摘要:
A clamping device for gripping a tool in a carrier. The clamping device has a hollow centering extension or spigot and an abutment surface surrounding it are provided on the tool. A tool receptacle provided in the carrier has a receiving bore matched to the centering extension and an end face surrounding the bore and against which the abutment surface can be pressed by a clamping arrangement. The clamping arrangement comprises a clamping sleeve movable coaxially with respect to the central axis and a clamping ring or collet movable in the opposite direction to the clamping sleeve, both of which are provided with clamping cones facing towards one another. The collet is movable axially on the clamping sleeve by means of a clamping nut screwable on the sleeve. A plurality of clamping jaws surround the clamping sleeve and the collet concentrically and are supported in each case by one end against their clamping cones. The clamping jaws have at their two ends clamping surfaces which cooperate with a conical surface of the tool receptacle and with a conical surface oppositely directed with respect to that conical surface in the centering extension.
摘要:
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds. These compounds are useful for therapy or prophylaxis in a mammal, and in particular as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.
摘要:
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
摘要:
This invention relates to compounds of the formula wherein X is O or NR8, Y is CR7 or N, and R1 to R8 are as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.
摘要:
This invention relates to compounds of the formula wherein A, R1 to R3 are as defined in the specification and G is benzoimidazole, quinoxaline, benzotriazole, dihydro-imidazo[4,5-c]pyridine and dihydro-isoindolone group as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.
摘要:
This invention relates to novel compounds having the Formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要:
This invention is concerned with compounds of the formula wherein A, R1 to R5 are as defined in the specification and G is a pyridine, quinoline or pyrimidine group as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.
摘要:
The invention pertains to a rotary feed-through for supplying a fluid to a rotating machine part with a hollow shaft (3) that is rotatably supported in a housing (1, 2) and has a first sliding surface (29), with a sealing bushing (31) that is arranged in a rotationally fixed fashion within the housing (1, 2) coaxial to the shaft (3) and has a second sliding surface (30) for contacting the first sliding surface (29), and with a collecting chamber (27) that is arranged within the housing (1, 2) and serves for collecting the leakage fluid escaping between the two sliding surfaces (29, 30). The leakage fluid collected within the rotary feed-through can be monitored with the aid of a detection channel (26, 33, 34, 37, 39, 47) in the housing (1, 2) that is connected to the collecting chamber (27) and contains a leakage sensor (41).
摘要:
The invention is concerned with novel 4-aminomethyl benzamidine derivatives of formula (I) wherein Ar and X are as defined in the description and in the claims, as well as prodrugs and pharmaceutically acceptable salts thereof These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
摘要:
The present invention relates to compounds of formula (I) wherein wherein R1, R2, R3, R4, R5, R6 and n are as described herein. The compounds of the present invention can be used as medicaments for the treatment and/or prevention of diseases which are modulated by PPARα and/or PPARγ agonists. Examples of such diseases are diabetes, particularly non-insulin dependent diabetes mellitus, elevated blood pressure, increased lipid and cholesterol levels, atherosclerotic diseases, metabolic syndrome, endothelial dysfunction, procoagulant state, dyslipidemia, polycystic ovary syndrome, inflammatory diseases (such as e.g. crown disease, inflammatory bowel disease, collitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as e.g. Alzheimer's disease or impaired/improvable cognitive function) and proliferative diseases.