Clamping device for gripping a tool in a tool carrier
    1.
    发明授权
    Clamping device for gripping a tool in a tool carrier 失效
    用于在工具载体中运送工具的夹紧装置

    公开(公告)号:US5186476A

    公开(公告)日:1993-02-16

    申请号:US674554

    申请日:1991-03-22

    摘要: A clamping device for gripping a tool in a carrier. The clamping device has a hollow centering extension or spigot and an abutment surface surrounding it are provided on the tool. A tool receptacle provided in the carrier has a receiving bore matched to the centering extension and an end face surrounding the bore and against which the abutment surface can be pressed by a clamping arrangement. The clamping arrangement comprises a clamping sleeve movable coaxially with respect to the central axis and a clamping ring or collet movable in the opposite direction to the clamping sleeve, both of which are provided with clamping cones facing towards one another. The collet is movable axially on the clamping sleeve by means of a clamping nut screwable on the sleeve. A plurality of clamping jaws surround the clamping sleeve and the collet concentrically and are supported in each case by one end against their clamping cones. The clamping jaws have at their two ends clamping surfaces which cooperate with a conical surface of the tool receptacle and with a conical surface oppositely directed with respect to that conical surface in the centering extension.

    摘要翻译: 一种用于将工具夹持在载体中的夹紧装置。 夹紧装置具有中空的中心延伸部或套管,并且在工具上设有围绕其的邻接表面。 设置在载体中的工具容器具有与定心延伸部相匹配的容纳孔和围绕孔的端面,抵靠面可以通过夹紧装置被压靠在该孔上。 夹紧装置包括可相对于中心轴线同轴运动的夹紧套筒和夹紧环或夹头,该夹紧环或夹头可在与夹紧套筒相反的方向上移动,两者都具有面向彼此的夹紧锥体。 夹头可通过可套在套筒上的夹紧螺母在夹紧套筒上轴向移动。 多个夹爪围绕夹紧套筒和夹头同心地围绕,并且在每种情况下由一端支撑在其夹紧锥体上。 夹爪在它们的两端处具有夹紧表面,该表面与工具容器的圆锥形表面配合,并且具有在定心延伸部中相对于该锥形表面相对定向的锥形表面。

    ARYLOXAZOLE, ARYLOXADIAZOLE AND BENZIMIDAZOLE DERIVATIVES
    4.
    发明申请
    ARYLOXAZOLE, ARYLOXADIAZOLE AND BENZIMIDAZOLE DERIVATIVES 审中-公开
    阿唑氧唑,阿魏酸和苯并咪唑衍生物

    公开(公告)号:US20080306116A1

    公开(公告)日:2008-12-11

    申请号:US12123508

    申请日:2008-05-20

    IPC分类号: A61K31/454 C07D405/12

    CPC分类号: C07D413/12 C07D401/12

    摘要: This invention relates to compounds of the formula wherein X is O or NR8, Y is CR7 or N, and R1 to R8 are as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

    摘要翻译: 本发明涉及下式的化合物,其中X为O或NR8,Y为CR7或N,R1至R8如说明书中所定义,及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物,其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

    PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES
    7.
    发明申请
    PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES 失效
    吡啶,喹啉和吡嗪衍生物

    公开(公告)号:US20080064697A1

    公开(公告)日:2008-03-13

    申请号:US11847467

    申请日:2007-08-30

    CPC分类号: C07D401/12

    摘要: This invention is concerned with compounds of the formula wherein A, R1 to R5 are as defined in the specification and G is a pyridine, quinoline or pyrimidine group as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

    摘要翻译: 本发明涉及下式的化合物,其中A,R 1至R 5如说明书中所定义,G为吡啶,喹啉或嘧啶基团,如 说明书及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物,其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

    ROTARY FEED-THROUGH WITH LEAKAGE SENSOR
    8.
    发明申请
    ROTARY FEED-THROUGH WITH LEAKAGE SENSOR 有权
    旋转进给 - 带泄漏传感器

    公开(公告)号:US20070034265A1

    公开(公告)日:2007-02-15

    申请号:US11460269

    申请日:2006-07-27

    IPC分类号: F16L27/08

    摘要: The invention pertains to a rotary feed-through for supplying a fluid to a rotating machine part with a hollow shaft (3) that is rotatably supported in a housing (1, 2) and has a first sliding surface (29), with a sealing bushing (31) that is arranged in a rotationally fixed fashion within the housing (1, 2) coaxial to the shaft (3) and has a second sliding surface (30) for contacting the first sliding surface (29), and with a collecting chamber (27) that is arranged within the housing (1, 2) and serves for collecting the leakage fluid escaping between the two sliding surfaces (29, 30). The leakage fluid collected within the rotary feed-through can be monitored with the aid of a detection channel (26, 33, 34, 37, 39, 47) in the housing (1, 2) that is connected to the collecting chamber (27) and contains a leakage sensor (41).

    摘要翻译: 本发明涉及一种用于向旋转机器部件供应流体的旋转馈通,所述旋转机器部分具有可旋转地支撑在壳体(1,2)中并具有第一滑动表面(29)的中空轴(3) 衬套(31),其以与所述轴(3)同轴的所述壳体(1,2)内以旋转固定的方式布置,并且具有用于接触所述第一滑动表面(29)的第二滑动表面(30) 室(27),其布置在壳体(1,2)内,并用于收集在两个滑动表面(29,30)之间逸出的泄漏流体。 可以借助于连接到收集室(27)的壳体(1,2)中的检测通道(26,33,34,37,39,47)来监测在旋转通过内收集的泄漏流体, )并且包含泄漏传感器(41)。

    Oxazole derivatives
    10.
    发明授权
    Oxazole derivatives 失效
    恶唑衍生物

    公开(公告)号:US06969725B2

    公开(公告)日:2005-11-29

    申请号:US10679604

    申请日:2003-10-06

    CPC分类号: C07D263/32

    摘要: The present invention relates to compounds of formula (I) wherein wherein R1, R2, R3, R4, R5, R6 and n are as described herein. The compounds of the present invention can be used as medicaments for the treatment and/or prevention of diseases which are modulated by PPARα and/or PPARγ agonists. Examples of such diseases are diabetes, particularly non-insulin dependent diabetes mellitus, elevated blood pressure, increased lipid and cholesterol levels, atherosclerotic diseases, metabolic syndrome, endothelial dysfunction, procoagulant state, dyslipidemia, polycystic ovary syndrome, inflammatory diseases (such as e.g. crown disease, inflammatory bowel disease, collitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as e.g. Alzheimer's disease or impaired/improvable cognitive function) and proliferative diseases.

    摘要翻译: 本发明涉及式(I)化合物,其中R 1,R 2,R 3,R 4, R 5,R 5,R 6和n如本文所述。 本发明的化合物可用作治疗和/或预防由PPARα和/或PPARγ激动剂调节的疾病的药物。 这些疾病的例子包括糖尿病,特别是非胰​​岛素依赖性糖尿病,升高的血压,升高的脂质和胆固醇水平,动脉粥样硬化疾病,代谢综合征,内皮功能障碍,促凝血状态,血脂异常,多囊卵巢综合征,炎性疾病(例如冠 疾病,炎性肠病,结肠炎,胰腺炎,胆汁郁积/肝脏纤维化,以及具有诸如阿尔茨海默病和受损/可改善的认知功能等炎症成分的疾病)和增殖性疾病。