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    Support for tissue regeneration and process for producing the same
    1.
    发明授权
    Support for tissue regeneration and process for producing the same 有权
    支持组织再生和生产过程

    公开(公告)号：US07445793B2

    公开(公告)日：2008-11-04

    申请号：US10527075

    申请日：2003-09-09

    申请人： Hideo Niwa ,  Takeshi Fukuchi ,  Ichiro Shimizu ,  Masao Sato ,  Akiko Nishi ,  Kenji Yamashita ,  Tadashi Kaneko ,  Hajime Ohgushi ,  Koji Hattori ,  Kota Uematsu

    发明人： Hideo Niwa ,  Takeshi Fukuchi ,  Ichiro Shimizu ,  Masao Sato ,  Akiko Nishi ,  Kenji Yamashita ,  Tadashi Kaneko ,  Hajime Ohgushi ,  Koji Hattori ,  Kota Uematsu

    IPC分类号： A61F2/02 ,  A61F2/00 ,  A61F2/28 ,  A61K9/14 ,  A61K48/00

    CPC分类号： A61L27/3895 ,  A61L27/3852 ,  A61L27/56 ,  A61L2430/06 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/40

    摘要： The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be secured, and particularly in the case of cartilage, fixation treatment such as suture can be carried out in the transplantation into affected parts after the culture, and the mechanical strength is provided sustainable for (weighted) compression at the initial stage of transplantation.The present invention relates to a 3-dimensional porous scaffold for tissue regeneration which comprises a structure composed of vertically long-shaped pores having a pore diameter of not less than 10 μm to not more than 500 μm and pore length of not less than 20 μm to not more than 1 cm being juxtaposedly arranged obtained by a production process comprising rapid freeze-drying as a key technology. Further, the invention relates to the above 3-dimensional porous scaffold in which seeding properties of cells are improved by a pore enlargement treatment of one side face by a separation operation, a salt elution operation of a surface part, or a combination of these operations. It becomes possible to produce a 3-dimensional cell combination having excellent degree of tissue formation and medical treatment effect by seeding a cell or precursor cell derived from a tissue in this scaffold, and culturing them in an artificial environment and/or the living body.

    摘要翻译： 本发明提供了一种支架，其中细胞可以在培养物中以均匀的分布状态稳定地保持和接枝，可以确保优选的增殖能力和活力，特别是在软骨的情况下，可以进行诸如缝合的定影处理 在培养后移植到受影响的部位，并且在移植的初始阶段提供可持续的（加权）压缩的机械强度。 本发明涉及用于组织再生的三维多孔支架，其包括由垂直长孔形成的结构，其孔径不小于10μm至不大于500μm，孔长度不小于20μm 通过包括快速冷冻干燥作为关键技术的生产方法并排布置而不超过1cm。 此外，本发明涉及上述三维多孔支架，其中通过分离操作，表面部分的盐洗脱操作或这些操作的组合，通过单侧面的孔扩大处理来提高细胞的接种性能 。 可以通过将来自该支架中的组织的细胞或前体细胞接种，并在人造环境和/或生物体中进行培养，来生产具有优异的组织形成程度和医疗效果的3维细胞组合。

    Support for tissue regeneration and process for producing the same
    2.
    发明申请
    Support for tissue regeneration and process for producing the same 有权
    支持组织再生和生产过程

    公开(公告)号：US20060127368A1

    公开(公告)日：2006-06-15

    申请号：US10527075

    申请日：2003-09-09

    申请人： Hideo Niwa ,  Takeshi Fukuchi ,  Ichiro Shimizu ,  Masao Sato ,  Akiko Nishi ,  Kenji Yamashita ,  Tadashi Kaneko ,  Hajime Ohgushi ,  Koji Hattori ,  Kota Uematsu

    发明人： Hideo Niwa ,  Takeshi Fukuchi ,  Ichiro Shimizu ,  Masao Sato ,  Akiko Nishi ,  Kenji Yamashita ,  Tadashi Kaneko ,  Hajime Ohgushi ,  Koji Hattori ,  Kota Uematsu

    IPC分类号： A61K35/12 ,  C12N5/00

    CPC分类号： A61L27/3895 ,  A61L27/3852 ,  A61L27/56 ,  A61L2430/06 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/40

    摘要： The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be secured, and particularly in the case of cartilage, fixation treatment such as suture can be carried out in the transplantation into affected parts after the culture, and the mechanical strength is provided sustainable for (weighted) compression at the initial stage of transplantation. The present invention relates to a 3-dimensional porous scaffold for tissue regeneration which comprises a structure composed of vertically long-shaped pores having a pore diameter of not less than 10 μm to not more than 500 μm and pore length of not less than 20 μm to not more than 1 cm being juxtaposedly arranged obtained by a production process comprising rapid freeze-drying as a key technology. Further, the invention relates to the above 3-dimensional porous scaffold in which seeding properties of cells are improved by a pore enlargement treatment of one side face by a separation operation, a salt elution operation of a surface part, or a combination of these operations. It becomes possible to produce a 3-dimensional cell combination having excellent degree of tissue formation and medical treatment effect by seeding a cell or precursor cell derived from a tissue in this scaffold, and culturing them in an artificial environment and/or the living body.

    摘要翻译： 本发明提供了一种支架，其中细胞可以在培养物中以均匀的分布状态稳定地保持和接枝，可以确保优选的增殖能力和活力，特别是在软骨的情况下，可以进行诸如缝合的定影处理 在培养后移植到受影响的部位，并且在移植的初始阶段提供可持续的（加权）压缩的机械强度。 本发明涉及用于组织再生的三维多孔支架，其包括由垂直长孔形成的结构，其孔径不小于10μm至不大于500μm，孔长度不小于20μm 通过包括快速冷冻干燥作为关键技术的生产方法并排布置而不超过1cm。 此外，本发明涉及上述三维多孔支架，其中通过分离操作，表面部分的盐洗脱操作或这些操作的组合，通过单侧面的孔扩大处理来提高细胞的接种性能 。 可以通过将来自该支架中的组织的细胞或前体细胞接种，并在人造环境和/或生物体中进行培养，来生产具有优异的组织形成程度和医疗效果的3维细胞组合。

    Transplant material and method for fabricating the same
    4.
    发明授权
    Transplant material and method for fabricating the same 失效
    移植材料及其制造方法

    公开(公告)号：US06989030B1

    公开(公告)日：2006-01-24

    申请号：US10129916

    申请日：2000-11-09

    申请人： Hajime Ohgushi

    发明人： Hajime Ohgushi

    IPC分类号： A61F2/28 ,  C12N5/00

    CPC分类号： A61L27/3821 ,  A61L27/365 ,  A61L27/3847 ,  A61L27/3895 ,  A61L2430/02

    摘要： A transplant material which is capable of imparting desired mechanical properties, elevating bone tissue repair speed and improving biocompatibility. This transplant material comprises an artificial and biologically inactive material, which is to be implanted in vivo as a substitute for bone tissue, and at least one type of cells selected from among osteoblasts and precursory osteoblasts which are adhered to the surface of the artificial material so that the artificial material is coated with the bone matrix produced by the cells. The artificial material involves not only a biologically inactive material but also a biologically inactive material coated with a biologically active substrate. This transplant material is produced by culturing mesenchymal stem cells collected from a living body to differentiate into at least one type of cells selected from among osteoblasts and precursory osteoblasts and then culturing the cells together with the artificial material to thereby adhere the differentiated cells on the surface of the artificial material and coat the surface of the artificial material with the bone matrix produced by the differentiated cells.

    摘要翻译： 能够赋予期望的机械性能，提高骨组织修复速度并提高生物相容性的移植材料。 这种移植材料包括人造和生物惰性材料，其将被植入体内作为骨组织的替代物，以及至少一种类型的细胞，其选自成骨细胞和前体成骨细胞，其粘附到人造材料的表面上 人造材料被细胞产生的骨基质包覆。 人造材料不仅涉及生物惰性材料，而且涉及涂覆有生物活性底物的生物惰性材料。 这种移植材料是通过培养从活体收集的间充质干细胞来分化成至少一种选自成骨细胞和前体成骨细胞的细胞，然后与人造材料一起培养细胞，从而将分化的细胞粘附在表面上 的人造材料，并用分化细胞产生的骨基质涂覆人造材料的表面。