公开(公告)号：US4992423A

公开(公告)日：1991-02-12

申请号：US153187

申请日：1988-02-08

申请人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

发明人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

IPC分类号： A23K20/195 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  A61P33/02 ,  C07H17/04 ,  C07H19/01 ,  C12P17/18 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03

CPC分类号： C07H19/01 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  Y10S435/825

摘要： A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization is swine and ruminants. Two minor components, where R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.

公开(公告)号：US4707493A

公开(公告)日：1987-11-17

申请号：US931587

申请日：1986-11-17

申请人： Walter D. Celmer ,  Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

发明人： Walter D. Celmer ,  Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

IPC分类号： C07H19/01 ,  C12P19/44 ,  C12P19/60 ,  C07D309/10

CPC分类号： C07H19/01 ,  C12P19/445 ,  C12P19/60 ,  C12R1/55

摘要： Antibiotic 19-epi-dianemycin, process for its preparation by fermenting a new strain of Streptomyces hygroscopicus, and isolation from the fermentation broth; and its use as an anticoccidial agent and antibacterial agent against gram-positive bacteria.

摘要翻译： 抗生素19-epi-dianemycin，其制备方法是通过发酵新的吸水链霉菌菌株和从发酵液中分离; 并作为抗球虫剂和抗革兰氏阳性菌的抗菌剂使用。

公开(公告)号：US4746650A

公开(公告)日：1988-05-24

申请号：US747613

申请日：1985-06-21

申请人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

发明人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

IPC分类号： A23K20/195 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  A61P33/02 ,  C07H17/04 ,  C07H19/01 ,  C12P17/18 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  A61K31/71 ,  A23G3/00

CPC分类号： C07H19/01 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  Y10S435/825

摘要： A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in swine and ruminants. Two minor components, wherein R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.

摘要翻译： 一种新的酸性多环醚抗生素UK-58,852具有以下分子式：其中R和R1都是氢，并且可以通过在放线菌属的水性营养培养基中浸没需氧繁殖来制备。 抗生素及其阳离子盐对各种微生物有活性，有效控制球虫病，肠炎，猪痢疾和腹膜炎，以及有效促进生长和/或提高猪和反刍动物饲料利用效率 。 从发酵中也分离出两个次要组分，其中R为H且R 1为CH 3，并且其中R和R 1均为CH 3。

公开(公告)号：US5100785A

公开(公告)日：1992-03-31

申请号：US628798

申请日：1990-12-17

申请人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

发明人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

IPC分类号： A23K20/195 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  A61P33/02 ,  C07H17/04 ,  C07H19/01 ,  C12P17/18 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03

CPC分类号： C07H19/01 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  Y10S435/825

摘要： A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in swine and ruminants. Two minor components, wherein R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.

公开(公告)号：US5891727A

公开(公告)日：1999-04-06

申请号：US849553

申请日：1992-03-11

申请人： John P. Dirlam ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

发明人： John P. Dirlam ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： A23K20/195 ,  C07H17/04 ,  C12P17/16 ,  C12P19/60 ,  C12N1/00

CPC分类号： C12P17/162 ,  A23K20/195 ,  C07H17/04 ,  C12P19/60 ,  Y10S435/825

摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53676. This novel antibiotic is useful as an anticoccidial in chickens and as a growth promotant in cattle and swine.

摘要翻译： 通过X射线晶体学建立的结构的酸性多环醚抗生素是通过发酵一种新型微生物Actinomadura sp。 ATCC 53676.这种新型抗生素在小鸡和牛和猪的生长促进剂中作为抗球虫病有用。

公开(公告)号：US5418152A

公开(公告)日：1995-05-23

申请号：US30086

申请日：1993-03-12

申请人： Walter P. Cullen ,  John P. Dirlam ,  Hiroshi Maeda ,  Junsuke Tone

发明人： Walter P. Cullen ,  John P. Dirlam ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： A23K1/16 ,  A23K1/17 ,  A23K1/18 ,  A61K31/35 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P33/02 ,  C07D493/10 ,  C07H17/04 ,  C07H19/01 ,  C12P17/18 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  C12P17/16

CPC分类号： C07H19/01 ,  A23K20/195 ,  A23K50/30 ,  C12P17/181 ,  C12P19/445 ,  C12R1/01

摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 55080. This novel antibiotic is useful as an anticoccidial in poultry, in the prevention and treatment of swine dysentery and as a growth promotant in cattle and swine.

摘要翻译： PCT No.PCT / US91 / 06084 Sec。 371日期1993年3月12日 102（e）1993年3月12日PCT 1991年8月30日PCT申请。具有通过X射线晶体学建立的结构的酸性多环醚类抗生素通过新型微生物Actinomadura sp。 ATCC 55080.这种新型抗生素可用作家禽中的抗球虫病，预防和治疗猪痢疾以及作为牛和猪的生长促进剂。

公开(公告)号：US5403738A

公开(公告)日：1995-04-04

申请号：US169566

申请日：1993-12-17

申请人： John P. Dirlam ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

发明人： John P. Dirlam ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： A23K1/17 ,  A23K1/18 ,  C07H19/01 ,  C12P17/18 ,  C12P19/44 ,  C12N1/20

CPC分类号： C07H19/01 ,  A23K20/195 ,  A23K50/30 ,  C12P17/18 ,  C12P19/44 ,  Y10S435/825

摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53764. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.

摘要翻译： 通过X射线晶体学建立的结构的酸性多环醚抗生素是通过发酵一种新型微生物Actinomadura sp。 ATCC 53764.这种新型抗生素可用作鸡的抗球虫病，预防或治疗猪痢疾，以及作为牛和猪的生长促进剂。

公开(公告)号：US4835141A

公开(公告)日：1989-05-30

申请号：US938219

申请日：1986-12-05

申请人： Walter P. Cullen ,  James R. Hauske ,  Hiroshi Maeda ,  Junsuke Tone

发明人： Walter P. Cullen ,  James R. Hauske ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： C07H17/08 ,  C12P19/58

CPC分类号： C07H17/08 ,  C12P19/58 ,  C12R1/465

摘要： An antibiotic complex, containing three major components, has been isolated from fermentations of a new strain of the microorganism Streptomyces hirsutus. The major components are new, neutral, macrolide antibiotic compounds, which are useful as antibacterial agents against certain gram-positive bacteria.

摘要翻译： 含有三个主要组分的抗生素复合物已经从微生物链霉菌链霉菌（Streptomyces hirsutus）的新菌株的发酵中分离出来。 主要成分是新的，中性的，大环内酯类抗生素化合物，它们可用作针对某些革兰氏阳性菌的抗菌剂。

公开(公告)号：US4956283A

公开(公告)日：1990-09-11

申请号：US322149

申请日：1989-03-10

申请人： Walter P. Cullen ,  James R. Hauske ,  Hiroshi Maeda ,  Junsuke Tone

发明人： Walter P. Cullen ,  James R. Hauske ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： C07H17/08 ,  C12P19/58

CPC分类号： C07H17/08 ,  C12P19/58 ,  C12R1/465 ,  Y10S435/886

摘要： An antibiotic complex, containing three major components, has been isolated from fermentations of a new strain of the microorganism Streptomyces hirautus. The major components are new, neutral, macrolide antibiotic compounds, which are useful as antibacterial agents against certain gram-positive bacteria.

摘要翻译： 含有三个主要成分的抗生素复合物已经从微生物链霉菌Streptomyces hirautus的新菌株的发酵中分离出来。 主要成分是新的，中性的，大环内酯类抗生素化合物，它们可用作针对某些革兰氏阳性菌的抗菌剂。

公开(公告)号：US4547523A

公开(公告)日：1985-10-15

申请号：US549378

申请日：1983-11-07

申请人： Walter D. Celmer ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

发明人： Walter D. Celmer ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： C07D493/10 ,  C12P17/18 ,  C07D263/56

CPC分类号： C07D493/10 ,  C12P17/181 ,  Y10S435/886

摘要： A new polyether antibiotic has been isolated from fermentations of a new microorganism of the genus Streptomyces. This new microorganism is designated as N478-13 and it has ben named Streptomyces routienii Huang sp. nov., (ATCC 39446). The new antibiotic exhibits antibacterial activity against a variety of gram-positive bacteria; it can be used to control swine dysentery; and it promotes increased efficiency of feed utilization (i.e. promotes increased growth) in swine and ruminants.

摘要翻译： 已经从链霉菌属的新微生物的发酵中分离出新的聚醚抗生素。 这种新的微生物被指定为N478-13，它具有本命名为Streptomyces routienii Huang sp。 nov。，（ATCC 39446）。 新型抗生素对各种革兰氏阳性菌具有抗菌活性; 可用于控制猪痢疾; 并且促进猪和反刍动物饲料利用效率提高（即促进生长增长）。