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公开(公告)号：US5214048A
公开(公告)日：1993-05-25
申请号：US439270
申请日：1989-11-20
申请人： Nobuyoshi Shimada , Shigeru Hasegawa , Takayuki Tomizawa , Seiichi Saito , Kyoichi Shibuya , Akio Fujii , Hiroo Hoshino , Kenichi Matsubara , Takemitsu Nagahata , Katsutoshi Takahashi , Yukihiro Nishiyama
发明人： Nobuyoshi Shimada , Shigeru Hasegawa , Takayuki Tomizawa , Seiichi Saito , Kyoichi Shibuya , Akio Fujii , Hiroo Hoshino , Kenichi Matsubara , Takemitsu Nagahata , Katsutoshi Takahashi , Yukihiro Nishiyama
IPC分类号： C07D473/00 , C07D501/00 , C07H19/02
CPC分类号： C07D473/00 , C07D501/00 , C07H19/02
摘要： This invention relates to novel oxetanocins represented by the following general formula (I): ##STR1## wherein R represents a group represented by ##STR2## and their pharmacologically acceptable salts which have antiviral activities.
摘要翻译： 本发明涉及由以下通式（I）表示的新型氧杂环丁酮：其中R表示由IMAGE＆lt; IMAGE＆gt;表示的基团及其具有抗病毒活性的药理学上可接受的盐。
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2.发明授权Oxetanocin-related compounds and pharmaceutical compositions containing them 失效含有氧杂环鸟胺的化合物和含有它们的药物组合物
公开(公告)号：US5041447A
公开(公告)日：1991-08-20
申请号：US325230
申请日：1989-03-17
申请人： Seiichi Saito , Shigeru Hasegawa , Katsutoshi Takahashi , Nobuyoshi Shimada , Jun-ichi Seki , Hiroo Hoshino , Yukihiro Nishiyama , Kenichi Matsubara , Takemitsu Nagahata
发明人： Seiichi Saito , Shigeru Hasegawa , Katsutoshi Takahashi , Nobuyoshi Shimada , Jun-ichi Seki , Hiroo Hoshino , Yukihiro Nishiyama , Kenichi Matsubara , Takemitsu Nagahata
IPC分类号： C07D305/06 , C07D305/08 , C07D305/10 , C07H19/02
CPC分类号： C07H19/02 , C07D305/06 , C07D305/08 , C07D305/10
摘要： This invention relates to oxetanocin-related compounds represented by the following formula (I): ##STR1## [in formula (I), R.sub.1, Y and B have the following meanings: (a) R.sub.1 represents --CH.sub.2 OH or --CH.sub.2 OCO-(alkyl),(b) Y represents ##STR2## provided that R.sub.2 is --H, --OH or --CH.sub.2 OH and R.sub.3 is --H, --OH, halogen atom, --CH.sub.2 OH, lower alkyl group, --CH.sub.2 -N.sub.3, --CH.sub.2 -F, --N.sub.3, --COOH, --NH.sub.2, --CH.sub.2 OSO.sub.3 H or --CH.sub.2 OCO-(lower alkyl), and(c) B represents a residue of purine base,(d) provided that R.sub.1 and R.sub.3 cannot simultaneously represents --CH.sub.2 OH]and their salts which have activities such as an antiviral activity and the like and are expectedly useful as a pharmaceutical and the like.
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公开(公告)号：US5179084A
公开(公告)日：1993-01-12
申请号：US504393
申请日：1990-04-04
申请人： Seiichi Saito , Shigeru Hasegawa , Masayuki Kitagawa , Nobuyoshi Shimada , Katsutoshi Takahashi , Jun-ichi Seki , Hiroo Hoshino , Yukihiro Nishiyama , Kenichi Matsubara , Takemitsu Nagahata
发明人： Seiichi Saito , Shigeru Hasegawa , Masayuki Kitagawa , Nobuyoshi Shimada , Katsutoshi Takahashi , Jun-ichi Seki , Hiroo Hoshino , Yukihiro Nishiyama , Kenichi Matsubara , Takemitsu Nagahata
IPC分类号： C07H19/02
CPC分类号： C07H19/02
摘要： The present invention relates to phosphoric acid esters of oxetanocins having an antiviral activity which are represented by general formula (I): ##STR1## wherein R.sub.1 represents a phosphoric acid ester residue, X represents hydrogen, hydroxy or hydroxymethyl group, and B represents a purine base residue, and pharmacologically acceptable salts thereof.
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公开(公告)号：US4845215A
公开(公告)日：1989-07-04
申请号：US54192
申请日：1987-05-26
申请人： Nobuyoshi Shimada , Takayuki Tomizawa , Shigeru Hasegawa , Kaoru Matsuo , Akio Fujii , Hiroo Hoshino
发明人： Nobuyoshi Shimada , Takayuki Tomizawa , Shigeru Hasegawa , Kaoru Matsuo , Akio Fujii , Hiroo Hoshino
IPC分类号： C12P19/40 , A61K31/52 , A61K31/522 , A61K31/70 , A61P31/12 , C07D473/30 , C07H19/02 , C07H19/16 , C12P19/28 , C12R1/01 , C12R1/05 , C12R1/07 , C12R1/19 , C12R1/365 , C12R1/37 , C12R1/465 , C12R1/685 , C12R1/77 , C12R1/80 , C12R1/82
CPC分类号： C07H19/02
摘要： The present invention relates to a novel compound having hypoxanthine base represented by the following formula: ##STR1## as well as to use of said compound and process for producing said compound.The novel compound of the present invention has an immunosuppressive and antiviral actions and is expected to be useful as a medical drug.
摘要翻译： 本发明涉及一种具有次黄嘌呤碱的新型化合物，其由下式表示：＆lt; IMAGE＆gt;以及所述化合物的使用及其制备方法。 本发明的新型化合物具有免疫抑制和抗病毒作用，并且预期可用作医药。
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公开(公告)号：US5283331A
公开(公告)日：1994-02-01
申请号：US804773
申请日：1991-12-09
申请人： Seiichi Saito , Akira Masuda , Masayuki Kitagawa , Nobuyoshi Shimada , Jun-ichi Seki , Hiroo Hoshino , Yukihiro Nishiyama
发明人： Seiichi Saito , Akira Masuda , Masayuki Kitagawa , Nobuyoshi Shimada , Jun-ichi Seki , Hiroo Hoshino , Yukihiro Nishiyama
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P31/12 , C07H19/02 , C07H19/16 , C07D473/40 , A61K31/52 , C07F7/18 , C07F9/09
CPC分类号： C07H19/02
摘要： It was found that 2-halogeno-oxetanocin A and 4'-phosphate thereof represented by the following general formula (1): ##STR1## wherein X represents a halogen atom and R represents a hydrogen atom or a phosphoric acid residue ##STR2## or salts thereof exhibit a strong antiviral activity and are useful as an active ingredient of therapeutic drug for viral diseases. Further, it was also found that the compounds of this invention are characterized in that they are not inactivated by adenosine deaminase widely present in living bodies and exhibit a high residual activity.
摘要翻译： 发现由以下通式（1）表示的2-卤代 - 氧杂环鸟菌素A和4'-磷酸酯：（*化学结构*）（1）其中X表示卤素原子，R表示氢原子或磷酸 酸性残基（*化学结构*）或其盐表现出强的抗病毒活性，可用作病毒性疾病的治疗药物的活性成分。 此外，还发现本发明的化合物的特征在于它们不被广泛存在于活体中的腺苷脱氨酶灭活，并且表现出高的残留活性。
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6.发明授权
公开(公告)号：US4904585A
公开(公告)日：1990-02-27
申请号：US115980
申请日：1987-11-02
IPC分类号： A61K31/70 , A61P31/04 , A61P31/12 , A61P35/00 , C07H19/02 , C12P19/38 , C12P19/40 , C12R1/11
CPC分类号： C07H19/02 , C12P19/385 , C12R1/11 , Y10S435/837
摘要： This invention relates to a novel antibiotic NK84-0218 of the formula: ##STR1## which exhibits antibacterial, antiviral and antineo-plastic activities and is expected as a pharmaceutical as well as a process for the production of the same.
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公开(公告)号：US4743689A
公开(公告)日：1988-05-10
申请号：US796114
申请日：1985-11-08
IPC分类号： A61K31/70 , A61P31/04 , A61P31/12 , A61P35/00 , C07H19/02 , C12P19/38 , C12P19/40 , C12R1/11 , C07D473/34 , A61K31/52
CPC分类号： C07H19/02 , C12P19/385 , C12R1/11 , Y10S435/837
摘要： This invention relates to a novel antibiotic NK84-0218 of the formula: ##STR1## which exhibits antibacterial, antiviral and antineoplastic activities and is expected as a pharmaceutical as well as a process for the production of the same.
摘要翻译： 本发明涉及一种具有抗菌，抗病毒和抗肿瘤活性的新型抗菌素NK84-0218，其具有下列优点：其具有抗菌，抗病毒和抗肿瘤活性，预期作为药物及其生产方法。
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公开(公告)号：US4992368A
公开(公告)日：1991-02-12
申请号：US508910
申请日：1990-04-12
IPC分类号： C07H19/16 , C07D473/34 , C07H19/02
CPC分类号： C07H19/02
摘要： The present invention provides a novel process for producing oxetanocin G by hydrolysis of alkoxylated 2-amino-oxetanocin A thereby to convert ##STR1## at the 6-position thereof into >C.dbd.O. Oxetanocin G is expectedly useful as an antiviral agent.
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公开(公告)号：US4892876A
公开(公告)日：1990-01-09
申请号：US172637
申请日：1988-03-24
申请人： Hiroo Hoshino , Nobuyoshi Shimada
发明人： Hiroo Hoshino , Nobuyoshi Shimada
IPC分类号： C07H19/16 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P35/00 , C07H19/02
摘要： A pharmaceutical composition for inhibiting Human Immunodeficiency Virus (HIV), which is characterized by comprising a compound represented by the formula (1) ##STR1## or a pharmaceutically acceptable salt thereof as an active ingredient.
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