摘要:
The present invention provides a polyester, a polyester composition and a pressure-sensitive adhesive composition capable of obtaining a pressure-sensitive adhesive which is global-environmentally friendly and is excellent in pressure-sensitive adhesion properties, using a plant-derived raw material; and a pressure-sensitive adhesive layer and a pressure-sensitive adhesive sheet which can be obtained by using the same. A polyester of the present invention is a polyester comprising at least a lactic acid unit, a dibasic acid unit and a glycol unit, wherein the dibasic acid unit contains dimer acid, and the polyester has a glass transition temperature as measured at a temperature rising rate of 20° C./minute using a differential scanning calorimeter, of −70 to −20° C., a weight average molecular weight of 20,000 to 300,000 and a hydroxyl value of 1 to 100 mgKOH/g.
摘要:
The present invention provides a polyester, a polyester composition and a pressure-sensitive adhesive composition capable of obtaining a pressure-sensitive adhesive which is global-environmentally friendly and is excellent in pressure-sensitive adhesion properties, using a plant-derived raw material; and a pressure-sensitive adhesive layer and a pressure-sensitive adhesive sheet which can be obtained by using the same. A polyester of the present invention is a polyester comprising at least a lactic acid unit, a dibasic acid unit and a glycol unit, wherein the dibasic acid unit contains dimer acid, and the polyester has a glass transition temperature as measured at a temperature rising rate of 20° C./minute using a differential scanning calorimeter, of −70 to −20° C., a weight average molecular weight of 20,000 to 300,000 and a hydroxyl value of 1 to 100 mgKOH/g.
摘要:
A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: wherein the ring X is a benzene ring or a pyridine ring; R1 and R2 are hydrogen or alkyl or together form a cycloalkene ring; R3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5 is a halogen atom or a hydrogen atom.
摘要翻译:一种治疗涉及Rho激酶的疾病的方法。 该方法通过向有需要的患者施用药学有效量的下式化合物或其药学上可接受的盐进行:其中环X是苯环或吡啶环; R1和R2是氢或烷基或一起形成环烯烃环; R 3是氢,取代的烷基,未取代的烯基,羧基或其酯或酰胺,氨基或氰基; R4是氢,羟基,取代或未取代的烷氧基,未取代的烯氧基,未取代的环烷基氧基取代或未取代的烷基,未取代的烯基,未取代的环烷基,氨基,取代或未取代的烷基氨基,硝基,氰基或单环杂环; R5为卤素原子或氢原子。
摘要:
A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: wherein the ring X is a benzene ring or a pyridine ring; R1 and R2 are hydrogen or alkyl or together form a cycloalkene ring; R3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy, substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5 is a halogen atom or a hydrogen atom.
摘要翻译:一种治疗涉及Rho激酶的疾病的方法。 该方法通过向有需要的患者施用药学有效量的下式化合物或其药学上可接受的盐进行:其中环X是苯环或吡啶环; R1和R2是氢或烷基或一起形成环烯烃环; R 3是氢,取代的烷基,未取代的烯基,羧基或其酯或酰胺,氨基或氰基; R4是氢,羟基,取代或未取代的烷氧基,未取代的烯氧基,未取代的环烷基氧基,取代或未取代的烷基,未取代的烯基,未被取代的环烷基,氨基,取代或未取代的烷基氨基,硝基,氰基或单环杂环; R5为卤素原子或氢原子。
摘要:
A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: , wherein the ring X is a benzene ring or a pyridine ring; R1 and R2 are hydrogen or alkyl or together form a cycloalkene ring; R3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy, substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5 is a halogen atom or a hydrogen atom.
摘要翻译:一种治疗涉及Rho激酶的疾病的方法。 该方法通过向有需要的患者施用药学有效量的下式化合物或其药学上可接受的盐进行:其中环X是苯环或吡啶环; R1和R2是氢或烷基或一起形成环烯烃环; R 3是氢,取代的烷基,未取代的烯基,羧基或其酯或酰胺,氨基或氰基; R4是氢,羟基,取代或未取代的烷氧基,未取代的烯氧基,未取代的环烷基氧基,取代或未取代的烷基,未取代的烯基,未被取代的环烷基,氨基,取代或未取代的烷基氨基,硝基,氰基或单环杂环; R5为卤素原子或氢原子。
摘要:
An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.
摘要翻译:本发明的目的是产生一种可用作药物的新型吲唑衍生物,并找到该衍生物的新药理作用。 本发明的化合物由式[I]表示,具有优异的Rho激酶抑制作用。 在该式中,环X为苯环或吡啶环; R1和R2是H或烷基; R 3和R 4是卤素,H,OH,烷氧基,烯氧基,炔氧基,环烷氧基,环烯氧基,芳氧基,烷基,烯基,炔基,环烷基,环烯基,芳基,羧基,烃基,烷基羰基等。 和R 5是卤素原子,H,OH,烷氧基,芳氧基,烷基或芳基。 每组可以替代。
摘要:
In lap joint welding of galvanized sheets, the occurence of blowhole and pit is prevented by applying a blowhole.multidot.pit preventing agent comprising a phosphorus compound as an effective ingredient prior to the arc-welding.
摘要:
A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: wherein the ring X is a benzene ring or a pyridine ring; R1 and R2 are hydrogen or alkyl or together form a cycloalkene ring; R3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5 is a halogen atom or a hydrogen atom.
摘要翻译:一种治疗涉及Rho激酶的疾病的方法。 该方法通过向有需要的患者施用药学有效量的下式化合物或其药学上可接受的盐进行:其中环X是苯环或吡啶环; R1和R2是氢或烷基或一起形成环烯烃环; R 3是氢,取代的烷基,未取代的烯基,羧基或其酯或酰胺,氨基或氰基; R4是氢,羟基,取代或未取代的烷氧基,未取代的烯氧基,未取代的环烷基氧基取代或未取代的烷基,未取代的烯基,未取代的环烷基,氨基,取代或未取代的烷基氨基,硝基,氰基或单环杂环; R5为卤素原子或氢原子。
摘要:
A method for treating glaucoma comprising administering to a patient pharmaceutically effective amounts of a Rho kinase inhibitor and a prostaglandin.
摘要:
A fluorine-containing prostaglandin derivative of the formula (1) (or a salt thereof) and a medicine containing it, particularly, a preventive or therapeutic medicine for an eye disease: ##STR1## wherein A is a vinylene group or the like, R.sup.1 is an aryloxyalkyl group or the like, R.sup.2 and R.sup.3 are hydrogen atoms or the like, and Z is OR.sup.4 (wherein OR.sup.4 is a hydrogen atom or an alkyl group) or the like.