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    SYSTEMS AND METHODS FOR 3-DIMENSIONAL INTERFEROMETRIC MICROSCOPY
    3.
    发明申请
    SYSTEMS AND METHODS FOR 3-DIMENSIONAL INTERFEROMETRIC MICROSCOPY 有权
    用于三维干涉显微镜的系统和方法

    公开(公告)号：US20140293015A1

    公开(公告)日：2014-10-02

    申请号：US14302153

    申请日：2014-06-11

    Applicant: Howard Hughes Medical Institute

    Inventor： Harald F. Hess

    IPC: G01B9/02 ,  H04N13/02 ,  G01N21/64

    CPC classification number: G01B9/02041 ,  G01B9/02007 ,  G01B9/02081 ,  G01B9/02097 ,  G01B9/04 ,  G01B2290/45 ,  G01B2290/55 ,  G01N21/6456 ,  G01N21/6458 ,  G02B21/0056 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/14 ,  G02B21/367 ,  H04N13/214

    Abstract: In one embodiment, an apparatus comprises an optical system with multiple detectors and a processor. The optical system is configured to produce images of an optical source in a first dimension and a second dimension substantially orthogonal to the first dimension at each detector at a given time. Each image from the images is based on an interference of an emission from the optical source in a first direction and an emission from the optical source in a second direction different from the first direction. The processor is configured to calculate a position in a third dimension based on the images. The third dimension is substantially orthogonal to the first dimension and the second dimension.

    Abstract translation: 在一个实施例中，一种装置包括具有多个检测器和处理器的光学系统。 光学系统被配置为在给定时间在每个检测器处产生第一尺寸和基本上垂直于第一尺寸的第二尺寸的光源的图像。 来自图像的每个图像基于来自第一方向上的来自光源的发射的干扰和来自与第一方向不同的第二方向的来自光源的发射。 处理器被配置为基于图像计算第三维度中的位置。 第三尺寸基本上与第一尺寸和第二尺寸正交。

    Enhanced FIB-SEM Systems for Large-Volume 3D Imaging
    6.
    发明申请
    Enhanced FIB-SEM Systems for Large-Volume 3D Imaging 审中-公开

    公开(公告)号：US20180218878A1

    公开(公告)日：2018-08-02

    申请号：US15883025

    申请日：2018-01-29

    Applicant: Howard Hughes Medical Institute

    Inventor： C. Shan Xu ,  Kenneth J. Hayworth ,  Harald F. Hess

    IPC: H01J37/28 ,  H01J37/30 ,  H01J37/31 ,  H01J37/244 ,  G01N23/2251

    Abstract: A microscopy system for imaging a sample can include a scanning electron microscope system configured for imaging a surface layer of the sample and a focused ion beam system configured for generating an ion beam for milling the surface layer away from a sample after it has been imaged. A movable mechanical shutter can be configured to be moved automatically into a position between the sample and the scanning electron microscope system, so that when the electron beam is not imaging the sample the movable mechanical shutter is positioned between the sample and the scanning electron microscope system.

    Sectioning volume samples
    8.
    发明授权
    Sectioning volume samples 有权

    公开(公告)号：US10054518B2

    公开(公告)日：2018-08-21

    申请号：US14533904

    申请日：2014-11-05

    Applicant: Howard Hughes Medical Institute

    Inventor： Harald F. Hess ,  David Peale ,  Patrick R. Lee

    IPC: B26D1/00 ,  G01N1/06

    CPC classification number: G01N1/06 ,  G01N2001/065 ,  Y10T83/0448 ,  Y10T83/148 ,  Y10T83/6577

    Abstract: A microtome includes a blade located at an end of a trough that defines a cavity for holding a liquid; a sample block in which the at least one sample is suspended, the sample block is moveable relative to the blade such that when the sample block is passed across the blade a section is cut from the sample block; a plate that includes a support frame that defines an opening, and a transparent film extending across the opening, the transparent film being transparent to electrons, a grasper being configured to receive and retain the plate, wherein the grasper is moveable relative to the blade; and a pusher section that lacks the sample pusher section.

    SECTIONING VOLUME SAMPLES
    9.
    发明申请
    SECTIONING VOLUME SAMPLES 审中-公开
    分批体积

    公开(公告)号：US20150135917A1

    公开(公告)日：2015-05-21

    申请号：US14533904

    申请日：2014-11-05

    Applicant: Howard Hughes Medical Institute

    Inventor： Harald F. Hess ,  David Peale ,  Patrick R. Lee

    IPC: G01N1/06

    CPC classification number: G01N1/06 ,  G01N2001/065 ,  Y10T83/0448 ,  Y10T83/148 ,  Y10T83/6577

    Abstract: A microtome includes a blade located at an end of a trough that defines a cavity for holding a liquid; a sample block in which the at least one sample is suspended, the sample block is moveable relative to the blade such that when the sample block is passed across the blade a section is cut from the sample block; a plate that includes a support frame that defines an opening, and a transparent film extending across the opening, the transparent film being transparent to electrons, a grasper being configured to receive and retain the plate, wherein the grasper is moveable relative to the blade; and a pusher section that lacks the sample pusher section.

    Abstract translation: 切片机包括位于槽的端部处的刀片，其限定用于保持液体的空腔; 其中所述至少一个样品悬挂在其中，所述样品块相对于所述叶片可移动，使得当所述样品块通过所述叶片时，从所述样品块切割切片; 包括限定开口的支撑框架的板和穿过所述开口延伸的透明膜，所述透明膜对于电子是透明的，抓持器构造成容纳和保持所述板，其中所述抓紧器可相对于所述叶片移动; 以及缺少样品推动器部分的推动器部分。

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