公开(公告)号：US5041447A

公开(公告)日：1991-08-20

申请号：US325230

申请日：1989-03-17

申请人： Seiichi Saito ,  Shigeru Hasegawa ,  Katsutoshi Takahashi ,  Nobuyoshi Shimada ,  Jun-ichi Seki ,  Hiroo Hoshino ,  Yukihiro Nishiyama ,  Kenichi Matsubara ,  Takemitsu Nagahata

发明人： Seiichi Saito ,  Shigeru Hasegawa ,  Katsutoshi Takahashi ,  Nobuyoshi Shimada ,  Jun-ichi Seki ,  Hiroo Hoshino ,  Yukihiro Nishiyama ,  Kenichi Matsubara ,  Takemitsu Nagahata

IPC分类号： C07D305/06 ,  C07D305/08 ,  C07D305/10 ,  C07H19/02

CPC分类号： C07H19/02 ,  C07D305/06 ,  C07D305/08 ,  C07D305/10

摘要： This invention relates to oxetanocin-related compounds represented by the following formula (I): ##STR1## [in formula (I), R.sub.1, Y and B have the following meanings: (a) R.sub.1 represents --CH.sub.2 OH or --CH.sub.2 OCO-(alkyl),(b) Y represents ##STR2## provided that R.sub.2 is --H, --OH or --CH.sub.2 OH and R.sub.3 is --H, --OH, halogen atom, --CH.sub.2 OH, lower alkyl group, --CH.sub.2 -N.sub.3, --CH.sub.2 -F, --N.sub.3, --COOH, --NH.sub.2, --CH.sub.2 OSO.sub.3 H or --CH.sub.2 OCO-(lower alkyl), and(c) B represents a residue of purine base,(d) provided that R.sub.1 and R.sub.3 cannot simultaneously represents --CH.sub.2 OH]and their salts which have activities such as an antiviral activity and the like and are expectedly useful as a pharmaceutical and the like.

公开(公告)号：US5214048A

公开(公告)日：1993-05-25

申请号：US439270

申请日：1989-11-20

申请人： Nobuyoshi Shimada ,  Shigeru Hasegawa ,  Takayuki Tomizawa ,  Seiichi Saito ,  Kyoichi Shibuya ,  Akio Fujii ,  Hiroo Hoshino ,  Kenichi Matsubara ,  Takemitsu Nagahata ,  Katsutoshi Takahashi ,  Yukihiro Nishiyama

发明人： Nobuyoshi Shimada ,  Shigeru Hasegawa ,  Takayuki Tomizawa ,  Seiichi Saito ,  Kyoichi Shibuya ,  Akio Fujii ,  Hiroo Hoshino ,  Kenichi Matsubara ,  Takemitsu Nagahata ,  Katsutoshi Takahashi ,  Yukihiro Nishiyama

IPC分类号： C07D473/00 ,  C07D501/00 ,  C07H19/02

CPC分类号： C07D473/00 ,  C07D501/00 ,  C07H19/02

摘要： This invention relates to novel oxetanocins represented by the following general formula (I): ##STR1## wherein R represents a group represented by ##STR2## and their pharmacologically acceptable salts which have antiviral activities.

摘要翻译： 本发明涉及由以下通式（I）表示的新型氧杂环丁酮：其中R表示由IMAGE＆lt; IMAGE＆gt;表示的基团及其具有抗病毒活性的药理学上可接受的盐。

公开(公告)号：US5179084A

公开(公告)日：1993-01-12

申请号：US504393

申请日：1990-04-04

申请人： Seiichi Saito ,  Shigeru Hasegawa ,  Masayuki Kitagawa ,  Nobuyoshi Shimada ,  Katsutoshi Takahashi ,  Jun-ichi Seki ,  Hiroo Hoshino ,  Yukihiro Nishiyama ,  Kenichi Matsubara ,  Takemitsu Nagahata

发明人： Seiichi Saito ,  Shigeru Hasegawa ,  Masayuki Kitagawa ,  Nobuyoshi Shimada ,  Katsutoshi Takahashi ,  Jun-ichi Seki ,  Hiroo Hoshino ,  Yukihiro Nishiyama ,  Kenichi Matsubara ,  Takemitsu Nagahata

IPC分类号： C07H19/02

CPC分类号： C07H19/02

摘要： The present invention relates to phosphoric acid esters of oxetanocins having an antiviral activity which are represented by general formula (I): ##STR1## wherein R.sub.1 represents a phosphoric acid ester residue, X represents hydrogen, hydroxy or hydroxymethyl group, and B represents a purine base residue, and pharmacologically acceptable salts thereof.

公开(公告)号：US4892876A

公开(公告)日：1990-01-09

申请号：US172637

申请日：1988-03-24

申请人： Hiroo Hoshino ,  Nobuyoshi Shimada

发明人： Hiroo Hoshino ,  Nobuyoshi Shimada

IPC分类号： C07H19/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P35/00 ,  C07H19/02

CPC分类号： A61K31/70 ,  C07H19/02

摘要： A pharmaceutical composition for inhibiting Human Immunodeficiency Virus (HIV), which is characterized by comprising a compound represented by the formula (1) ##STR1## or a pharmaceutically acceptable salt thereof as an active ingredient.

公开(公告)号：US5283331A

公开(公告)日：1994-02-01

申请号：US804773

申请日：1991-12-09

申请人： Seiichi Saito ,  Akira Masuda ,  Masayuki Kitagawa ,  Nobuyoshi Shimada ,  Jun-ichi Seki ,  Hiroo Hoshino ,  Yukihiro Nishiyama

发明人： Seiichi Saito ,  Akira Masuda ,  Masayuki Kitagawa ,  Nobuyoshi Shimada ,  Jun-ichi Seki ,  Hiroo Hoshino ,  Yukihiro Nishiyama

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P31/12 ,  C07H19/02 ,  C07H19/16 ,  C07D473/40 ,  A61K31/52 ,  C07F7/18 ,  C07F9/09

CPC分类号： C07H19/02

摘要： It was found that 2-halogeno-oxetanocin A and 4'-phosphate thereof represented by the following general formula (1): ##STR1## wherein X represents a halogen atom and R represents a hydrogen atom or a phosphoric acid residue ##STR2## or salts thereof exhibit a strong antiviral activity and are useful as an active ingredient of therapeutic drug for viral diseases. Further, it was also found that the compounds of this invention are characterized in that they are not inactivated by adenosine deaminase widely present in living bodies and exhibit a high residual activity.

摘要翻译： 发现由以下通式（1）表示的2-卤代 - 氧杂环鸟菌素A和4'-磷酸酯：（*化学结构*）（1）其中X表示卤素原子，R表示氢原子或磷酸 酸性残基（*化学结构*）或其盐表现出强的抗病毒活性，可用作病毒性疾病的治疗药物的活性成分。 此外，还发现本发明的化合物的特征在于它们不被广泛存在于活体中的腺苷脱氨酶灭活，并且表现出高的残留活性。

公开(公告)号：US4845215A

公开(公告)日：1989-07-04

申请号：US54192

申请日：1987-05-26

申请人： Nobuyoshi Shimada ,  Takayuki Tomizawa ,  Shigeru Hasegawa ,  Kaoru Matsuo ,  Akio Fujii ,  Hiroo Hoshino

发明人： Nobuyoshi Shimada ,  Takayuki Tomizawa ,  Shigeru Hasegawa ,  Kaoru Matsuo ,  Akio Fujii ,  Hiroo Hoshino

IPC分类号： C12P19/40 ,  A61K31/52 ,  A61K31/522 ,  A61K31/70 ,  A61P31/12 ,  C07D473/30 ,  C07H19/02 ,  C07H19/16 ,  C12P19/28 ,  C12R1/01 ,  C12R1/05 ,  C12R1/07 ,  C12R1/19 ,  C12R1/365 ,  C12R1/37 ,  C12R1/465 ,  C12R1/685 ,  C12R1/77 ,  C12R1/80 ,  C12R1/82

CPC分类号： C07H19/02

摘要： The present invention relates to a novel compound having hypoxanthine base represented by the following formula: ##STR1## as well as to use of said compound and process for producing said compound.The novel compound of the present invention has an immunosuppressive and antiviral actions and is expected to be useful as a medical drug.

摘要翻译： 本发明涉及一种具有次黄嘌呤碱的新型化合物，其由下式表示：＆lt; IMAGE＆gt;以及所述化合物的使用及其制备方法。 本发明的新型化合物具有免疫抑制和抗病毒作用，并且预期可用作医药。

公开(公告)号：US5164500A

公开(公告)日：1992-11-17

申请号：US619032

申请日：1990-11-28

申请人： Seiichi Saito ,  Shigeru Hasegawa ,  Masayuki Kitagawa ,  Nobuyoshi Shimada

发明人： Seiichi Saito ,  Shigeru Hasegawa ,  Masayuki Kitagawa ,  Nobuyoshi Shimada

IPC分类号： C07H19/02

CPC分类号： C07H19/02

摘要： Oxetanocin G which is expectedly useful as an antiviral agent.

摘要翻译： 预期可用作抗病毒剂的氧新霉素G。

公开(公告)号：US3984390A

公开(公告)日：1976-10-05

申请号：US337575

申请日：1973-03-02

申请人： Hamao Umezawa ,  Akio Fujii ,  Tomohisa Takita ,  Nobuyoshi Shimada

发明人： Hamao Umezawa ,  Akio Fujii ,  Tomohisa Takita ,  Nobuyoshi Shimada

IPC分类号： C12P21/00 ,  A61K35/74 ,  A61K38/00 ,  C07D277/56 ,  C07H15/26 ,  C07K9/00 ,  C12P1/06 ,  C12P19/58 ,  C12R1/465 ,  C07C103/52

CPC分类号： C07K9/003 ,  Y10S435/886 ,  Y10S930/19

摘要： By adding a specific amine in culturing under aerobic conditions actinomycetales capable of producing phleomycin group antibiotics, which have been inoculated into a nutrient medium to produce antitumor phleomycin group antibiotics, it is possible to obtain specific phleomycin group antibiotics having a side chain structure corresponding to said amine. The phleomycin group antibiotics thus produced are collected from the culture medium in a conventional way.

摘要翻译： 通过在需氧条件下培养特定的胺，其能够产生已经接种到营养培养基中以产生抗腐霉素腐霉素组抗生素的福来霉素组抗生素的放线菌素，可以获得具有对应于所述抗生素的侧链结构的特定的腐草霉素组抗生素 胺。 以常规方式从培养基中收集由此产生的腐草霉素组抗生素。

公开(公告)号：US4721005A

公开(公告)日：1988-01-26

申请号：US870999

申请日：1986-06-05

申请人： Takeo Yoshiji ,  Kimitake Uzuyama ,  Nobuyoshi Shimada ,  Takayuki Hoshino

发明人： Takeo Yoshiji ,  Kimitake Uzuyama ,  Nobuyoshi Shimada ,  Takayuki Hoshino

IPC分类号： B25J5/02 ,  B25J5/04 ,  B25J9/02 ,  B25J18/02 ,  B25J19/00 ,  G05G11/00

CPC分类号： B25J9/023 ,  B25J18/02 ,  B25J19/0025 ,  Y10T74/20323

摘要： A robot apparatus is operable in a Cartesian coordinate system for moving a workpiece gripped by a hand thereof. The robot apparatus includes a self-propelled X-axis slide unit movably mounted on an X-axis rail unit extending in the direction of the X-axis of the Cartesian coordinate system. A Y-axis slide unit extending in the Y-axis direction normal to the X-axis direction has one end fixed to the X-axis slide unit. A self-propelled Z-axis slide unit is movably mounted on the Y-axis slide unit, and a slide base to which the robot hand is attached is mounted on the Z-axis slide unit. Lead wires connected to drive mechanisms for driving the X-axis slide unit, the Y-axis slide unit, and the Z-axis slide unit pass through case members, and are housed in the X-axis rail unit and connected to a terminal box secured to an end of the X-axis rail unit. The X-axis, Y-axis, and Z-axis slide units are prevented from interfering with the respective tracks of other units during operation of the robot apparatus, so that the working envelope of the robot apparatus can be increased.

摘要翻译： 机器人装置在笛卡尔坐标系中可操作，用于移动由其手抓住的工件。 机器人装置包括可自由移动地安装在沿笛卡尔坐标系X轴方向延伸的X轴轨道单元上的自推进X轴滑动单元。 在与X轴方向垂直的Y轴方向上延伸的Y轴滑动单元的一端固定于X轴滑动单元。 自行式Z轴滑动单元可移动地安装在Y轴滑动单元上，并且附接有机器人手的滑动基座安装在Z轴滑动单元上。 与驱动X轴滑动单元，Y轴滑动单元和Z轴滑动单元的驱动机构连接的引线穿过壳体，并被容纳在X轴导轨单元中并连接到接线盒 固定在X轴导轨单元的一端。 在机器人装置的操作期间，防止X轴，Y轴和Z轴滑动单元干扰其他单元的各个轨迹，从而可以增加机器人装置的工作范围。

公开(公告)号：US4495347A

公开(公告)日：1985-01-22

申请号：US439446

申请日：1982-11-05

申请人： Hamao Umezawa ,  Nobuyoshi Shimada ,  Hiroshi Naganawa ,  Tomohisa Takita ,  Masa Hamada ,  Tomio Takeuchi

发明人： Hamao Umezawa ,  Nobuyoshi Shimada ,  Hiroshi Naganawa ,  Tomohisa Takita ,  Masa Hamada ,  Tomio Takeuchi

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07H19/24 ,  C12P19/28 ,  C12P19/40 ,  C12R1/465 ,  C07H17/00

CPC分类号： C12R1/465 ,  C07H19/24 ,  C12P19/28 ,  Y10S435/886 ,  Y10S514/908

摘要： The novel antibiotic, oxanosine, having the structure ##STR1## inhibits the growth of Gram-negative bacteria and has antiviral activity. It is produced by cultivation of an oxanosine-producing microorganism of the genus Streptomyces, preferably Streptomyces capreolus MG265-CF3, ATCC No. 31963.