公开(公告)号：US08837663B2

公开(公告)日：2014-09-16

申请号：US12975941

申请日：2010-12-22

申请人： Hiroki Koike ,  Kazuya Yamaji ,  Daisuke Sato ,  Shinobu Tsubota ,  Hideki Matsumoto

发明人： Hiroki Koike ,  Kazuya Yamaji ,  Daisuke Sato ,  Shinobu Tsubota ,  Hideki Matsumoto

IPC分类号： G21C17/00 ,  G21C17/108 ,  G21D3/00

CPC分类号： G21D3/001 ,  G21C17/108 ,  Y02E30/40

摘要： [Solving Means] A resonance calculation program is configured to calculate an effective cross section including Step S4 of setting a calculation point in the gray range in the resonance region; Step S5 of calculating a neutron flux set at the calculation point and corresponding to a macroscopic cross section based on Method of Characteristics; Step S6 of fitting a fitting equation to the calculated macroscopic cross section and the calculated neutron flux, and calculating first and second rational coefficients; Step S7 of calculating a background cross section based on the first rational coefficient; Step S8 of interpolating the effective cross section, with the background cross section used as an argument; Step S9 of calculating the neutron flux based on the background cross section; and Step S10 of calculating the effective cross section based on the effective cross section, the neutron flux, and the second rational coefficient obtained at the coefficient calculation step.

摘要翻译： [解决方案]共振计算程序被配置为计算包括在共振区域中设置灰度范围中的计算点的步骤S4的有效截面; 基于特征方法计算在计算点设置的中子通量并对应于宏观横截面的步骤S5; 将拟合方程拟合到计算的宏观横截面和计算的中子通量的步骤S6，并计算第一和第二有理系数; 基于第一理性系数计算背景横截面的步骤S7; 内插有效截面的步骤S8，以背景横截面作为参数; 基于背景横截面计算中子通量的步骤S9; 以及基于在系数计算步骤中获得的有效截面，中子通量和第二有理系数来计算有效截面的步骤S10。

公开(公告)号：US08583376B2

公开(公告)日：2013-11-12

申请号：US13195355

申请日：2011-08-01

申请人： Hiroki Koike ,  Hideki Matsumoto ,  Kazuya Yamaji ,  Daisuke Sato ,  Shinobu Tsubota

发明人： Hiroki Koike ,  Hideki Matsumoto ,  Kazuya Yamaji ,  Daisuke Sato ,  Shinobu Tsubota

IPC分类号： G06F19/00

CPC分类号： G21D3/001 ,  G21C17/063 ,  G21D2003/002 ,  G21D2003/004 ,  Y02E30/40

摘要： [Problem to be Solved] To provide a resonance calculation program capable of evaluating a physical quantity such as an effective cross section in a radial direction of a circular region of a fuel rod by making a resonance calculation based on the equivalence principle.[Solution] A resonance calculation program for calculating an effective cross section by performing a resonance calculation based on an equivalence principle includes a radial-distribution calculation step S8 of calculating a distribution of the effective cross section in a radial direction of a circular region by calculating the effective cross section defined by a predetermined calculation expression including a geographical coefficient for each of a plurality of annular regions while a neutron escape probability in a resonance region is expressed by a polynomial rational expression including the geographical coefficient serving as a factor representing geographical shapes of a plurality of annular regions that are circumferentially annular and that are obtained by radially dividing the circular region that is an axial cross section of a fuel rod at predetermined intervals.

摘要翻译： [待解决的问题]提供一种能够通过基于等效原理进行共振计算来评价燃料棒的圆形区域的径向方向上的有效截面的物理量的共振计算程序。 [解决方案]通过基于等效原理执行谐振计算来计算有效截面的共振计算程序包括：径向分布计算步骤S8，其计算圆形区域的径向方向上的有效截面的分布， 包括用于多个环形区域中的每一个的地理系数的预定计算表达式限定的有效横截面，而在谐振区域中的中子逃逸概率由多项式理性表达式表示，该多项式理性表达式包括用作表示地理形状 多个环形区域，其周向环形，并且通过以预定间隔径向分割作为燃料棒的轴向截面的圆形区域获得。

公开(公告)号：US20120215444A1

公开(公告)日：2012-08-23

申请号：US13195355

申请日：2011-08-01

申请人： Hiroki Koike ,  Hideki Matsumoto ,  Kazuya Yamaji ,  Daisuke Sato ,  Shinobu Tsubota

发明人： Hiroki Koike ,  Hideki Matsumoto ,  Kazuya Yamaji ,  Daisuke Sato ,  Shinobu Tsubota

IPC分类号： G06F19/00

CPC分类号： G21D3/001 ,  G21C17/063 ,  G21D2003/002 ,  G21D2003/004 ,  Y02E30/40

摘要： [Problem to be Solved] To provide a resonance calculation program capable of evaluating a physical quantity such as an effective cross section in a radial direction of a circular region of a fuel rod by making a resonance calculation based on the equivalence principle.[Solution] A resonance calculation program for calculating an effective cross section by performing a resonance calculation based on an equivalence principle includes a radial-distribution calculation step S8 of calculating a distribution of the effective cross section in a radial direction of a circular region by calculating the effective cross section defined by a predetermined calculation expression including a geographical coefficient for each of a plurality of annular regions while a neutron escape probability in a resonance region is expressed by a polynomial rational expression including the geographical coefficient serving as a factor representing geographical shapes of a plurality of annular regions that are circumferentially annular and that are obtained by radially dividing the circular region that is an axial cross section of a fuel rod at predetermined intervals.

摘要翻译： [待解决的问题]提供一种能够通过基于等效原理进行共振计算来评价燃料棒的圆形区域的径向方向上的有效截面的物理量的共振计算程序。 [解决方案]通过基于等效原理执行谐振计算来计算有效截面的共振计算程序包括：径向分布计算步骤S8，其计算圆形区域的径向方向上的有效截面的分布， 包括用于多个环形区域中的每一个的地理系数的预定计算表达式限定的有效横截面，而在谐振区域中的中子逃逸概率由多项式理性表达式表示，该多项式理性表达式包括用作表示地理形状 多个环形区域，其周向环形，并且通过以预定间隔径向分割作为燃料棒的轴向截面的圆形区域获得。

公开(公告)号：US20120209576A1

公开(公告)日：2012-08-16

申请号：US13206219

申请日：2011-08-09

申请人： Kazuya Yamaji ,  Hiroki Koike ,  Daisuke Sato ,  Shinobu Tsubota ,  Hideki Matsumoto

发明人： Kazuya Yamaji ,  Hiroki Koike ,  Daisuke Sato ,  Shinobu Tsubota ,  Hideki Matsumoto

IPC分类号： G06F17/10

CPC分类号： G21D3/001 ,  G21C17/063 ,  Y02E30/40

摘要： [Problem to be Solved] To provide a nuclear-characteristic calculating program that can suppress an increase of calculation time without degrading calculation accuracy when calculating a nuclear characteristic of a fuel rod that contains burnable poison.[Solution] A nuclear-characteristic calculating program for calculating a nuclear characteristic of a fuel rod that contains nuclear fuel and burnable poison includes a first scattering model that can represent a simple scattering of the neutron and a second scattering model that can represent a complicated scattering of the neutron. The nuclear-characteristic calculating program includes Step S3 of calculating, when a burnup of the fuel rod is before a set burnup at which the burnable poison is considered to lose neutron absorption capability, the nuclear characteristic of the fuel rod by using the second scattering model, Step S11 of switching, when the burnup of the fuel rod is the set burnup, the scattering model from the second scattering model to the first scattering model, and Step S13 of calculating, after performing Step S11, the nuclear characteristic of the fuel rod by using the first scattering model.

摘要翻译： [待解决的问题]提供一种在计算包含可燃毒物的燃料棒的核特性时能够抑制计算时间的增加而不降低计算精度的核特性计算程序。 [解决方案]用于计算包含核燃料和可燃毒物的燃料棒的核特性的核特征计算程序包括可以表示中子的简单散射的第一散射模型和可表示复杂散射的第二散射模型 的中子。 核特征计算程序包括步骤S3，当燃料棒的燃耗在可燃毒物被认为失去中子吸收能力的设定燃耗之前时，计算燃料棒的核特性，通过使用第二散射模型 ，当燃料棒的燃耗是设定燃耗时，从第二散射模型到第一散射模型的散射模型，以及在执行步骤S11之后计算燃料棒的核特性的步骤S11， 通过使用第一散射模型。

公开(公告)号：US08583409B2

公开(公告)日：2013-11-12

申请号：US13206219

申请日：2011-08-09

申请人： Kazuya Yamaji ,  Hiroki Koike ,  Daisuke Sato ,  Shinobu Tsubota ,  Hideki Matsumoto

发明人： Kazuya Yamaji ,  Hiroki Koike ,  Daisuke Sato ,  Shinobu Tsubota ,  Hideki Matsumoto

IPC分类号： G06F17/17 ,  G06N7/06

CPC分类号： G21D3/001 ,  G21C17/063 ,  Y02E30/40

摘要： A nuclear-characteristic calculating program for calculating a nuclear characteristic of a fuel rod that contains nuclear fuel and burnable poison includes a first scattering model that can represent a simple scattering of the neutron and a second scattering model that can represent a complicated scattering of the neutron. The nuclear-characteristic calculating program includes step of calculating, when a burnup of the fuel rod is before a set burnup at which the burnable poison is considered to lose neutron absorption capability, the nuclear characteristic of the fuel rod by using the second scattering model, step of switching, when the burnup of the fuel rod is the set burnup, the scattering model from the second scattering model to the first scattering model, and step of calculating, after performing step of switching, the nuclear characteristic of the fuel rod by using the first scattering model.

摘要翻译： 用于计算包含核燃料和可燃毒物的燃料棒的核特性的核特征计算程序包括可以表示中子的简单散射的第一散射模型和可以代表中子的复杂散射的第二散射模型 。 核特征计算程序包括以下步骤：当燃料棒的燃耗在可燃毒物被认为失去中子吸收能力的设定燃耗之前时，计算使用第二散射模型的燃料棒的核特性， 当燃料棒的燃耗是设定燃耗时，从第二散射模型到第一散射模型的散射模型，以及在执行切换步骤之后计算燃料棒的核特性的步骤，通过使用 第一个散射模型。

公开(公告)号：US20120057667A1

公开(公告)日：2012-03-08

申请号：US12975941

申请日：2010-12-22

申请人： Hiroki Koike ,  Kazuya Yamaji ,  Daisuke Sato ,  Shinobu Tsubota ,  Hideki Matsumoto

发明人： Hiroki Koike ,  Kazuya Yamaji ,  Daisuke Sato ,  Shinobu Tsubota ,  Hideki Matsumoto

IPC分类号： G21C17/00

CPC分类号： G21D3/001 ,  G21C17/108 ,  Y02E30/40

摘要： [Solving Means] A resonance calculation program is configured to calculate an effective cross section including Step S4 of setting a calculation point in the gray range in the resonance region; Step S5 of calculating a neutron flux set at the calculation point and corresponding to a macroscopic cross section based on Method of Characteristics; Step S6 of fitting a fitting equation to the calculated macroscopic cross section and the calculated neutron flux, and calculating first and second rational coefficients; Step S7 of calculating a background cross section based on the first rational coefficient; Step S8 of interpolating the effective cross section, with the background cross section used as an argument; Step S9 of calculating the neutron flux based on the background cross section; and Step S10 of calculating the effective cross section based on the effective cross section, the neutron flux, and the second rational coefficient obtained at the coefficient calculation step.

摘要翻译： [解决方案]共振计算程序被配置为计算包括在共振区域中设置灰度范围中的计算点的步骤S4的有效截面; 基于特征方法计算在计算点设置的中子通量并对应于宏观横截面的步骤S5; 将拟合方程拟合到计算的宏观横截面和计算的中子通量的步骤S6，并计算第一和第二有理系数; 基于第一理性系数计算背景横截面的步骤S7; 内插有效截面的步骤S8，以背景横截面作为参数; 基于背景横截面计算中子通量的步骤S9; 以及基于在系数计算步骤中获得的有效截面，中子通量和第二有理系数来计算有效截面的步骤S10。

公开(公告)号：US07723321B2

公开(公告)日：2010-05-25

申请号：US11612583

申请日：2006-12-19

申请人： Takeshi Hanazawa ,  Hiroki Koike

发明人： Takeshi Hanazawa ,  Hiroki Koike

IPC分类号： A61K31/4184 ,  C07D405/02 ,  C07D407/02

CPC分类号： C07D405/12 ,  C07D409/12

摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, B, X, R1, R2, R3, R4, R5, R6, R7 and R8 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中：A，B，X，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8各自如本文所述， 可接受的盐和含有这些化合物的组合物，以及这些化合物在治疗由酸泵拮抗活性（例如但不限于胃肠疾病，胃食管疾病，胃食管反流病（GERD）），消化性溃疡 ，胃溃疡，十二指肠溃疡，NSAID诱发的溃疡，胃炎，幽门螺杆菌感染，消化不良，功能性消化不良，佐林格 - 埃利森综合征，非侵蚀性反流病（NERD），内脏痛，胃灼热，恶心，食管炎，吞咽困难，过度激素 ，气道障碍或哮喘。

公开(公告)号：US07718809B2

公开(公告)日：2010-05-18

申请号：US11916671

申请日：2006-06-02

申请人： Hiroki Koike ,  Sachiko Sakakibara

发明人： Hiroki Koike ,  Sachiko Sakakibara

IPC分类号： A61K31/4184 ,  C07D405/12

CPC分类号： C07D405/12 ,  C07D405/14

摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, B, X, R1, R2, R3, R4, R5 and R6, R7, R8 and R9 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中：A，B，X，R 1，R 2，R 3，R 4，R 5和R 6，R 7，R 8和R 9各自如本文所述或 药学上可接受的盐，以及含有这些化合物的组合物，以及这些化合物在治疗由酸泵拮抗活性介导的病症中的用途，例如但不限于胃肠道疾病，胃食管疾病，胃食管反流病（GERD）， 消化性溃疡，胃溃疡，十二指肠溃疡，NSAID诱导的溃疡，胃炎，幽门螺杆菌感染，消化不良，功能性消化不良，佐林格 - 埃里森综合征，非侵蚀性反流疾病（NERD），内脏痛，胃灼热，恶心，食管炎，吞咽困难 ，过度激活，气道障碍或哮喘。

公开(公告)号：US20100107744A1

公开(公告)日：2010-05-06

申请号：US12607739

申请日：2009-10-28

申请人： Kazuya FUKUDA ,  Hiroki Koike ,  Hironori Katsumi ,  Takashi Yamato ,  Masayuki Ikeda ,  Tsuyoshi Fukuzaki ,  Daisuke Nakano ,  Masanori Imazu ,  Nobuhiro Kitagawa

发明人： Kazuya FUKUDA ,  Hiroki Koike ,  Hironori Katsumi ,  Takashi Yamato ,  Masayuki Ikeda ,  Tsuyoshi Fukuzaki ,  Daisuke Nakano ,  Masanori Imazu ,  Nobuhiro Kitagawa

IPC分类号： G01N1/10 ,  G01N35/00

CPC分类号： G01N35/1065 ,  G01N35/00722 ,  G01N35/0092 ,  G01N35/025 ,  G01N35/026 ,  G01N35/1016 ,  G01N35/1079 ,  G01N35/1081 ,  G01N2035/00752 ,  G01N2035/00801 ,  G01N2035/0403 ,  G01N2035/0444 ,  G01N2035/1086

摘要： A specimen analyzing apparatus comprising: a detector for detecting component information regarding a component in a specimen contained in each of analyzing containers, the analyzing containers comprising first and second analyzing containers; an analyzing part for analyzing the component information detected by the detector; a transporting device for transporting specimen containers each containing a specimen, the specimen containers comprising first and second specimen containers; an operation mode selector for selecting one of a first operation mode and a second operation mode; a first supplying device for supplying the specimen of a first amount; a second supplying device for supplying the specimen of a second amount grater than the first amount; and a supply controller for controlling the first and second supplying devices in accordance with an operation mode selected by the operation mode selector, is disclosed. A specimen analyzing method is also disclosed.

摘要翻译： 一种样本分析装置，包括：检测器，用于检测包含在每个分析容器中的样本中的成分的成分信息，所述分析容器包括第一和第二分析容器; 用于分析由检测器检测到的分量信息的分析部件; 一个运送装置，用于运送每个包含试样的标本容器，该样本容器包括第一和第二标本容器; 操作模式选择器，用于选择第一操作模式和第二操作模式之一; 第一供给装置，其供给第一量的试样; 第二供给装置，其供给比第一量的第二量磨机的试样; 以及用于根据由操作模式选择器选择的操作模式来控制第一和第二供应装置的供应控制器。 还公开了一种样本分析方法。

公开(公告)号：US20050267170A1

公开(公告)日：2005-12-01

申请号：US11118497

申请日：2005-04-29

申请人： Hiroki Koike ,  Kana Kon-i ,  Yukari Matsumoto ,  Kazunari Nakao ,  Yoshiyuki Okumura ,  Tatsuya Yamagishi

发明人： Hiroki Koike ,  Kana Kon-i ,  Yukari Matsumoto ,  Kazunari Nakao ,  Yoshiyuki Okumura ,  Tatsuya Yamagishi

IPC分类号： A61K31/195 ,  A61K31/455 ,  C07C235/42 ,  C07C235/46 ,  C07C235/70 ,  C07D213/56 ,  C07D213/65 ,  C07D213/74 ,  C07D213/82 ,  C07D213/89

CPC分类号： C07D213/74 ,  C07C235/42 ,  C07C235/46 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/65 ,  C07D213/82 ,  C07D213/89

摘要： This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.

摘要翻译： 本发明提供式（I）的化合物：其中X表示碳原子等：Y表示亚氨基等：R 1表示具有1至6个碳原子的烷基 R 2，R 3和R 3独立地表示氢原子等。 这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。 本发明还提供了包含上述化合物的药物组合物。