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公开(公告)号：US06635684B2
公开(公告)日：2003-10-21
申请号：US10083242
申请日：2001-10-19
申请人： Huey-Min Lai , Chun-Hui Chang , Chun-Jen Liao , Chin-Fu Chen , Kuei-Hung Wu , Yuan-Chia Chang , Yu-Yen Jan , Tsung-Yi Mou
发明人： Huey-Min Lai , Chun-Hui Chang , Chun-Jen Liao , Chin-Fu Chen , Kuei-Hung Wu , Yuan-Chia Chang , Yu-Yen Jan , Tsung-Yi Mou
IPC分类号： C08J900
CPC分类号： C08L5/08 , C07K17/08 , C08B37/003 , C08H1/06 , C08J9/26 , C08J2201/0462 , C08L89/06 , C08L2666/02
摘要： The present invention discloses a method for preparing a hydrophilic porous polymeric material comprising the step of mixing a hydrophilic polymeric material with a hydrophobic material; solvent sintering the surface of the hydrophilic polymeric material with water or an aqueous solution; and removing the hydrophobic material contained within the hydrophilic polymeric material with a massive organic solvent. Thus, the hydrophilic porous polymeric material with high porosity and stable structure is rapidly mass produced.
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公开(公告)号：US07767445B2
公开(公告)日：2010-08-03
申请号：US11808117
申请日：2007-06-06
申请人： Chun-Jen Liao , Yu-Ju Lin , Chin-Fu Chen , Ken-Yuan Chang , Shu-Fang Chiang
发明人： Chun-Jen Liao , Yu-Ju Lin , Chin-Fu Chen , Ken-Yuan Chang , Shu-Fang Chiang
CPC分类号： C12N5/0655 , C12N5/0062 , C12N2533/40
摘要： A porous chamber for tissue culture in vitro. The porous chamber includes a main body made of porous biologically absorbable polymer material, comprising an inner surface surrounding a hollow cavity, the hollow cavity having an aperture opened at an upper surface of the main body, wherein the aperture is communicated with outside of the main body for seeding tissue blocks in the hollow cavity, and an upper cover passing through the upper surface of the main body to seal the aperture to prevent the tissue blocks from outflowing.
摘要翻译： 用于组织培养的多孔室。 所述多孔室包括由多孔生物可吸收聚合物材料制成的主体，包括围绕中空腔的内表面，所述中空腔具有在所述主体的上表面处开口的孔，其中所述孔与所述主体的外部连通 在中空腔中播种组织块的主体，以及穿过主体的上表面的上盖，以密封孔以防止组织块流出。
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公开(公告)号：US20090011506A1
公开(公告)日：2009-01-08
申请号：US12031415
申请日：2008-02-14
申请人： Chung-Nun CHEN , Chun-Jen Liao , Chin-Yu Lin , Chin-Fu Chen , Yung-Chih Wu
发明人： Chung-Nun CHEN , Chun-Jen Liao , Chin-Yu Lin , Chin-Fu Chen , Yung-Chih Wu
CPC分类号： B08B3/102 , B01L3/502 , B01L2300/045 , B01L2300/046 , B01L2300/0681 , B01L2300/0832 , B01L2400/0478 , C12M47/12
摘要： An apparatus for washing cells and/or tissue includes an outer sleeve, an inner assembly, and a filter. The outer sleeve includes a closed end and an open end. The inner assembly is axially movable in the outer sleeve. The filter is affixed to the inner assembly, wherein a chamber is formed by the filter, the outer sleeve, and the inner assembly. Furthermore, a process for washing cells and/or tissue comprising: (a) providing an apparatus as described above, wherein the cells and/or tissue and washing liquid are disposed in the chamber, and (b) axially moving the inner assembly to wash the cells and/or tissue.
摘要翻译： 用于洗涤细胞和/或组织的装置包括外套筒，内组件和过滤器。 外套筒包括封闭端和开口端。 内部组件可在外套筒中轴向移动。 过滤器固定在内部组件上，其中通过过滤器，外部套筒和内部组件形成腔室。 此外，用于洗涤细胞和/或组织的方法包括：（a）提供如上所述的装置，其中细胞和/或组织和洗涤液体设置在腔室中，和（b）轴向移动内部组件以洗涤 细胞和/或组织。
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公开(公告)号：US06884621B2
公开(公告)日：2005-04-26
申请号：US10620339
申请日：2003-07-17
申请人： Chun-Jen Liao , Yu-Ju Lin , Chin-Fu Chen
发明人： Chun-Jen Liao , Yu-Ju Lin , Chin-Fu Chen
CPC分类号： A61L27/3847 , A61L27/56 , C12N5/0068 , C12N2533/40
摘要： The present invention provides method and carrier for culturing multi-layered tissue in vitro, wherein few amounts of tissue blocks and cells are positioned within a porous multi-layer carrier consisting of a cavity structure. By taking advantage of the structure of the carrier, tissue blocks and cells are separated into different layers according to their sizes, and incubated in vitro to reconstruct a multi-layered tissue for tissue repair.
摘要翻译： 本发明提供体外培养多层组织的方法和载体，其中少量的组织块和细胞位于由空腔结构构成的多孔多层载体内。 通过利用载体的结构，将组织块和细胞根据其大小分成不同的层，并在体外温育以重建用于组织修复的多层组织。
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公开(公告)号：US08623641B2
公开(公告)日：2014-01-07
申请号：US12104685
申请日：2008-04-17
申请人： Chung-Nun Chen , Chun-Jen Liao , Chin-Yu Lin , Chin-Fu Chen , Yung-chih Wu
发明人： Chung-Nun Chen , Chun-Jen Liao , Chin-Yu Lin , Chin-Fu Chen , Yung-chih Wu
CPC分类号： B08B3/102 , B01L3/502 , B01L2300/045 , B01L2300/046 , B01L2300/0681 , B01L2300/0832 , B01L2400/0478 , C12M47/12
摘要： In a general aspect, an apparatus for washing biological material is provided which includes an outer sleeve, and an inner sleeve disposed within the outer sleeve. The outer sleeve has an open end for receiving the biological material, and an opposed closed end. The inner sleeve is detachably and slidably positioned within the outer sleeve, and includes a first port for receiving and dispensing washing liquid, a second port defining a liquid flow path between an interior of the inner sleeve and an interior of the outer sleeve, and a filter disposed in the second port. The filter allows passage of washing liquid but not passage of the biological material therethrough. A chamber, formed between the filter and the closed end of the outer sleeve, is configured to permit flow of washing liquid via the filter while retaining the biological material therein.
摘要翻译： 在一般方面，提供了一种用于洗涤生物材料的装置，其包括外套筒和设置在外套筒内的内套筒。 外套筒具有用于接收生物材料的开口端和相对的封闭端。 所述内套筒可拆卸地且可滑动地定位在所述外套筒内，并且包括用于接收和分配清洗液体的第一端口，限定在所述内套筒的内部和所述外套筒的内部之间的液体流路的第二端口， 过滤器设置在第二端口中。 过滤器允许洗涤液体通过，但不允许生物材料通过。 形成在过滤器和外套管的封闭端之间的室被构造成允许经由过滤器流动清洗液体，同时将生物材料保持在其中。
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公开(公告)号：US06436426B1
公开(公告)日：2002-08-20
申请号：US09870370
申请日：2001-05-30
申请人： Chun-Jen Liao , Chin-Fu Chen , Jui-Hsiang Chen , Ken-Yuan Chang , Yure-Ru Lin , Shu-Fang Chiang
发明人： Chun-Jen Liao , Chin-Fu Chen , Jui-Hsiang Chen , Ken-Yuan Chang , Yure-Ru Lin , Shu-Fang Chiang
IPC分类号： A61F200
CPC分类号： C08J9/26 , C08J2201/0444 , C08J2201/046 , C08J2201/0542
摘要： The present invention provides a process for producing porous polymer materials. In the present invention, a polymer material and a soluble material are mixed in their solid states. The surface of the polymer material is partially dissolved and fused by introducing a solvent. The present invention makes use of a pressure difference while introducing a non-solvent into the polymer material to solidify and resolve the solved polymer material. Then, a substantial amount of water is used to wash the inside soluble material out. Therefore, the porous polymer materials with high porosity and interconnecting pores inside the materials are produced massively and rapidly.
摘要翻译： 本发明提供一种生产多孔聚合物材料的方法。 在本发明中，将聚合物材料和可溶性材料以其固态混合。 通过引入溶剂将聚合物材料的表面部分溶解并熔融。 本发明利用压力差，同时将非溶剂引入聚合物材料中以固化和分解溶解的聚合物材料。 然后，大量的水被用来洗涤内部的可溶性材料。 因此，材料内部具有高孔隙率和互连孔的多孔聚合物材料大量且快速地产生。
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公开(公告)号：US20090007937A1
公开(公告)日：2009-01-08
申请号：US12104685
申请日：2008-04-17
申请人： Chung-Nun Chen , Chun-Jen Liao , Chin-Yu Lin , Chin-Fu Chen , Yung-chih Wu
发明人： Chung-Nun Chen , Chun-Jen Liao , Chin-Yu Lin , Chin-Fu Chen , Yung-chih Wu
IPC分类号： B08B3/04
CPC分类号： B08B3/102 , B01L3/502 , B01L2300/045 , B01L2300/046 , B01L2300/0681 , B01L2300/0832 , B01L2400/0478 , C12M47/12
摘要： In a general aspect, an apparatus for washing biological material is provided which includes an outer sleeve, and an inner sleeve disposed within the outer sleeve. The outer sleeve has an open end for receiving the biological material, and an opposed closed end. The inner sleeve is detachably and slidably positioned within the outer sleeve, and includes a first port for receiving and dispensing washing liquid, a second port defining a liquid flow path between an interior of the inner sleeve and an interior of the outer sleeve, and a filter disposed in the second port. The filter allows passage of washing liquid but not passage of the biological material therethrough. A chamber, formed between the filter and the closed end of the outer sleeve, is configured to permit flow of washing liquid via the filter while retaining the biological material therein.
摘要翻译： 在一般方面，提供了一种用于洗涤生物材料的装置，其包括外套筒和设置在外套筒内的内套筒。 外套筒具有用于接收生物材料的开口端和相对的封闭端。 所述内套筒可拆卸地且可滑动地定位在所述外套筒内，并且包括用于接收和分配洗涤液体的第一端口，限定所述内套筒的内部和所述外套筒的内部之间的液体流路的第二端口，以及 过滤器设置在第二端口中。 过滤器允许洗涤液体通过，但不允许生物材料通过。 形成在过滤器和外套管的封闭端之间的室被构造成允许经由过滤器流动清洗液体，同时将生物材料保持在其中。
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公开(公告)号：US20080026455A1
公开(公告)日：2008-01-31
申请号：US11808117
申请日：2007-06-06
申请人： Chun-Jen Liao , Yu-Ju Lin , Chin-Fu Chen , Ken-Yuan Chang , Shu-Fang Chiang
发明人： Chun-Jen Liao , Yu-Ju Lin , Chin-Fu Chen , Ken-Yuan Chang , Shu-Fang Chiang
IPC分类号： C12M3/00
CPC分类号： C12N5/0655 , C12N5/0062 , C12N2533/40
摘要： A porous chamber for tissue culture in vitro. The porous chamber includes a main body made of porous biologically absorbable polymer material, comprising an inner surface surrounding a hollow cavity, the hollow cavity having an aperture opened at an upper surface of the main body, wherein the aperture is communicated with outside of the main body for seeding tissue blocks in the hollow cavity, and an upper cover passing through the upper surface of the main body to seal the aperture to prevent the tissue blocks from outflowing.
摘要翻译： 用于组织培养的多孔室。 所述多孔室包括由多孔生物可吸收聚合物材料制成的主体，包括围绕中空腔的内表面，所述中空腔具有在所述主体的上表面处开口的孔，其中所述孔与所述主体的外部连通 在中空腔中播种组织块的主体，以及穿过主体的上表面的上盖，以密封孔以防止组织块流出。
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公开(公告)号：US06824716B2
公开(公告)日：2004-11-30
申请号：US10241440
申请日：2002-09-12
申请人： Chun-Jen Liao , Yu-Ju Lin , Chin-Fu Chen , Ken-Yuan Chang
发明人： Chun-Jen Liao , Yu-Ju Lin , Chin-Fu Chen , Ken-Yuan Chang
IPC分类号： B29C6720
CPC分类号： C08J9/26 , B29C67/202 , C08J2201/042 , C08J2201/044 , C08J2201/0464
摘要： A process for producing porous polymer material. The method combines a polymer and water-soluble granules to form a mixture. The mixture is placed into a mold; the surface of the polymer is dissolved to cause cohesion and form a polymer structure having water-soluble granules dispersed within, and water is introduced into the inner part of the polymer structure so that the polymer is solidified and water-soluble granules are washed out to obtain a porous polymer material. According to the invention, single or multiple layers of porous polymer material with different apertures, porosities, or made with different materials, are obtained by combining different polymer materials and water-soluble granules having different particle sizes in different weight ratios.
摘要翻译： 一种多孔聚合物材料的制造方法。 该方法结合聚合物和水溶性颗粒以形成混合物。 将混合物放入模具中; 溶解聚合物的表面以引起内聚，并形成分散在其中的水溶性颗粒的聚合物结构，并且将水引入聚合物结构的内部，使得聚合物固化并将水溶性颗粒冲洗至 获得多孔聚合物材料。 根据本发明，通过将不同聚合物材料和具有不同重量比的不同粒度的水溶性颗粒结合，获得具有不同孔径，孔隙率或不同材料制成的单层或多层多孔聚合物材料。
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公开(公告)号：US20120323279A1
公开(公告)日：2012-12-20
申请号：US13161705
申请日：2011-06-16
申请人： Yang-Hwei Tsuang , Chun-Jen Liao , Huang-Chien Liang , Shih-Jui Han , Fon-Yih Tsuang , Chang-Jung Chiang
发明人： Yang-Hwei Tsuang , Chun-Jen Liao , Huang-Chien Liang , Shih-Jui Han , Fon-Yih Tsuang , Chang-Jung Chiang
IPC分类号： A61B17/88
CPC分类号： A61B17/8863 , A61B17/0625 , A61B17/7002 , A61B17/7083 , A61B17/7085 , A61B17/7089 , A61B17/7091 , A61B2090/037
摘要： A spinal fixation assembly includes a pedicle rod and pedicle screws which secure the pedicle rod to the spine. Each pedicle screw includes a head configured to receive a portion of the pedicle rod, and a threaded portion extending from a first end of the head and configured to engage a vertebra. The pedicle rod is secured to the head by a fastener. The head includes a breakaway region that defines a location in which at least a first portion of the head can be easily separated from the remainder of the head upon application of sufficient force to the first portion. A minimally invasive method of implanting the spinal fixation assembly is disclosed.
摘要翻译： 脊柱固定组件包括将椎弓根杆固定到脊柱的椎弓根杆和椎弓根螺钉。 每个椎弓根螺钉包括构造成接收椎弓根杆的一部分的头部，以及从头部的第一端延伸并被配置为接合椎骨的螺纹部分。 椎弓根杆通过紧固件固定到头部。 头部包括一个分离区域，该区域限定了一个位置，其中当对第一部分施加足够的力时，头部的至少第一部分可以容易地与头部的其余部分分离。 公开了一种植入脊柱固定组件的微创方法。
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