-
公开(公告)号：US07662385B2
公开(公告)日：2010-02-16
申请号：US11704185
申请日：2007-02-09
IPC分类号： C12N5/00 , C12N5/06 , A61K39/00 , A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/2842 , C07K2317/73
摘要： The object of the present invention is to provide methods for inhibiting proliferation of neural stem cells, an agent for inhibiting proliferation of neural stem cells, and methods for using the same. According to the method of the present invention, a galectin-1 inhibitor such as anti-galectin-1 antibody and/or an integrin β1 inhibitor such as anti-integrin β1 antibody is administered to a human or a vertebrate other than human for inhibiting proliferation of neural stem cells. This method can be used for treatment of nerve injury and nerve tumors.
摘要翻译： 本发明的目的是提供抑制神经干细胞增殖的方法，抑制神经干细胞增殖的药剂及其使用方法。 根据本发明的方法，向除人以外的人或脊椎动物施用抗半凝乳素-1抗体和/或整联蛋白β1抑制剂如抗整联蛋白β1抗体的半乳凝素-1抑制剂以抑制增殖 的神经干细胞。 该方法可用于治疗神经损伤和神经瘤。
-
公开(公告)号：US20070248592A1
公开(公告)日：2007-10-25
申请号：US11704185
申请日：2007-02-09
IPC分类号： A61K39/395 , A61K39/00 , C12N5/06
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/2842 , C07K2317/73
摘要： The object of the present invention is to provide methods for inhibiting proliferation of neural stem cells, an agent for inhibiting proliferation of neural stem cells, and methods for using the same. According to the method of the present invention, a galectin-1 inhibitor such as anti-galectin-1 antibody and/or an integrin β1 inhibitor such as anti-integrin β1 antibody is administered to a human or a vertebrate other than human for inhibiting proliferation of neural stem cells. This method can be used for treatment of nerve injury and nerve tumors.
摘要翻译： 本发明的目的是提供抑制神经干细胞增殖的方法，抑制神经干细胞增殖的药剂及其使用方法。 根据本发明的方法，向除人以外的人或脊椎动物施用抗半凝乳素-1抗体和/或整联蛋白β1抑制剂如抗整联蛋白β1抗体的半乳凝素-1抑制剂以抑制增殖 的神经干细胞。 该方法可用于治疗神经损伤和神经瘤。
-
公开(公告)号：US20100120146A1
公开(公告)日：2010-05-13
申请号：US12295814
申请日：2007-04-04
IPC分类号： C12N5/02
CPC分类号： C12N5/0623
摘要： The present invention is directed to providing the activator of the integrin signaling in neural stem cells or neural progenitors and the method for using the same. The activator of the integrin signaling comprises galectin-1 and can be used as a regulator that regulates maintenance, survival, or differentiation of a neural stem cells or a neural progenitor.
摘要翻译： 本发明涉及在神经干细胞或神经祖细胞中提供整联蛋白信号传导的激活剂及其使用方法。 整联蛋白信号传导的激活剂包含半乳凝素-1，可用作调节神经干细胞或神经祖细胞的维持，存活或分化的调节剂。
-
公开(公告)号：US08335441B2
公开(公告)日：2012-12-18
申请号：US13046020
申请日：2011-03-11
申请人： Hideki Kubo , Jun Hirabayashi , Megumi Ito , Sumito Tanaka
发明人： Hideki Kubo , Jun Hirabayashi , Megumi Ito , Sumito Tanaka
CPC分类号： G03G15/08 , G03G15/0266 , G03G15/0849 , G03G15/0889 , G03G15/5041 , G03G15/556
摘要： This invention is to provide a technique of always obtaining a stable output image in image formation using toner. A supplier (1217) supplies toner in a decided toner supply amount. A developing device (1206) agitates the supplied toner and supplies the agitated toner to an electrostatic latent image formed on a photosensitive drum (1203), thereby developing a toner image on the photosensitive drum (1203). A correction amount calculation unit (1106) estimates the toner charge amount by calculating a function model that approximates the variation characteristic of the toner charge amount using the toner consumption necessary for printing a print target image, the toner supply amount necessary for printing the print target image, and the toner agitation time. At least one of an image processing condition and a process condition is controlled using the estimated toner charge amount.
摘要翻译： 本发明提供一种使用调色剂在图像形成中始终获得稳定的输出图像的技术。 供应商（1217）将根据决定的碳粉供应量供应碳粉。 显影装置（1206）搅动供应的调色剂并将搅拌的调色剂供应到形成在感光鼓（1203）上的静电潜像，从而在感光鼓（1203）上显影调色剂图像。 校正量计算单元（1106）通过使用打印目标图像所需的调色剂消耗量来计算近似调色剂充电量的变化特性的功能模型来估计调色剂充电量，打印目标图像所需的调色剂供给量 图像和调色剂搅拌时间。 使用估计的调色剂充电量来控制图像处理条件和处理条件中的至少一个。
-
公开(公告)号：US20120190576A1
公开(公告)日：2012-07-26
申请号：US13384031
申请日：2010-07-12
申请人： Hisashi Narimatsu , Jun Hirabayashi , Yuzuru Ikehara , Takashi Angata , Hiroyuki Kaji , Atsushi Kuno , Takashi Ohkura , Toshihide Shikanai , Maki Sogabe , Akira Togayachi , Makoto Ochou , Yasuhito Tanaka , Masashi Mizokami
发明人： Hisashi Narimatsu , Jun Hirabayashi , Yuzuru Ikehara , Takashi Angata , Hiroyuki Kaji , Atsushi Kuno , Takashi Ohkura , Toshihide Shikanai , Maki Sogabe , Akira Togayachi , Makoto Ochou , Yasuhito Tanaka , Masashi Mizokami
CPC分类号： C07K9/00 , C07K14/47 , G01N33/57438 , G01N33/57469 , G01N2400/02 , G01N2800/085
摘要： The present invention is directed to developing a glycan markers capable of detecting a hepatic disease, and more specifically to developing a glycan marker indicating a hepatic disease-state. Furthermore, the present invention is also directed to developing a glycan marker capable of distinguishing hepatic disease-states with the progress of hepatocarcinoma. The present inventors identified, among the serum glycoproteins, glycopeptides and glycoproteins in which a glycan structure specifically changes due to a hepatic diseases including hepatocarcinoma and provide these as novel glycan markers (glycopeptide and glycoprotein) specific to hepatic disease-states.
摘要翻译： 本发明涉及开发能够检测肝脏疾病的聚糖标记物，更具体地说，涉及发展表达肝病状态的聚糖标记物。 此外，本发明还涉及开发能够区分肝脏疾病状态与肝癌进展的聚糖标记。 本发明人鉴定了血清糖蛋白中由于包括肝癌在内的肝脏疾病而特异性地改变聚糖结构的糖肽和糖蛋白，并将其提供为肝脏疾病状态特异性的新型聚糖标记（糖肽和糖蛋白）。
-
公开(公告)号：US20120128380A1
公开(公告)日：2012-05-24
申请号：US13285337
申请日：2011-10-31
申请人： Jun Hirabayashi
发明人： Jun Hirabayashi
IPC分类号： G03G15/00
CPC分类号： G03G15/5041 , G03G15/0848
摘要： This invention provides an image forming apparatus capable of bringing the output density close to a target density even if the charge amount of toner particles changes. The image forming apparatus includes an image forming unit having an image carrier and a developing unit, a storage unit having the saturation charge amount of toner particles, and a control unit. The control unit forms a patch image using the image forming unit, measures the density of the patch image to obtain a first potential that is a contrast potential corresponding to a target density, estimates the charge amount of the toner particles in the developing unit to obtain a first charge amount, obtains a second potential from the first potential, the first charge amount and the saturation charge amount, and set the second potential as the contrast potential.
摘要翻译： 本发明提供了即使调色剂颗粒的电荷量变化，也能够使输出密度接近目标密度的图像形成装置。 图像形成装置包括具有图像载体和显影单元的图像形成单元，具有调色剂颗粒的饱和电荷量的存储单元和控制单元。 控制单元使用图像形成单元形成贴片图像，测量贴片图像的密度以获得作为对应于目标密度的对比度电位的第一电位，估计显影单元中的调色剂颗粒的电荷量以获得 第一充电量，从第一电位，第一充电量和饱和电荷量获得第二电位，并将第二电位设置为对比电位。
-
公开(公告)号：US20110164888A1
公开(公告)日：2011-07-07
申请号：US13046020
申请日：2011-03-11
申请人： Hideki Kubo , Jun Hirabayashi , Megumi Ito , Sumito Tanaka
发明人： Hideki Kubo , Jun Hirabayashi , Megumi Ito , Sumito Tanaka
IPC分类号： G03G15/08
CPC分类号： G03G15/08 , G03G15/0266 , G03G15/0849 , G03G15/0889 , G03G15/5041 , G03G15/556
摘要： This invention is to provide a technique of always obtaining a stable output image in image formation using toner. A supplier (1217) supplies toner in a decided toner supply amount. A developing device (1206) agitates the supplied toner and supplies the agitated toner to an electrostatic latent image formed on a photosensitive drum (1203), thereby developing a toner image on the photosensitive drum (1203). A correction amount calculation unit (1106) estimates the toner charge amount by calculating a function model that approximates the variation characteristic of the toner charge amount using the toner consumption necessary for printing a print target image, the toner supply amount necessary for printing the print target image, and the toner agitation time. At least one of an image processing condition and a process condition is controlled using the estimated toner charge amount.
摘要翻译： 本发明提供一种使用调色剂在图像形成中始终获得稳定的输出图像的技术。 供应商（1217）将根据决定的碳粉供应量供应碳粉。 显影装置（1206）搅动供应的调色剂并将搅拌的调色剂供应到形成在感光鼓（1203）上的静电潜像，从而在感光鼓（1203）上显影调色剂图像。 校正量计算单元（1106）通过使用打印目标图像所需的调色剂消耗量来计算近似调色剂充电量的变化特性的功能模型来估计调色剂充电量，打印目标图像所需的调色剂供给量 图像和调色剂搅拌时间。 使用估计的调色剂充电量来控制图像处理条件和处理条件中的至少一个。
-
8.发明授权Galectin-glycosaminoglycan complex and method for controlling galectin activity 有权半乳凝素 - 糖胺聚糖复合物和半乳凝素活性的控制方法公开(公告)号：US07687609B2
公开(公告)日：2010-03-30
申请号：US11751106
申请日：2007-05-21
CPC分类号： G01N33/53 , A61K38/1703 , G01N2400/40
摘要： A complex consisting of galectin-3 and chondroitin oligosaccharide and methods for seperating and detecting the chondroitin oligosaccharide in a sample using the immobilized complex.
摘要翻译： 由半乳凝素-3和软骨素寡糖组成的复合物以及使用固定化复合物分离和检测样品中软骨素寡糖的方法。
-
9.发明申请公开(公告)号：US20090117599A1
公开(公告)日：2009-05-07
申请号：US12095013
申请日：2006-12-14
CPC分类号： C12Q1/48 , C08B37/00 , G01N33/53 , G01N2333/4724 , G01N2333/91091 , G01N2400/00
摘要： It is intended to provide a method by which sugar chains having GlcNAc transferred by GnT-V can be accurately detected, screened and purified. In this detection method, two kinds of lectins differing in detailed GlcNAc-specificity are used together. As shown in FIG. 1(I), for example, a sample containing sugar chains having GlcNAc transferred by GnT-V is screened by using a lectin GSL-II, which recognizes sugar chains having GlcNAc transferred by GnT-V, and then the screened sample is screened again by using another lectin BLL, which does not recognizes sugar chains having GlcNAc transferred by GnT-V, to thereby detect, screen and purify the sugar chains having GlcNAc transferred by GnT-V alone.
摘要翻译： 旨在提供可以精确地检测，筛选和纯化由GnT-V转移的具有GlcNAc的糖链的方法。 在该检测方法中，两种不同的GlcNAc特异性的凝集素一起使用。 如图所示。 如图1（I）所示，通过使用凝集素GSL-II筛选含有通过GnT-V转移的GlcNAc的糖链的样品，凝集素GSL-II识别通过GnT-V转移的具有GlcNAc的糖链，然后再次筛选筛选的样品 通过使用不识别由GnT-V转移的GlcNAc的糖链的另一种凝集素BLL，从而检测，筛选和纯化仅由GnT-V转移的GlcNAc的糖链。
-
10.发明授权Contact-type charging device having a plurality of projections over the surface of the charging device 失效接触式充电装置在充电装置的表面上具有多个突起公开(公告)号：US06473582B2
公开(公告)日：2002-10-29
申请号：US09152297
申请日：1998-09-14
IPC分类号： G06G1502
CPC分类号： G03G15/0233 , G03G2221/0005
摘要： A charging apparatus includes a charging member for being supplied with a voltage to charge a member to be charged, the charging member including an elastic member for forming a nip with the member to be charged, and said elastic member having a surface provided with a plurality of projections; wherein a speed A of a surface of said charging member (mm/sec) and a speed B of a surface of the member to be charged (mm/sec) satisfy: when B−A>0, said projections are inclined toward upstream with respect to a movement direction of the surface of the member to be charged in said nip, and when B−A
摘要翻译： 充电装置包括充电构件，用于向被充电构件充电的电压被充电，充电构件包括用于与要充电的构件形成压区的弹性构件，并且所述弹性构件具有设置有多个 的预测 其特征在于，所述充电部件的表面的速度A（mm / sec）和被充电部件的表面的速度B满足：当BA> 0时，所述突起相对于 要被充电的部件的表面的移动方向，当BA <0时，突起相对于要在所述辊隙中被填充的部件的表面的移动方向向下游倾斜。
-
-
-
-
-
-
-
-
-
搜索结果
67 条记录 (耗时 0.037 秒)
