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    ANTIGEN-AND-DRUG VEHICLE COMPRISING SYNTHETIC PEPTIDE, AND MUCOSAL VACCINE USING THE SAME
    2.
    发明申请
    ANTIGEN-AND-DRUG VEHICLE COMPRISING SYNTHETIC PEPTIDE, AND MUCOSAL VACCINE USING THE SAME 有权
    包含合成肽的抗病毒药物和使用它的胶原疫苗

    公开(公告)号：US20110110971A1

    公开(公告)日：2011-05-12

    申请号：US12936075

    申请日：2009-03-30

    申请人： Hiroshi Kido ,  Tsunetomo Takei ,  Dai Mizuno

    发明人： Hiroshi Kido ,  Tsunetomo Takei ,  Dai Mizuno

    IPC分类号： A61K39/00 ,  A61K38/10 ,  A61K38/16 ,  A61K39/35 ,  A61P31/00 ,  A61P37/08

    CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/541 ,  A61K2039/6018 ,  A61K2039/6031 ,  C07K7/08 ,  C07K14/001 ,  C12N2760/16134

    摘要： Disclosed are an antigen-and-drug (AD) vehicle and a mucosal vaccine utilizing a novel synthetic peptide.The antigen-and-drug (AD) vehicle capable of inducing the production of secretory IgA antibodies, which is a complex of a synthetic peptide having the following amino acid sequence: PVHLKRLm (m is 11 to 15 or 16 to 20, e.g., peptide of SEQ. ID. NO: 1) or KnLm (n is 4 to 8 and m is 11 to 20, e.g., peptide of SEQ. ID. NO: 2 or 3), and a lipid(s). The mucosal vaccine is obtainable by allowing a mucosal-immunity-IgA-inducing amount of an antigen to coexist with, contact, be captured by, or be adsorbed onto the AD vehicle.

    摘要翻译： 公开了使用新型合成肽的抗原和药物（AD）载体和粘膜疫苗。 能够诱导产生分泌型IgA抗体的抗原和药物（AD）载体，其是具有以下氨基酸序列的合成肽的复合物：PVHLKRLm（m为11至15或16至20，例如肽 SEQ ID NO：1）或KnLm（n为4至8，m为11至20，例如SEQ ID NO：2或3的肽）和脂质。 通过使粘膜免疫-1AA诱导量的抗原与AD载体共存，接触，捕获或被吸附到AD载体上而获得粘膜疫苗。

    MUCOSAL VACCINES
    3.
    发明申请
    MUCOSAL VACCINES 有权
    粘液疫苗

    公开(公告)号：US20130045232A1

    公开(公告)日：2013-02-21

    申请号：US13582160

    申请日：2011-03-01

    申请人： Hiroshi Kido ,  Dai Mizuno

    发明人： Hiroshi Kido ,  Dai Mizuno

    IPC分类号： A61K39/39 ,  A61P37/04 ,  A61P37/08 ,  A61K39/35

    CPC分类号： C07K14/005 ,  A61K9/0043 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K47/32 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  C12N2760/16122 ,  C12N2760/16134 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/466

    摘要： A mucosal vaccine producing an antigen-specific mucosal IgA and a blood IgG in the levels capable of exerting an effective immune induction and an infection-preventing effect, which comprises: (a) an AD vehicle consisting of a synthetic peptide and a lipid(s), wherein the synthetic peptide consisting of the amino acid sequence KnLm (wherein n is 4 to 8 and m is 11 to 20); (b) a carboxylvinyl polymer; and, (c) an antigenic protein, in an amount incapable of producing a sufficient mucosal IgA and blood IgG for exerting an effective immune induction and an infection-preventing effect when used by itself. The mucosal vaccine of the invention has an antibody producing ability which is more potent than those of mucosal vaccines of the prior art, and as a result it can exert an excellent effect even with an extremely small amount of an antigen.

    摘要翻译： 一种在能够发挥有效免疫诱导和感染预防作用的水平中产生抗原特异性粘膜IgA和血液IgG的粘膜疫苗，其包括：（a）由合成肽和脂质组成的AD载体 ），其中由氨基酸序列KnLm（其中n为4至8且m为11至20）组成的合成肽; （b）羧基乙烯基聚合物; 和（c）抗原性蛋白质，其量不足以产生足够的粘膜IgA和血液IgG，用于在自身使用时发挥有效的免疫诱导和感染预防作用。 本发明的粘膜疫苗具有比现有技术的粘膜疫苗更有效的抗体生成能力，结果即使使用极少量的抗原也能发挥优异的效果。

    Antigen-Drug Vehicle Enabling Switch From Selective Production of IgA Antibody to Production of Both of IgA and IgG Antibodies and Transnasal/Mucosal Vaccine Using the Same
    4.
    发明申请
    Antigen-Drug Vehicle Enabling Switch From Selective Production of IgA Antibody to Production of Both of IgA and IgG Antibodies and Transnasal/Mucosal Vaccine Using the Same 有权
    抗IgC抗体携带IgA抗体选择性生产的抗原 - 药物载体启动切换与IgA和IgG抗体的生产以及使用该抗体的跨膜/粘膜疫苗

    公开(公告)号：US20090130131A1

    公开(公告)日：2009-05-21

    申请号：US11990001

    申请日：2006-08-04

    申请人： Hiroshi Kido ,  Dai Mizuno

    发明人： Hiroshi Kido ,  Dai Mizuno

    IPC分类号： A61K39/385

    CPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/35 ,  A61K39/385 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/6031 ,  C07K14/47 ,  C12N2760/16134

    摘要： In the aim of practical utilization of a safe and effective transnasal/inactivated/mucosal vaccine and establishment of a technology for imparting capacity of producing both of IgA and IgG antibodies to a conventional inactivated vaccine, toxoid; allergen, or the like, a means for prevention and treatment of allergy, and the like, it is intended to provide an antigen-drug vehicle (AD vehicle) enabling transnasal, transmucosal, and transdermal administrations, an inactivated vaccine simultaneously inducing a mucosal immunity and humoral immunity by using the AD vehicle, a production method of the inactivated vaccine, an AD vehicle enabling a switch from induction of selective production of IgA antibody to induction of both of IgA and IgG antibodies, and a transnasal vaccine, a mucosal vaccine, a therapeutic/prophylactic agent for allergy, and the like using the AD vehicle.

    摘要翻译： 为了实际应用安全有效的经鼻/灭活/粘膜疫苗和建立一种赋予常规灭活疫苗，类毒素的IgA和IgG抗体产生能力的技术的目的。 过敏原等，预防和治疗过敏等的手段，旨在提供能够经鼻，经粘膜和透皮给药的抗原药物载体（AD载体），同时诱导粘膜免疫的灭活疫苗 和使用AD载体的体液免疫，灭活疫苗的制备方法，能够从诱导选择性产生IgA抗体转变成诱导IgA和IgG抗体两者的AD载体，以及经鼻疫苗，粘膜疫苗， 使用AD载体的用于过敏的治疗/预防剂等。

    Antigen-drug vehicle enabling transmucosal and transdermal administration, and method of inducing mucosal immunity and mucosal vaccine and dds using the same
    5.
    发明申请
    Antigen-drug vehicle enabling transmucosal and transdermal administration, and method of inducing mucosal immunity and mucosal vaccine and dds using the same 有权
    能够进行经粘膜和透皮给药的抗原药物，以及诱导粘膜免疫和粘膜疫苗的方法和使用其的dds

    公开(公告)号：US20070141073A1

    公开(公告)日：2007-06-21

    申请号：US11547650

    申请日：2005-03-22

    申请人： Hiroshi Kido ,  Dai Mizuno

    发明人： Hiroshi Kido ,  Dai Mizuno

    IPC分类号： A61K39/00

    CPC分类号： A61K39/00 ,  A61K2039/541

    摘要： Disclosed are an antigen-drug vehicle (AD vehicle) exerting a function of inducing the preferential and selective production of an antigen-specific secretory IgA antibody, local immunity or mucosal immunity; a method of inducing mucosal immunity, a mucosal vaccine and a preventive or a remedy for allergy using the above AD vehicle; and a transmucosal or transdermal DDS using the above vehicle.

    摘要翻译： 公开了具有诱导抗原特异性分泌型IgA抗体的优先选择性产生的功能的抗原 - 药物载体（AD载体），局部免疫或粘膜免疫; 使用上述AD载体诱导粘膜免疫的方法，粘膜疫苗和用于过敏的预防或补救措施; 和使用上述载体的经粘膜或透皮DDS。

    Antigen-and-drug vehicle comprising synthetic peptide, and mucosal vaccine using the same
    8.
    发明授权
    Antigen-and-drug vehicle comprising synthetic peptide, and mucosal vaccine using the same 有权
    包含合成肽的抗原和药物载体，以及使用其的粘膜疫苗

    公开(公告)号：US08287887B2

    公开(公告)日：2012-10-16

    申请号：US12936075

    申请日：2009-03-30

    申请人： Hiroshi Kido ,  Tsunetomo Takei ,  Dai Mizuno

    发明人： Hiroshi Kido ,  Tsunetomo Takei ,  Dai Mizuno

    IPC分类号： A61K45/00 ,  A61K39/12

    CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/541 ,  A61K2039/6018 ,  A61K2039/6031 ,  C07K7/08 ,  C07K14/001 ,  C12N2760/16134

    摘要： The present invention is an antigen-and-drug (AD) vehicle and a mucosal vaccine utilizing a novel synthetic peptide. The antigen-and-drug (AD) vehicle is capable of inducing the production of secretory IgA antibodies, and is a complex of a synthetic peptide having the following amino acid sequence: PVHLKRLm (e.g., peptide of SEQ ID NO 1, 6, or 7) or KnLm (e.g., peptide of SEQ ID NO 2, 3, or 8), and a lipid(s). The mucosal vaccine is obtainable by allowing a mucosal-immunity-IgA-inducing amount of an antigen to coexist with, contact, be captured by, or be adsorbed onto the AD vehicle.

    摘要翻译： 本发明是使用新型合成肽的抗原和药物（AD）载体和粘膜疫苗。 抗原和药物（AD）载体能够诱导分泌型IgA抗体的产生，并且是具有以下氨基酸序列的合成肽的复合物：PVHLKRLm（例如，SEQ ID NO 1,6或 7）或KnLm（例如，SEQ ID NO 2,3或8的肽）和脂质。 通过使粘膜免疫-1AA诱导量的抗原与AD载体共存，接触，捕获或被吸附到AD载体上而获得粘膜疫苗。

    Mucosal vaccine enabling switching from production of IgA antibody to production of both of IgA and IgG antibodies
    9.
    发明授权
    Mucosal vaccine enabling switching from production of IgA antibody to production of both of IgA and IgG antibodies 有权
    粘膜疫苗能够从IgA抗体的生产切换到IgA和IgG抗体两者的生产

    公开(公告)号：US08211442B2

    公开(公告)日：2012-07-03

    申请号：US11990001

    申请日：2006-08-04

    申请人： Hiroshi Kido ,  Dai Mizuno

    发明人： Hiroshi Kido ,  Dai Mizuno

    IPC分类号： A61K39/12

    CPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/35 ,  A61K39/385 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/6031 ,  C07K14/47 ,  C12N2760/16134

    摘要： In the aim of practical utilization of a safe and effective transnasal/inactivated/mucosal vaccine and establishment of a technology for imparting capacity of producing both of IgA and IgG antibodies to a conventional inactivated vaccine, toxoid, allergen, or the like, a means for prevention and treatment of allergy, and the like, it is intended to provide an antigen-drug vehicle (AD vehicle) enabling transnasal, transmucosal, and transdermal administrations, an inactivated vaccine simultaneously inducing a mucosal immunity and humoral immunity by using the AD vehicle, a production method of the inactivated vaccine, an AD vehicle enabling a switch from induction of selective production of IgA antibody to induction of both of IgA and IgG antibodies, and a transnasal vaccine, a mucosal vaccine, a therapeutic/prophylactic agent for allergy, and the like using the AD vehicle.

    摘要翻译： 为了实际应用安全有效的经鼻/灭活/粘膜疫苗并建立一种赋予常规灭活疫苗，类毒素，变应原等IgA和IgG抗体产生能力的技术， 预防和治疗过敏等，旨在提供通过使用AD载体同时诱导粘膜免疫和体液免疫的灭活疫苗，能够进行经鼻，经粘膜和透皮给药的抗原药物载体（AD载体） 灭活疫苗的制备方法，能够切换诱导IgA抗体诱导IgA和IgG抗体诱导的AD载体的AD载体，以及经鼻疫苗，粘膜疫苗，过敏治疗/预防剂，以及 类似于使用AD车辆。

    LOAD DETERMINATION DEVICE AND ILLUMINATION APPARATUS USING SAME
    10.
    发明申请
    LOAD DETERMINATION DEVICE AND ILLUMINATION APPARATUS USING SAME 有权
    使用相同的负载确定装置和照明装置

    公开(公告)号：US20110234104A1

    公开(公告)日：2011-09-29

    申请号：US13071762

    申请日：2011-03-25

    申请人： Masanori MISHIMA ,  Hiroshi Kido ,  Shohei Yamamoto ,  Masanao Okawa ,  Hirofumi Konishi ,  Katunobu Hamamoto

    发明人： Masanori MISHIMA ,  Hiroshi Kido ,  Shohei Yamamoto ,  Masanao Okawa ,  Hirofumi Konishi ,  Katunobu Hamamoto

    IPC分类号： H01J7/42

    CPC分类号： H05B33/0848 ,  H05B33/08 ,  H05B33/0896 ,  Y02B20/32

    摘要： An illumination load determination device includes an illumination load; a voltage applying unit for applying a voltage to the illumination load; a connection unit for connecting the illumination load and the voltage applying unit; a detection unit for detecting at least one of a current flowing through the illumination load and a voltage across the illumination load when the voltage is applied to the illumination load from the voltage applying unit via the connection unit; and a determination unit for determining a type of the illumination load based on an output from the detection unit. The determination unit has a comparator for comparing a detection value detected by the detection unit to a predetermined threshold, and determines that the illumination load has a capacitance based on an output of the comparator. The voltage applying unit lights on the determined illumination load with a rated driving voltage.

    摘要翻译： 照明负载确定装置包括照明负载; 电压施加单元，用于向照明负载施加电压; 用于连接照明负载和电压施加单元的连接单元; 检测单元，用于当电压经由连接单元从电压施加单元施加到照明负载时，检测流过照明负载的电流和照明负载两端的电压中的至少一个; 以及确定单元，用于基于来自检测单元的输出来确定照明负载的类型。 确定单元具有用于将由检测单元检测的检测值与预定阈值进行比较的比较器，并且基于比较器的输出确定照明负载具有电容。 电压施加单元以额定驱动电压对确定的照明负载点亮。