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    Aldehyde-functionalized polysaccharides
    3.
    发明授权
    Aldehyde-functionalized polysaccharides 有权
    醛官能化多糖

    公开(公告)号：US08580951B2

    公开(公告)日：2013-11-12

    申请号：US12996477

    申请日：2010-07-01

    申请人： Helen S. M. Lu ,  Steven W. Shuey

    发明人： Helen S. M. Lu ,  Steven W. Shuey

    IPC分类号： C08B1/00 ,  C08B11/02 ,  C08B11/04 ,  C08B11/08 ,  C08B11/12 ,  C08B31/18 ,  C08B37/02 ,  C08B37/12 ,  C08B37/18 ,  C08L1/02 ,  C08L1/28 ,  C08L5/02 ,  C08L5/08 ,  C08L5/12

    CPC分类号： C08B37/00 ,  C08B15/02 ,  C08B31/18 ,  C08B37/0021 ,  C08B37/0054 ,  C08L1/04 ,  C08L3/10 ,  C08L5/00 ,  C08L5/02

    摘要： Novel aldehyde-functionalized polysaccharide compositions are described that are more stable in aqueous solution than oxidized polysaccharides or other types of polysaccharides containing pendant aldehyde groups. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.

    摘要翻译： 描述了新型醛官能化多糖组合物，其在水溶液中比氧化多糖或其它类型的含醛侧基的多糖更稳定。 醛官能化多糖可以与各种含胺聚合物反应以形成可用于医学应用的水凝胶组织粘合剂和密封剂，例如伤口闭合，补充或替换缝合或缝合在内部外科手术如肠吻合和血管吻合中 ，组织修复，防止流体如血液，胆汁，胃肠道液体和脑脊液的渗漏，眼科手术，药物递送和预防手术后粘连。

    Method for preparing glycidyloxystyrene monomers and polymers thereof
    5.
    发明授权
    Method for preparing glycidyloxystyrene monomers and polymers thereof 失效
    缩水甘油氧基苯乙烯单体的制备方法及其聚合物

    公开(公告)号：US07468415B2

    公开(公告)日：2008-12-23

    申请号：US11961093

    申请日：2007-12-20

    申请人： Keith Kunitsky ,  Mukesh C. Shah ,  Steven W. Shuey ,  Mark E. Wagman

    发明人： Keith Kunitsky ,  Mukesh C. Shah ,  Steven W. Shuey ,  Mark E. Wagman

    IPC分类号： C08F2/00 ,  C07D301/28 ,  C08F12/22

    CPC分类号： C08F12/22 ,  C07D303/23

    摘要： It was found that glycidyloxystyrenes, including glycidyloxystyrene and substituted glycidyloxystyrene, can be synthesized from hydroxycinnamic acid or substituted hydroxycinnamic acids in a one-pot, two-step process. The substrate can be thermally decarboxylated and then without purification, reacted in the presence of a halomethyl-oxirane and a base. The resulting product can be polymerized or coppolymerized to a fully substituted product.

    摘要翻译： 发现缩水甘油氧基苯乙烯，包括缩水甘油氧基苯乙烯和取代的缩水甘油氧基苯乙烯，可以一锅二步法从羟基肉桂酸或取代的羟基肉桂酸合成。 底物可以热脱羧，然后不经纯化，在卤代甲基 - 环氧乙烷和碱的存在下反应。 所得产物可以被聚合或共聚合成完全取代的产物。

    Tissue coating for preventing undesired tissue-to-tissue adhesions
    6.
    发明授权
    Tissue coating for preventing undesired tissue-to-tissue adhesions 有权
    用于防止不想要的组织粘附的组织涂层

    公开(公告)号：US08932622B2

    公开(公告)日：2015-01-13

    申请号：US12989843

    申请日：2009-06-01

    申请人： Steven W. Shuey

    发明人： Steven W. Shuey

    IPC分类号： A61K9/00 ,  A61K31/721 ,  A61P17/02 ,  A61K9/14 ,  A61K31/717 ,  A61P43/00 ,  A61L31/14 ,  A61L31/04

    CPC分类号： A61L31/145 ,  A61L31/041 ,  C08L5/02 ,  C08L1/28

    摘要： Disclosed herein are a kit and a method for forming a tissue coating that prevents undesired tissue-to-tissue adhesions resulting from trauma, surgery, infection, or other stimulus. The tissue coating is a hydrogel formed by reacting an aminocarboxymethyldextran containing primary amine groups with an oxidized carboxymethylcellulose containing aldehyde groups.

    摘要翻译： 本文公开了一种用于形成组织涂层的试剂盒和方法，其防止由创伤，手术，感染或其它刺激引起的不希望的组织与组织粘连。 组织包衣是通过使含有伯胺基的氨基羧甲基葡聚糖与含有醛基的氧化羧甲基纤维素反应而形成的水凝胶。

    TISSUE COATING FOR PREVENTING UNDESIRED TISSUE-TO-TISSUE ADHESIONS
    8.
    发明申请
    TISSUE COATING FOR PREVENTING UNDESIRED TISSUE-TO-TISSUE ADHESIONS 有权
    用于防止不利的组织组织粘连的组织涂层

    公开(公告)号：US20110045075A1

    公开(公告)日：2011-02-24

    申请号：US12989843

    申请日：2009-06-01

    申请人： Steven W. Shuey

    发明人： Steven W. Shuey

    IPC分类号： A61K9/00 ,  A61K31/721 ,  A61P17/02

    CPC分类号： A61L31/145 ,  A61L31/041 ,  C08L5/02 ,  C08L1/28

    摘要： Disclosed herein are a kit and a method for forming a tissue coating that prevents undesired tissue-to-tissue adhesions resulting from trauma, surgery, infection, or other stimulus. The tissue coating is a hydrogel formed by reacting an aminocarboxymethyldextran containing primary amine groups with an oxidized carboxymethylcellulose containing aldehyde groups.

    摘要翻译： 本文公开了一种用于形成组织涂层的试剂盒和方法，其防止由创伤，手术，感染或其它刺激引起的不希望的组织与组织粘连。 组织包衣是通过使含有伯胺基的氨基羧甲基葡聚糖与含有醛基的氧化羧甲基纤维素反应而形成的水凝胶。

    Organometallic complexes
    10.
    发明申请
    Organometallic complexes 失效
    有机金属配合物

    公开(公告)号：US20100264380A1

    公开(公告)日：2010-10-21

    申请号：US11654773

    申请日：2007-01-18

    申请人： Norman Herron ,  Steven W. Shuey ,  Jeffrey A. Merlo

    发明人： Norman Herron ,  Steven W. Shuey ,  Jeffrey A. Merlo

    IPC分类号： H01B1/12 ,  C07F15/00

    CPC分类号： H01L51/5016 ,  C09K11/06 ,  C09K2211/186 ,  H01L51/0081 ,  H01L51/0084 ,  H01L51/5048 ,  H05B33/20

    摘要： The present disclosure relates to organometallic complexes and electronic devices containing the complexes. The complexes have the formula MYnZ, where n is 1, 2, or 3; M is a metal in a +2, +3, or +4 oxidation state, Y is selected from an 8-hydroxyquinolate and a substituted 8-hydroxyquinolate, and Z is a phenolate. At least one Y is a substituted 8-hydroxyquinolate having the formula where: R1 and R2 are the same or different at each occurrence and each represents one or more of a substituent selected from the group consisting of H, alkyl, fluoroalkyl, aryl, fluoroaryl, alkylaryl, alkoxy, aryloxy, fluoroalkoxy, fluoroaryloxy, heteroalkyl, fluoroheteroalkyl, heteroaryl, fluoroheteroaryl, heteroalkylaryl, heteroalkoxy, heteroaryloxy, fluoroheteroalkoxy, fluoroheteroaryloxy, a solvent-solubilizing group, and a Tg enhancing group, wherein at least one of R1 and R2 is a solvent-solubilizing or Tg enhancing group; and R3 is selected from the group consisting of H, an alkyl group, and a substituted alkyl group.

    摘要翻译： 本公开涉及含有该配合物的有机金属配合物和电子装置。 络合物具有式MYnZ，其中n为1,2或3; M是+2，+3或+4氧化态的金属，Y选自8-羟基喹啉酸盐和取代的8-羟基喹喔啉，Z是酚盐。 至少一个Y是具有下式的取代的8-羟基喹诺酸盐：其中：R1和R2在每次出现时相同或不同，并且各自表示一个或多个选自H，烷基，氟代烷基，芳基，氟代芳基 烷基芳基，烷氧基，芳氧基，氟代烷氧基，氟芳氧基，杂烷基，氟杂芳基，杂芳基，氟杂芳基，杂烷基芳基，杂烷氧基，杂芳氧基，氟代杂环氧基，氟代杂芳基氧基，溶剂增溶基团和Tg增强基团，其中R1和R2中的至少一个是 溶剂增溶或Tg增强基团; 并且R 3选自H，烷基和取代的烷基。