染的用途公开(公告)号：US06328954B1
公开(公告)日：2001-12-11
申请号：US09363192
申请日：1999-07-29
IPC分类号： A61K4500
CPC分类号： G01N33/6893 , A61K38/177 , A61K38/1793 , A61K38/217 , A61K39/35 , B01D53/502 , G01N33/566 , G01N33/56905 , G01N33/56911 , G01N33/56961 , G01N33/56983 , G01N33/6866 , G01N33/6869 , G01N2800/24 , Y02A50/41 , Y02A50/412 , Y02A50/423 , A61K2300/00
摘要： The use of the IL-4 receptor for the therapy, prophylaxis and diagnosis of allergic, viral, parasitic and bacterial diseases and of fungal infections. The invention relates to the use of the IL-4 receptor or of derivatives thereof for the therapy, prophylaxis and diagnosis of allergic, viral, parasitic and bacterial diseases and of fungal infections.
摘要翻译： IL-4受体用于治疗，预防和诊断过敏性，病毒性，寄生性和细菌性疾病以及真菌感染的用途本发明涉及IL-4受体或其衍生物在治疗，预防中的用途 并诊断过敏，病毒，寄生虫和细菌性疾病以及真菌感染。
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4.发明授权IL-4 receptor for the therapy, prophylaxis and diagnosis of allergic, viral, and bacterial diseases and of fungal infections 失效用于治疗，预防和诊断过敏，病毒和细菌疾病以及真菌感染的IL-4受体公开(公告)号：US06210661B1
公开(公告)日：2001-04-03
申请号：US08692446
申请日：1996-08-05
IPC分类号： A61K4500
CPC分类号： G01N33/6893 , A61K38/177 , A61K38/1793 , A61K38/217 , A61K39/35 , B01D53/502 , G01N33/566 , G01N33/56905 , G01N33/56911 , G01N33/56961 , G01N33/56983 , G01N33/6866 , G01N33/6869 , G01N2800/24 , Y02A50/41 , Y02A50/412 , Y02A50/423 , A61K2300/00
摘要： The IL-4 receptor for the therapy, prophylaxis and diagnosis of allergic, viral, parasitic and bacterial diseases and of fungal infections. The invention relates to the il-4 receptor or variants thereof for the therapy, prophylaxis and diagnosis of allergic, viral, parasitic and bacterial diseases and of fungal infections.
摘要翻译： 用于治疗，预防和诊断过敏性，病毒性，寄生性和细菌性疾病以及真菌感染的IL-4受体。 本发明涉及用于治疗，预防和诊断过敏，病毒，寄生和细菌疾病和真菌感染的il-4受体或其变体。
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公开(公告)号：US07045601B2
公开(公告)日：2006-05-16
申请号：US10636542
申请日：2003-08-08
申请人： Hubert Metzner , Uwe Liebing , Gerhardt Kumpe , Stefan Schulte , Volker Gawantka , Karlheinz Enssle
发明人： Hubert Metzner , Uwe Liebing , Gerhardt Kumpe , Stefan Schulte , Volker Gawantka , Karlheinz Enssle
CPC分类号： A61K38/39
摘要： The present invention relates to a novel storage-stable formulation for fibrinogen in liquid or viscous liquid form comprising divalent metal ions. The fibrinogen formulation may comprise other conventional formulation ingredients and particularly preferably comprises a complexing agent. The invention further relates to the production and use of the fibrinogen formulation of the invention.
摘要翻译： 本发明涉及用于包含二价金属离子的液体或粘稠液体形式的纤维蛋白原的新型储存稳定剂型。 纤维蛋白原制剂可以包含其它常规制剂成分，特别优选包含络合剂。 本发明还涉及本发明的纤维蛋白原制剂的生产和使用。
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公开(公告)号：US20050080009A1
公开(公告)日：2005-04-14
申请号：US10636542
申请日：2003-08-08
申请人： Hubert Metzner , Uwe Liebing , Gerhardt Kumpe , Stefan Schulte , Volker Gawantka , Karlheinz Enssle
发明人： Hubert Metzner , Uwe Liebing , Gerhardt Kumpe , Stefan Schulte , Volker Gawantka , Karlheinz Enssle
IPC分类号： A61K9/08 , A61K35/14 , A61K38/39 , A61K38/48 , A61K47/04 , A61K47/12 , A61K47/18 , A61K47/42 , A61L24/00 , A61L31/00 , A61P7/00 , A61P7/04 , A61K38/36
CPC分类号： A61K38/39
摘要： The present invention relates to a novel storage-stable formulation for fibrinogen in liquid or viscous liquid form comprising divalent metal ions. The fibrinogen formulation may comprise other conventional formulation ingredients and particularly preferably comprises a complexing agent. The invention further relates to the production and use of the fibrinogen formulation of the invention.
摘要翻译： 本发明涉及用于包含二价金属离子的液体或粘稠液体形式的纤维蛋白原的新型储存稳定剂型。 纤维蛋白原制剂可以包含其它常规制剂成分，特别优选包含络合剂。 本发明还涉及本发明的纤维蛋白原制剂的生产和使用。
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公开(公告)号：US06475717B1
公开(公告)日：2002-11-05
申请号：US08900576
申请日：1997-07-25
申请人： Karlheinz Enssle , Roland Kurrle , Klaus-Dieter Langner , Leander Lauffer , Josef-Urban Pauly , Friedrich-Robert Seiler
发明人： Karlheinz Enssle , Roland Kurrle , Klaus-Dieter Langner , Leander Lauffer , Josef-Urban Pauly , Friedrich-Robert Seiler
IPC分类号： C12Q170
CPC分类号： G01N33/6863
摘要： The invention relates to a method for detecting and determining mediators and/or their derivatives in fluids, the mediator being detected directly or indirectly with the aid of a recombinant, soluble receptor for the mediator to be detected.
摘要翻译： 本发明涉及用于检测和测定流体中的介体和/或其衍生物的方法，所述介体是借助于要检测的介体的重组可溶性受体直接或间接检测的。
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