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公开(公告)号：US5663602A
公开(公告)日：1997-09-02
申请号：US404199
申请日：1995-03-13
申请人： Hideo Shimizu , Jun Inoue
发明人： Hideo Shimizu , Jun Inoue
CPC分类号： H02K5/124 , F16C35/06 , H02K5/1737
摘要： The inner wall of a hub has a step surface between an upper bearing mounting surface and a magnet mounting surface. A spacer of ring-like shape is directly mounted to the step surface of the hub for determining the upper position of a rotor magnet. The inside diameter of the spacer is smaller than the inner wall at the bearing mounting surface of the hub so that a space is created between the bearing mounting surface, the spacer, and the bearing for holding a portion of adhesive. When a portion of the adhesive applied for bonding the bearing to the bearing mounting surface of the hub remains uncured, it will be retained in the space and prevented from entering the interior of the motor.
摘要翻译： 毂的内壁在上轴承安装表面和磁体安装表面之间具有台阶表面。 环形形状的间隔件直接安装在轮毂的台阶表面上，用于确定转子磁体的上部位置。 间隔件的内径小于轮毂的轴承安装表面处的内壁，从而在轴承安装表面，间隔件和用于保持粘合剂的一部分的轴承之间产生空间。 当用于将轴承粘合到轮毂的轴承安装表面的粘合剂的一部分保持未固化时，其将被保持在该空间中并防止其进入电动机的内部。
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公开(公告)号：US08802705B2
公开(公告)日：2014-08-12
申请号：US12451564
申请日：2008-05-20
申请人： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue
发明人： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue
IPC分类号： A61K31/422 , A61K31/427
CPC分类号： A61K31/427 , A61K31/421 , A61K31/426 , C07D263/32 , C07D277/24 , C07D417/06
摘要： Provision of an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, and a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.
摘要翻译： 提供用于促进睑板腺上皮细胞或角膜上皮细胞增殖的药剂，以及眼部疾病如睑板腺功能障碍，干眼症等的治疗剂。 含有[3- [2- [4-异丙基-2-（4-三氟甲基）苯基-5-噻唑基]乙基] -5-甲基-1,2-苯并异恶唑-6-基]氧基乙酸[4- [3- [2-（4-三氟甲基）苯基-4-异丙基-5-噻唑基]丙酰] -2-甲基苯氧基]乙酸或[4- [3- [2-（2-羟基-4-氯苯基） 5-异丙基-4-恶唑基]丙酰基] -2-甲基苯氧基]乙酸或其药理学上可接受的盐作为活性成分用作促进睑板腺上皮细胞或角膜上皮细胞增殖的试剂，以及 诸如睑板腺功能障碍，干眼症等眼部疾病的治疗剂。
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公开(公告)号：US08216785B2
公开(公告)日：2012-07-10
申请号：US12568569
申请日：2009-09-28
申请人： Johji Inazawa , Issei Imoto , Jun Inoue
发明人： Johji Inazawa , Issei Imoto , Jun Inoue
CPC分类号： G01N33/57407 , A61K38/00 , C12Q1/6886 , C12Q2600/154
摘要： The present invention is intended to provide a means for judging the malignancy of neuroblastoma and the progress of spontaneous regression thereof. The present invention provides a method for detecting cancer which comprises detecting activation or inactivation of the lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) gene and amplification of the MYCN gene in a specimens to evaluate the malignancy of the specimens and the progress of spontaneous regression.
摘要翻译： 本发明旨在提供一种判断神经母细胞瘤的恶性程度及其自发消退的方法。 本发明提供一种检测癌症的方法，其包括检测样品中溶酶体相关蛋白多能跨膜5（LAPTM5）基因的活化或失活以及MYCN基因的扩增，以评估标本的恶性程度和自发回归的进展 。
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4.发明申请公开(公告)号：US20110178299A1
公开(公告)日：2011-07-21
申请号：US13120800
申请日：2009-06-10
申请人： Jun Inoue , Hiroshi Kawasaki , Sohei Asakura
发明人： Jun Inoue , Hiroshi Kawasaki , Sohei Asakura
IPC分类号： C07D239/52
CPC分类号： C07D239/52 , A01N43/54
摘要： The present invention aims at providing an optically active difluoromethanesulfonanilide derivative exhibiting an excellent herbicidal activity at a low dose.An optically active (R)-2′-(4,6-dimethoxy-pyrimidin-2-yl)hydroxymethyl-1,1-difluoromethanesulfonanilide derivative is represented by the formula (I) (in the formula, R1 is a hydrogen atom, a C1-C4 alkyl group or a C1-C4 alkoxy C1-C4 alkyl group). and this difluoromethanesulfonanilide derivative is produced by subjecting to optical resolution a racemate of 2′-(4,6-dimethoxypyrimidin-2-yl)hydroxymethyl-1,1-difluoromethanesul-fonanilide derivative.
摘要翻译： 本发明的目的在于提供一种在低剂量下表现出优异除草活性的光学活性二氟甲磺酰苯胺衍生物。 光学活性（R）-2' - （4,6-二甲氧基 - 嘧啶-2-基）羟甲基-1,1-二氟甲磺酰苯胺衍生物由式（I）表示（式中，R1是氢原子， C1-C4烷基或C1-C4烷氧基C1-C4烷基）。 该二氟甲磺酰苯胺衍生物是通过光学拆分2' - （4,6-二甲氧基嘧啶-2-基）羟甲基-1,1-二氟甲磺酰氟苯胺衍生物的外消旋物制得的。
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公开(公告)号：US20090074849A1
公开(公告)日：2009-03-19
申请号：US12153342
申请日：2008-05-16
申请人： Akiko Misawa , Jun Inoue , Issei Imoto , Johji Inazawa
发明人： Akiko Misawa , Jun Inoue , Issei Imoto , Johji Inazawa
CPC分类号： C07K14/70567 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , G01N33/57407
摘要： It is an object of the present invention to provide a cancer-suppressing agent comprising a novel cancer-suppressing gene based on the discovery of such cancer-suppressing gene. The present invention provides a cancer-suppressing agent which comprises NR1I2 gene or a homologous gene thereof; and a cancer-suppressing agent which comprises NR1I2 protein or a homologous protein thereof.
摘要翻译： 本发明的目的是提供一种基于这种癌症抑制基因的发现而含有新型癌抑制基因的癌抑制剂。 本发明提供了包含NR1I2基因或其同源基因的癌抑制剂; 以及包含NR1I2蛋白或其同源蛋白质的癌抑制剂。
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公开(公告)号：US20070154915A1
公开(公告)日：2007-07-05
申请号：US11591470
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in large intestine cancer as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在大肠癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US07228073B2
公开(公告)日：2007-06-05
申请号：US10615394
申请日：2003-07-09
CPC分类号： H04J14/08
摘要： An optical signal transmission device for transmitting phase information of optical signals is provided. The device includes a multiplexing formatted optical signal generator arranged to generate multiplexing formatted optical signals. The device also includes an optical phase generator arranged to receive the multiplexing formatted optical signals. An optical information transmission method for transmitting optical signal information including phase information is also provided. The method includes receiving multiplexing formatted optical signals generated by a multiplexing formatted optical signal generator at an optical phase generator. The method also includes phase conjugating the multiplexing formatted optical signals by means of four wave mixing (FWM).
摘要翻译： 提供一种用于发送光信号的相位信息的光信号传输装置。 该设备包括多路复用格式化的光信号发生器，被布置为产生复用格式化的光信号。 该装置还包括光学相位发生器，其布置成接收复用格式化的光信号。 还提供了一种用于发送包括相位信息的光信号信息的光信息传输方法。 该方法包括在光相位发生器处接收由复用格式化的光信号发生器产生的格式化的光信号复用。 该方法还包括通过四波混频（FWM）将复用格式化的光信号相位共轭。
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公开(公告)号：US07202274B2
公开(公告)日：2007-04-10
申请号：US10507831
申请日：2003-03-14
申请人： Masayuki Nakamura , Jun Inoue
发明人： Masayuki Nakamura , Jun Inoue
IPC分类号： A61K31/341 , C07D307/20 , C07D307/22
CPC分类号： C07D307/22
摘要： A compound represented by the following formula (I) wherein R1 is a lower alkyl group, R2 is a hydrogen, a halogen, a cyano group, a lower alkyl group or a lower alkoxy group, and n is 0 or 1, which has a calpain inhibitory activity, is provided.
摘要翻译： 由下式（I）表示的化合物
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公开(公告)号：US06214800B1
公开(公告)日：2001-04-10
申请号：US09282501
申请日：1999-04-09
申请人： Chiho Fukiage , Mitsuyoshi Azuma , Jun Inoue , Masayuki Nakamura , Yuka Yoshida
发明人： Chiho Fukiage , Mitsuyoshi Azuma , Jun Inoue , Masayuki Nakamura , Yuka Yoshida
IPC分类号： A61K3800
CPC分类号： A61K38/55 , C07C311/19 , C07D303/48
摘要： An angiogenesis inhibitor comprising a cysteine protease inhibitory compound. As the preferable cysteine protease inhibitory compound, epoxysuccinic acid compounds, peptide halohydrazide compounds, calpain inhibitory compounds, compounds of the formula (I) and compounds of the formula (VI) can be used. The angiogenesis inhibitor of the present invention suppresses new formation of blood vessels in the living tissues, so that it can be used as a superior therapeutic or prophylactic agent of angiogenesis associated with wound healing, inflammation, growth of tumor and the like; and angiogenesis as seen in diabetic retinopathy, prematurity retinopathy, retinal venous occlusion, senile discoid macular degeneration and the like, as well as for prevention of metastasis of tumors.
摘要翻译： 一种包含半胱氨酸蛋白酶抑制化合物的血管生成抑制剂。 作为优选的半胱氨酸蛋白酶抑制化合物，可以使用环氧琥珀酸化合物，肽卤代酰肼化合物，钙蛋白酶抑制化合物，式（I）的化合物和式（VI）的化合物。 本发明的血管发生抑制剂抑制活组织中血管的新形成，可以用作与伤口愈合，炎症，肿瘤生长等有关的血管生成的优异治疗或预防剂。 和血管生成，如糖尿病视网膜病变，早产儿视网膜病变，视网膜静脉闭塞，老年性盘状黄斑变性等，以及用于预防肿瘤转移。
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公开(公告)号：US08317171B2
公开(公告)日：2012-11-27
申请号：US12101600
申请日：2008-04-11
申请人： Jun Inoue
发明人： Jun Inoue
CPC分类号： B62K25/08 , B62K2025/047 , B62K2025/048 , F16F9/461 , F16F9/56
摘要： A bicycle suspension including a stroke adjustment unit, a suspension damper, and a damper adjustment unit. The stroke adjustment unit is configured to adjust a stroke of the bicycle suspension, which is configured to expand and contract within the stroke. The suspension damper is configured to apply damping force to the bicycle suspension, and the damper adjustment unit is configured to adjust the damping force applied by the suspension damper in accordance with the stroke adjusted by the stroke adjustment unit.
摘要翻译： 一种自行车悬架，包括行程调节单元，悬架阻尼器和阻尼器调节单元。 行程调节单元构造成调节自行车悬架的行程，该行程构造成在行程内膨胀和收缩。 悬架阻尼器构造成对自行车悬架施加阻尼力，并且阻尼器调节单元构造成根据由行程调节单元调节的行程来调节由悬架阻尼器施加的阻尼力。
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