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    Albumin-fixed resin, production thereof, and therapeutical use thereof
    1.
    发明授权
    Albumin-fixed resin, production thereof, and therapeutical use thereof 失效
    白蛋白固定树脂，其制备及其治疗用途

    公开(公告)号：US4323486A

    公开(公告)日：1982-04-06

    申请号：US205997

    申请日：1980-11-12

    申请人： Hideaki Suzuki ,  Gentaro Yamashita

    发明人： Hideaki Suzuki ,  Gentaro Yamashita

    IPC分类号： A61L33/00 ,  A61L33/06 ,  A61M1/36 ,  B01D15/08 ,  B01J20/32 ,  C08G18/58 ,  C08G81/00 ,  C08H1/00 ,  C08L63/00 ,  C07G7/00 ,  C08L89/00 ,  C09J3/24

    CPC分类号： C08G81/00 ,  A61L33/068 ,  A61M1/3687 ,  B01D15/08 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28019 ,  B01J20/3092 ,  B01J20/3212 ,  B01J20/3221 ,  B01J20/3274 ,  C08G18/3228 ,  C08G18/3246 ,  C08G18/325 ,  C08G18/58 ,  C08G18/584 ,  C08G18/7671 ,  C08L63/00 ,  B01J2220/58

    摘要： The present invention provides an albumin-fixed resin comprising a crosslinked water-insoluble resin and albumin chemically bound thereto, said water-insoluble resin being a crosslinked epoxy resin containing about 1 to about 30 milliequivalents of amino groups and about 1 to about 50 milliequivalents of hydroxyl groups per gram thereof, said albumin being ionically bound to the amino groups of the epoxy resin and to the hydroxyl groups by hydrogen bonding, and the amount of said albumin fixed being at least about 25% by weight based on the epoxy resin, and also provides a process for producing the albumin-fixed resin, which comprises(1) (a) subjecting a polyepoxy compound containing at least two epoxy groups in the molecule and a polyamine compound containing at least two primary and/or secondary amino groups in the molecule to addition reaction in an inert medium to produce a fully crosslinked resin, or (b) subjecting said compounds to addition reaction to produce an insufficiently crosslinked pre-polymer, and then reacting the pre-polymer with at least one compound selected from the group consisting of organic polyisocyanates, organic polyisothiocyanates and organic polycarboxylic acid halides to crosslink it fully, and(2) contacting the resulting crosslinked epoxy resin containing about 1 to about 30 milliequivalents of amino groups and about 1 to about 50 milliequivalents of hydroxyl groups per gram thereof intimately with an aqueous solution containing albumin optionally after partially neutralizing the amino groups of the epoxy resin.The albumin-fixed resin is useful for removing albumin-binding noxious substances such as bilirubin contained in the blood of a warm-blooded animal.

    摘要翻译： 本发明提供一种白蛋白固定树脂，其包含交联的水不溶性树脂和化学键合的白蛋白，所述水不溶性树脂是交联的环氧树脂，其含有约1至约30毫当量的氨基和约1至约50毫当量的 羟基，其中所述白蛋白通过氢键键合到环氧树脂的氨基和羟基上，并且所述白蛋白的量相对于环氧树脂为至少约25重量％，和 还提供了生产白蛋白固定树脂的方法，其包括（1）（a）在分子中使含有至少两个环氧基的多环氧化合物和包含至少两个伯和/或仲氨基的多胺化合物在 在惰性介质中进行加成反应以产生完全交联的树脂，或（b）使所述化合物进行加成反应以产生不充分的 交联预聚物，然后使预聚物与选自有机多异氰酸酯，有机多异氰酸酯和有机多羧酸卤化物中的至少一种化合物反应以使其完全交联，和（2）使所得到的交联环氧树脂 1至约30毫当量的氨基和约1至约50毫克的羟基/克，与含有白蛋白的水溶液密切相关，任选地在部分中和环氧树脂的氨基之后。 白蛋白固定树脂可用于除去白血病结合的有毒物质如温血动物血液中所含的胆红素。

    Operating machine and maintenance and inspection information generating apparatus
    5.
    发明授权
    Operating machine and maintenance and inspection information generating apparatus 有权
    操作机维修检查信息生成装置

    公开(公告)号：US09292011B2

    公开(公告)日：2016-03-22

    申请号：US14113633

    申请日：2012-04-24

    申请人： Hideaki Suzuki ,  Kozo Nakamura ,  Shinya Yuda ,  Hiroki Uchiyama ,  Takashi Saeki ,  Kesaaki Minemura ,  Jyunsuke Fujiwara

    发明人： Hideaki Suzuki ,  Kozo Nakamura ,  Shinya Yuda ,  Hiroki Uchiyama ,  Takashi Saeki ,  Kesaaki Minemura ,  Jyunsuke Fujiwara

    IPC分类号： G05B15/02 ,  E02F9/26 ,  G06Q10/00

    CPC分类号： G05B15/02 ,  E02F9/267 ,  G06Q10/20

    摘要： A hydraulic shovel includes: a storage unit which stores an operation history of a target component of the shovel targeted for life span estimation, a discrimination threshold value used for classifying usage of the target component into a plurality of usage modes based on the operation history, and a usage mode-specific estimated life span indicative of an estimated life span of the target component in each of the usage modes; and an arithmetic and control unit which calculates an operating time of the target component in each of the usage modes in accordance with the operation history and the discrimination threshold value, and estimates the life span of the target component based on the operating time calculated for each of the usage modes and on the usage mode-specific estimated life span.

    摘要翻译： 液压挖掘机包括：存储单元，其存储针对寿命估计的铲的目标分量的操作历史;基于操作历史将用于将目标分量的使用分类为多个使用模式的鉴别阈值， 以及指示每个使用模式中目标组件的估计使用寿命的使用模式特定估计寿命; 以及算术和控制单元，其根据操作历史和鉴别阈值来计算每个使用模式中的目标分量的操作时间，并且基于针对每个使用模式计算的操作时间来估计目标分量的寿命 的使用模式和使用模式特定的估计寿命。

    In-vehicle handsfree apparatus
    6.
    发明授权
    In-vehicle handsfree apparatus 有权

    公开(公告)号：US09026184B2

    公开(公告)日：2015-05-05

    申请号：US12378707

    申请日：2009-02-18

    申请人： Hideaki Suzuki

    发明人： Hideaki Suzuki

    IPC分类号： H04M1/00 ,  H04W4/16 ,  H04M1/60 ,  H04W88/04 ,  H04W92/08

    CPC分类号： H04W4/16 ,  H04M1/6091 ,  H04W88/04 ,  H04W92/08

    摘要： An in-vehicle handsfree apparatus establishes a handsfree profile connection with a first cellular phone and a second cellular phone simultaneously. It is assumed that while the first cellular phone is in a calling state, the second cellular phone receives an incoming call. When a user operates a response to the second cellular phone in the incoming call receiving state, a suspension request signal is transmitted to the first cellular phone in the calling state to thereby switch the call link of the first cellular phone to a suspending state. In contrast, an incoming call response request signal is transmitted to the second cellular phone to thereby switch the call link of the second cellular phone from the incoming call receiving state to a calling state. The connection partner of a call sound path is changed from the first cellular phone to the second cellular phone.

    Novel biomarker for non-alcoholic fatty liver disease, and method for detecting non-alcoholic fatty liver disease by using the biomarker
    8.
    发明申请
    Novel biomarker for non-alcoholic fatty liver disease, and method for detecting non-alcoholic fatty liver disease by using the biomarker 审中-公开
    用于非酒精性脂肪肝疾病的新型生物标志物，以及通过使用生物标志物检测非酒精性脂肪肝疾病的方法

    公开(公告)号：US20130281309A1

    公开(公告)日：2013-10-24

    申请号：US13119724

    申请日：2009-09-16

    申请人： Kohji Meno ,  Hideaki Suzuki

    发明人： Kohji Meno ,  Hideaki Suzuki

    IPC分类号： C40B30/04 ,  G01N33/576 ,  C07K7/08 ,  G01N21/55 ,  C07K14/47 ,  C07K16/38 ,  H01J49/26 ,  G01N21/64 ,  C07K7/06

    CPC分类号： G01N33/6893 ,  C07K14/8114 ,  G01N2333/811 ,  G01N2800/085

    摘要： The present invention aims to present methods to detect nonalcoholic fatty liver disease including nonalcoholic steatohepatitis by using a protein or its partial peptide that differs in presence or absence, or in quantity between healthy human subjects and patients with nonalcoholic fatty liver disease or nonalcoholic steatohepatitis or between patients with fatty liver and nonalcoholic steatohepatitis and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect nonalcoholic fatty liver disease including nonalcoholic steatohepatitis. Specifically, 35 kDa protein fragment consisting of amino acid sequence expressed by Sequence No. 2 and its partial peptide consisting of amino acid sequence expressed by Sequence No. 3 (including its glycated form) of inter-alpha-trypsin inhibitor heavy chain H4 precursor consisting of amino acid sequence expressed by Sequence No. 1 could be used as biomarkers to detect nonalcoholic fatty liver disease including nonalcoholic steatohepatitis.

    摘要翻译： 本发明旨在提供使用在健康人受试者与非酒精性脂肪性肝病或非酒精性脂肪性肝炎患者之间或者在非酒精性脂肪性肝炎之间或者在非酒精性脂肪性肝炎之间或者在非酒精性脂肪性肝炎之间 患有脂肪肝和非酒精性脂肪性肝炎的患者，并且还旨在提供包含所述蛋白质和所述部分肽的生物标志物，用于检测非酒精性脂肪肝疾病，包括非酒精性脂肪性肝炎。 具体地，由序列号2表示的氨基酸序列组成的35kDa蛋白质片段及其由序列号3所示的氨基酸序列部分肽（包括其糖基化形式）的α-谷氨酸蛋白酶抑制剂重链H4前体组成 由序列号1表示的氨基酸序列可用作生物标志物来检测非酒精性脂肪肝疾病，包括非酒精性脂肪性肝炎。

    Apparatus and system for diagnosing devices included in working machine
    9.
    发明授权
    Apparatus and system for diagnosing devices included in working machine 有权
    用于诊断工作机器中包含的装置的装置和系统

    公开(公告)号：US08532865B2

    公开(公告)日：2013-09-10

    申请号：US12532001

    申请日：2008-08-11

    申请人： Hideaki Suzuki ,  Yoshinori Furuno ,  Kouichi Shibata ,  Hiroshi Watanabe ,  Yutaka Watanabe

    发明人： Hideaki Suzuki ,  Yoshinori Furuno ,  Kouichi Shibata ,  Hiroshi Watanabe ,  Yutaka Watanabe

    IPC分类号： G06F7/00

    CPC分类号： E02F9/268 ,  E02F9/2054 ,  G07C3/00

    摘要： A device diagnostic apparatus (201) comprising: data judgment means (101) for, when device information (121) including operating condition information and internal state information is inputted, comparing the operating condition information of the device information with operating condition information stored in a database (111) beforehand to judge whether or not both of the operating condition information agree with each other, and then outputting judgment result information; and state diagnosis means (103) for, when the judgment result information indicates that both of the operating condition information agree with each other, comparing the internal state information in the device information with internal state information stored in the database beforehand, and then outputting the result of the comparison. This makes it possible to reduce the possibility that false judgment result will be output, and to achieve the efficiency of maintenance work.

    摘要翻译： 一种设备诊断装置（201），包括：数据判断装置（101），当输入包括操作条件信息和内部状态信息的设备信息（121）时，将设备信息的操作条件信息与存储在 数据库（111），以判断操作条件信息是否一致，然后输出判断结果信息; 和状态诊断装置（103），用于当判断结果信息指示两个操作条件信息彼此一致时，将设备信息中的内部状态信息与存储在数据库中的内部状态信息进行比较，然后输出 比较结果。 这样可以减少输出虚假判断结果并实现维护工作的效率的可能性。