公开(公告)号：US20080188729A1

公开(公告)日：2008-08-07

申请号：US12014311

申请日：2008-01-15

申请人： Hiroki Sato ,  Akiko Obata ,  Atsushi Maki ,  Kazutaka Ozaki ,  Takaomi Yasuhara ,  Ichiro Moda

发明人： Hiroki Sato ,  Akiko Obata ,  Atsushi Maki ,  Kazutaka Ozaki ,  Takaomi Yasuhara ,  Ichiro Moda

IPC分类号： A61B5/1455

CPC分类号： A61B5/4011 ,  A61B5/04842 ,  A61B5/04847 ,  A61B5/14553 ,  A61B5/4017 ,  A61B5/486

摘要： Appropriate measurement and analysis parameters are set according to cerebral function to be measured. To measure gustatory function, a time period of absence of cerebral activity to be measured is set so as not to contain a period of 60 seconds after start of stimulation, an activity period for analysis for an oxyhemoglobin concentration change signal is set so as to contain a period between an instant after a lapse of 16 seconds, and an instant after a lapse of 25 seconds, after the start of the stimulation, and an activity period for analysis for a deoxyhemoglobin concentration change signal is set so as to contain a period between an instant after a lapse of 28 seconds and an instant after a lapse of 37 seconds after the start of the stimulation. Moreover, a time interval between stimulations is set to 80 seconds or more.

摘要翻译： 根据要测量的脑功能设定适当的测量和分析参数。 为了测定放气功能，设定要测定的脑活动不存在的时间段，以使刺激开始后不含有60秒的期间，设定氧合血红蛋白浓度变化信号的分析活动期，使其含有 在经过16秒之后的瞬间与经过25秒之后的瞬间之间的时间之间，以及用于分析脱氧血红蛋白浓度改变信号的活动期间，设定为包含： 经过28秒之后的瞬间，以及在刺激开始后经过了37秒的瞬间。 此外，刺激之间的时间间隔设定为80秒以上。

公开(公告)号：US08521243B2

公开(公告)日：2013-08-27

申请号：US12014311

申请日：2008-01-15

申请人： Hiroki Sato ,  Akiko Obata ,  Atsushi Maki ,  Kazutaka Ozaki ,  Takaomi Yasuhara ,  Ichiro Moda

发明人： Hiroki Sato ,  Akiko Obata ,  Atsushi Maki ,  Kazutaka Ozaki ,  Takaomi Yasuhara ,  Ichiro Moda

IPC分类号： A61B5/1455

CPC分类号： A61B5/4011 ,  A61B5/04842 ,  A61B5/04847 ,  A61B5/14553 ,  A61B5/4017 ,  A61B5/486

摘要： Appropriate measurement and analysis parameters are set according to cerebral function to be measured. To measure gustatory function, a time period of absence of cerebral activity to be measured is set so as not to contain a period of 60 seconds after start of stimulation, an activity period for analysis for an oxyhemoglobin concentration change signal is set so as to contain a period between an instant after a lapse of 16 seconds, and an instant after a lapse of 25 seconds, after the start of the stimulation, and an activity period for analysis for a deoxyhemoglobin concentration change signal is set so as to contain a period between an instant after a lapse of 28 seconds and an instant after a lapse of 37 seconds after the start of the stimulation. Moreover, a time interval between stimulations is set to 80 seconds or more.

摘要翻译： 根据要测量的脑功能设定适当的测量和分析参数。 为了测定放气功能，设定要测定的脑活动不存在的时间段，以使刺激开始后不含有60秒的期间，设定氧合血红蛋白浓度变化信号的分析活动期，使其含有 在经过16秒之后的瞬间与经过25秒之后的瞬间之间的时间之间，以及用于分析脱氧血红蛋白浓度改变信号的活动期间，设定为包含： 经过28秒之后的瞬间，以及在刺激开始后经过了37秒的瞬间。 此外，刺激之间的时间间隔设定为80秒以上。

公开(公告)号：US20060100525A1

公开(公告)日：2006-05-11

申请号：US11205160

申请日：2005-08-17

申请人： Takusige Katura ,  Naoki Tanaka ,  Hiroki Sato ,  Akiko Obata ,  Atsushi Maki

发明人： Takusige Katura ,  Naoki Tanaka ,  Hiroki Sato ,  Akiko Obata ,  Atsushi Maki

IPC分类号： A61B6/00

CPC分类号： A61B5/6814 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/14553

摘要： A typical task assigned for measuring a brain activity signal lasts from 10 to 30 seconds. The frequency band of the Mayer wave noise signal is very close to the frequency bands of brain activity signals, a result, it is difficult to reduce the Mayer wave noise signal using a bandpass filter or a bandcut filter. Light irradiating units and light detecting units for detecting the emitted light that has been passed through or reflected within the tissue are provided. A biological signal measuring unit measures at least one of the pulsation, breathing, blood pressure, and temperature. The relationship between an optical signal obtained by the light detecting unit and a biological signal using non-linear analysis; and a computation for separating the biological noise signal from the optical signal on the basis of the obtained relationship.

公开(公告)号：US07565192B2

公开(公告)日：2009-07-21

申请号：US11205160

申请日：2005-08-17

申请人： Takusige Katura ,  Naoki Tanaka ,  Hiroki Sato ,  Akiko Obata ,  Atsushi Maki

发明人： Takusige Katura ,  Naoki Tanaka ,  Hiroki Sato ,  Akiko Obata ,  Atsushi Maki

IPC分类号： A61B5/00

CPC分类号： A61B5/6814 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/14553

摘要： A typical task assigned for measuring a brain activity signal lasts from 10 to 30 seconds. The frequency band of the Mayer wave noise signal is very close to the frequency bands of brain activity signals, a result, it is difficult to reduce the Mayer wave noise signal using a bandpass filter or a bandcut filter. Light irradiating units and light detecting units for detecting the emitted light that has been passed through or reflected within the tissue are provided. A biological signal measuring unit measures at least one of the pulsation, breathing, blood pressure, and temperature. The relationship between an optical signal obtained by the light detecting unit and a biological signal using non-linear analysis; and a computation for separating the biological noise signal from the optical signal on the basis of the obtained relationship.

摘要翻译： 分配给测量大脑活动信号的典型任务持续10到30秒。 梅耶尔波噪声信号的频带非常接近脑活动信号的频带，结果是难以使用带通滤波器或带通滤波器来减少梅耶波噪声信号。 提供了用于检测已经通过或反射在组织内的发射光的光照射单元和光检测单元。 生物信号测量单元测量脉动，呼吸，血压和温度中的至少一个。 由光检测单元获得的光信号与使用非线性分析的生物信号之间的关系; 以及基于所获得的关系从生物噪声信号与光信号分离的计算。

公开(公告)号：US20060241361A1

公开(公告)日：2006-10-26

申请号：US11348441

申请日：2006-02-07

申请人： Akiko Obata ,  Atsushi Maki ,  Kanehisa Morimoto

发明人： Akiko Obata ,  Atsushi Maki ,  Kanehisa Morimoto

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/7264

摘要： There is provided a living body light measuring device capable of monitoring a time curve of a blood substance concentration as time curves of parameters of a signal waveform and judging or analyzing characteristic traits of a subject relevant to the parameters of the signal waveform, wherein a signal processor extracts parameters such as a peak value and latency from a hemoglobin signal waveform measured before and after substance intake of a testee, and generates and displays a time curve graph having a parameter and time respectively as its ordinate and abscissa. Influence of an intake substance upon blood component concentrations and blood flow can be monitored by monitoring the time curves of parameters of the signal waveform. A category processor classifies measurement data into categories, analyzes time curves of a plurality of parameters every category, and displays a result on a result viewer.

摘要翻译： 本发明提供一种生物体光测定装置，其能够将血液物质浓度的时间曲线作为信号波形的参数的时间曲线进行监视，并且判断或分析与信号波形的参数相关的被检体的特征特征，其中，信号 处理器从被测者的物质摄取之前和之后测量的血红蛋白信号波形提取诸如峰值和延迟的参数，并且生成并显示具有参数和时间的时间曲线图作为其纵坐标和横坐标。 摄入物质对血液成分浓度和血流量的影响可通过监测信号波形参数的时间曲线来监测。 类别处理器将测量数据分类，分析每个类别的多个参数的时间曲线，并在结果查看器上显示结果。

公开(公告)号：US08003907B2

公开(公告)日：2011-08-23

申请号：US12607209

申请日：2009-10-28

申请人： Takeshi Hoshino ,  Akiko Obata (nee Nakajima) ,  Atsushi Maki ,  Yukari Yamamoto ,  Manabu Yanagimoto ,  Yujin Tsukada ,  Chizuko Sasanabe

发明人： Takeshi Hoshino ,  Akiko Obata (nee Nakajima) ,  Atsushi Maki ,  Yukari Yamamoto ,  Manabu Yanagimoto ,  Yujin Tsukada ,  Chizuko Sasanabe

IPC分类号： H01H13/83

CPC分类号： B66B3/00

摘要： To reduce the number of erroneous operations, on an operation apparatus conducting mutually different operations such as opening and closing operations, a concretized human pictogram indicating mutually different state changes such as state changes represented by use of a face with opened eyes and a face with closed eyes associated with operation signals assigned to a pair of operation switches and a pictogram in which the human pictogram is combined with an operation pictogram representing a state in which a door concretizing an operation target to operate in response to an operation signal is opened or is being completely closed are respectively attached to the operation switches disposed adjacent to each other.

摘要翻译： 为了减少错误操作的数量，在进行诸如打开和关闭操作的相互不同的操作的操作装置上，指示表示相互不同的状态变化的具体化的人象形图，例如使用打开的眼睛的脸部和用闭合的面部表示的状态变化 与分配给一对操作开关的操作信号相关联的眼睛和其中将人体象形图与表示将操作对象混合以操作的门对应于操作信号的状态的操作象形图组合的象形图被打开或正在被 完全闭合分别附接到彼此相邻布置的操作开关。

公开(公告)号：US07349727B2

公开(公告)日：2008-03-25

申请号：US11348441

申请日：2006-02-07

申请人： Akiko Obata ,  Atsushi Maki ,  Kanehisa Morimoto

发明人： Akiko Obata ,  Atsushi Maki ,  Kanehisa Morimoto

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/7264

摘要： There is provided a living body light measuring device capable of monitoring a time curve of a blood substance concentration as time curves of parameters of a signal waveform and judging or analyzing characteristic traits of a subject relevant to the parameters of the signal waveform, wherein a signal processor extracts parameters such as a peak value and latency from a hemoglobin signal waveform measured before and after substance intake of a testee, and generates and displays a time curve graph having a parameter and time respectively as its ordinate and abscissa. Influence of an intake substance upon blood component concentrations and blood flow can be monitored by monitoring the time curves of parameters of the signal waveform. A category processor classifies measurement data into categories, analyzes time curves of a plurality of parameters every category, and displays a result on a result viewer.

摘要翻译： 本发明提供一种生物体光测定装置，其能够将血液物质浓度的时间曲线作为信号波形的参数的时间曲线进行监视，并且判断或分析与信号波形的参数相关的被检体的特征特征，其中，信号 处理器从被测者的物质摄取之前和之后测量的血红蛋白信号波形提取诸如峰值和延迟的参数，并且生成并显示具有参数和时间的时间曲线图作为其纵坐标和横坐标。 摄入物质对血液成分浓度和血流量的影响可通过监测信号波形参数的时间曲线来监测。 类别处理器将测量数据分类，分析每个类别的多个参数的时间曲线，并在结果查看器上显示结果。

公开(公告)号：US07974671B2

公开(公告)日：2011-07-05

申请号：US10572357

申请日：2004-09-03

申请人： Michiyuki Fujiwara ,  Tsuneaki Kawaguchi ,  Fumio Kawaguchi ,  Shingo Kawasaki ,  Atsushi Maki ,  Yukiko Hirabayashi ,  Yukari Yamamoto ,  Masashi Kiguchi ,  Hiroki Sato ,  Tsuyoshi Yamamoto ,  Takushige Katsura ,  Hideo Kawaguchi

发明人： Michiyuki Fujiwara ,  Tsuneaki Kawaguchi ,  Fumio Kawaguchi ,  Shingo Kawasaki ,  Atsushi Maki ,  Yukiko Hirabayashi ,  Yukari Yamamoto ,  Masashi Kiguchi ,  Hiroki Sato ,  Tsuyoshi Yamamoto ,  Takushige Katsura ,  Hideo Kawaguchi

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/0482 ,  A61B5/0484 ,  A61B5/0488 ,  A61B5/11 ,  A61B5/6822 ,  A61B5/742 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/046

摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.

摘要翻译： 一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部 并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光， 通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号 共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。

公开(公告)号：US07516021B2

公开(公告)日：2009-04-07

申请号：US11570558

申请日：2005-06-08

申请人： Hiroki Sato ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Masashi Kiguchi

发明人： Hiroki Sato ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Masashi Kiguchi

IPC分类号： G01N31/00

CPC分类号： A61B5/7264 ,  A61B5/0059 ,  A61B5/7425 ,  A61B5/743 ,  G06F19/00 ,  G16H40/63

摘要： Apparatus and method for hemoglobin measurement including irradiating light to a living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; irradiating light to the living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; classifying the data measured at the first step and the data measured at the second step according to each of an increase or a decrease in the concentration of oxidized hemoglobin and an increase or a decrease in the concentration of deoxidized hemoglobin; and displaying the classifications determined at the third step.

摘要翻译： 用于血红蛋白测量的装置和方法，包括向生物体照射光，检测通过活体传播的光，并获取表示生物体中氧化血红蛋白浓度变化的测量数据和脱氧浓度变化 血红蛋白 对生物体照射光，检测通过生物体传播的光，获取表示生物体中氧化血红蛋白浓度变化的测定数据和脱氧血红蛋白浓度的变化; 根据氧化血红蛋白浓度的增加或减少以及脱氧血红蛋白浓度的增加或减少，分别在第一步骤测量的数据和在第二步骤测量的数据; 并显示在第三步确定的分类。

公开(公告)号：US07933723B2

公开(公告)日：2011-04-26

申请号：US11646468

申请日：2006-12-28

申请人： Hiroki Sato ,  Atsushi Maki

发明人： Hiroki Sato ,  Atsushi Maki

IPC分类号： G01N31/00

CPC分类号： A61B5/0059 ,  A61B5/14535 ,  A61B5/14553 ,  A61B5/6814 ,  A61B5/7264 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/046

摘要： At each of measurement sites, changes in plural biological data (such as an oxy-Hb signal species and a deoxy-Hb signal species) in a predetermined period are statistically tested independently of each other. By combining results of the plural biological data, the measurement sites are each classified into one out of plural categories. The classified results are each displayed in a single chart. Effective is also a method of setting different activity periods correspondingly to plural Hb signal species, deciding whether or not each of the signal species shows activity or estimating the strength of the signal species, and displaying classification results based on combination of activities of the plural Hb signal species in a single chart. A living body light measuring device using the brain activity analyzing method and displaying method of the invention makes it possible to detect sites where brain activity is generated with a high precision.

摘要翻译： 在每个测量位置，在预定时间段内的多个生物数据（例如氧基-Hb信号物质和脱氧-Hb信号物质）中的变化被彼此独立地进行统计学测试。 通过组合多个生物数据的结果，将测量点分类为多个类别中的一个。 分类结果分别显示在单个图表中。 有效还是对应于多个Hb信号种类设定不同活动期的方法，决定每个信号种类是否显示活动或估计信号种类的强度，以及基于多个Hb的活动的组合来显示分类结果 信号种类在一个单一的图表。 使用本发明的脑活动分析方法和显示方法的生物体光测量装置可以高精度地检测产生脑活动的部位。