公开(公告)号：US11959060B1

公开(公告)日：2024-04-16

申请号：US16875897

申请日：2020-05-15

申请人： Humacyte, Inc.

发明人： Heather L. Prichard ,  Dustin Cashman ,  Joshua McCall ,  Laura E. Niklason ,  Benjamin Orbon ,  Justin T. Strader

IPC分类号： C12M1/00 ,  C12M1/34

CPC分类号： C12M29/14 ,  C12M23/14 ,  C12M29/26 ,  C12M41/12 ,  C12M41/40

摘要： Embodiments of the present disclosure are directed to systems, apparatuses, devices and methods for tissue cultivating. Such systems may comprise a plurality of bioreactors, each bioreactor comprising a bag having a mandrel tube arranged therein, and a fluid management system for managing fluid flow among the plurality of bioreactors. The fluid management system can include at least one intra-luminal pump, configured to flow intra-luminal fluid in a first direction in the bioreactors, at least one media pump, configured to flow biomedia fluid in the bioreactors in a second direction opposite to the first direction, and a plurality of valves and/or clamps to effect at least one of filling, flowing, cessation of flow, and draining of at least one of the intra-luminal fluid and biomedia fluid tubes among the bioreactors.

公开(公告)号：US09657265B2

公开(公告)日：2017-05-23

申请号：US14495339

申请日：2014-09-24

申请人： Humacyte, Inc.

发明人： Shannon L. M. Dahl ,  Laura E. Niklason ,  Juliana Blum ,  Justin T. Strader ,  William E. Tente ,  Heather L. Prichard ,  Joseph J. Lundquist

IPC分类号： A61F2/06 ,  C12N5/00 ,  A61F2/04 ,  B29C53/00 ,  B29C53/36 ,  A61L27/34 ,  B29K67/00 ,  B29K105/00 ,  B29L23/00 ,  B29L31/00

CPC分类号： C12N5/0068 ,  A61F2/04 ,  A61F2/06 ,  A61F2002/047 ,  A61F2002/048 ,  A61L27/16 ,  A61L27/18 ,  A61L27/34 ,  A61L27/3633 ,  A61L27/38 ,  A61L27/3895 ,  A61L27/54 ,  A61L27/58 ,  B29C53/005 ,  B29C53/36 ,  B29K2067/043 ,  B29K2105/256 ,  B29K2995/0056 ,  B29K2995/006 ,  B29L2023/00 ,  B29L2031/7532 ,  C12N2533/30 ,  C12N2533/40 ,  Y10T156/1038 ,  C08L67/04

摘要： The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.

公开(公告)号：US20210246419A1

公开(公告)日：2021-08-12

申请号：US17159817

申请日：2021-01-27

申请人： Humacyte, Inc.

发明人： Shannon L.M. DAHL ,  Laura E. NIKLASON ,  Justin T. STRADER ,  William E. TENTE ,  Joseph J. LUNDQUIST ,  Juliana Blum ,  Heather L. Prichard

IPC分类号： C12N5/00 ,  A61L27/34 ,  A61F2/06 ,  A61F2/04 ,  B29C53/00 ,  B29C53/36 ,  A61L27/16 ,  A61L27/18 ,  A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58

摘要： The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.