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公开(公告)号：US4847387A
公开(公告)日：1989-07-11
申请号：US199043
申请日：1988-03-17
申请人： Hirofumi Nakano , Isami Takahashi , Fusao Tomita , Kozo Asano , Toru Yasuzawa , Tadashi Ashizawa , Keiichi Takahashi
发明人： Hirofumi Nakano , Isami Takahashi , Fusao Tomita , Kozo Asano , Toru Yasuzawa , Tadashi Ashizawa , Keiichi Takahashi
摘要： The present invention relates to novel compounds DC-92B and DC-92D having anthraquinone moiety and represented by the following planar structural formula (I) and to a process for producing the same. These compounds can be produced by culture of a microorganism belonging to the genus Actinomadura, and are useful as medicaments because of their antibacterial and anti-tumor activities. ##STR1## wherein R is a group represented by formula (II) or formula (III): ##STR2##
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2.发明授权Pyrindamycins A and B and duocarmycin A antibiotics derived from certain streptomyces culture 失效来自某些链霉菌培养物的青霉素A和B以及二焦霉素A抗生素
公开(公告)号：US4923990A
公开(公告)日：1990-05-08
申请号：US242788
申请日：1988-09-09
申请人： Hirofumi Nakano , Isami Takahashi , Michio Ichimura , Isao Kawamoto , Kozo Asasno , Fusao Tomita , Hiroshi Sano , Toru Yasuzawa , Makoto Morimoto , Kazuhisa Fujimoto
发明人： Hirofumi Nakano , Isami Takahashi , Michio Ichimura , Isao Kawamoto , Kozo Asasno , Fusao Tomita , Hiroshi Sano , Toru Yasuzawa , Makoto Morimoto , Kazuhisa Fujimoto
CPC分类号： C12P1/06
摘要： The present invention relates to DC-88A and DC-89A1 and their production. These compounds are obtained by fermentation of microorganisms belonging to the genus Streptomyces. These compounds have antibacterial and anti-tumor activities and are useful as medicaments.
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公开(公告)号：US5101038A
公开(公告)日：1992-03-31
申请号：US458543
申请日：1989-12-28
申请人： Hirofumi Nakano , Isami Takahashi , Isao Kawamoto , Toru Yasuzawa , Keiichi Takahashi , Eiji Kobayashi
发明人： Hirofumi Nakano , Isami Takahashi , Isao Kawamoto , Toru Yasuzawa , Keiichi Takahashi , Eiji Kobayashi
IPC分类号： A61K31/40 , A61P35/00 , C07D487/04 , C07D487/10 , C12N1/20 , C12P17/18 , C12R1/465
CPC分类号： C07D487/10 , C12P17/182
摘要： A novel fermentation product, DC113, represented by the formula ##STR1## which has antimicrobial and antitumor activities.
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公开(公告)号：US5138059A
公开(公告)日：1992-08-11
申请号：US380379
申请日：1989-07-17
申请人： Keiichi Takahashi , Michio Ichimura , Shigeo Katsumata , Tatsuhiro Ogawa , Makoto Morimoto , Tadashi Ashizawa , Masaji Kasai , Kenichi Muroi , Hiromitsu Saito , Hiroshi Sano , Toru Yasuzawa
发明人： Keiichi Takahashi , Michio Ichimura , Shigeo Katsumata , Tatsuhiro Ogawa , Makoto Morimoto , Tadashi Ashizawa , Masaji Kasai , Kenichi Muroi , Hiromitsu Saito , Hiroshi Sano , Toru Yasuzawa
IPC分类号： C12P17/18 , A61K31/40 , A61K31/435 , A61P31/04 , A61P35/00 , C07D471/04 , C07D487/04 , C12N1/20 , C12R1/465
CPC分类号： C07D471/04 , C07D487/04
摘要： Novel DC-89 compounds represented by the general formula: ##STR1## wherein X represents a single bond or --CH.sub.2 --; and when X represents a single bond, Y represents --CH.sub.2 Br or --CH.sub.2 Cl and when X represents --CH.sub.2 --, Y represents Br, are obtained by the present invention. The compounds have antibacterial and anti-tumor activity.
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公开(公告)号：US4952576A
公开(公告)日：1990-08-28
申请号：US223193
申请日：1988-07-22
IPC分类号： A61K31/58 , A61P25/04 , C07D493/02 , C07D493/08 , C07D493/10 , C07J71/00
CPC分类号： C07D493/10 , C07J71/0005
摘要： Compounds having analgesic activity which have the formula ##STR1## wherein R.sub.1 -R.sub.6 represent hydrogen or a substituent and X and Y together represent inter alia as epoxyethylene, ethylene halohydrin, haloethylene or a --CH.dbd.CH-group.
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公开(公告)号：US4914198A
公开(公告)日：1990-04-03
申请号：US946842
申请日：1986-12-29
申请人： Hirofumi Nakano , Mitsunobu Hara , Yoshinori Yamashita , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Toru Yasuzawa , Katsuichi Shuto
发明人： Hirofumi Nakano , Mitsunobu Hara , Yoshinori Yamashita , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Toru Yasuzawa , Katsuichi Shuto
CPC分类号： C12P33/00 , C07J71/001
摘要： Novel substance UCY1003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities: ##STR1##
摘要翻译： 通过培养微生物产生的新物质UCY1003具有以下化学结构和镇痛，降血压和抗真菌活性：
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公开(公告)号：US5223637A
公开(公告)日：1993-06-29
申请号：US889388
申请日：1992-05-28
申请人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
发明人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
IPC分类号： C07C323/20 , C07C327/26 , C12P7/00
CPC分类号： C07C323/20 , C07C327/26 , C12P7/00
摘要： KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.
摘要翻译： 通过培养属于被孢霉属属的微生物来产生具有抑制环核苷酸磷酸二酯酶的活性的KS-506a，KS-506x和KS-506g以及具有抑制组胺释放活性的KS-506m和KS-506h。
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公开(公告)号：US4990693A
公开(公告)日：1991-02-05
申请号：US465892
申请日：1990-01-16
申请人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
发明人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
CPC分类号： C12R1/645 , C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P17/02 , C12P7/02 , C12P7/24
摘要： Novel physiologically active substances KS-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.
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公开(公告)号：US5004833A
公开(公告)日：1991-04-02
申请号：US408192
申请日：1989-09-15
申请人： Toru Yasuzawa , Satoshi Nakanishi , Chikara Murakata , Hiroshi Kase , Hiroshi Sano , Koji Yamada
发明人： Toru Yasuzawa , Satoshi Nakanishi , Chikara Murakata , Hiroshi Kase , Hiroshi Sano , Koji Yamada
IPC分类号： C07H15/203
CPC分类号： C07H15/203
摘要： Disclosed are KS-501 derivatives represented by the formula (I) ##STR1## wherein X represents a hydrogen atom or COOR.sub.3, Y represents hydroxy or ##STR2## and R.sub.1, R.sub.2 and R.sub.3 are the same or different and represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, provided that when R.sub.1, R.sub.2 and R.sub.3 are simultaneously hydrogen atoms, and when R.sub.1, R.sub.2 and X are simultaneously hydrogen atoms, Y does not represent ##STR3## and a pharmaceutically acceptable acid addition salt thereof. The KS-501 derivatives have a platelet aggregation-inhibiting property, and are expected to be useful as antithrombotic agent.
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公开(公告)号：US5142096A
公开(公告)日：1992-08-25
申请号：US329329
申请日：1989-03-27
申请人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
发明人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
IPC分类号： C07C323/20 , C07C327/26 , C12P7/00
CPC分类号： C07C327/26 , C07C323/20 , C12P7/00
摘要： KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.
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