公开(公告)号：US4992369A

公开(公告)日：1991-02-12

申请号：US366576

申请日：1989-06-15

申请人： Hiroshi Maeda ,  Junsuke Tone ,  John C. Ruddock ,  Kelvin S. Holdom

发明人： Hiroshi Maeda ,  Junsuke Tone ,  John C. Ruddock ,  Kelvin S. Holdom

IPC分类号： A23K20/195 ,  A61K38/00 ,  A61P31/04 ,  A61P33/02 ,  A61P43/00 ,  C07K1/20 ,  C07K1/22 ,  C07K9/00 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12P21/02 ,  C12R1/045

CPC分类号： C12R1/045 ,  C07K9/008 ,  Y10S435/827

摘要： A new glycopeptide antibiotic UK-68,597 can be prepared by submerged aerobic propagation in aqueous nutrient media of Actinoplanes sp. ATCC 53533. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in poultry, swine and ruminants.

公开(公告)号：US4920215A

公开(公告)日：1990-04-24

申请号：US133752

申请日：1987-12-16

申请人： Kelvin S. Holdom ,  John C. Ruddock ,  Junsuke Tone ,  Hiroshi Maeda ,  Martin R. Jefson

发明人： Kelvin S. Holdom ,  John C. Ruddock ,  Junsuke Tone ,  Hiroshi Maeda ,  Martin R. Jefson

IPC分类号： C12P19/44 ,  A23K20/195 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P3/00 ,  A61P31/04 ,  C07H17/04 ,  C12N1/20 ,  C12P19/60 ,  C12R1/01

CPC分类号： C07H17/04 ,  A23K20/195 ,  Y10S435/872 ,  Y10S435/886 ,  Y10S514/867

摘要： The antibiotic of the formula: ##STR1## wherein R is ##STR2## The antibiotic is useful for the treatment of swine dysentery and for promoting growth and/or increasing the efficiency of food utilization in poultry, swine and ruminants.

公开(公告)号：US4954482A

公开(公告)日：1990-09-04

申请号：US384052

申请日：1989-07-20

申请人： Hiroshi Maeda ,  Junsuke Tone ,  John C. Ruddock ,  Kelvin S. Holdom

发明人： Hiroshi Maeda ,  Junsuke Tone ,  John C. Ruddock ,  Kelvin S. Holdom

IPC分类号： A23K20/195 ,  A61K38/00 ,  A61P31/04 ,  A61P33/02 ,  A61P43/00 ,  C07K1/20 ,  C07K1/22 ,  C07K9/00 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12P21/02 ,  C12R1/045

CPC分类号： C12R1/045 ,  C07K9/008 ,  Y10S435/827

摘要： A new glycopeptide antibiotic UK-68,597 can be prepared by submerged aerobic propagation in aqueous nutrient media of Actinoplanes sp. ATCC 53533. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in poultry, swine and ruminants.

摘要翻译： 一种新的糖肽抗生素UK-68,597可以通过淹没有氧繁殖在肌动蛋白平板的水性营养培养基中制备。 抗生素及其阳离子盐对多种微生物具有活性，有效控制球虫病，肠炎，猪痢疾和败血症，以及有效促进家禽，猪的生长和/或提高饲料利用效率。 和反刍动物。

公开(公告)号：US4746650A

公开(公告)日：1988-05-24

申请号：US747613

申请日：1985-06-21

申请人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

发明人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

IPC分类号： A23K20/195 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  A61P33/02 ,  C07H17/04 ,  C07H19/01 ,  C12P17/18 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  A61K31/71 ,  A23G3/00

CPC分类号： C07H19/01 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  Y10S435/825

摘要： A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in swine and ruminants. Two minor components, wherein R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.

摘要翻译： 一种新的酸性多环醚抗生素UK-58,852具有以下分子式：其中R和R1都是氢，并且可以通过在放线菌属的水性营养培养基中浸没需氧繁殖来制备。 抗生素及其阳离子盐对各种微生物有活性，有效控制球虫病，肠炎，猪痢疾和腹膜炎，以及有效促进生长和/或提高猪和反刍动物饲料利用效率 。 从发酵中也分离出两个次要组分，其中R为H且R 1为CH 3，并且其中R和R 1均为CH 3。

公开(公告)号：US4707493A

公开(公告)日：1987-11-17

申请号：US931587

申请日：1986-11-17

申请人： Walter D. Celmer ,  Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

发明人： Walter D. Celmer ,  Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

IPC分类号： C07H19/01 ,  C12P19/44 ,  C12P19/60 ,  C07D309/10

CPC分类号： C07H19/01 ,  C12P19/445 ,  C12P19/60 ,  C12R1/55

摘要： Antibiotic 19-epi-dianemycin, process for its preparation by fermenting a new strain of Streptomyces hygroscopicus, and isolation from the fermentation broth; and its use as an anticoccidial agent and antibacterial agent against gram-positive bacteria.

摘要翻译： 抗生素19-epi-dianemycin，其制备方法是通过发酵新的吸水链霉菌菌株和从发酵液中分离; 并作为抗球虫剂和抗革兰氏阳性菌的抗菌剂使用。

公开(公告)号：US5100785A

公开(公告)日：1992-03-31

申请号：US628798

申请日：1990-12-17

申请人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

发明人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

IPC分类号： A23K20/195 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  A61P33/02 ,  C07H17/04 ,  C07H19/01 ,  C12P17/18 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03

CPC分类号： C07H19/01 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  Y10S435/825

摘要： A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in swine and ruminants. Two minor components, wherein R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.

公开(公告)号：US4992423A

公开(公告)日：1991-02-12

申请号：US153187

申请日：1988-02-08

申请人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

发明人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

IPC分类号： A23K20/195 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  A61P33/02 ,  C07H17/04 ,  C07H19/01 ,  C12P17/18 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03

CPC分类号： C07H19/01 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  Y10S435/825

摘要： A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization is swine and ruminants. Two minor components, where R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.

公开(公告)号：US5891727A

公开(公告)日：1999-04-06

申请号：US849553

申请日：1992-03-11

申请人： John P. Dirlam ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

发明人： John P. Dirlam ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： A23K20/195 ,  C07H17/04 ,  C12P17/16 ,  C12P19/60 ,  C12N1/00

CPC分类号： C12P17/162 ,  A23K20/195 ,  C07H17/04 ,  C12P19/60 ,  Y10S435/825

摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53676. This novel antibiotic is useful as an anticoccidial in chickens and as a growth promotant in cattle and swine.

摘要翻译： 通过X射线晶体学建立的结构的酸性多环醚抗生素是通过发酵一种新型微生物Actinomadura sp。 ATCC 53676.这种新型抗生素在小鸡和牛和猪的生长促进剂中作为抗球虫病有用。

公开(公告)号：US5510372A

公开(公告)日：1996-04-23

申请号：US378997

申请日：1995-01-27

申请人： Mark A. Haxell ,  David A. Perry ,  Hiroshi Maeda ,  Junsuke Tone

发明人： Mark A. Haxell ,  David A. Perry ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： A01N43/90 ,  A01N63/02 ,  A61K31/365 ,  A61K31/37 ,  A61P33/00 ,  A61P33/10 ,  C07D493/22 ,  C07H9/02 ,  C07H19/01 ,  C12N1/20 ,  C12P17/18 ,  C12P19/44 ,  C12R1/55 ,  A61K31/35

CPC分类号： C07H19/01 ,  A01N43/90 ,  C12P17/181 ,  C12P19/445 ,  C12R1/55 ,  Y10S435/898

摘要： The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pest, acari, free-living nematodes and endo- and ectoparasites. This invention also relates to pharmaceutical and other compositions comprising such compounds, methods of using such compounds, the microorganism Streptomyces hygroscopicus ATCC 53718 and mutants or genetically transformed or recombinant form thereof, and processes for producing such compounds.

摘要翻译： 本发明涉及本文中称为N787-182化合物的某些抗生素化合物及其衍生物，其为抗寄生虫病，抗病虫，螨虫，自由活生生线虫和内寄生虫和外寄生虫的抗寄生虫剂。 本发明还涉及包含这种化合物的药物和其它组合物，使用这些化合物的方法，微生物吸水链霉菌Streptomyces ATCC 53718以及其突变体或遗传转化或重组形式，以及制备这些化合物的方法。

公开(公告)号：US5418152A

公开(公告)日：1995-05-23

申请号：US30086

申请日：1993-03-12

申请人： Walter P. Cullen ,  John P. Dirlam ,  Hiroshi Maeda ,  Junsuke Tone

发明人： Walter P. Cullen ,  John P. Dirlam ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： A23K1/16 ,  A23K1/17 ,  A23K1/18 ,  A61K31/35 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P33/02 ,  C07D493/10 ,  C07H17/04 ,  C07H19/01 ,  C12P17/18 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  C12P17/16

CPC分类号： C07H19/01 ,  A23K20/195 ,  A23K50/30 ,  C12P17/181 ,  C12P19/445 ,  C12R1/01

摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 55080. This novel antibiotic is useful as an anticoccidial in poultry, in the prevention and treatment of swine dysentery and as a growth promotant in cattle and swine.

摘要翻译： PCT No.PCT / US91 / 06084 Sec。 371日期1993年3月12日 102（e）1993年3月12日PCT 1991年8月30日PCT申请。具有通过X射线晶体学建立的结构的酸性多环醚类抗生素通过新型微生物Actinomadura sp。 ATCC 55080.这种新型抗生素可用作家禽中的抗球虫病，预防和治疗猪痢疾以及作为牛和猪的生长促进剂。