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23 条记录 (耗时 0.028 秒)

    Method of extracting and method of purifying an effective substance
    4.
    发明授权
    Method of extracting and method of purifying an effective substance 有权
    提取方法和纯化有效物质的方法

    公开(公告)号：US07282150B2

    公开(公告)日：2007-10-16

    申请号：US10489639

    申请日：2002-09-19

    申请人： Takashi Kuriki ,  Takahisa Nishimura ,  Kazuhisa Sugimoto

    发明人： Takashi Kuriki ,  Takahisa Nishimura ,  Kazuhisa Sugimoto

    IPC分类号： B01D11/00 ,  C07G3/00

    CPC分类号： C07H17/00 ,  C07B63/00 ,  C07C51/48 ,  C07H1/06 ,  C07C59/52

    摘要： A method for extracting a hydrophobic group-containing water-soluble organic compound, comprising the step of bringing an aqueous solution containing the hydrophobic group-containing water-soluble organic compound and a saccharide into contact with a polar organic solvent to obtain an aqueous phase and an organic phase, whereby the hydrophobic group-containing water-soluble organic compound is transferred to the organic phase. The saccharide concentration of the aqueous solution may be at least 12 g per 100 ml of the aqueous solution. The aqueous solution may further contain a phase separation assisting agent. The phase separation assisting agent may be selected from the group consisting of sodium chloride, sodium citrate, magnesium sulfate, and ammonium sulfate.

    摘要翻译： 一种含有疏水基团的水溶性有机化合物的提取方法，其特征在于，包括使含有疏水性基团的水溶性有机化合物和糖类的水溶液与极性有机溶剂接触的步骤，得到水相， 有机相，其中将含疏水基团的水溶性有机化合物转移到有机相中。 水溶液的糖浓度可以为每100毫升水溶液至少12克。 水溶液还可以含有相分离助剂。 相分离辅助剂可以选自氯化钠，柠檬酸钠，硫酸镁和硫酸铵。

    Production method and preparation method of glucans
    6.
    发明授权
    Production method and preparation method of glucans 有权
    葡聚糖的制备方法和制备方法

    公开(公告)号：US07229801B2

    公开(公告)日：2007-06-12

    申请号：US10475943

    申请日：2002-05-27

    申请人： Kazutoshi Fujii ,  Yoshinobu Terada ,  Michiyo Yanase ,  Koji Odan ,  Hiroki Takata ,  Takeshi Takaha ,  Takashi Kuriki ,  Shigetaka Okada

    发明人： Kazutoshi Fujii ,  Yoshinobu Terada ,  Michiyo Yanase ,  Koji Odan ,  Hiroki Takata ,  Takeshi Takaha ,  Takashi Kuriki ,  Shigetaka Okada

    IPC分类号： C12P19/60 ,  C12N9/10

    CPC分类号： C08B37/0009 ,  C08B30/20 ,  C08B33/00 ,  C12P19/18

    摘要： A first method for producing glucan comprises the step of allowing a reaction solution containing sucrose, a primer, inorganic phosphate or glucose-1-phosphate, sucrose phosphorylase, and glucan phosphorylase to react to produce glucans. The maximum value of the sucrose-phosphate ratio of the reaction solution from the start of the reaction to the end of the reaction is no more than about 17. A second method for producing glucan comprises the step of allowing a reaction solution containing sucrose, a primer, inorganic phosphate or glucose-1-phosphate, sucrose phosphorylase, and glucan phosphorylase to react to produce glucans. The reaction is conducted at a temperature of about 40 C to about 70 C.

    摘要翻译： 制备葡聚糖的第一种方法包括使含有蔗糖，底漆，无机磷酸盐或葡萄糖-1-磷酸，蔗糖磷酸化酶和葡聚糖磷酸化酶的反应溶液反应生成葡聚糖的步骤。 从反应开始到反应结束的反应溶液的蔗糖磷酸酯比例的最大值不超过约17。第二种葡聚糖的制备方法包括以下步骤：使含有蔗糖的反应溶液， 底物，无机磷酸盐或葡萄糖-1-磷酸盐，蔗糖磷酸化酶和葡聚糖磷酸化酶反应产生葡聚糖。 反应在约40℃至约70℃的温度下进行。

    Additive for tablets
    7.
    发明申请
    Additive for tablets 审中-公开
    片剂添加剂

    公开(公告)号：US20070071810A1

    公开(公告)日：2007-03-29

    申请号：US10569582

    申请日：2004-08-24

    申请人： Kenichi Kudo ,  Mamoru Wada ,  Michihiro Sunako ,  Junichi Takahara ,  Takeshi Takaha ,  Kazutoshi Fujii ,  Takashi Kuriki

    发明人： Kenichi Kudo ,  Mamoru Wada ,  Michihiro Sunako ,  Junichi Takahara ,  Takeshi Takaha ,  Kazutoshi Fujii ,  Takashi Kuriki

    IPC分类号： A61K9/20 ,  A61K31/715 ,  A61K31/716

    CPC分类号： A61K47/36 ,  A61K9/205 ,  A61K31/167

    摘要： A disintegrant for tablets consisting of an α-1,4-glucan having a degree of polymerization of not less than 180 and less than 1230 and a dispersity (weight average molecular weight “Mw”/number average molecular weight “Mn”) of not more than 1.25 or a modified product thereof. A binder for tablets consisting of an α-1,4-glucan having a degree of polymerization of not less than 1230 and not more than 37000 and a dispersity of not more than 1.25, or a modified product thereof. A binding-disintegrating agent for tablets consisting of a low molecular weight α-1,4-glucan or a modified product thereof, and a high molecular weight α-1,4-glucan or a modified product thereof, wherein the low molecular weight α-1,4-glucan has a degree of polymerization of not less than 180 and less than 1230 and a dispersity of not more than 1.25, and wherein the high molecular weight α-1,4-glucan has a degree of polymerization of not less than 1230 and not less than 37000 and a dispersity of not more than 1.25.

    摘要翻译： 由聚合度不低于180且小于1230的α-1,4-葡聚糖和不分散性（重均分子量“Mw”/数均分子量“Mn”）组成的片剂的崩解剂 大于1.25或其改性产物。 用于由聚合度不小于1230且不大于37000，分散度不大于1.25的α-1,4-葡聚糖或其改性产物组成的片剂的粘合剂。 一种由低分子量α-1,4-葡聚糖或其改性产物组成的片剂和高分子量α-1,4-葡聚糖或其改性产物的粘合崩解剂，其中低分子量α -1,4-葡聚糖的聚合度不低于180度且小于1230，分散度不大于1.25，其中高分子量的α-1,4-葡聚糖的聚合度不低于 超过1230，不低于37000，分散度不超过1.25。

    Method for improving the thermostability of sucrose phosphorylase (SP)
    10.
    发明授权
    Method for improving the thermostability of sucrose phosphorylase (SP) 有权
    提高蔗糖磷酸化酶（SP）热稳定性的方法

    公开(公告)号：US07968309B2

    公开(公告)日：2011-06-28

    申请号：US10566224

    申请日：2004-08-31

    申请人： Kazutoshi Fujii ,  Masae Iiboshi ,  Michiyo Yanase ,  Hiroki Takata ,  Takeshi Takaha ,  Takashi Kuriki

    发明人： Kazutoshi Fujii ,  Masae Iiboshi ,  Michiyo Yanase ,  Hiroki Takata ,  Takeshi Takaha ,  Takashi Kuriki

    IPC分类号： C12Q1/48 ,  C12N9/12

    CPC分类号： C12N9/1051

    摘要： A sucrose phosphorylase (SP) having improved thermostability obtained by modifying a natural SP and a method for producing the SP having improved thermostability is provided. This SP having improved thermostability has an amino acid residue which is different from that of the natural sucrose phosphorylase, in at least one position selected from the group consisting of a position corresponding to position 14, a position corresponding to position 29 and a position corresponding to position 44 in motif sequence 1; a position corresponding to position 7, a position corresponding to position 19, a position corresponding to position 23 and a position corresponding to position 34 in motif sequence 2; and a position corresponding to position 19 in motif sequence 3, and wherein the enzyme activity of the SP having improved thermostability at 37° C., after heating the SP having improved thermostability in 20 mM Tris buffer (pH 7.0) at 55° C. for 20 minutes, is 20% or more of enzyme activity of the SP having improved thermostability at 37° C. before heating.

    摘要翻译： 提供了通过改善天然SP获得的具有改进的热稳定性的蔗糖磷酸化酶（SP）和具有改善的热稳定性的制备SP的方法。 具有改善的热稳定性的SP具有与天然蔗糖磷酸化酶不同的氨基酸残基，在选自对应于位置14的位置，对应于位置29的位置和对应于 基序序列1中的位置44; 对应于位置7的位置，对应于位置19的位置，对应于位置23的位置和对应于图案序列2中的位置34的位置; 和与基序序列3中的位置19相对应的位置，并且其中在55℃下加热在20mM Tris缓冲液（pH7.0）中具有改善的热稳定性的SP后，SP的酶活性在37℃下具有改善的热稳定性。 20分钟，在加热前在37℃下具有改善的热稳定性的SP的酶活性的20％或更多。