公开(公告)号：US11998334B2

公开(公告)日：2024-06-04

申请号：US17323567

申请日：2021-05-18

申请人： Tasso, Inc.

发明人： Erwin Berthier ,  Ben Casavant ,  Ben Moga

IPC分类号： A61B5/15 ,  A61B5/151 ,  B01L3/00

CPC分类号： A61B5/150358 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150251 ,  A61B5/150343 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150977 ,  A61B5/15113 ,  A61B5/15142 ,  B01L3/502715 ,  B01L2400/0406 ,  B01L2400/0457

摘要： The disclosed apparatus, systems and methods relate to the collection of bodily fluids through the use of gravity and microfluidic properties by way of a collector. The collector can make use of microfluidic networks connected to collection sites on the skin of a subject to gather and shuttle blood into a reservoir by a combination of capillary action and gravitational forces. The collected fluid is moved through the microfluidic networks and into the reservoir by a variety of approaches.

公开(公告)号：US20180242890A1

公开(公告)日：2018-08-30

申请号：US15693666

申请日：2017-09-01

申请人： Seventh Sense Biosystems, Inc.

发明人： Donald E. Chickering, III ,  Shawn Davis ,  Ramin Haghgooie ,  Howard Bernstein ,  Douglas A. Levinson

IPC分类号： A61B5/145 ,  A61B5/15 ,  A61B5/151 ,  A61B5/00 ,  A61B5/157

CPC分类号： A61B5/6849 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150297 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685

摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

公开(公告)号：US20180008183A1

公开(公告)日：2018-01-11

申请号：US15545380

申请日：2016-01-28

申请人： Seventh Sense Biosystems, Inc.

发明人： Donald E. Chickering, III ,  Li Yang Chu ,  Sergey Grigoryants ,  Scott James ,  Jacob Wachlin

IPC分类号： A61B5/15 ,  A61B5/157

CPC分类号： A61B5/150946 ,  A61B5/002 ,  A61B5/14503 ,  A61B5/150022 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150091 ,  A61B5/150099 ,  A61B5/150267 ,  A61B5/150312 ,  A61B5/150335 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/15113 ,  A61B5/154 ,  A61B5/157 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0064 ,  A61B10/007 ,  A61B2010/008 ,  A61B2560/0214 ,  A61M5/1413 ,  A61M37/0015 ,  A61M2005/14268 ,  A61M2005/1585 ,  A61M2037/0023

摘要： The present invention generally relates to collecting, determining and/or transmitting information associated with the process of receiving bodily fluid through a device opening and/or delivering substances to a subject. In one aspect, the device includes an information collecting portion and a fluid receiving portion. In another aspect, the two portions are constructed and designed to attach to one another. In one embodiment, actuation of one of the portions causes the other portion to actuate. Methods of time keeping and information transmission are also discussed.

公开(公告)号：US20170172482A1

公开(公告)日：2017-06-22

申请号：US15448891

申请日：2017-03-03

申请人： Magnolia Medical Technologies, Inc.

发明人： Richard G. PATTON

IPC分类号： A61B5/15 ,  A61B5/155

CPC分类号： A61B5/150221 ,  A61B5/1422 ,  A61B5/1438 ,  A61B5/15003 ,  A61B5/150099 ,  A61B5/150251 ,  A61B5/150343 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150977 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/154 ,  A61B5/1545 ,  A61B5/155 ,  A61B10/0045 ,  A61B10/0048 ,  A61B10/0051 ,  A61B10/007 ,  A61B10/0096 ,  A61B10/0233 ,  A61B2010/0061 ,  A61B2010/0077 ,  B01L3/502 ,  B01L2200/026 ,  B01L2200/141 ,  B01L2300/0672 ,  B01L2400/082

摘要： The present invention is directed to the parenteral procurement of bodily-fluid samples. The present invention is also directed to systems and methods for parenterally procuring bodily-fluid samples with reduced contamination from dermally-residing microbes. In some embodiments, a bodily-fluid withdrawing system is used to withdraw bodily fluid from a patient for incubation in culture media in one or more sample vessels. Prior to withdrawing bodily fluid into the one or more sample vessels for incubation, an initial volume of withdrawn bodily fluid is placed in one or more pre-sample reservoirs and is not used for the incubation in culture media.

公开(公告)号：US20170150913A1

公开(公告)日：2017-06-01

申请号：US15432310

申请日：2017-02-14

申请人： Magnolia Medical Technologies, Inc.

发明人： Richard G. PATTON

IPC分类号： A61B5/15 ,  A61B5/155 ,  A61B10/00 ,  A61B5/154

CPC分类号： A61B5/150221 ,  A61B5/1422 ,  A61B5/1438 ,  A61B5/15003 ,  A61B5/150099 ,  A61B5/150251 ,  A61B5/150343 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150977 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/154 ,  A61B5/1545 ,  A61B5/155 ,  A61B10/0045 ,  A61B10/0048 ,  A61B10/0051 ,  A61B10/007 ,  A61B10/0096 ,  A61B10/0233 ,  A61B2010/0061 ,  A61B2010/0077 ,  B01L3/502 ,  B01L2200/026 ,  B01L2200/141 ,  B01L2300/0672 ,  B01L2400/082

摘要： The present invention is directed to the parenteral procurement of bodily-fluid samples. The present invention is also directed to systems and methods for parenterally procuring bodily-fluid samples with reduced contamination from dermally-residing microbes. In some embodiments, a bodily-fluid withdrawing system is used to withdraw bodily fluid from a patient for incubation in culture media in one or more sample vessels. Prior to withdrawing bodily fluid into the one or more sample vessels for incubation, an initial volume of withdrawn bodily fluid is placed in one or more pre-sample reservoirs and is not used for the incubation in culture media.

公开(公告)号：US09392968B2

公开(公告)日：2016-07-19

申请号：US12018648

申请日：2008-01-23

申请人： Steven Schraga

发明人： Steven Schraga

IPC分类号： A61B17/14 ,  A61B5/15 ,  A61B5/00 ,  A61B5/151 ,  A61B5/145

CPC分类号： A61B5/1411 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150183 ,  A61B5/150412 ,  A61B5/150473 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150748 ,  A61B5/150977 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15182 ,  A61B5/411

摘要： Assembly for use on a device includes a member comprising a plurality of lancet needles arranged generally parallel to each other and one of a cap comprising a single lancet opening structured and arranged to receive therein an end portion of a finger tip and a cap comprising a plurality of openings which are each sized to allow one of the lancet needles to pass therethrough. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

摘要翻译： 在装置上使用的装置包括一个构件，该构件包括大体平行地布置的多个刺血针，并且其中一个帽包括单个刺血针开口，该单个刺血针开口构造和布置成在其中容纳指尖的端部和包括多个 每个开口的尺寸被设计成允许一个刺血针穿过其中。 本摘要不旨在限定说明书中公开的发明，也不旨在以任何方式限制本发明的范围。

公开(公告)号：US08057404B2

公开(公告)日：2011-11-15

申请号：US11545468

申请日：2006-10-11

申请人： Masaki Fujiwara ,  Noriyoshi Terashima ,  Shusei Aibara

发明人： Masaki Fujiwara ,  Noriyoshi Terashima ,  Shusei Aibara

IPC分类号： A61B5/00

CPC分类号： A61B5/150977 ,  A61B5/14535 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150511 ,  A61B5/150541 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/157

摘要： A blood sensor including a base (12), a detection part (16) disposed on the base (12), a blood collection needle (13) disposed at a front end (12a) of the base (12), a negative pressure generation part (17) for applying negative pressure to a portion of the blood collection needle (13), and a supply path (15) for supplying blood collected by the blood collection needle (13) to a detection part (16).

摘要翻译： 一种血液传感器，包括基部（12），设置在基部（12）上的检测部（16），设置在基部（12）的前端（12a）的采血针（13），负压产生 用于向采血针（13）的一部分施加负压的部分（17），以及用于将由采血针（13）收集的血液供应到检测部分（16）的供给路径（15）。

公开(公告)号：US20100121368A1

公开(公告)日：2010-05-13

申请号：US12452314

申请日：2008-07-21

申请人： Stanley I. Kim

发明人： Stanley I. Kim

IPC分类号： A61B17/34

CPC分类号： A61B5/150969 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150198 ,  A61B5/150396 ,  A61B5/150412 ,  A61B5/150427 ,  A61B5/150519 ,  A61B5/150549 ,  A61B5/150587 ,  A61B5/150603 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/150916 ,  A61B5/150938 ,  A61B5/150977 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15142 ,  A61B5/1519 ,  A61B5/15194

摘要： A lancing system comprising a lancet with a handle portion to and a needle bearing portion, the needle bearing portion retaining a thin needle protected by a safety cap. The safety cap includes first and second chambers, where the first chamber acts as a sheath and the second chamber having a surface positioned to compromise the structure of the needle when the needle bearing portion of the lancet body is inserted into the second chamber.

摘要翻译： 一种牵引系统，包括具有手柄部分的刺血针和滚针轴承部分，所述滚针轴承部分保持由安全帽保护的细针。 安全帽包括第一和第二腔室，其中第一腔室用作护套，并且第二腔室具有定位成当柳叶刀体的针轴承部分插入第二腔室时破坏针的结构的表面。

公开(公告)号：US20100049126A1

公开(公告)日：2010-02-25

申请号：US12496477

申请日：2009-07-01

申请人： Zeev BRONFELD ,  Yossi RAUCH

发明人： Zeev BRONFELD ,  Yossi RAUCH

IPC分类号： A61M5/32

CPC分类号： A61F7/02 ,  A61B5/150022 ,  A61B5/150114 ,  A61B5/150129 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150824 ,  A61B5/150854 ,  A61B5/150954 ,  A61B5/150977 ,  A61B5/15109 ,  A61B5/15186 ,  A61F2007/0001 ,  A61F2007/0075 ,  A61F2007/0285 ,  A61M5/1452 ,  A61M5/20 ,  A61M5/24 ,  A61M5/422 ,  A61M2205/13 ,  A61M2205/3368 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/3606 ,  A61M2205/3673 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/583

摘要： This invention generally relates to an injector for painlessly piercing a region of a patient's skin. The injector comprises (a) piercing mechanism, comprises: (i) at least one reciprocating needle; said at least one needle is characterized by diameter K; said needle penetrates to depth D in said skin; said depth D is characterized by an initial temperature T; (ii) at least one container having a medicament to be delivered to said patient. The injector further comprises (b) cooling mechanism, comprises at least one attachable cooling means, especially a Peltier Cooled Cold Plate (PCCP), in connection with a radiator and sufficient DC power supply; said PCCP is characterized by an effective surface area S; said effective surface S is optimized such that said pain caused by said piercing is eliminated; said PCCP is characterized by temperature TiPCCP; said PCCP adapted for cooling a portion of said skin prior to and/or during and/or after piercing thereof by said piercing mechanism such that the cooling is obtained at said depth D; said depth D is cooled from said initial temperature T to a final temperature TD(ΔT) in a period of time t (dt) by said PCCP; said final temperature TD Of said depth D is higher than about 0 and lower than about 13 degrees C.; said ΔT/dt is optimized such that said pain caused to said patient is eliminated. The injector further comprises (c) at least one aperture through which said needle is reversibly piercing said skin.

摘要翻译： 本发明总体上涉及一种用于无痛地刺穿患者皮肤区域的注射器。 喷射器包括（a）穿刺机构，包括：（i）至少一个往复针; 所述至少一个针的特征在于直径K; 所述针穿透所述皮肤中的深度D; 所述深度D的特征在于初始温度T; （ii）至少一个容器，其具有要递送到所述患者的药物。 喷射器还包括（b）冷却机构，其包括与散热器和足够的DC电源相关联的至少一个可连接的冷却装置，特别是珀尔帖冷却冷板（PCCP）; 所述PCCP的特征在于有效表面积S; 所述有效表面S被优化，使得由所述穿孔引起的所述疼痛被消除; 所述PCCP的特点是温度TiPCCP; 所述PCCP适于在所述刺穿机构刺穿之前和/或之前和/或之后冷却所述皮肤的一部分，使得在所述深度D处获得冷却; 所述深度D在所述PCCP的时间t（dt）中从所述初始温度T冷却到最终温度TD（＆Dgr; T）; 所述深度D的最终温度TD高于约0且低于约13℃; 所述＆Dgr; T / dt被优化，使得所述患者所引起的疼痛被消除。 注射器还包括（c）至少一个孔，所述针穿过该孔可逆地刺穿所述皮肤。

公开(公告)号：US06306152B1

公开(公告)日：2001-10-23

申请号：US09264598

申请日：1999-03-08

申请人： Edward D. Verdonk ,  Paul Lum

发明人： Edward D. Verdonk ,  Paul Lum

IPC分类号： A61B1734

CPC分类号： A61B5/150977 ,  A61B5/150022 ,  A61B5/150114 ,  A61B5/150152 ,  A61B5/150282 ,  A61B5/150435 ,  A61B5/15117 ,  A61B5/1519

摘要： A device for puncturing the skin of a patient. The device includes a lancet for puncturing the skin and a skin stabilizer associated with the lancet for stabilizing the skin to reduce its freedom of movement when the lancet strikes it. The skin stabilizer has an opening through which the lancet can pass to puncture the skin. The skin stabilizer applies pressure on the skin around the opening. The application of pressure, in additional to reducing the freedom of movement of the skin directly held by the skin stabilizer, also increases the tautness of the skin in the opening prior to the lancet penetrating the skin. The opening is not substantially larger than the size of the lancet.

摘要翻译： 一种用于刺穿患者皮肤的装置。 该装置包括用于刺穿皮肤的刺血针和与柳叶刀相关联的皮肤稳定器，用于稳定皮肤以减少当柳叶刀撞击皮肤时的运动自由度。 皮肤稳定器具有刺血针穿过的开口以刺穿皮肤。 皮肤稳定剂对开口周围的皮肤施加压力。 施加压力，除了降低由皮肤稳定剂直接保持的皮肤的运动自由之外，还增加了刺血针穿透皮肤之前的开口中的皮肤的紧张度。 开口面积不大于柳叶刀的尺寸。