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    MICROFLUIDIC CHIP-BASED DNA COMPUTER
    1.
    发明申请
    MICROFLUIDIC CHIP-BASED DNA COMPUTER 审中-公开
    基于微流控芯片的DNA计算机

    公开(公告)号：US20110177980A1

    公开(公告)日：2011-07-21

    申请号：US11759048

    申请日：2007-06-06

    申请人： Bingcheng Lin ,  Bowel Li ,  Hua Xie ,  Jianhua Qin ,  Yisheng Zhu ,  Zhende Huang

    发明人： Bingcheng Lin ,  Bowel Li ,  Hua Xie ,  Jianhua Qin ,  Yisheng Zhu ,  Zhende Huang

    IPC分类号： C40B60/08

    CPC分类号： B82Y10/00 ,  G06N99/007

    摘要： The present invention relates to computer science, molecular biology and microfluidics technique which provides a DNA molecular computer based on microfluidic chip. The objective is to provide a DNA molecular computer which uses the microfluidic chip as a operation platform, mainly including: using DNA molecules as operation media, using the microfluidic chip as the operation platform of a DNA molecular operator; using DNA molecules as storage media, using the microfluidic chip as the operation platform of a DNA molecular storage; using a electronic computer and a detector as the kernel of a controller; said microfluidic chip includes a DNA molecular computation region and a DNA molecular storage region. The microfluidic chip consists of digestion, ligation, PCR amplification and chip electrophoresis unit connected by microchannels in turn, and carries out the liquid control through micropumps and microvalves.

    摘要翻译： 本发明涉及计算机科学，分子生物学和微流体技术，其提供了基于微流控芯片的DNA分子计算机。 目的是提供一种使用微流控芯片作为操作平台的DNA分子计算机，主要包括：使用DNA分子作为操作介质，使用微流控芯片作为DNA分子操作者的操作平台; 使用DNA分子作为存储介质，使用微流控芯片作为DNA分子存储的操作平台; 使用电子计算机和检测器作为控制器的内核; 所述微流体芯片包括DNA分子计算区域和DNA分子存储区域。 微流控芯片由消化，连接，PCR扩增和芯片电泳单元依次由微通道连接，并通过微泵和微型阀进行液体控制。

    Wound dressing devices and methods
    2.
    发明申请
    Wound dressing devices and methods 有权
    伤口敷料装置及方法

    公开(公告)号：US20100172958A1

    公开(公告)日：2010-07-08

    申请号：US12387378

    申请日：2009-05-01

    申请人： Lisa Lucchesi ,  Hua Xie

    发明人： Lisa Lucchesi ,  Hua Xie

    IPC分类号： A61K31/722 ,  A61L15/26 ,  A61P17/02

    CPC分类号： A61L15/28 ,  C08L5/08

    摘要： The present invention provides an absorbent wound dressing assembly that can be used to stanch, seal, or stabilize a site of tissue injury, tissue trauma, or tissue access. The wound dressing assembly is flexible so that it can be adapted and used to fit in narrow and small wound sites. Generally the wound dressing assembly comprises a flexible carrier material that is impregnated with a non-mammalian material for control of severe bleeding. The preferred non-mammalian material is poly [β-(1→4)-2-amino-2-deoxy-D-glucopyranose] more commonly referred to as chitosan.

    摘要翻译： 本发明提供一种吸收性伤口敷料组件，其可用于对组织损伤，组织创伤或组织进入部位进行固定，密封或稳定。 伤口敷料组件是柔性的，使得它可以适应并用于适应狭窄和小的伤口部位。 伤口敷料组件通常包括用非哺乳动物材料浸渍以控制严重出血的柔性载体材料。 优选的非哺乳动物材料是通常被称为壳聚糖的聚[和（1→4）-2-氨基-2-脱氧-D-吡喃葡萄糖]。

    Methods and systems for measuring mechanical property of a vascular wall and method and system for determining health of a vascular structure
    3.
    发明授权
    Methods and systems for measuring mechanical property of a vascular wall and method and system for determining health of a vascular structure 有权
    用于测量血管壁的机械性能的方法和系统，以及用于确定血管结构健康的方法和系统

    公开(公告)号：US07318804B2

    公开(公告)日：2008-01-15

    申请号：US10731302

    申请日：2003-12-09

    申请人： William F. Weitzel ,  Kang Kim ,  Matthew O'Donnell ,  Jonathan M. Rubin ,  Hua Xie ,  Xunchang Chen

    发明人： William F. Weitzel ,  Kang Kim ,  Matthew O'Donnell ,  Jonathan M. Rubin ,  Hua Xie ,  Xunchang Chen

    IPC分类号： A61B8/00

    CPC分类号： A61B8/485 ,  A61B8/08

    摘要： Methods and systems for measuring mechanical property of a vascular wall and a method and system for determining health of a vascular structure are provided wherein local deformation of a vessel wall resulting from physiologic pressures with altered transmural forces is measured. A non-invasive free-hand ultrasound scanning-procedure was performed to apply external force, comparable to the force generated in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. When the applied pressure matched the internal baseline diastolic pressure, strain and strain rate increased by a factor of 10 over a cardiac cycle. Radial arterial strain was assessed in the vessel wall over the entire deformation procedure using a phase-sensitive, two-dimensional speckle-tracking algorithm. An elastic modulus reconstruction procedure was developed to estimate the non-linear elastic properties of the vascular wall.

    摘要翻译： 提供了用于测量血管壁的机械性能的方法和系统以及用于确定血管结构健康的方法和系统，其中测量由具有改变的透壁力的生理压力引起的血管壁的局部变形。 进行非侵入性自由手超声扫描程序以施加外力，与测量受试者血压时产生的力相当，以通过平衡内部动脉基线压力来实现更高的应变。 当施加的压力与内部基线舒张压相匹配时，应变和应变率在心脏周期上增加10倍。 使用相敏二维斑点跟踪算法，在整个变形过程的血管壁中评估径向动脉应变。 开发弹性模量重建程序来估计血管壁的非线性弹性性质。

    User preference techniques for support vector machines in content based image retrieval
    4.
    发明申请
    User preference techniques for support vector machines in content based image retrieval 失效
    基于内容的图像检索中支持向量机的用户偏好技术

    公开(公告)号：US20060112095A1

    公开(公告)日：2006-05-25

    申请号：US11243501

    申请日：2005-10-03

    申请人： Hua Xie ,  Antonio Ortega

    发明人： Hua Xie ,  Antonio Ortega

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30029 ,  G06F17/30038 ,  G06F17/30047 ,  G06K9/6253 ,  G06K9/6269

    摘要： Searching multimedia information which allows determining preferences based on very little amounts of data. The preferences are nonparametrically determined. Each preference is quantized into one of a plurality of bins. By doing the quantization, the distances between positive and negative samples are increased. The quantization amount may change depending on the number of samples which are used. The quantization can be used in a support vector machine or the like.

    摘要翻译： 搜索允许基于非常少量的数据来确定偏好的多媒体信息。 偏好是非参数确定的。 每个偏好被量化成多个箱体之一。 通过进行量化，正和负样本之间的距离增加。 量化量可以根据所使用的样本的数量而变化。 量化可以用在支持向量机等中。

    Wound dressing devices and methods
    5.
    发明授权
    Wound dressing devices and methods 有权
    伤口敷料装置及方法

    公开(公告)号：US09205170B2

    公开(公告)日：2015-12-08

    申请号：US12387378

    申请日：2009-05-01

    申请人： Lisa Lucchesi ,  Hua Xie

    发明人： Lisa Lucchesi ,  Hua Xie

    IPC分类号： A61L15/28

    CPC分类号： A61L15/28 ,  C08L5/08

    摘要： The present invention provides an absorbent wound dressing assembly that can be used to stanch, seal, or stabilize a site of tissue injury, tissue trauma, or tissue access. The wound dressing assembly is flexible so that it can be adapted and used to fit in narrow and small wound sites. Generally the wound dressing assembly comprises a flexible carrier material that is impregnated with a non-mammalian material for control of severe bleeding. The preferred non-mammalian material is poly [β-(1→4)-2-amino-2-deoxy-D-glucopyranose] more commonly referred to as chitosan.

    摘要翻译： 本发明提供一种吸收性伤口敷料组件，其可用于对组织损伤，组织创伤或组织进入部位进行固定，密封或稳定。 伤口敷料组件是柔性的，使得它可以适应和用于适应狭窄和小的伤口部位。 伤口敷料组件通常包括用非哺乳动物材料浸渍以控制严重出血的柔性载体材料。 优选的非哺乳动物材料是通常被称为壳聚糖的聚[和（1→4）-2-氨基-2-脱氧-D-吡喃葡萄糖]。

    PUSH/TRACKING SEQUENCES FOR SHEAR WAVE DISPERSION VIBROMETRY
    6.
    发明申请
    PUSH/TRACKING SEQUENCES FOR SHEAR WAVE DISPERSION VIBROMETRY 有权
    用于剪切波分散振动的推/拉序列

    公开(公告)号：US20120123262A1

    公开(公告)日：2012-05-17

    申请号：US13379741

    申请日：2010-06-30

    申请人： Hua Xie ,  Anna Teresa Fernandez ,  Michael R. Burcher ,  Douglas Maxwell

    发明人： Hua Xie ,  Anna Teresa Fernandez ,  Michael R. Burcher ,  Douglas Maxwell

    IPC分类号： A61B8/00

    CPC分类号： A61B8/00 ,  A61B5/0048 ,  A61B5/0051 ,  A61B8/085 ,  A61B8/485 ,  A61B8/5223 ,  G01S7/52022

    摘要： Shear Wave Dispersion Vibrometry (SDUV) is performed such that, after a single instance of their push pulse (218), a plurality of tracking pulses (222) are issued to sample, more than once, each of a plurality of locations (120, 148) on an associated monochromatic shear wave (116) in sampling that at least one of scans the plural locations in separate passes and, with a pulse of the plural tracking pulses, samples multiple ones of the plural locations concurrently. In a supplementary aspect, phase difference, for a given moment, is determined by taking into account intersample delay (156), if the determination relies on samples that are taken at different times.

    摘要翻译： 执行剪切波分散振动波谱（SDUV），使得在其单次推送脉冲（218）之后，发出多个跟踪脉冲（222）以多次采样多个位置（120,120）中的每一个， 148）在相关联的单色剪切波（116）上进行采样，以便在单独的通过中的多个位置的扫描中的至少一个并且多个跟踪脉冲中的脉冲同时对多个位置中的多个位置进行采样。 在补充方面，如果确定依赖于在不同时间拍摄的样本，则通过考虑采样间延迟（156）来确定给定时刻的相位差。

    METHOD AND DEVICE FOR PRODUCING IMAGES OF HEATING TINES NEAR A TISSUE PART
    7.
    发明申请
    METHOD AND DEVICE FOR PRODUCING IMAGES OF HEATING TINES NEAR A TISSUE PART 有权
    用于生产靠近组织部分的加热片图像的方法和装置

    公开(公告)号：US20110184286A1

    公开(公告)日：2011-07-28

    申请号：US12673206

    申请日：2008-07-30

    申请人： Matt Bruce ,  Thomas Gauthier ,  Hua Xie ,  Anna T. Fernandez

    发明人： Matt Bruce ,  Thomas Gauthier ,  Hua Xie ,  Anna T. Fernandez

    IPC分类号： A61B8/00

    CPC分类号： A61B18/1477 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/4416 ,  A61B8/485 ,  A61B18/02 ,  A61B2017/00084 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2090/378

    摘要： A device (D1) is intended for producing images of heating tines (HT) coupled to a needle (N) positioned near a chosen tissue part of tissues located in an area of a body. This device (D1) comprises i) a means (ME) for estimating tissue thermal strains, induced by means of the heating tines (HT) into the tissue surrounding the chosen tissue part, from received ultrasound image data, and for deducing relative positions of these heating tines (HT) to the chosen tissue part from the estimated tissue thermal strains, and ii) a means (MC) for combining the received ultrasound image data with position data representative of the deduced relative positions to produce images of the area with thermal strain information showing the relative positions of the heating tines (HT) to the chosen tissue part.

    摘要翻译： 设备（D1）用于产生耦合到位于身体的区域中的选定的组织部分附近的针（N）的加热尖头（HT）的图像。 该装置（D1）包括i）用于估计从接收的超声图像数据通过加热尖（HT）诱导到围绕所选择的组织部分的组织中的组织热应变的装置（ME），并且用于推定 这些加热尖（HT）从估计的组织热应变到所选择的组织部分，以及ii）用于将接收到的超声图像数据与表示推导的相对位置的位置数据组合的装置（MC），以产生具有热的区域的图像 显示加热尖（HT）到所选择的组织部分的相对位置的应变信息。

    Method for suturelessly attaching a biomaterial to an implantable bioprosthesis frame
    8.
    发明授权
    Method for suturelessly attaching a biomaterial to an implantable bioprosthesis frame 失效
    将生物材料无缝连接到可植入生物假体框架的方法

    公开(公告)号：US07322932B2

    公开(公告)日：2008-01-29

    申请号：US10770978

    申请日：2004-02-02

    申请人： Hua Xie ,  Lisa A. Buckley

    发明人： Hua Xie ,  Lisa A. Buckley

    IPC分类号： A61F2/04

    CPC分类号： A61F2/2418 ,  A61F2/2475 ,  A61F2220/0075 ,  A61F2230/0026

    摘要： A bioprosthetic valve graft comprises a valve frame and valve flaps, the latter acting to open or close a valve aperture to directionally control fluid flow through the bioprosthesis. The bioprosthetic valve graft comprises method for suturelessly attaching a biomaterial suturelessly bonded to the A method for securing a biomaterial to a valve frame includes positioning a flexible valve frame defining an open area on a first major surface of a biomaterial sheet having a peripheral edge, wherein positioning serves to approximate the valve frame and the peripheral edge of the biomaterial sheet to form an at least first bonding locus; and suturelessly bonding the biomaterial to the valve frame at the at least first bonding locus. The method avoids the disadvantages associated with conventional sutures and substantially reduces medical complications in implantations.

    摘要翻译： 生物假体瓣膜移植物包括阀框架和瓣瓣，后者用于打开或关闭阀孔以定向地控制通过生物假体的流体流动。 生物假体瓣膜移植物包括用于将无缝结合到A方法上的生物材料无缝连接的方法，用于将生物材料固定到瓣膜框架上的方法包括将限定开口区域的柔性瓣膜框架定位在具有周边边缘的生物材料片材的第一主表面上，其中 定位用于近似生物材料板的阀框架和周边边缘以形成至少第一粘合位置; 以及在所述至少第一接合位置处将所述生物材料无缝地结合到所述阀框架。 该方法避免了与常规缝线相关的缺点并且显着减少了植入物中的医疗并发症。