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    Functionalized glycosaminoglycan polymer and medical instruments and drugs by using the same
    1.
    发明授权
    Functionalized glycosaminoglycan polymer and medical instruments and drugs by using the same 有权
    官能化的糖胺聚糖和医疗仪器和药物使用相同

    公开(公告)号：US07005513B1

    公开(公告)日：2006-02-28

    申请号：US09937991

    申请日：2000-03-30

    申请人： Hirofumi Yura ,  Yoshio Saito ,  Masayuki Ishihara ,  Katsuaki Ono ,  Keiichi Ishikawa

    发明人： Hirofumi Yura ,  Yoshio Saito ,  Masayuki Ishihara ,  Katsuaki Ono ,  Keiichi Ishikawa

    IPC分类号： C08B37/00 ,  C07H7/00

    CPC分类号： C08F246/00 ,  C08B37/0063

    摘要： The present invention provides a functionalized polymer which can be used extensively in the field of medical drugs as well as medical devices and which is obtainable in an organic synthetic manner from glycosaminoglycan controlling adhesion, migration and proliferation of cells via linkage to various cellular growth factors or cytokines or direct interactions with the cells. The functionalized polymer of the present invention is characterized in that it comprises a carbohydrate corresponding to at least a part of the basic structure of glycosaminoglycan introduced into a vinyl-type polymer chain.

    摘要翻译： 本发明提供了可广泛用于医疗药物以及医疗器械领域的官能化聚合物，其可以通过与各种细胞生长因子的连接控制细胞粘附，迁移和增殖的糖胺聚糖以有机合成方式获得，或 细胞因子或与细胞的直接相互作用。 本发明的官能化聚合物的特征在于，其包含对应于导入乙烯基型聚合物链的糖胺聚糖的至少一部分碱性结构的碳水化合物。

    Functional chitosan derivative
    3.
    发明授权
    Functional chitosan derivative 有权
    功能性壳聚糖衍生物

    公开(公告)号：US07125968B2

    公开(公告)日：2006-10-24

    申请号：US10819490

    申请日：2004-04-07

    申请人： Hirofumi Yura ,  Yoshio Saito ,  Masayuki Ishihara ,  Katsuaki Ono ,  Shiro Saeki

    发明人： Hirofumi Yura ,  Yoshio Saito ,  Masayuki Ishihara ,  Katsuaki Ono ,  Shiro Saeki

    IPC分类号： C08B37/08 ,  C07H5/04

    CPC分类号： A61Q19/00 ,  A61K8/736 ,  A61K2800/57 ,  A61L15/28 ,  A61L33/08 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/08 ,  C08B37/003 ,  C08L5/08

    摘要： A functional chitosan derivative which comprises a chitin/chitosan, which is a natural polysaccharide, and incorporated therein at least one of a carbohydrate, a photo-reactive functional group, an amphipathic group, e.g. a polyoxyethylene alkyl ether, and a glycosaminoglycan and which, due to the incorporation, has solubility in a neutral medium, self-crosslinking ability, the property of highly containing water or healing wounds, and antithrombotic properties. Namely, the derivative has various properties required of health care materials such as medical products and cosmetics.

    摘要翻译： 一种功能性壳聚糖衍生物，其包含几丁质/壳聚糖，其为天然多糖，并且其中并入至少一种碳水化合物，光反应性官能团，两亲性基团等。 聚氧乙烯烷基醚和糖胺聚糖，由于其结合，在中性介质中具有溶解性，自交联能力，高含水或愈合伤口的性质以及抗血栓性质。 即，该衍生物具有医疗用品，化妆品等保健品所需的各种特性。

    Liquid composition for bulging mucous membrane for use in endoscopic surgery comprising a chitosan derivative containing carbohydrate chains
    6.
    发明授权
    Liquid composition for bulging mucous membrane for use in endoscopic surgery comprising a chitosan derivative containing carbohydrate chains 失效
    用于内窥镜手术中用于膨胀粘膜的液体组合物，其包含含有碳水化合物链的壳聚糖衍生物

    公开(公告)号：US07476659B2

    公开(公告)日：2009-01-13

    申请号：US10576745

    申请日：2004-10-21

    申请人： Takuya Hayashi ,  Masayuki Ishihara ,  Hirofumi Yura

    发明人： Takuya Hayashi ,  Masayuki Ishihara ,  Hirofumi Yura

    IPC分类号： A61K31/715 ,  A61B17/94 ,  C07B37/08 ,  A61F13/00

    CPC分类号： A61K31/70 ,  A61K41/0042 ,  A61K49/00

    摘要： The present invention provides a liquid composition to make the mucous membrane bulge during endoscopic surgery characterized in that it comprises a chitosan derivative containing carbohydrate chains. The use of the composition of the present invention as a liquid for bulging the mucous membrane during endoscopic surgery, maintain the bulge of the mucous membrane for a long period, and prevent perforation, resulting in the improved reliability of endoscopic surgery. The composition of the present invention also demonstrates prevention and inhibition of bleeding from the incised portion. The introduction of a photo-reactive group to the above chitosan derivative with carbohydrate chains allows the easy formation of a hydrogel through photo-crosslinking, leading to the further improvement in retention of the bulge and prevention of bleeding.

    摘要翻译： 本发明提供了一种在内窥镜手术中使粘膜膨胀的液体组合物，其特征在于其包含含有碳水化合物链的壳聚糖衍生物。 在内窥镜手术中使用本发明的组合物作为液体膨胀粘膜，长时间保持粘膜的隆起，防止穿孔，从而提高内窥镜手术的可靠性。 本发明的组合物还表现出预防和抑制切开部分的渗色。 用碳水化合物链向上述壳聚糖衍生物引入光反应性基团可以通过光交联容易地形成水凝胶，从而进一步改进了凸起的保留和防止出血。

    Liquid composition for bulging mucous membrane for use in endoscopic surgery comprising a chitosan derivative containing carbohydrate chains
    7.
    发明申请
    Liquid composition for bulging mucous membrane for use in endoscopic surgery comprising a chitosan derivative containing carbohydrate chains 失效
    用于内窥镜手术中用于膨胀粘膜的液体组合物，其包含含有碳水化合物链的壳聚糖衍生物

    公开(公告)号：US20070078108A1

    公开(公告)日：2007-04-05

    申请号：US10576745

    申请日：2004-10-21

    申请人： Takuya Hayashi ,  Masayuki Ishihara ,  Hirofumi Yura

    发明人： Takuya Hayashi ,  Masayuki Ishihara ,  Hirofumi Yura

    IPC分类号： A61K31/722

    CPC分类号： A61K31/70 ,  A61K41/0042 ,  A61K49/00

    摘要： The present invention provides a liquid composition to make the mucous membrane bulge during endoscopic surgery characterized in that it comprises a chitosan derivative containing carbohydrate chains. The use of the composition of the present invention as a liquid for bulging the mucous membrane during endoscopic surgery, maintain the bulge of the mucous membrane for a long period, and prevent perforation, resulting in the improved reliability of endoscopic surgery. The composition of the present invention also demonstrates prevention and inhibition of bleeding from the incised portion. The introduction of a photo-reactive group to the above chitosan derivative with carbohydrate chains allows the easy formation of a hydrogel through photo-crosslinking, leading to the further improvement in retention of the bulge and prevention of bleeding.

    摘要翻译： 本发明提供了一种在内窥镜手术中使粘膜膨胀的液体组合物，其特征在于其包含含有碳水化合物链的壳聚糖衍生物。 在内窥镜手术中使用本发明的组合物作为液体膨胀粘膜，长时间保持粘膜的隆起，防止穿孔，从而提高内窥镜手术的可靠性。 本发明的组合物还表现出预防和抑制切开部分的渗色。 用碳水化合物链向上述壳聚糖衍生物引入光反应性基团可以通过光交联容易地形成水凝胶，从而进一步改进了凸起的保留和防止出血。

    ANTI-TUMOR COMPOSITION COMPRISING TISSUE-ACCUMULATING CHITOSAN GEL
    8.
    发明申请
    ANTI-TUMOR COMPOSITION COMPRISING TISSUE-ACCUMULATING CHITOSAN GEL 审中-公开
    包含组织积累性CHITOSAN凝胶的抗肿瘤组合物

    公开(公告)号：US20100093660A1

    公开(公告)日：2010-04-15

    申请号：US12525809

    申请日：2008-02-07

    申请人： Masayuki Ishihara ,  Yasuhiro Kanatani ,  Yoshiharu Matahira ,  Hirofumi Yura

    发明人： Masayuki Ishihara ,  Yasuhiro Kanatani ,  Yoshiharu Matahira ,  Hirofumi Yura

    IPC分类号： A61K31/722 ,  A61P17/02

    CPC分类号： A61K31/722 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/726 ,  A61K47/183 ,  A61K47/26 ,  A61K47/61 ,  A61K47/6903 ,  C08B37/003 ,  C08L5/08

    摘要： The present invention is achieved based on a novel finding that chitosan gel having retentivity in tissue has an antitumor activity and provides an antitumor composition containing chitosan gel having retentivity in tissue. The chitosan gel having retentivity in tissue of the present invention is preferably chitosan gel formed of a chitosan derivative having a carbohydrate chain introduced thereto as a base, to which a photoreactive group is further introduced to form crosslink with photo-irradiation; or chitosan gel formed of a polyion complex, which is formed of a carbohydrate chain-containing chitosan derivative and another substance, for example, an acidic polysaccharide. The antitumor composition of the present invention can suppress growth of a tumor without bringing it into contact with the tumor but by simply arranging it near the tumor.

    摘要翻译： 基于在组织中具有保留性的壳聚糖凝胶具有抗肿瘤活性并提供含有在组织中具有保留性的壳聚糖凝胶的抗肿瘤组合物的新发现来实现本发明。 在本发明的组织中具有保持性的壳聚糖凝胶优选为壳聚糖凝胶，其由导入有碳水化合物链的壳聚糖衍生物形成，作为基底，进一步引入光反应性基团以通过光照射形成交联; 或由聚糖配合物形成的壳聚糖凝胶，其由含碳水化合物链的壳聚糖衍生物和另一种物质例如酸性多糖形成。 本发明的抗肿瘤成分可以抑制肿瘤的生长而不使其与肿瘤接触，而是简单地将其设置在肿瘤附近。

    System and method for managing product reserve
    10.
    发明授权
    System and method for managing product reserve 有权
    管理产品储备的制度和方法

    公开(公告)号：US08046276B2

    公开(公告)日：2011-10-25

    申请号：US12029975

    申请日：2008-02-12

    申请人： Yukihiro Ogawa ,  Koichi Endo ,  Masayuki Ishihara ,  Koji Miyoshi ,  Takashi Tsuji

    发明人： Yukihiro Ogawa ,  Koichi Endo ,  Masayuki Ishihara ,  Koji Miyoshi ,  Takashi Tsuji

    IPC分类号： G06Q10/00

    CPC分类号： G06Q10/087 ,  G06Q10/0875 ,  G06Q30/0601 ,  G06Q30/0605 ,  G06Q30/0621

    摘要： A receiving section receives a supply request for product from a terminal set up at a shop or a terminal used by a client. A first determination processing section determines whether a product in stock can be reserved for an order. A first reserve processing section reserves the product in stock for the order when the first determination processing section determines that the product can be reserved. A second determination processing section determines whether a semifinished product necessary for manufacturing a final product can be reserved when the first determination processing section determines that the product reserve is inadequate. A second reserve processing section reserves the semifinished product for the order when the second determination processing section determines that the semifinished product can be reserved.

    摘要翻译： 接收部分从在客户端使用的商店或终端设置的终端接收对产品的供应请求。 第一确定处理部分确定是否可以为订单预留库存商品。 当第一确定处理部确定可以保留产品时，第一保留处理部分保留有关订单的产品。 第二确定处理部确定当第一确定处理部确定产品储备不足时，是否可以保留制造最终产品所需的半成品。 当第二确定处理部确定可以保留半成品时，第二保留处理部分保留订单的半成品。