公开(公告)号：US20100248256A1

公开(公告)日：2010-09-30

申请号：US12452216

申请日：2008-06-16

申请人： Hirotaka Minagawa ,  Kenji Miyazaki ,  Yo Tabuse ,  Kenichi Kamijo ,  Shuichi Kaneko

发明人： Hirotaka Minagawa ,  Kenji Miyazaki ,  Yo Tabuse ,  Kenichi Kamijo ,  Shuichi Kaneko

IPC分类号： G01N33/53 ,  C07K14/435

CPC分类号： C07K14/4748 ,  G01N33/57438

摘要： Provided are: a method of assessing hepatocellular carcinoma by using a protein with a different phosphorylated state in hepatocellular carcinoma cells compared with non-hepatocellular carcinoma cells; and a hepatocellular carcinoma protein marker for detecting hepatocellular carcinoma formed of the protein. The hepatocellular carcinoma protein marker for detecting hepatocellular carcinoma includes tumor rejection antigen gp96 formed of the amino acid represented by SEQ ID NO: 1, and is measured for its phosphorylated state to detect the presence or absence of hepatocellular carcinoma.

摘要翻译： 提供：与非肝细胞癌细胞相比，通过使用肝细胞癌细胞中具有不同磷酸化状态的蛋白质来评估肝细胞癌的方法; 和用于检测由蛋白质形成的肝细胞癌的肝细胞癌蛋白标记物。 用于检测肝细胞癌的肝细胞癌蛋白标志物包括由SEQ ID NO：1表示的氨基酸形成的肿瘤排斥抗原gp96，并测量其磷酸化状态以检测肝细胞癌的存在或不存在。

公开(公告)号：US20120225440A1

公开(公告)日：2012-09-06

申请号：US13471629

申请日：2012-05-15

申请人： Hirotaka Minagawa ,  Kenji Miyazaki ,  Yo Tabuse ,  Kenichi Kamijo ,  Shuichi Kaneko

发明人： Hirotaka Minagawa ,  Kenji Miyazaki ,  Yo Tabuse ,  Kenichi Kamijo ,  Shuichi Kaneko

IPC分类号： G01N33/574 ,  G01N27/62 ,  G01N21/64

CPC分类号： C07K14/4748 ,  G01N33/57438

摘要： A method of detecting hepatocellular carcinoma includes using an isolated protein including an amino acid sequence represented by SEQ ID NO: 1.

摘要翻译： 检测肝细胞癌的方法包括使用包含SEQ ID NO：1所示氨基酸序列的分离蛋白。

公开(公告)号：US08207301B2

公开(公告)日：2012-06-26

申请号：US12452216

申请日：2008-06-16

申请人： Hirotaka Minagawa ,  Kenji Miyazaki ,  Yo Tabuse ,  Kenichi Kamijo ,  Shuichi Kaneko

发明人： Hirotaka Minagawa ,  Kenji Miyazaki ,  Yo Tabuse ,  Kenichi Kamijo ,  Shuichi Kaneko

IPC分类号： C07K14/435

CPC分类号： C07K14/4748 ,  G01N33/57438

摘要： Provided are: a method of assessing hepatocellular carcinoma by using a protein with a different phosphorylated state in hepatocellular carcinoma cells compared with non-hepatocellular carcinoma cells; and a hepatocellular carcinoma protein marker for detecting hepatocellular carcinoma formed of the protein. The hepatocellular carcinoma protein marker for detecting hepatocellular carcinoma includes tumor rejection antigen gp96 formed of the amino acid represented by SEQ ID NO: 1, and is measured for its phosphorylated state to detect the presence or absence of hepatocellular carcinoma.

摘要翻译： 提供：与非肝细胞癌细胞相比，通过使用肝细胞癌细胞中具有不同磷酸化状态的蛋白质来评估肝细胞癌的方法; 和用于检测由蛋白质形成的肝细胞癌的肝细胞癌蛋白标记物。 用于检测肝细胞癌的肝细胞癌蛋白标志物包括由SEQ ID NO：1表示的氨基酸形成的肿瘤排斥抗原gp96，并测量其磷酸化状态以检测肝细胞癌的存在或不存在。

公开(公告)号：US06524949B2

公开(公告)日：2003-02-25

申请号：US10003192

申请日：2001-10-29

申请人： Shuichi Kaneko ,  Hironori Aoki ,  Akio Iwabuchi

发明人： Shuichi Kaneko ,  Hironori Aoki ,  Akio Iwabuchi

IPC分类号： H01L214763

CPC分类号： H01L21/76804

摘要： There is formed on a semiconductor substrate a lamination of a first insulating film of nondoped silicon glass or the like and, on this first insulating film, a second insulating film of boron phosphor silicate glass or the like, with a conductor layer between the two insulating films. A hole is first dry-etched in the second insulating film, leaving the substrate surface covered by the first insulating film. Then the second insulating film is heated to a reflow temperature such that the hole is thermally deformed, flaring as it extends away from the insulating film. Then a second hole is dry-etched in the first insulating film through the first recited hole in the second insulating film, with the consequent exposure of the semiconductor surface. Then a contract electrode is fabricated by filling the first and the second hole with an electroconductive material into direct contact with the substrate surface. Being covered by the first insulating film, the substrate surface is not to be contaminated with impurities during the heating of the second insulating film.

公开(公告)号：US08053830B2

公开(公告)日：2011-11-08

申请号：US12169207

申请日：2008-07-08

申请人： Keiji Hannuki ,  Shuichi Kaneko

发明人： Keiji Hannuki ,  Shuichi Kaneko

IPC分类号： H01L29/76 ,  H01L29/94 ,  H01L31/062 ,  H01L31/113 ,  H01L31/119

CPC分类号： H01L29/7802 ,  H01L23/3677 ,  H01L23/3735 ,  H01L29/0657 ,  H01L29/41725 ,  H01L29/41741 ,  H01L29/7395 ,  H01L29/7811 ,  H01L29/7813 ,  H01L2924/0002 ,  H01L2924/00

摘要： A semiconductor device including a semiconductor section including a semiconductor element and a recess formed in one of main surfaces and a metallic member at least a part of which is embedded in the recess. A void is formed in a region of the metallic member corresponding to the recess.

摘要翻译： 一种半导体器件，包括半导体部件和半导体部件，所述半导体部件包括半导体元件和形成在主表面之一中的凹部和至少一部分嵌入在所述凹部中的金属部件。 在对应于凹部的金属构件的区域中形成空隙。

公开(公告)号：USRE40965E1

公开(公告)日：2009-11-10

申请号：US11065718

申请日：2005-02-24

申请人： Shuichi Kaneko ,  Hironori Aoki ,  Akio Iwabuchi

发明人： Shuichi Kaneko ,  Hironori Aoki ,  Akio Iwabuchi

IPC分类号： H01L21/4763

CPC分类号： H01L21/76804

摘要： There is formed on a semiconductor substrate a lamination of a first insulating film of nondoped silicon glass or the like and, on this first insulating film, a second insulating film of boron phosphor silicate glass or the like, with a conductor layer between the two insulating films. A hole is first dry-etched in the second insulating film, leaving the substrate surface covered by the first insulating film. Then the second insulating film is heated to a reflow temperature such that the hole is thermally deformed, flaring as it extends away from the insulating film. Then a second hole is dry-etched in the first insulating film through the first recited hole in the second insulating film, with the consequent exposure of the semiconductor surface. Then a contract electrode is fabricated by filling the first and the second hole with an electroconductive material into direct contact with the substrate surface. Being covered by the first insulating film, the substrate surface is not to be contaminated with impurities during the heating of the second insulating film.

公开(公告)号：US06600014B2

公开(公告)日：2003-07-29

申请号：US09380644

申请日：1999-11-09

申请人： Eiji Ogino ,  Michio Nomura ,  Takashi Asahi ,  Shuichi Kaneko ,  Akito Sakai

发明人： Eiji Ogino ,  Michio Nomura ,  Takashi Asahi ,  Shuichi Kaneko ,  Akito Sakai

IPC分类号： C07K1700

CPC分类号： A61M1/3633 ,  A61M1/3679 ,  A61M2205/7509 ,  B01J20/262 ,  B01J20/265 ,  B01J20/28078 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3255 ,  B01J20/3274 ,  B01J2220/58 ,  Y10S530/81

摘要： An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon therapy, an HCV adsorption apparatus including said adsorbent, and a adsorbing method for removing HCV are provided. An adsorbent for removing hepatitis C virus which comprises a compound capable of adsorbing hepatitis C virus as immobilized on a water-insoluble carrier, an adsorption apparatus including said adsorbent, and an adsorbing method for removing HCV.

摘要翻译： 一种用于除去丙型肝炎病毒的吸附剂，其具有从患者身体血液中安全地并以高效率和高选择性安全地吸收HCV颗粒，特别是免疫复合物HCV颗粒的能力，以提高干扰素疗法的功效，HCV吸附装置包括所述 吸附剂和用于除去HCV的吸附方法。一种用于除去丙型肝炎病毒的吸附剂，其包含固定在水不溶性载体上的能够吸附丙型肝炎病毒的化合物，包括所述吸附剂的吸附装置和吸附方法 去除HCV。

公开(公告)号：US20120258578A1

公开(公告)日：2012-10-11

申请号：US13527163

申请日：2012-06-19

申请人： Hironori AOKI ,  Shuichi Kaneko

发明人： Hironori AOKI ,  Shuichi Kaneko

IPC分类号： H01L21/336

CPC分类号： H01L29/7813 ,  H01L29/0696 ,  H01L29/0878 ,  H01L29/66734 ,  H01L29/7397

摘要： A semiconductor device includes an epitaxial layer having a first conduction type, a base layer formed adjacent and on the epitaxial layer and having an opposite second conduction type to the first conduction type, a source layer formed selectively on the base layer and having the first conduction type, a trench which passes through the base layer and the source layer and which reaches the epitaxial layer, an insulation film formed along an interior wall of the trench, a control electrode formed within the trench via the insulation film, and a semiconductor region formed along the bottom part of the trench at the epitaxial layer and having the first conduction type.

摘要翻译： 半导体器件包括具有第一导电类型的外延层，与外延层相邻并且在外延层上形成并具有与第一导电类型相反的第二导电类型的基极层，源层选择性地形成在基极层上并具有第一导电 类型，通过基底层和源极层并到达外延层的沟槽，沿着沟槽的内壁形成的绝缘膜，经由绝缘膜形成在沟槽内的控制电极和形成的半导体区域 沿着沟槽的底部在外延层处并具有第一导电类型。

公开(公告)号：US20120157341A1

公开(公告)日：2012-06-21

申请号：US13391858

申请日：2010-08-03

申请人： Shuichi Kaneko ,  Masao Honda ,  Yoshio Sakai ,  Taro Yamashita

发明人： Shuichi Kaneko ,  Masao Honda ,  Yoshio Sakai ,  Taro Yamashita

IPC分类号： C40B30/04 ,  C40B40/06

CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.

摘要翻译： 本发明提供了通过分析与消化器官癌相关的变化的表达水平（外周血）的基因来检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法和试剂， 胃癌，结肠直肠癌，胰腺癌或胆道癌，与正常健康人相比。 具体地，基于表达谱，检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法包括获得至少一种基因的表达谱，所述基因选自对应于具有 与正常健康受试者相比，消化器官癌，胃癌，结肠直肠癌，胰腺癌和胆道癌患者的表达水平（外周血）差异不大。 用于检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌的试剂含有由至少一种基因的核苷酸序列组成的核苷酸或其部分序列，所述核苷酸序列选自下组的探针：表达水平在 消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌，或含有与其互补的序列的核苷酸。

公开(公告)号：US07381435B2

公开(公告)日：2008-06-03

申请号：US10547548

申请日：2004-03-04

申请人： Satoshi Yoshida ,  Shuichi Kaneko

发明人： Satoshi Yoshida ,  Shuichi Kaneko

IPC分类号： A61K36/42 ,  A61K36/286 ,  A61K36/68 ,  A61K36/355

CPC分类号： A61K36/286 ,  A61K36/355 ,  A61K36/42 ,  A61K36/68 ,  A61K2300/00

摘要： By administering a composition comprising pumpkin seed, safflower, plantain and honeysuckle, subjective symptoms (for example, general malaise and abdominal swelling) of a patient with chronic hepatitis C can be eliminated and, moreover, objective symptoms diagnosed by a medical doctor (for example, liver enlargement and palm erythema) can be relieved or eliminated. From 1 to 3 months after the administration of the composition, a significant decrease in hepatitis C virus RNA level is gradually observed. Therefore, the above composition is useful at least as a composition for treating chronic hepatitis C. In particular, it is advantageous in treating a chronic hepatitis C patient showing a high chronic hepatitis C virus RNA level.

摘要翻译： 通过施用包含南瓜籽，红花，车前草和金银花的组合物，可以消除患有慢性丙型肝炎患者的主观症状（例如，一般不适和腹部肿胀），此外，由医生诊断的客观症状（例如， ，肝肿大和棕红斑）可以缓解或消除。 在组合物施用后1至3个月，逐渐观察到丙型肝炎病毒RNA水平的显着降低。 因此，上述组合物至少可用作治疗慢性丙型肝炎的组合物。特别是，治疗显示高的慢性丙型肝炎病毒RNA水平的慢性丙型肝炎患者是有利的。