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    METHOD FOR PRODUCING L-GLUTAMIC ACID BY FERMENTATION ACCOMPANIED BY PRECIPITATION
    1.
    发明申请
    METHOD FOR PRODUCING L-GLUTAMIC ACID BY FERMENTATION ACCOMPANIED BY PRECIPITATION 审中-公开
    通过降解发酵产生L-谷氨酸的方法

    公开(公告)号：US20090162907A1

    公开(公告)日：2009-06-25

    申请号：US12266921

    申请日：2008-11-07

    申请人： Hiroshi IZUI ,  Mika Moriya ,  Seiko Hirano ,  Yoshihiko Hara ,  Hisao Ito ,  Kazuhiko Matsui

    发明人： Hiroshi IZUI ,  Mika Moriya ,  Seiko Hirano ,  Yoshihiko Hara ,  Hisao Ito ,  Kazuhiko Matsui

    IPC分类号： C12P13/14

    CPC分类号： C12N9/0016 ,  C12N9/88 ,  C12P13/14 ,  C12R1/01

    摘要： A microorganism which can metabolize a carbon source at a specific pH in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source, and has ability to accumulate L-glutamic acid in an amount exceeding the amount corresponding to the saturation concentration in the liquid medium at the pH; and a method for producing L-glutamic acid by fermentation, which comprises culturing the microorganism in a liquid medium of which pH is adjusted to a pH at which L-glutamic acid is precipitated, to produce and accumulate L-glutamic acid and precipitate L-glutamic acid in the medium.

    摘要翻译： 在含有饱和浓度的L-谷氨酸和碳源的液体培养基中，能够在特定pH下代谢碳源的微生物，并且具有以超过相应于饱和浓度的量累积L-谷氨酸的能力 在液体介质中的pH值; 以及通过发酵生产L-谷氨酸的方法，其包括在将pH调节至L-谷氨酸沉淀的pH的液体培养基中培养微生物以产生并积累L-谷氨酸并将L-谷氨酸沉淀， 培养基中的谷氨酸。

    Method for producing L-glutamic acid by fermentation accompanied by precipitation
    2.
    发明授权
    Method for producing L-glutamic acid by fermentation accompanied by precipitation 有权
    通过发酵伴随沉淀生产L-谷氨酸的方法

    公开(公告)号：US07015010B1

    公开(公告)日：2006-03-21

    申请号：US09641892

    申请日：2000-08-18

    申请人： Hiroshi Izui ,  Mika Moriya ,  Seiko Hirano ,  Yoshihiko Hara ,  Hisao Ito ,  Kazuhiko Matsui

    发明人： Hiroshi Izui ,  Mika Moriya ,  Seiko Hirano ,  Yoshihiko Hara ,  Hisao Ito ,  Kazuhiko Matsui

    IPC分类号： C12Q1/04

    CPC分类号： C12N9/0016 ,  C12N9/88 ,  C12P13/14 ,  C12R1/01

    摘要： A microorganism which can metabolize a carbon source at a specific pH in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source, and has ability to accumulate L-glutamic acid in an amount exceeding the amount corresponding to the saturation concentration in the liquid medium at the pH; and a method for producing L-glutamic acid by fermentation, which comprises culturing the microorganism in a liquid medium of which pH is adjusted to a pH at which L-glutamic acid is precipitated, to produce and accumulate L-glutamic acid and precipitate L-glutamic acid in the medium.

    摘要翻译： 在含有饱和浓度的L-谷氨酸和碳源的液体培养基中，能够在特定pH下代谢碳源的微生物，并且具有以超过相应于饱和浓度的量累积L-谷氨酸的能力 在液体介质中的pH值; 以及通过发酵生产L-谷氨酸的方法，其包括在将pH调节至L-谷氨酸沉淀的pH的液体培养基中培养微生物以产生并积累L-谷氨酸并将L-谷氨酸沉淀， 培养基中的谷氨酸。

    Method for producing L-glutamic acid by fermentation accompanied by precipitation
    3.
    再颁专利
    Method for producing L-glutamic acid by fermentation accompanied by precipitation 有权
    通过发酵伴随沉淀生产L-谷氨酸的方法

    公开(公告)号：USRE42350E1

    公开(公告)日：2011-05-10

    申请号：US12429421

    申请日：2009-04-24

    申请人： Hiroshi Izui ,  Mika Moriya ,  Seiko Hirano ,  Yoshihiko Hara ,  Hisao Ito ,  Kazuhiko Matsui

    发明人： Hiroshi Izui ,  Mika Moriya ,  Seiko Hirano ,  Yoshihiko Hara ,  Hisao Ito ,  Kazuhiko Matsui

    IPC分类号： C12P13/14 ,  C12N15/00 ,  C12N1/20 ,  C12N1/36 ,  C12N15/63

    CPC分类号： C12N9/0016 ,  C12N9/88 ,  C12P13/14 ,  C12R1/01

    摘要： A microorganism is provided which can metabolize a carbon source at a specific pH in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source, and which has ability to accumulate L-glutamic acid in an amount exceeding the amount corresponding to the saturation concentration in the liquid medium at the pH. Also provided is a method for producing L-glutamic acid by fermentation, which comprises culturing the microorganism in a liquid medium of which pH is adjusted to a pH at which L-glutamic acid is precipitated, to produce and accumulate L-glutamic acid and precipitate L-glutamic acid in the medium.

    摘要翻译： 提供了能够在饱和浓度和碳源的含有L-谷氨酸的液体培养基中在特定pH下代谢碳源的微生物，并且具有将L-谷氨酸的积累量超过对应于 在液体介质中的饱和浓度在pH值。 还提供了通过发酵生产L-谷氨酸的方法，其包括在将pH调节至L-谷氨酸沉淀的pH的液体培养基中培养微生物以产生并积累L-谷氨酸并沉淀 培养基中的L-谷氨酸。

    Method for producing L-glutamic acid by fermentation accompanied by precipitation
    4.
    发明授权
    Method for producing L-glutamic acid by fermentation accompanied by precipitation 有权
    通过发酵伴随沉淀生产L-谷氨酸的方法

    公开(公告)号：US07208296B2

    公开(公告)日：2007-04-24

    申请号：US11150265

    申请日：2005-06-13

    申请人： Hiroshi Izui ,  Mika Moriya ,  Seiko Hirano ,  Yoshihiko Hara ,  Hisao Ito ,  Kazuhiko Matsui

    发明人： Hiroshi Izui ,  Mika Moriya ,  Seiko Hirano ,  Yoshihiko Hara ,  Hisao Ito ,  Kazuhiko Matsui

    IPC分类号： C12P13/14 ,  C12N15/00 ,  C12N1/20 ,  C12N1/36 ,  C12N15/63

    CPC分类号： C12N9/0016 ,  C12N9/88 ,  C12P13/14 ,  C12R1/01

    摘要： A microorganism is provided which can metabolize a carbon source at a specific pH in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source, and which has ability to accumulate L-glutamic acid in an amount exceeding the amount corresponding to the saturation concentration in the liquid medium at the pH. Also provided is a method for producing L-glutamic acid by fermentation, which comprises culturing the microorganism in a liquid medium of which pH is adjusted to a pH at which L-glutamic acid is precipitated, to produce and accumulate L-glutamic acid and precipitate L-glutamic acid in the medium.

    摘要翻译： 提供了能够在饱和浓度和碳源的含有L-谷氨酸的液体培养基中在特定pH下代谢碳源的微生物，并且具有将L-谷氨酸的积累量超过对应于 在液体介质中的饱和浓度在pH值。 还提供了通过发酵生产L-谷氨酸的方法，其包括在将pH调节至L-谷氨酸沉淀的pH的液体培养基中培养微生物以产生并积累L-谷氨酸并沉淀 培养基中的L-谷氨酸。

    METHOD FOR PRODUCING L-GLUTAMIC ACID BY FERMENTATION ACCOMPANIED BY PRECIPITATION
    5.
    发明申请
    METHOD FOR PRODUCING L-GLUTAMIC ACID BY FERMENTATION ACCOMPANIED BY PRECIPITATION 审中-公开
    通过降解发酵产生L-谷氨酸的方法

    公开(公告)号：US20070134773A1

    公开(公告)日：2007-06-14

    申请号：US11668079

    申请日：2007-01-29

    申请人： Hiroshi Izui ,  Mika Moriya ,  Seiko Hirano ,  Yoshihiko Hara ,  Hisao Ito ,  Kazuhiko Matsui

    发明人： Hiroshi Izui ,  Mika Moriya ,  Seiko Hirano ,  Yoshihiko Hara ,  Hisao Ito ,  Kazuhiko Matsui

    IPC分类号： C12P13/14 ,  C12N1/21

    CPC分类号： C12N9/0016 ,  C12N9/88 ,  C12P13/14 ,  C12R1/01

    摘要： A microorganism which can metabolize a carbon source at a specific pH in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source, and has ability to accumulate L-glutamic acid in an amount exceeding the amount corresponding to the saturation concentration in the liquid medium at the pH; and a method for producing L-glutamic acid by fermentation, which comprises culturing the microorganism in a liquid medium of which pH is adjusted to a pH at which L-glutamic acid is precipitated, to produce and accumulate L-glutamic acid and precipitate L-glutamic acid in the medium.

    摘要翻译： 在含有饱和浓度的L-谷氨酸和碳源的液体培养基中，能够在特定pH下代谢碳源的微生物，并且具有以超过相应于饱和浓度的量累积L-谷氨酸的能力 在液体介质中的pH值; 以及通过发酵生产L-谷氨酸的方法，其包括在将pH调节至L-谷氨酸沉淀的pH的液体培养基中培养微生物，以产生并积累L-谷氨酸并将L-谷氨酸沉淀， 培养基中的谷氨酸。

    L-glutamic acid-producing bacterium and method for producing L-glutamic acid
    9.
    发明授权
    L-glutamic acid-producing bacterium and method for producing L-glutamic acid 有权
    L-谷氨酸生产菌和L-谷氨酸的生产方法

    公开(公告)号：US06682912B2

    公开(公告)日：2004-01-27

    申请号：US09737580

    申请日：2000-12-18

    申请人： Mika Moriya ,  Hiroshi Izui ,  Eiji Ono ,  Kazuhiko Matsui ,  Hisao Ito ,  Yoshihiko Hara

    发明人： Mika Moriya ,  Hiroshi Izui ,  Eiji Ono ,  Kazuhiko Matsui ,  Hisao Ito ,  Yoshihiko Hara

    IPC分类号： C12P1314

    CPC分类号： C12N9/0016 ,  C12N9/88 ,  C12P13/14 ,  C12R1/01 ,  C12R1/18 ,  C12R1/22 ,  Y10S435/847 ,  Y10S435/852

    摘要： A method for producing L-glutamic acid which comprises culturing a microorganism belonging to the genus Klebsiella, Erwinia or Pantoea and having an ability to produce L-glutamic acid in a culture medium, and collecting produced L-glutamic acid from the culture medium. The microbial strain used is preferably a strain which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, or a strain which increase in an activity of an enzyme catalyzing a reaction for L-glutamic acid biosynthesis.

    摘要翻译： 一种L-谷氨酸的制造方法，其特征在于，在培养基中培养属于克雷伯氏菌属，欧文氏菌属或泛菌属的微生物，并具有生产L-谷氨酸的能力，从培养基中收集L-谷氨酸。 所用的微生物菌株优选是一种在L-谷氨酸生物合成途径中催化分支反应并产生除L-谷氨酸以外的化合物的酶的活性降低或缺乏的菌株或增加 催化L-谷氨酸生物合成反应的酶的活性。