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公开(公告)号：US5968765A
公开(公告)日：1999-10-19
申请号：US961942
申请日：1997-10-31
申请人： Henry M. Grage , Joel S. Douglas , Pat S. Lee
发明人： Henry M. Grage , Joel S. Douglas , Pat S. Lee
CPC分类号： G01N33/52 , B01D69/141 , C12Q1/26 , C12Q1/54 , G01N33/5002 , G01N33/521 , Y10S435/968 , Y10S435/97
摘要： A test strip for use in determining the presence or concentration of an analyte in whole blood is disclosed. The test strip is a porous membrane having disposed thereon (a) a separating agent capable of separating from whole blood, red blood cells and a fluid component substantially free of red blood cells; (b) an indicating reagent system capable of indicating the presence or concentration of an analyte in the fluid component by producing a spectrophotometric change upon contact with the fluid component; and (c) an opaque filler capable of reducing spectrophotometric interference caused by the presence of the red blood cells. Also disclosed are methods of testing whole blood for the presence or concentration of an analyte using the test strip.
摘要翻译： 公开了一种用于确定全血中分析物的存在或浓度的测试条。 测试条是其上设置有多孔膜（a）能够从全血，红细胞和基本上不含红细胞的流体组分分离的分离剂; （b）指示试剂系统，其能够通过在与流体组分接触时产生分光光度变化来指示流体组分中分析物的存在或浓度; 和（c）能够减少由红细胞存在引起的分光光度干扰的不透明填料。 还公开了使用测试条测试全血的分析物的存在或浓度的方法。
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公开(公告)号：US6048352A
公开(公告)日：2000-04-11
申请号：US857335
申请日：1997-05-16
申请人： Joel S. Douglas , Jeffrey N. Roe , Ryszard Radwanski , Brent G. Duchon , Michael J. Sanchez , Henry M. Grage
发明人： Joel S. Douglas , Jeffrey N. Roe , Ryszard Radwanski , Brent G. Duchon , Michael J. Sanchez , Henry M. Grage
CPC分类号： B82Y30/00 , A61B10/0045 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150343 , A61B5/150419 , A61B5/150427 , A61B5/150519 , A61B5/150824 , A61B5/150977 , A61B5/15111 , A61B5/15117 , A61B5/15194 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A disposable lancing element is adapted for use in a lancing device for making an incision through a user's skin. The lancing element includes a body which defines a longitudinal axis, and has a skin-lancing member projecting from a front end thereof. A capillary tube is mounted in the body in laterally spaced relationship to the skin-lancing member and is slidable longitudinally relative to the body so as to be extended forwardly past the skin-lancing member. The body includes a plurality of circumferentially spaced, radially outwardly projecting bosses formed thereon for guiding the disposable element installation in a carrier element. The skin-lancing member may comprise a plurality of needles or barbs arranged in parallel side-by-side relationship. In lieu of a skin-lancing member, the disposable element may possess a longitudinal through-hole for conducting a skin-piercing laser light beam or pressurized fluid. A capillary tube may have an outwardly flared lower (inlet) end. A capillary tube may possess a sensor for sensing a level of fluid rising therein.
摘要翻译： 一次性穿刺元件适用于穿刺用具穿过使用者皮肤进行切口的穿刺装置。 穿刺元件包括限定纵向轴线的主体，并且具有从其前端突出的皮肤刺穿部件。 毛细管以与皮肤穿刺构件横向间隔的关系安装在身体中，并且可相对于身体纵向滑动，以便向前延伸穿过皮肤穿刺部件。 主体包括形成在其上的多个周向间隔开的径向向外突出的凸台，用于将一次性元件安装件引导到载体元件中。 皮肤刺穿构件可以包括平行并排布置的多个针或倒钩。 代替皮肤刺穿部件，一次性部件可以具有纵向通孔，用于引导皮肤刺激的激光束或加压流体。 毛细管可以具有向外扩张的下（入口）端。 毛细管可以具有用于感测在其中升高的液体水平的传感器。
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公开(公告)号：US20110046515A1
公开(公告)日：2011-02-24
申请号：US12938784
申请日：2010-11-03
申请人： Joel S. Douglas , Jeffrey N. Roe , Henry M. Grage
发明人： Joel S. Douglas , Jeffrey N. Roe , Henry M. Grage
IPC分类号： A61B5/151
CPC分类号： A61B5/15194 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150412 , A61B5/150503 , A61B5/15111 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B10/0045 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.
摘要翻译： 体液例如血液或间质液的样品通过使用者的皮肤的一部分优选在指尖以外的区域穿刺而从身体获得，以形成切口。 在针从切口移除之后，施加力以形成与切口周围关系的形成凹陷的身体组织的环的方式来压下皮肤，导致切口凸起并且切口的两侧打开，由此 体液通过切口的开口被迫出来。 刺激构件安装到用于施加力的刺血针承载壳体的端部。 刺激器构件可以相对于壳体可移动，并且可以被加热或振动以促进体液的移动。
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公开(公告)号：US06319210B1
公开(公告)日：2001-11-20
申请号：US09586969
申请日：2000-06-05
申请人： Joel S. Douglas , Jeffrey N. Roe , Henry M. Grage
发明人： Joel S. Douglas , Jeffrey N. Roe , Henry M. Grage
IPC分类号： A61B500
CPC分类号： A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150412 , A61B5/15109 , A61B5/15117 , A61B5/15186 , A61B5/15194 , A61B10/0045 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.
摘要翻译： 体液例如血液或间质液的样品通过使用者的皮肤的一部分优选在指尖以外的区域穿刺而从身体获得，以形成切口。 在针从切口移除之后，施加力以形成与切口周围关系的凹陷的身体组织环的方式来压下皮肤，导致切口凸起并且切口的两侧打开，由此 体液通过切口的开口被迫出来。 刺激构件安装到用于施加力的刺血针承载壳体的端部。 刺激器构件可以相对于壳体可移动，并且可以被加热或振动以促进体液的移动。
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公开(公告)号：US07828749B2
公开(公告)日：2010-11-09
申请号：US11562496
申请日：2006-11-22
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/150022 , A61B5/150076 , A61B5/150083 , A61B5/150183 , A61B5/15019 , A61B5/150213 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150343 , A61B5/150358 , A61B5/150396 , A61B5/150503 , A61B5/150946 , A61B5/150977 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/15136 , A61B5/1519 , A61B5/15196
摘要： A device and method for lancing a patient, virtually simultaneously producing and collecting a small fluid sample from a body. The device comprises a blood collection system including a lancing needle (16), drive mechanism (11), kneading or vibration mechanism (25), optional suction system (7), and sample ejection mechanism. The device is preferably sized to be hand-held in one hand and operable with one hand. The device can optionally contain integral testing or analysis component (83) for receiving the sample and providing testing or analysis indication or readout for the user. A method involves piercing the skin at a rapid rate, kneading the surrounding area by ultrasonic action, piezoelectric or mechanical oscillation to stimulate the blood flow from the wound, drawing the fluid using a pumping system.
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公开(公告)号：US20100106058A1
公开(公告)日：2010-04-29
申请号：US12644528
申请日：2009-12-22
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/150022 , A61B5/150076 , A61B5/150083 , A61B5/150183 , A61B5/15019 , A61B5/150213 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150343 , A61B5/150358 , A61B5/150396 , A61B5/150503 , A61B5/150946 , A61B5/150977 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/15136 , A61B5/1519 , A61B5/15196
摘要： A device and method for lancing a patient, virtually simultaneously producing and collecting a small fluid sample from a body. The device comprises a blood collection system including a lancing needle (16), drive mechanism (11), kneading or vibration mechanism (25), optional suction system (7), and sample ejection mechanism. The device is preferably sized to be hand-held in one hand and operable with one hand. The device can optionally contain integral testing or analysis component (83) for receiving the sample and providing testing or analysis indication or readout for the user. A method involves piercing the skin at a rapid rate, kneading the surrounding area by ultrasonic action, piezoelectric or mechanical oscillation to stimulate the blood flow from the wound, drawing the fluid using a pumping system.
摘要翻译： 用于穿刺患者的装置和方法，实际上同时从身体产生和收集小的液体样品。 该装置包括采血系统，其包括穿刺针（16），驱动机构（11），揉搓或振动机构（25），可选的抽吸系统（7）和样品排出机构。 该装置的尺寸优选为一只手中的手持式并且用一只手可操作。 该设备可以可选地包含用于接收样品并为用户提供测试或分析指示或读出的整体测试或分析组件（83）。 一种方法包括以快速的速度刺穿皮肤，通过超声波作用，压电或机械振动来捏合周围区域，以刺激来自伤口的血液流动，使用泵送系统拉伸流体。
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公开(公告)号：US6071250A
公开(公告)日：2000-06-06
申请号：US238140
申请日：1999-01-28
申请人： Joel S. Douglas , Jeffrey N. Roe , Henry M. Grage
发明人： Joel S. Douglas , Jeffrey N. Roe , Henry M. Grage
CPC分类号： A61B5/14532 , A61B10/0045 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150412 , A61B5/15109 , A61B5/15117 , A61B5/15186 , A61B5/15194 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.
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公开(公告)号：US08740813B2
公开(公告)日：2014-06-03
申请号：US13561672
申请日：2012-07-30
申请人： Joel S. Douglas , Jeffrey N. Roe , Henry M. Grage
发明人： Joel S. Douglas , Jeffrey N. Roe , Henry M. Grage
IPC分类号： A61B5/00
CPC分类号： A61B5/15194 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150412 , A61B5/150503 , A61B5/15111 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B10/0045 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.
摘要翻译： 体液例如血液或间质液的样品通过使用者的皮肤的一部分优选在指尖以外的区域穿刺而从身体获得，以形成切口。 在针从切口移除之后，施加力以形成与切口周围关系的凹陷的身体组织环的方式来压下皮肤，导致切口凸起并且切口的两侧打开，由此 体液通过切口的开口被迫出来。 刺激构件安装到用于施加力的刺血针承载壳体的端部。 刺激器构件可以相对于壳体可移动，并且可以被加热或振动以促进体液的移动。
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公开(公告)号：US07666150B2
公开(公告)日：2010-02-23
申请号：US10835094
申请日：2004-04-29
IPC分类号： A61B5/00
CPC分类号： A61B10/0045 , A61B5/14532 , A61B5/150022 , A61B5/150083 , A61B5/15019 , A61B5/150198 , A61B5/150358 , A61B5/150396 , A61B5/150503 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/15136 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A device and method for lancing a patient, virtually simultaneously producing and collecting a small fluid sample from a body. The device comprises a blood collection system including a lancing needle (16), drive mechanism (11), kneading or vibration mechanism (25), optional suction system (7), and sample ejection mechanism. The device is preferably sized to be hand-held in one hand and operable with one hand. The device can optionally contain integral testing or analysis component (83) for receiving the sample and providing testing or analysis indication or readout for the user. A method involves piercing the skin at a rapid rate, kneading the surrounding area by ultrasonic action, piezoelectric or mechanical oscillation to stimulate the blood flow from the wound, drawing the fluid using a pumping system.
摘要翻译： 用于穿刺患者的装置和方法，实际上同时从身体产生和收集小的液体样品。 该装置包括采血系统，其包括穿刺针（16），驱动机构（11），揉搓或振动机构（25），可选的抽吸系统（7）和样品排出机构。 该装置的尺寸优选为一只手中的手持式并且用一只手可操作。 该设备可以可选地包含用于接收样品并为用户提供测试或分析指示或读出的整体测试或分析组件（83）。 一种方法包括以快速的速度刺穿皮肤，通过超声波作用，压电或机械振动来捏合周围区域，以刺激来自伤口的血液流动，使用泵送系统拉伸流体。
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公开(公告)号：US06793633B2
公开(公告)日：2004-09-21
申请号：US09988799
申请日：2001-11-20
IPC分类号： A61B500
CPC分类号： A61B5/14532 , A61B5/150022 , A61B5/150076 , A61B5/150083 , A61B5/150091 , A61B5/150099 , A61B5/150183 , A61B5/15019 , A61B5/150236 , A61B5/150244 , A61B5/150358 , A61B5/150396 , A61B5/150412 , A61B5/150503 , A61B5/150977 , A61B5/15113 , A61B5/15117 , A61B5/15136 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B10/0045 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A device and method for lancing a patient, virtually simultaneously producing and collecting a small fluid sample from a body. The device comprises a blood collection system including a lancing needle (16), drive mechanism (11), kneading or vibration mechanism (25), optional suction system (7), and sample ejection mechanism. The device is preferably sized to be hand-held in one hand and operable with one hand. The device can optionally contain integral testing or analysis component (83) for receiving the sample and providing testing or analysis indication or readout for the user. A method involves piercing the skin at a rapid rate, kneading the surrounding area by ultrasonic action, piezoelectric or mechanical oscillation to stimulate the blood flow from the wound, drawing the fluid using a pumping system.
摘要翻译： 用于穿刺患者的装置和方法，实际上同时从身体产生和收集小的液体样品。 该装置包括采血系统，其包括穿刺针（16），驱动机构（11），揉搓或振动机构（25），可选的抽吸系统（7）和样品排出机构。 该装置的尺寸优选为一只手中的手持式并且用一只手可操作。 该设备可以可选地包含用于接收样品并为用户提供测试或分析指示或读出的整体测试或分析组件（83）。 一种方法包括以快速的速度刺穿皮肤，通过超声波作用，压电或机械振动来捏合周围区域，以刺激来自伤口的血液流动，使用泵送系统拉伸流体。
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